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Combigan Ophthalmic Solution 5 ml is used to lower intraocular pressure in conditions like glaucoma and ocular hypertension. It works by decreasing the production of aqueous humour and increasing the amount of liquid that is drained. In some cases, this medicine may cause side effects such as a burning sensation, eye redness, itching, irritation, and vision disturbances. Avoid touching the container's tip to the eye, eyelids, or surrounding areas, as it may contaminate the product.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Allergan Healthcare India Pvt Ltd

Consume Type :

Ophthalmic

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Combigan Ophthalmic Solution 5 ml

Combigan Ophthalmic Solution 5 ml is a prescription eye drop used to lower high pressure inside the eyes of adults with open-angle glaucoma or ocular hypertension. High eye pressure can slowly damage the optic nerve, much like too much pressure inside an over-inflated tyre can cause damage over time. By lowering this pressure, the medicine helps protect the optic nerve and reduce the risk of gradual vision loss. This medicine is specifically formulated to combine the benefits of two active pressure-reducing ingredients into a single bottle.

For the best results, you must use Combigan Ophthalmic Solution 5 ml consistently and exactly as directed by your doctor. It is typically applied once or twice a day, and maintaining a regular daily schedule is crucial for keeping your eye pressure stable. Along with using these eye drops, making healthy lifestyle choices—such as scheduling regular eye examinations and avoiding smoking—can further support your overall eye health.

Like many eye medications, Combigan Ophthalmic Solution 5 ml can cause mild, temporary side effects such as eye redness, stinging, or blurred vision immediately after application. While these mild symptoms usually fade quickly, you should contact your doctor right away if you experience serious side effects, such as severe eye pain, changes in your vision, or a very slow heart rate. It is important to monitor how your eyes and body respond to the drops.

Do not use this medicine if you have certain health conditions, including asthma, chronic obstructive pulmonary disease (COPD), or serious heart conditions like a slow heartbeat or heart failure. Before starting Combigan Ophthalmic Solution 5 ml, always talk to your doctor or pharmacist if you have a history of diabetes, overactive thyroid, or poor blood circulation. Your doctor will help determine if this is the safest treatment option for your specific medical background.

This medicine can interact with other treatments, including oral blood pressure medicines, heart medications, or sedatives, which may cause your blood pressure or heart rate to drop too low. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to weigh the benefits and potential risks before using these drops. It is also wise to limit alcohol consumption while using this medicine, as it can increase feelings of sleepiness. It is not recommended for children younger than 2 years of age because brimonidine may cause serious side effects affecting the brain and breathing, including excessive sleepiness, low body temperature, and breathing difficulties.

Uses of Combigan Ophthalmic Solution 5 ml

This medicine is used to lower increased pressure inside the eye and help protect the optic nerve from damage. It is commonly prescribed for long-term management of conditions associated with raised eye pressure. The detailed uses of Combigan Ophthalmic Solution 5 ml are as follows:

  • Open-angle glaucoma: Combigan Ophthalmic Solution 5 ml helps by lowering the high fluid pressure inside the eye, which prevents progressive damage to the optic nerve and preserves your eyesight.
  • Ocular hypertension: Combigan Ophthalmic Solution 5 ml works to reduce elevated pressure within the eye even if you do not have active nerve damage, helping to protect your eyes from developing future vision complications.

Key Benefits

This medicine helps lower eye pressure and protect your vision by reducing the risk of damage caused by increased pressure inside the eye. Its benefits include:

  • Helps lower high pressure inside the eye and maintain it within a healthy range.
  • Protects the optic nerve and helps reduce the risk of vision loss caused by glaucoma.
  • Provides long-term protection even when high eye pressure does not cause noticeable symptoms.
  • Combines two pressure-lowering medicines in one eye drop for effective treatment.
  • Reduces the need to use multiple separate eye drops, making treatment simpler and more convenient.

Directions for Use

  • It is recommended to use Combigan Ophthalmic Solution 5 ml twice daily, approximately 12 hours apart, or as advised by your doctor.
  • Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the prescribed number of drops into the pocket. Close your eyes for 1-2 minutes.
  • Avoid touching the container tip to the eye or eyelids to prevent contamination.

How Combigan Ophthalmic Solution 5 ml Works

Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine Tartrate: is an alpha-2 adrenergic agonist (a type of medicine that lowers eye pressure). It works by reducing the amount of fluid produced inside the eye while helping fluid drain out more easily, which lowers eye pressure. Timolol: It is a beta-blocker (a type of medicine that reduces fluid production inside the eye). By producing less fluid, the pressure inside the eye decreases, helping protect the optic nerve. Benzalkonium Chloride: It is a preservative that helps keep the eye drops free from bacterial contamination and maintains the sterility of the solution during use.
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Alcohol

Caution

It is not known if alcohol interacts with Combigan Ophthalmic Solution 5 ml. Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding. Your doctor will decide if Combigan Ophthalmic Solution 5 ml can be used by breastfeeding mothers or not.

