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Combipara-TR Tablet is used in the symptomatic treatment of moderate to severe pain. It works by blocking the release of certain chemical messengers in the brain that cause pain. Also, it blocks the transmission of pain signals to the brain to lower pain perception. It may cause nausea, vomiting, anxiety, stomach pain, indigestion, loss of appetite, dryness in the mouth, dizziness, dleepiness, and heartburn. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ACECLOFENAC-100MG+PARACETAMOL-325MG+TRAMADOL-37.5MG

Manufacturer/Marketer :

Delcure Life Sciences Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Combipara-TR Tablet

Combipara-TR Tablet is a prescription medicine used to relieve moderate to severe pain, including joint pain, arthritis-related pain, and musculoskeletal injuries. It helps reduce pain and improve daily comfort by combining three pain-relieving medicines that work through different mechanisms.

For optimal results, it is important to take this combination pain tablet consistently and exactly at the intervals recommended by your doctor. You should always take this oral medication with food or a glass of milk to help reduce stomach irritation. Incorporating gentle, low-impact movements and staying well-hydrated can also support your physical recovery during treatment.

While taking this medication, you may experience some common side effects such as nausea, dizziness, or mild drowsiness. However, you should contact your doctor immediately if you experience serious symptoms like difficulty breathing, severe skin reactions, or yellowing of your eyes and skin. Monitoring how your body responds to the medicine is key to a safe recovery.

Before you begin taking Combipara-TR Tablet , you must talk to your doctor if you have a history of stomach ulcers, asthma, or kidney issues. Do not take this medication if you have severe liver damage, active internal bleeding, or a known allergy to any of its components. Sharing your complete medical history helps ensure this medicine is safe for you.

This medication can interact with other substances; for instance, combining it with sleeping aids can cause dangerous drowsiness, while smoking may worsen stomach irritation and delay healing. You should completely avoid alcohol because it increases the risk of severe liver damage. Pregnant women, breastfeeding mothers, and elderly individuals must consult their doctor before using this medicine, as special precautions are required.

Uses of Combipara-TR Tablet

Combipara-TR Tablet is used in the symptomatic treatment of moderate to severe pain. The detailed uses of Combipara-TR Tablet are as follows:

  • Moderate to severe acute pain: Combipara-TR Tablet helps by blocking pain signals in the brain and reducing local tissue inflammation.
  • Osteoarthritis: Combipara-TR Tablet helps by reducing joint pain, swelling, and stiffness, making physical movement easier.
  • Rheumatoid arthritis: Combipara-TR Tablet helps relieve chronic joint inflammation and autoimmune-related pain.
  • Ankylosing spondylitis: Combipara-TR Tablet targets painful inflammation in the spine and pelvis to restore flexibility.
  • Post-operative pain: Combipara-TR Tablet helps manage acute discomfort following surgical procedures to aid smoother recovery.

Key Benefits

  • Combipara-TR Tablet provides comprehensive pain relief by targeting pain at both the tissue level and within the central nervous system. This dual action helps relieve stubborn discomfort that single-ingredient pain relievers might not fully address.
  • By significantly reducing inflammation and pain, this medicine supports faster physical recovery, allowing you to return to your daily activities and regain pain-free movement.
  • It helps improve sleep quality and overall daily functioning by keeping severe, throbbing pain under control throughout the day and night.
Side effects of Combipara-TR Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet, as this can release the medication too quickly and increase the risk of side effects.
  • Take the tablet with or immediately after a meal to minimise stomach upset.
  • Always follow your doctor's exact instructions regarding how often to take this medicine, and never take more than the prescribed amount.

How Combipara-TR Tablet Works

Combipara-TR Tablet contains three active ingredients that work together to relieve pain and reduce inflammation: • Aceclofenac: This is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the action of chemical messengers called cyclooxygenase (COX) enzymes, which stops the production of prostaglandins—the chemicals responsible for causing pain and swelling at the site of injury. • Paracetamol: This is a mild pain reliever and fever reducer. It acts primarily in the central nervous system to block pain signals and lower body temperature by affecting the heat-regulating center in the brain. • Tramadol: This is an opioid pain reliever. It works by binding to specific receptors in the brain and spinal cord to block the transmission of pain signals, while also increasing levels of chemical messengers like serotonin and norepinephrine to alter how your brain perceives pain.
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Alcohol

Unsafe

Taking excessive alcohol with Combipara-TR Tablet can cause liver damage. So, it is advisable to avoid or limit intake of alcohol during the treatment with Combipara-TR Tablet .

