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compositionComposition:ETHAMBUTOL-1000MG
prescription
Prescription Medicine
info
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Combutol 1000 Tablet is used to treat and prevent tuberculosis (TB). It contains Ethambutol that destroys the Mycobacterium tuberculosis bacteria. It may cause side effects such as nausea, vomiting, loss of appetite, headaches, dizziness or confusion. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ETHAMBUTOL-1000MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Combutol 1000 Tablet

Combutol 1000 Tablet is an oral prescription medication used to treat tuberculosis, a serious bacterial infection that primarily affects the lungs. It works by targeting and slowing the growth of the bacteria responsible for the infection, allowing your body's immune system to fight it off. This medicine is always prescribed alongside other tuberculosis treatments to ensure complete recovery and prevent the bacteria from becoming resistant.

To get the best results, you must take Combutol 1000 Tablet consistently every single day at the exact same time as directed by your healthcare provider. It can be taken with or without food, though taking it with a meal can help if you experience stomach upset. Making simple lifestyle choices, such as eating a nutrient-rich diet and staying well-hydrated, can support your body's recovery process during your treatment.

While taking Combutol 1000 Tablet , some people may experience mild side effects like a temporary loss of appetite or headache. However, you must contact your doctor immediately if you experience any serious side effects, particularly changes in your vision, such as blurred vision or difficulty telling colours apart. Your doctor will likely want to monitor your eyesight regularly throughout your treatment.

Before you begin taking this medicine, talk to your doctor if you have a history of gout, kidney disease, or pre-existing eye conditions. Do not take this if you already have optic neuritis (inflammation of the nerve in the eye) or if you are unable to report vision changes, such as very young children or patients who are unconscious. Discussing these factors ensures your treatment plan is safe and effective for you.

It is important to tell your doctor about all other medicines you take, as some products like aluminium-containing antacids can reduce the absorption of Combutol 1000 Tablet . You should also avoid drinking alcohol during treatment, as it can place extra strain on your liver and kidneys. If you are pregnant, planning to breastfeed, or an older adult, consult your doctor or pharmacist to discuss the safest way to manage your therapy.

Uses of Combutol 1000 Tablet

Combutol 1000 Tablet is used to treat tuberculosis. The detailed uses of Combutol 1000 Tablet are as follows:

  • Tuberculosis: Combutol 1000 Tablet is used to treat active tuberculosis infections in the lungs and other organs. It stops the bacteria from growing and multiplying, which helps clear the infection when used in combination with other prescribed tuberculosis medications.

Key Benefits

Combutol 1000 Tablet helps you regain your health by stopping the progression of tuberculosis. As the medicine controls the bacterial growth, you will notice a gradual reduction in your symptoms, leading to real-world relief.

  • Relief from chronic symptoms: It helps resolve persistent coughing, chest pain, and night sweats, allowing you to breathe easier and sleep more comfortably.
  • Restored energy levels: By clearing the infection, Combutol 1000 Tablet helps your body recover its strength, reducing the constant fatigue and weakness associated with tuberculosis.
  • Protection against drug resistance: By working effectively in combination with other therapies, it ensures the infection is completely cleared, protecting you from future recurrences.
Side effects of Combutol 1000 Tablet
  • Avoid touching your face without washing your hands.
  • Avoid contact with sick people.
  • Wear protective eyewear when playing sports or doing other activities that could cause eye injuries.
  • Take B vitamins like Vitamins B1, B6, and B12 are important for maintaining the health of the optic nerve.
  • Avoid bright lights or use dark glasses to protect the eyes.

Directions for Use

To get the full benefit of Combutol 1000 Tablet and minimise side effects, follow these simple guidelines:

  • Take Combutol 1000 Tablet exactly as prescribed by your doctor.
  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed into your body.
  • You may take this medicine with or without food. If you find that it upsets your stomach, taking it with a light meal may help prevent discomfort.
  • Always try to take your dose at the same time each day to maintain steady levels of the medicine in your body.
  • Remember to always follow your doctor's exact instructions and complete the full course of treatment, even if you start feeling better after a few weeks.

