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Cotrinios Injection 5 ml is a combination medicine used in the treatment of bacterial infections of the urinary tract, respiratory tract, ear, lungs, skin, brain and toxoplasmosis. It contains trimethoprim and sulfamethoxazole which stops the production of tetrahydrofolic acid and dihydrofolic acid and thereby stops the growth of the infection-causing bacteria. Sometimes, your may experience common side effects like headache, nausea, diarrhoea, and skin rashes.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Aionios Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Cotrinios Injection 5 ml

Cotrinios Injection 5 ml is a prescription antibiotic injection used to treat severe or life-threatening bacterial infections. It is commonly prescribed for serious lung infections, severe urinary tract infections, and intense gut infections when oral medications are not an option. Because it is a parenteral medication, it is injected directly into a vein to ensure rapid delivery throughout the body.

This medicine is given at regular intervals to maintain a consistent level in your system, which is crucial for completely clearing the infection. Your healthcare team will schedule and inject each dose as prescribed by your doctor. While receiving this treatment, staying well-hydrated is one of the most important steps you can take to help your kidneys process the medication safely.

Like many strong antibiotics, Cotrinios Injection 5 ml can cause mild side effects such as nausea, vomiting, or skin rashes. However, you must contact your doctor immediately if you experience severe symptoms like persistent watery diarrhoea, extreme skin peeling, or difficulty breathing. Your healthcare team will monitor you closely during treatment to catch any unusual reactions early.

Do not take this if you have a history of severe allergic reactions to sulfa-based medications, severe liver damage, or certain types of anaemia. Before starting treatment, it is vital to tell your doctor if you have kidney disease, asthma, or a history of blood disorders. Discussing your complete medical history helps prevent serious complications.

This medicine can interact with other substances, including blood thinners, certain blood pressure drugs, and alcohol, which may increase the risk of side effects or affect how well your treatments work. Special care and close monitoring are required for elderly individuals, pregnant women, and breastfeeding mothers. Always consult your doctor to ensure this therapy is safe for your specific situation.
 

Uses of Cotrinios Injection 5 ml

Cotrinios Injection 5 ml is used to treat severe or life-threatening bacterial infections. The detailed uses of Cotrinios Injection 5 ml are as follows:

  • Pneumocystis pneumonia: Helps treat and prevent this severe and life-threatening lung infection, which primarily affects individuals with weakened immune systems.
  • Severe urinary tract infections (UTIs): Targets and eliminates complicated or resistant bacterial infections in the bladder and kidneys when oral antibiotics are not suitable.
  • Shigellosis: Clears severe bacterial infections of the digestive tract, helping to stop intense abdominal cramps and contagious, watery diarrhoea.
  • Severe systemic infections: Treats other serious, lab-confirmed bacterial infections in various parts of the body as determined by your healthcare provider.

 

Key Benefits

Cotrinios Injection 5 ml provides fast and effective treatment for serious bacterial infections through injectable administration. By delivering the medicine directly into the bloodstream and combining two complementary antibacterial agents, it helps control infections quickly, relieve symptoms, and support a faster recovery.

  • Rapid Action Against Severe Infections: Because this medicine is administered by injection, it reaches the bloodstream immediately and begins fighting bacteria quickly, making it especially useful for severe or rapidly progressing infections.
  • Dual-Action Antibacterial Protection: The combination of two active components works through complementary mechanisms to effectively eliminate infection-causing bacteria, including those that may be difficult to treat with a single antibiotic.
  • Promotes Faster Recovery: By reducing the bacterial load, this medicine helps relieve symptoms such as fever, pain, inflammation, and discomfort, supporting a smoother and more comfortable recovery.
     

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Cotrinios Injection 5 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Cotrinios Injection 5 ml Works

This medicine contains two active cooperative ingredients that work together to stop bacterial growth. Individually, each component targets a specific stage of the bacteria's life cycle; together, they deliver a highly effective treatment. The first component, trimethoprim, prevents bacteria from utilising a natural substance they need to synthesise folic acid. Folic acid is essential for bacteria to grow and replicate. Without it, the bacteria cannot survive. The second component, sulfamethoxazole, blocks the very next step in the pathway, preventing the bacteria from turning folic acid into its active, usable form. This dual-block mechanism prevents the bacteria from producing the DNA and proteins necessary for multiplication, ultimately leading to their destruction while sparing human cells, which absorb folic acid from food.
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Alcohol

Caution

Avoid alcohol consumption while taking Cotrinios Injection 5 ml to prevent unpleasant side effects.

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Pregnancy

Caution

Please inform your doctor before taking Cotrinios Injection 5 ml if you are pregnant. Cotrinios Injection 5 ml may cause fetal harm. Your doctor will prescribe Cotrinios Injection 5 ml only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Cotrinios Injection 5 ml as it may cause bilirubin displacement and kernicterus (brain damage resulting from high levels of bilirubin in the blood). Please consult your doctor if you have any concerns.

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Driving

Caution

It is unknown whether Cotrinios Injection 5 ml affects your ability to drive and operate machinery. Drive only if you are physically stable and mentally focused.

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Liver

Caution

Please inform your doctor before taking Cotrinios Injection 5 ml if you have liver impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative if necessary based on your condition.

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Kidney

Caution

Please inform your doctor before taking Cotrinios Injection 5 ml if you have kidney impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative if necessary based on your condition.

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Children

Caution

Cotrinios Injection 5 ml is not recommended for infants below 6 weeks.

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Heart

Caution

Cotrinios Injection 5 ml can be used in heart patients, but with caution due to potential drug interactions. It may increase levels of medications like digoxin or procainamide, so close monitoring is essential.