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Pregnancy

Caution

Combipara-TR Tablet can have harmful effects on pregnancy. If you are pregnant, consult your doctor before taking this medicine. See medical advice if you become pregnant while on treatment with Combipara-TR Tablet .

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Breast Feeding

Caution

If you are breastfeeding, you may experience some harmful effects of Combipara-TR Tablet . In case you experience any of these, discontinue its use until you consult your doctor.

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Driving

Caution

Avoid driving or operating heavy machinery after taking Combipara-TR Tablet as you may feel sleepy.

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Liver

Caution

The liver can be affected by Combipara-TR Tablet . If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart Combipara-TR Tablet only after medical advice.

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Kidney

Caution

Combipara-TR Tablet rarely may affect kidneys. If you experience unwanted symptoms while using this medicine, seek medical advice.

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Children

Caution

Combipara-TR Tablet should not be administered to children unless a child expert has prescribed it. The dose of the medication will be determined by your doctor based on your child's weight and the severity of the problem.

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Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Combipara-TR Tablet should be used with extreme caution in elderly patients due to an increased risk of adverse effects. Dose adjustments maybe needed in some patients.

What if I have taken an overdose of Combipara-TR Tablet

If you suspect an overdose or have taken more than the recommended amount, seek immediate medical attention or contact emergency services. Symptoms of an overdose can include severe drowsiness, pinpoint pupils, breathing difficulties, or loss of consciousness.

Diet & Lifestyle Advise

  • Fiber-rich diet: Since some components of this medicine can cause constipation, increase your intake of dietary fiber by eating more fruits, vegetables, and whole grains.
  • Adequate hydration: Drink plenty of water throughout the day to support kidney function and help prevent constipation associated with strong pain relievers.
  • Stomach protection: Avoid spicy, acidic, or highly fried foods that can irritate your stomach lining while taking pain medications.
  • Gentle mobility: Engage in light stretching or low-impact exercises, like walking, as recommended by your physical therapist to prevent joint stiffness without worsening pain.
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Have a query?

How Soon It Starts Working

  • The time required for Combipara-TR Tablet to start to work: Combipara-TR Tablet ideally shows its action within 1 to 2 hours after administration.
  • The time for which the effects of Combipara-TR Tablet last: The duration of action for Combipara-TR Tablet is unknown.

What if you forget to take Combipara-TR Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check the packaging before use to ensure the blister strip is intact and the tablets are not broken or discolored.
  • Avoid driving, operating heavy machinery, or performing tasks that require mental alertness until you know how this medicine affects you, as it can cause dizziness and drowsiness.
  • Never take other medications containing paracetamol (acetaminophen) while taking Combipara-TR Tablet , as this can lead to accidental overdose and serious liver damage.
  • Do not stop taking this medicine suddenly if you have been using it for a prolonged period, as this may trigger withdrawal symptoms. Speak with your doctor about gradually reducing the dose if treatment needs to be stopped.
  • Monitor your breathing, especially during the first few days of treatment and after dose increases, as tramadol can occasionally cause slow or shallow breathing.
  • Use only for the prescribed duration: This medicine is generally intended for short-term pain management. Do not continue taking it for longer than prescribed, particularly because it contains an opioid component (tramadol), which may increase the risk of dependence and other side effects with prolonged use.
  • Tell your doctor if you have kidney problems: Patients with renal impairment may require dose adjustments or closer monitoring. Always follow your doctor's dosing instructions carefully.
  • If you have had a head injury or have pressure building inside your skull, tell your doctor, as tramadol may mask important symptoms. Extra caution is needed in conditions where slowed breathing could pose additional risks.
  • Children and adolescents: This medicine is generally not recommended for children under 12 years of age. Use in adolescents should be based on a doctor's assessment of the benefits and risks.

Drug-Drug Interactions

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Drug-Drug Interactions:

  • Taking this medicine with other central nervous system depressants, such as sleeping pills or anti-anxiety drugs, can lead to extreme drowsiness and dangerous breathing difficulties.
  • Combining this medication with blood thinners like warfarin can increase the risk of stomach bleeding.
  • Using this drug alongside certain antidepressants (like SSRIs or MAOIs) may increase the risk of a rare but serious condition called serotonin syndrome.