How Combutol 1000 Tablet Works

Combutol 1000 Tablet works by targeting the unique structure of the tuberculosis bacteria. It specifically blocks the production of an essential building block that the bacteria need to construct their protective outer cell wall. Without this protective barrier, the bacteria cannot grow, multiply, or maintain their structure. This weakens the bacterial population significantly, making it much easier for your body's natural immune system to target and destroy the remaining infection.
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Alcohol

Unsafe

Avoid consuming alcohol along with Combutol 1000 Tablet as it can lead to liver injury.

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Pregnancy

Safe if prescribed

Your doctor will calculate the potential risks to benefit ratio before prescribing it to you. Please consult your doctor if you are pregnant or trying to get pregnant.

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Breast Feeding

Safe if prescribed

Combutol 1000 Tablet is safe to use during breastfeeding. Human studies suggest that a significant amount of drug does not pass into breast milk and is therefore not harmful to the baby.

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Driving

Unsafe

Combutol 1000 Tablet may cause side effects impairing your ability to drive. It occasionally causes sight problems and tingling or numbness in the hand or feet. After taking this medicine, you should not drive to ensure safety.

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Liver

Caution

Combutol 1000 Tablet is used with caution in patients with liver disease. Dose adjustment may be needed. Please consult your doctor.

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Kidney

Caution

Combutol 1000 Tablet is used with caution in patients with kidney disease. Dose adjustment may be needed. Please consult your doctor.

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Children

Safe if prescribed

Combutol 1000 Tablet is recommended for treatment in children under 12 years of age who are infected with tuberculosis. The initial dose would be high for the first two months, and the next dose may be reduced if necessary depending on the child's response to the Combutol 1000 Tablet treatment.

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Heart

Safe if prescribed

Combutol 1000 Tablet can be used safely in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Consult your doctor

Limited information is available for use in erderly patients. Please consult your doctor.

What if I have taken an overdose of Combutol 1000 Tablet

Do not take more than the prescribed dose of Combutol 1000 Tablet as it may cause overdose. The symptoms of overdose include stomach pain, joint pain, gastrointestinal upset, itching, dizziness, headache, malaise (general discomfort), disorientation, hallucinations and mental confusion. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Prioritise a nutrient-rich diet: Focus on meals high in protein, healthy fats, and complex carbohydrates to help your body rebuild muscle tissue and recover from chronic infection.
  • Avoid alcohol entirely: Alcohol can increase the risk of liver damage when combined with tuberculosis treatments, so it is best to avoid it completely during your therapy.
  • Stay well-hydrated: Drink plenty of water throughout the day to support your kidneys, which play an important role in filtering and clearing this medication from your system.
  • Monitor your vision: Keep a simple colourful object nearby (like a coloured book or chart) to perform quick daily self-checks on your ability to distinguish red and green colours.

Health Queries

I am in my first trimester of pregnancy and have been diagnosed with tuberculosis (TB). Is it safe to take TB medications during the first trimester of pregnancy?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Congratulations on your pregnancy. Yes, it is safe and highly recommended to treat tuberculosis (TB) during your first trimester. Untreated TB poses a much greater risk to both you and your developing baby than the treatment itself. Standard first-line TB medications, including isoniazid, rifampicin, and ethambutol, are safe to use during pregnancy. Your doctor will also prescribe vitamin B6 (pyridoxine) to prevent nerve-related side effects. Please do not delay therapy; starting treatment promptly ensures a healthy pregnancy. Your healthcare team will monitor you closely throughout the process. Always take your medications exactly as prescribed by your doctor.

For how many days should I take Combutol 1000 and Oflomac 400 as part of my regular Anti-Tuberculosis Therapy (ATT) course?

Vikas Singh

Vikas Singh

M Pharmacy

The exact duration for taking Combutol 1000 and Oflomac 400 depends entirely on your specific type of tuberculosis (drug-sensitive or drug-resistant) and your doctor's protocol. Typically, Combutol (Ethambutol) is used during the intensive phase of TB treatment, which usually lasts for 2 months. Oflomac (Ofloxacin) is a second-line drug often used for drug-resistant TB, where the course can extend from 9 to 24 months. Because TB regimens are highly personalized, you must strictly follow the exact duration prescribed by your pulmonologist. Never stop these medications early, as incomplete treatment can lead to dangerous drug resistance.