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Geriatrics

Caution

Geriatric patients can receive Cotrinios Injection 5 ml, but it may be more prone to side effects like kidney impairment or electrolyte imbalances. Dose adjustments and regular monitoring help ensure safe use.

What if I have taken an overdose of Cotrinios Injection 5 ml

Because this medicine is prepared and given by medical professionals, an overdose is highly unlikely. However, if you suspect an overdose or experience severe nausea, confusion, dizziness, or vomiting, alert your healthcare provider immediately or seek emergency medical attention.

Diet & Lifestyle Advise

  • Increase fluid intake: Drink plenty of water throughout the day. This helps your kidneys flush out the medicine and prevents the formation of painful drug crystals in your urine.
  • Protect your skin: This medicine can make your skin highly sensitive to sunlight. Avoid tanning beds, limit your time in direct sunlight, wear protective clothing, and apply a broad-spectrum sunscreen when outdoors.
  • Avoid alcohol: Do not consume alcohol during your treatment, as it can worsen stomach upset, cause flushing, or increase your risk of dehydration.
  • Support your gut health: Consider eating yoghurt with live cultures or taking a probiotic supplement after finishing your antibiotic course to help restore healthy gut bacteria. Talk to your doctor before starting any new supplements.
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How Soon It Starts Working

The time required for Cotrinios Injection 5 ml to start to work: The onset time of Cotrinios Injection 5 ml has not been clinically established. The time for which the effects of Cotrinios Injection 5 ml last: The duration of Cotrinios Injection 5 ml’s effect is clinically not established.

What if you forget to take Cotrinios Injection 5 ml

Since this medicine is given by a healthcare provider, missed doses are rare. However, if you miss an appointment or suspect a dose was skipped, contact your clinic or healthcare provider immediately to reschedule. Do not double the dose to make up for a missed one.

Storage

• Store the unopened vials or infusion bags of Cotrinios Injection 5 ml at room temperature, typically between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Always inspect the liquid inside the vial or infusion bag before it is used. It should be clear and colourless to pale yellow. Do not use it if you see floating particles, cloudiness, or discolouration.
  • If you are receiving this infusion at home, ensure proper needle safety and rotate injection sites regularly to reduce the risk of vein irritation or infection.
  • Alert your nurse or doctor immediately if you feel any burning, coldness, pain, or swelling around the injection site during the infusion.
  • Be prepared for regular blood and kidney function tests if you are receiving this treatment for more than a few days.
    Watch out for signs of a secondary infection, such as oral thrush (white patches in the mouth) or vaginal itching, which can sometimes occur after antibiotic use.
     

verifiedApollotooltip
  • Blood thinners: May increase the effects of medications like warfarin, raising your risk of bleeding.
  • Blood pressure medications: Combining this with ACE inhibitors or potassium-sparing water pills can cause your blood potassium levels to rise dangerously high.
  • Seizure and immune therapies: May increase the levels of medications like phenytoin or methotrexate in your body, leading to an increased risk of toxicity.
     

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verifiedApollotooltip
  • Potassium-rich foods: Consuming high quantities of bananas, leafy greens, or potassium supplements while on this medication can occasionally lead to elevated blood potassium levels

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTIC COMBINATION]

FAQs

Cotrinios Injection 5 ml belongs to the group of medicines called antibiotics used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma).
Cotrinios Injection 5 ml is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, Cotrinios Injection 5 ml kills the bacteria and stops their growth. Thus, it helps to treat bacterial infections.
Cotrinios Injection 5 ml causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.
Diarrhoea might be a side-effect of Cotrinios Injection 5 ml. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, inform your doctor. Do not take anti-diarrheal medicine on your own.
Cotrinios Injection 5 ml may affect certain laboratory test results. Inform the lab technician that you are taking Cotrinios Injection 5 ml.
Cotrinios Injection 5 ml may cause high levels of potassium in the blood, which could lead to abnormal heartbeats (palpitations). Regular monitoring of potassium levels and heart rate is advised while taking Cotrinios Injection 5 ml.
No, Cotrinios Injection 5 ml is an antibiotic specifically designed to target and kill bacteria. It is completely ineffective against viruses, including the common cold or flu. Talk to your doctor if you suspect you have a viral illness.
This medicine is generally not recommended during pregnancy, particularly in the first and third trimesters, because it can interfere with folic acid levels and affect the baby's development. Talk to your doctor to discuss safer alternatives.
You should report any skin rash to your doctor immediately. While some rashes are mild, others can be signs of a serious, life-threatening allergic reaction. Do not receive your next dose until a medical professional has evaluated your rash.
High fluid intake helps your kidneys process and excrete the medicine efficiently. It prevents the drug from crystallising in your urine, which can damage your kidneys. Talk to your doctor or pharmacist about how much water you should drink daily.
Some patients experience dizziness, tiredness, or lightheadedness after receiving this medicine. If you experience these side effects, do not drive or operate heavy machinery. Talk to your doctor if you feel unsafe or persistently dizzy.
It is highly recommended to avoid alcohol during your treatment. Combining alcohol with this medicine can increase your risk of severe dehydration, stomach upset, headache, and a rapid heart rate. Talk to your doctor or pharmacist for more personalised safety advice.
Tell your healthcare provider right away if you notice pain, redness, coldness, or swelling at the injection site. This can mean the medicine is leaking into surrounding tissues or irritating the vein, requiring the needle to be moved. Talk to your doctor if the pain persists after your treatment ends.

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Country of origin

India

Manufacturer/Marketer address

Unit No: 105, First floor, No:18/1, Sufiya Elite Cunnigham Road, Bangalore – 560001
Other Info - COT0235
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