Drug-Food Interactions:

  • Grapefruit or grapefruit juice may interact with this medication, potentially altering how the body processes it and increasing the risk of side effects.

Drug-Disease Interactions:

  • Liver disease: This medication can worsen liver function and increase the risk of liver damage in individuals with pre-existing liver conditions.
  • Kidney disease: Use with caution, as the ingredients are cleared through the kidneys and can cause fluid retention or worsen kidney function.
  • Asthma: Individuals with a history of aspirin-sensitive asthma may experience bronchospasm (sudden tightening of the airways that makes breathing difficult).
  • Epilepsy or seizures: This medication can make seizures more likely to occur, increasing the risk of seizures in prone individuals.
Aceclofenac + Paracetamol + TramadolSafinamide
Critical
Aceclofenac + Paracetamol + TramadolZiprasidone
Critical

Drug-Drug Interactions

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Aceclofenac + Paracetamol + TramadolSafinamide
Critical
How does the drug interact with Combipara-TR Tablet:
Taking Aceclofenac, Paracetamol and Tramadol with Safinamide can increase the risk of high blood pressure, serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Aceclofenac, Paracetamol and Tramadol with Safinamide is generally avoided, it can be taken together if prescribed by a doctor. However, if you experience fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. Avoid consuming tyramine rich foods, beverages. It is advised to maintain at least 14 days of gap between both the medications. Do not stop using any medications without a doctor's advice.
Aceclofenac + Paracetamol + TramadolZiprasidone
Critical
How does the drug interact with Combipara-TR Tablet:
Co-administration of Aceclofenac, Paracetamol and Tramadol with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Aceclofenac, Paracetamol and Tramadol with Ziprasidone is avoided as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience sudden dizziness, breathing difficulty, rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
Aceclofenac + Paracetamol + TramadolPhenelzine
Critical
How does the drug interact with Combipara-TR Tablet:
Using Aceclofenac, Paracetamol and Tramadol with Phenelzine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Aceclofenac, Paracetamol and Tramadol with Phenelzine is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. It is advised to maintain at least 14 days of gap between both the medications. Do not stop using any medications without a doctor's advice.
Aceclofenac + Paracetamol + TramadolAlvimopan
Critical
How does the drug interact with Combipara-TR Tablet:
Co-administration of Aceclofenac, Paracetamol and Tramadol with Alvimopan can increase the side effects.

How to manage the interaction:
Taking Aceclofenac, Paracetamol and Tramadol with Alvimopan is not recommended, it can be taken if prescribed by the doctor. However, if you experience symptoms such as abdominal pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting the doctor.
Aceclofenac + Paracetamol + TramadolTranylcypromine
Critical
How does the drug interact with Combipara-TR Tablet:
Taking Aceclofenac, Paracetamol and Tramadol with Tranylcypromine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Using Aceclofenac, Paracetamol and Tramadol with Tranylcypromine is not recommended, it can be taken together if prescribed by a doctor. However, if you experience sudden dizziness, fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. It is advised to maintain at least 14 days of gap between both the medications. Do not stop using any medications without a doctor's advice.
Aceclofenac + Paracetamol + TramadolLinezolid
Critical
How does the drug interact with Combipara-TR Tablet:
Co-administration of Aceclofenac, Paracetamol and Tramadol with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Aceclofenac, Paracetamol and Tramadol with Linezolid is generally avoided, it can be taken if advised by the doctor. However, if you experience fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. It is advised to maintain at least 14 days of gap between both the medications. Do not stop using any medications without a doctor's advice.
Aceclofenac + Paracetamol + TramadolRasagiline
Critical
How does the drug interact with Combipara-TR Tablet:
Taking Aceclofenac, Paracetamol and Tramadol with rasagiline can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Aceclofenac, Paracetamol and Tramadol with rasagiline is not recommended, it can be taken if advised by your doctor. However, if you experience sudden dizziness, fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. It is advised to maintain at least 14 days of gap between both the medications. Do not stop using any medications without a doctor's advice.
Aceclofenac + Paracetamol + TramadolGabapentin
Severe
How does the drug interact with Combipara-TR Tablet:
Using Aceclofenac, Paracetamol and Tramadol with Gabapentin can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although there is a possible interaction between Aceclofenac, Paracetamol and Tramadol with Gabapentin, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you have any symptoms such as dizziness, drowsiness, difficulty concentrating, loss of control of movements. Avoid driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
Aceclofenac + Paracetamol + TramadolClonazepam
Severe
How does the drug interact with Combipara-TR Tablet:
Co-administration of Aceclofenac, Paracetamol and Tramadol with Clonazepam may lead to side effects such as respiratory distress(a condition in which fluid builds up in the lungs).