I have been taking Combutol 1000 mg daily for 100 days for tuberculosis (TB). My doctor has now advised me to stop it. Is it safe to stop the medication at this stage, since TB treatment usually should not be interrupted?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

If your doctor, who is familiar with your treatment progress, has advised stopping Combutol (Ethambutol), it is generally safe to follow their guidance. Ethambutol is often used during the initial phase of TB treatment and may be stopped once your doctor is confident that the remaining medications can complete the treatment effectively. Do not stop or restart any medicine on your own, and make sure to continue all other prescribed TB drugs exactly as directed to fully cure the infection and prevent resistance. If you have any concerns about your treatment plan, discuss them with your doctor.
health query

Have a query?

How Soon It Starts Working

The time required for Combutol 1000 Tablet to start to work: Combutol 1000 Tablet ideally shows its action within 2 to 4 hours after administration. The time for which the effects of Combutol 1000 Tablet last: The effect of Combutol 1000 Tablet lasts for 9 to 12 hours.

What if you forget to take Combutol 1000 Tablet

If you miss a dose of Combutol 1000 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store Combutol 1000 Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the medication in its original packaging or container to protect it from moisture and direct light.

Drug Warnings

  • Schedule a comprehensive eye exam before you start taking Combutol 1000 Tablet to establish a baseline for your vision.
  • Perform a quick self-check of your colour vision every morning; if red and green objects start looking grey or blurry, contact your doctor immediately.
  • Always separate your dose of Combutol 1000 Tablet from any aluminium-containing antacids by at least 4 hours, as these antacids can stop your body from absorbing the medicine.
  • Never skip doses or stop your treatment early, even if you feel completely cured, to prevent the tuberculosis bacteria from returning in a drug-resistant form.
  • Inform any healthcare provider you visit that you are taking this medicine, especially if you are scheduled for kidney function or vision tests.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Aluminum-containing antacids: May decrease the absorption of Combutol 1000 Tablet , making the medication less effective. Separate these doses by at least 4 hours.

Drug-Disease Interactions

  • Kidney disease: May reduce the clearance of the medicine from your body, increasing the risk of side effects. Your doctor may need to adjust your dose.
  • Optic neuritis or vision problems: May worsen pre-existing nerve issues in the eye, potentially causing severe vision impairment.
  • Gout: May increase uric acid levels in your blood, which can trigger painful gout attacks or joint swelling.
EthambutolLeflunomide
Severe
EthambutolMipomersen
Severe

Drug-Drug Interactions

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EthambutolLeflunomide
Severe
How does the drug interact with Combutol 1000 Tablet:
Coadministration of Combutol 1000 Tablet with Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although taking Combutol 1000 Tablet with Leflunomide can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
EthambutolMipomersen
Severe
How does the drug interact with Combutol 1000 Tablet:
Coadministration of mipomersen with Combutol 1000 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although taking Combutol 1000 Tablet and Mipomersen together can cause an interaction, it can be taken if your doctor has suggested it. However, contact your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting your doctor.
EthambutolTeriflunomide
Severe
How does the drug interact with Combutol 1000 Tablet:
Coadministration of Combutol 1000 Tablet with teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Combutol 1000 Tablet with Teriflunomide can result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting your doctor.
EthambutolLomitapide
Severe
How does the drug interact with Combutol 1000 Tablet:
Taking Lomitapide and Combutol 1000 Tablet together can increase the risk of liver problems.

How to manage the interaction:
Although taking Combutol 1000 Tablet and Lomitapide together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
EthambutolKetoconazole
Severe
How does the drug interact with Combutol 1000 Tablet:
Taking Ketoconazole with Combutol 1000 Tablet can increase the risk of liver problems

How to manage the interaction:
Although there is an interaction, Ketoconazole can be taken with Combutol 1000 Tablet if prescribed by the doctor. However, consult the doctor if you experience symptoms such as fever, joint pain or swelling, unusual bleeding or bruising, skin rash, nausea, vomiting, dark urine, skin or eye yellowing. Do not stop using any medications without talking to the doctor.
EthambutolVigabatrin
Severe
How does the drug interact with Combutol 1000 Tablet:
Co-administration of Vigabatrin with Combutol 1000 Tablet may increase the risk of serious side effects associated with vision loss, especially if used together for prolonged periods.