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Driving

Caution

Combigan Ophthalmic Solution 5 ml might cause tiredness, drowsiness, and blurred/abnormal vision. So, avoid driving or operating machinery until your vision is clear.

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Liver

Caution

Please consult your doctor if you have any concerns regarding the usage of Combigan Ophthalmic Solution 5 ml in patients with liver impairment.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding the usage of Combigan Ophthalmic Solution 5 ml in patients with kidney impairment.

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Children

Unsafe

Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years, as safety and effectiveness have not been established.

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Heart

Consult your doctor

Please consult your doctor if you have any concerns regarding using Combigan Ophthalmic Solution 5 ml in patients with heart problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Combigan Ophthalmic Solution 5 ml should be used in elderly patients only if prescribed by a doctor. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Combigan Ophthalmic Solution 5 ml

If you accidentally put too many drops in your eye, rinse your eye thoroughly with clean, warm water. If the medicine is swallowed accidentally, or if you experience severe symptoms like a dangerously slow heart rate, extreme dizziness, or difficulty breathing, seek immediate medical attention or contact a poison control center right away.

Diet & Lifestyle Advise

  • Elevate your head while sleeping: Keep your head slightly raised (using an extra pillow or elevating the head of your bed by 20 degrees) to help lower your eye pressure during the night.
  • Avoid prolonged head-down positions: Avoid activities that require you to keep your head down for long periods, such as heavy weightlifting, straining, or certain yoga poses, as these can temporarily increase pressure in your head and eyes.
  • Limit caffeine intake: Large amounts of caffeine can cause a temporary rise in eye pressure. Try to limit your consumption of coffee, energy drinks, and strong teas.
  • Avoid smoking: Tobacco use harms your blood vessels and can reduce the blood flow to your optic nerve, which can worsen glaucoma damage. Quitting smoking is highly beneficial for your eyes.
  • Schedule regular eye examinations: Visit your eye care specialist regularly to have your eye pressure and visual field checked, as this is the only way to ensure your treatment is working effectively.
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How Soon It Starts Working

The time required for Combigan Ophthalmic Solution 5 ml to start to work: The effect Combigan Ophthalmic Solution 5 ml starts to show its action within 30 minutes of administration.

The time for which the effects of Combigan Ophthalmic Solution 5 ml last: Combigan Ophthalmic Solution 5 ml effect lasts for 12 hours.

What if you forget to take Combigan Ophthalmic Solution 5 ml

If you miss a dose of Combigan Ophthalmic Solution 5 ml, apply the missed drop as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular routine. Do not apply a double dose of eye drops to make up for a missed one.

Storage

• Store Combigan Ophthalmic Solution 5 ml at room temperature between 15°C and 25°C (59°F to 77°F). •keep the bottle tightly closed when not in use. Store the bottle in a dry place away from direct light and high heat,

Drug Warnings

  • Check the solution before use: Always inspect the liquid inside the bottle. It should be clear and pale yellow; do not use the drops if the solution is cloudy, discolored, or contains visible particles.
  • Remove contact lenses first: The preservative in Combigan Ophthalmic Solution 5 ml can be absorbed by soft contact lenses and cause discoloration. Always remove your lenses before applying the drops and wait at least 15 minutes before reinserting them.
  • Avoid touching the dropper tip: To prevent eye infections and keep the medicine sterile, never let the tip of the bottle touch your eye, eyelid, skin, or any other surface.
  • Be careful when driving: These drops can cause temporary blurred vision or mild sleepiness. Do not drive, ride a bicycle, or use tools or machinery until your vision is completely clear and you feel fully alert.
  • Tell your surgical team: If you need any type of surgery, including dental work, tell your surgeon or anesthesiologist that you use Combigan Ophthalmic Solution 5 ml, as the ingredients can interact with certain anesthetic medications.

Drug-Drug Interactions

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  • Oral beta-blockers: Taking these eye drops together with beta-blocker tablets (such as metoprolol or atenolol) may make both medicines work more strongly, increasing the risk of low blood pressure and a slow heart rate.
  • Calcium channel blockers and digoxin: Combining these drops with heart medications can increase the risk of heart block or dangerously slow heartbeats.
  • Certain antidepressants: Some older medicines used to treat depression may interact with Combigan Ophthalmic Solution 5 ml and increase the risk of drowsiness or changes in blood pressure. Tell your doctor or pharmacist about all antidepressants you are taking so they can check for possible interactions.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Alcohol: Avoid drinking alcohol while using Combigan Ophthalmic Solution 5 ml, as it can worsen side effects like drowsiness, dizziness, and slow reflexes.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[OPHTHALMOLOGIC AGENTS]