How to manage the interaction:
Taking Aceclofenac, Paracetamol and Tramadol with Clonazepam can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you notice dizziness, drowsiness, difficulty concentrating, loss of control of movements. Avoid driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
Aceclofenac + Paracetamol + TramadolBaclofen
Severe
How does the drug interact with Combipara-TR Tablet:
Co-administration of Aceclofenac, Paracetamol and Tramadol with Baclofen can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Aceclofenac, Paracetamol and Tramadol with baclofen together can result in an interaction, it can be taken on a doctor's advice. However, consult a doctor if you have any symptoms such as dizziness, drowsiness, difficulty concentrating, loss of control of movements. Avoid driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

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Therapeutic Class

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FAQs

Combipara-TR Tablet is used in the symptomatic treatment of moderate to severe pain.
Your doctor decides the dose and duration of the medicine depending on your health condition. In general, it is not used for more than five days, as prolonged usage may lead to dependence.
Combipara-TR Tablet , when taken by patients who are allergic to painkillers or NSAIDs, can be harmful. It should also be avoided in a person with a history of heart failure, kidney or liver disease, and stomach ulcers.
No. Combipara-TR Tablet is not indicated for stomach pain. If you have stomach pain, refer to the doctor, as it may be a sign of stomach ulcer or gastric bleeding.
It is highly recommended to take Combipara-TR Tablet with or after food to protect your stomach lining from irritation and reduce the risk of nausea. Talk to your doctor if you experience ongoing stomach upset.
Yes, Combipara-TR Tablet contains active components that can cause drowsiness and dizziness as common side effects. Avoid driving or operating machinery while taking this medication until you know how it affects you. Talk to your doctor if drowsiness becomes severe.
No, you should avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage, stomach bleeding, excessive drowsiness, and breathing problems. Talk to your doctor or pharmacist if you have concerns.
One of the active ingredients in Combipara-TR Tablet is tramadol, an opioid medicine that can lead to physical dependence if used for a prolonged period or in higher doses than prescribed. Always take this medication exactly as directed and discuss your treatment duration with your doctor.
You should not take other pain relievers, especially those containing paracetamol or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, without consulting a healthcare professional. Combining medicines may increase the risk of overdose or serious side effects. Talk to your doctor before taking additional pain medications.
This medication is generally not recommended during pregnancy or breastfeeding unless specifically prescribed by your doctor. Some of its ingredients may affect the baby or pass into breast milk. Talk to your doctor to discuss the potential risks and available alternatives.
Constipation is a common side effect of tramadol. Drinking plenty of water, eating high-fiber foods, and staying physically active can help. Talk to your doctor if constipation is severe, persistent, or causing significant discomfort.
This combination is generally intended for short-term use unless your doctor advises otherwise. Long-term use may increase the risk of stomach problems, liver injury, kidney problems, dependence, and other side effects. Do not continue treatment beyond the prescribed duration without medical supervision.
This medicine may be prescribed for moderate to severe back pain when your doctor believes stronger pain relief is needed. However, it is not suitable for every type of back pain. Your doctor will determine whether it is appropriate based on the cause and severity of your symptoms.
The maximum daily dose depends on the specific product strength, your age, medical conditions, and other medicines you may be taking. Do not exceed the dose prescribed by your doctor, as taking too much can lead to serious side effects, including liver damage, breathing problems, and overdose. If you are unsure about your dose, consult your doctor or pharmacist.
Yes. Combipara-TR Tablet is available under various brand names in India. If your prescribed brand contains these three active ingredients, the information on uses, precautions, side effects, and interactions generally applies to your medicine as well. Always check the label and follow your doctor's instructions.

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Country of origin

India

Manufacturer/Marketer address

Kerom 3Rd Floor Plot No A112, Near State Bank Of India Road No 22, Wagle Industrial Estate Thane (W) Pin: 400604
Other Info - COM0550

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