How to manage the interaction:
Co-administration of Combutol 1000 Tablet with Vigabatrin can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Combutol 1000 Tablet is used to treat and prevent tuberculosis (TB)
Combutol 1000 Tablet contains 'Ethambutol' that works by destroying the Mycobacterium tuberculosis bacteria, causing lung infection known as Tuberculosis (TB).
No, it would help if you did not take a double dose or extra dose to make up the missed one. Taking an extra dose can cause unpleasant side effects and lead to toxicity.
Yes, Combutol 1000 Tablet treatment can be for more than two months based on your medical condition. After two months, if the investigations show that the bacteria are still active, then its usage may be extended for one more month.
Yes, Combutol 1000 Tablet is used as both the first and second line of treatment for tuberculosis. So, if you get tuberculosis for the second time it works by killing the harmful bacteria; however, the dose adjustments are made by your doctor accordingly.
No, you should tell the doctor before taking Combutol 1000 Tablet if you have eye problems (like diabetic retinopathy, optic neuritis, cataracts). Using Combutol 1000 Tablet in the eye conditions might get worsen and can lead to even vision loss.
Yes, it is necessary to take other medications with Combutol 1000 Tablet for tuberculosis if prescribed by the doctor. These additional medications help to eliminate the bacteria more effectively and also reduce the risk of developing drug resistance, ensuring the treatment is successful.
No, there is no single medicine that can cure tuberculosis with just one dose. TB treatment requires a combination of medications taken over a prescribed duration of time to kill the bacteria fully and prevent resistance. Always follow the full treatment plan prescribed by the doctor for a complete cure.
Combutol 1000 Tablet has a half-life of approximately 3.3 hours in patients with normal kidney function. However, due to the reduced clearance rate from the body, the half-life can extend to 7 hours or longer in individuals with renal failure.
If your child vomited within 30 minutes of taking Combutol 1000 Tablet , give the same dose again as the medication may not have been absorbed.
Drug resistance is the ability of microorganisms, like fungi, bacteria, viruses, or parasites, to resist the effects of drugs that once killed or inhibited them. It develops when these organisms mutate or acquire resistance genes, often due to overuse or misuse of medications. As a result, infections become harder to treat, requiring stronger or alternative treatments.
Yes, you may develop resistance to Combutol 1000 Tablet , if Combutol 1000 Tablet is not taken correctly, such as missing doses or stopping treatment early. This can lead to multi-drug-resistant tuberculosis (MDR-TB), making the infection harder to treat. Therefore, take Combutol 1000 Tablet for the dose and duration prescribed by the doctor to treat the condition effectively.
You should stop taking Combutol 1000 Tablet if you experience any of the following warning signs like colour blindness, blurred vision or any kidney problems like decreased amount of urine and swelling of your legs and feet. Please consult the doctor immediately for further guidance.
The side effects of Combutol 1000 Tablet include nausea, vomiting, dizziness, headache, confusion and loss of appetite. Consult the doctor if any of these symptoms persist or worsen.
It is highly recommended to avoid alcohol while taking Combutol 1000 Tablet . Alcohol can place extra strain on your liver and kidneys, increasing the risk of side effects during your treatment. Talk to your doctor for more guidance.
This medicine can occasionally affect the nerve in your eye, leading to vision changes. Checking your eyes beforehand gives your doctor a baseline to compare against during your treatment. Talk to your doctor if you notice any changes in your sight.
You should only take Combutol 1000 Tablet during pregnancy if your doctor determines that the benefits clearly outweigh the risks. Always tell your healthcare provider if you are pregnant or planning to become pregnant before starting this medication.
Yes, some patients may experience tingling, numbness, or a burning sensation in their extremities while taking this medicine. If you experience these symptoms, contact your doctor or pharmacist right away.
Yes, avoid taking antacids that contain aluminium within 4 hours of your Combutol 1000 Tablet dose. Aluminium can block the absorption of the medicine, making it less effective at fighting the infection.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - COM0016
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