FAQs

Combigan Ophthalmic Solution 5 ml is indicated for lowering elevated intraocular pressure in patients with glaucoma or ocular hypertension.
Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.
Combigan Ophthalmic Solution 5 ml might cause blurred vision and vision disturbances. So, avoid driving or operating machinery until your vision is clear to prevent any mishappening.
Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you have hypertension. Regularly monitor blood pressure levels while taking Combigan Ophthalmic Solution 5 ml to prevent unpleasant events.
Dry mouth could be a side-effect of Combigan Ophthalmic Solution 5 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Combigan Ophthalmic Solution 5 ml can be used with other eye medications if prescribed by the doctor. However, maintain a gap of 5-10minutes between Combigan Ophthalmic Solution 5 ml and other eye medications.
Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you are diabetic as Combigan Ophthalmic Solution 5 ml contains timolol; it might lower the blood glucose levels and may mask the symptoms of low blood sugar levels. Regular monitoring of blood glucose levels whilst taking Combigan Ophthalmic Solution 5 ml is advised.
Combigan Ophthalmic Solution 5 ml is a highly effective eye drop combination for reducing intraocular pressure (IOP) in glaucoma or ocular hypertension patients. Clinical studies have demonstrated that this combination reduces IOP by 25-30% or more, and its efficacy is superior to either brimonidine or timolol alone. Additionally, Combigan Ophthalmic Solution 5 ml has a rapid onset of action, with significant IOP reduction observed within 1-2 hours, and its effectiveness is maintained over time with long-term use.
Combigan Ophthalmic Solution 5 ml should be stored in a cool, dry place at a temperature between 15°C to 30°C (59°F to 86°F). Do not refrigerate or freeze.
Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the number of drops advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes. If any liquid spills out of your eye, gently blot it away with a clean tissue.
Storage: Store Combigan Ophthalmic Solution 5 ml at room temperature between 15°C and 30°C (59°F and 86°F). Keep the bottle away from direct light and excessive heat. Always replace the cap tightly after use to prevent contamination. Disposal: Do not dispose of unused or expired medication in household trash or wastewater. Follow local regulations for proper medication disposal. Dispose of empty bottles according to local guidelines for medical waste.
Combigan Ophthalmic Solution 5 ml has several contraindications, including hypersensitivity to its components, reactive airway disease, severe cardiovascular disease, and certain heart conditions. It is also not recommended for neonates, infants, pregnant, or breastfeeding women, unless the benefits outweigh the risks. However, this list is not exhaustive, and it's crucial to consult with your doctor before using this medication. They will evaluate your individual situation and provide personalized guidance on safe use.
No, you should not apply these drops while wearing soft contact lenses. The preservative in Combigan Ophthalmic Solution 5 ml can be absorbed by the lenses, which can damage or discolor them. You must remove your contact lenses before applying the drops and wait at least 15 minutes before putting them back in. Talk to your doctor or pharmacist if you need more advice on contact lens care.
Pressing the inner corner of your eye (near your nose) for 1 to 2 minutes keeps the medicine in your eye where it is needed. This simple step stops the drops from draining into your nose and throat, which reduces the amount of medicine absorbed into your bloodstream and lowers the risk of body-wide side effects. Talk to your doctor or pharmacist to learn the correct application technique.
A mild, temporary burning or stinging sensation right after applying the drops is quite common and usually goes away within a few minutes. However, if the stinging is severe, causes persistent eye pain, or is accompanied by swelling or itching, stop using the drops and talk to your doctor or pharmacist immediately.
Yes, one of the active ingredients in Combigan Ophthalmic Solution 5 ml can cause drowsiness, fatigue, or a feeling of tiredness in some people. Because of this, you should avoid driving, riding a bike, or operating machinery until you are certain how this medicine affects your alertness. Talk to your doctor or pharmacist if this sleepiness interferes with your daily activities.
No, you should not use Combigan Ophthalmic Solution 5 ml if you have asthma, severe chronic obstructive pulmonary disease (COPD), or a history of wheezing. One of the active ingredients is a beta-blocker that can be absorbed into your body and cause serious, life-threatening breathing difficulties. Talk to your doctor or pharmacist to find a safer alternative for your eye pressure.
If you stop using Combigan Ophthalmic Solution 5 ml without consulting your healthcare provider, the fluid pressure inside your eye can rise rapidly. This hidden increase in pressure can damage your optic nerve, potentially leading to permanent vision loss. Talk to your doctor or pharmacist before making any changes to your eye drop routine.
There is limited safety information about using Combigan Ophthalmic Solution 5 ml during pregnancy, so it should only be used if your doctor determines that the benefits clearly outweigh the risks to your baby. If you are pregnant, planning to become pregnant, or are breastfeeding, talk to your doctor or pharmacist to discuss your options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

No.3, Kasturba Road, Level 2, Prestige Obelisk, Bangalore – 560 001., KARNATAKA, INDIA
Other Info - COM0005
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