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compositionComposition:CRIZOTINIB-250MG
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Prescription Medicine
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Crizano-250 Capsule 30's is an anti-cancer medicine used in the treatment of Non-small cell lung cancer (NSCLC). This medicine contains crizotinib which works by stopping the tyrosine kinase enzyme and stops the cancerous cell growth. Common side effects include visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

CRIZOTINIB-250MG

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Crizano-250 Capsule 30's

The prescription medication Crizano-250 Capsule 30's is a treatment designed to target specific genetic abnormalities in cancer cells. It is primarily used to treat adults with advanced non-small cell lung cancer that has spread to other parts of the body. By focusing on specific cellular pathways, it helps manage the growth and spread of the disease.

This medication is typically taken twice a day, and it is crucial to take it consistently at the same times each day to keep a steady amount of the medicine in your body. You can take this oral capsule with or without food, depending on your preference. Maintaining a balanced diet and staying well-hydrated are key lifestyle adjustments that can support your body during this treatment.

While taking Crizano-250 Capsule 30's, you may experience common side effects such as mild vision changes, nausea, or swelling in your limbs. However, you must contact your doctor immediately if you experience serious side effects, such as signs of liver damage or sudden breathing difficulties. Regular medical check-ups are necessary to ensure the treatment is working safely.

Before starting this medicine, tell your doctor if you have a history of liver disease, kidney problems, or heart rhythm issues. Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as the medication can harm a developing baby. Your healthcare team will help determine if this treatment is appropriate for you.

This medicine can interact with several common prescription drugs, alcohol, and grapefruit products, which may alter how the drug behaves in your system. If you are an older adult or have pre-existing health conditions, consult your doctor or pharmacist to ensure this treatment is safe for your specific situation. Always keep a complete list of everything you take to share with your healthcare provider.

Uses of Crizano-250 Capsule 30's

Crizano-250 Capsule 30's is used to treat the following types of cancer with specific genetic changes:

  • ALK-positive Non-Small Cell Lung Cancer (NSCLC): It helps block abnormal proteins that cause cancer cells to grow and spread in patients whose tumours test positive for the anaplastic lymphoma kinase (ALK) gene change.
  • ROS1-positive Non-Small Cell Lung Cancer (NSCLC): It targets and inhibits the ROS1 protein to slow down or stop the growth of cancer cells in patients with this specific genetic marker.

Key Benefits

The following are the benefits of taking Crizano-250 Capsule 30's as prescribed:

  • Slows cancer progression: Targets and blocks the abnormal ALK or ROS1 proteins that drive cancer growth, helping slow or stop the spread of the disease.
  • Helps relieve cancer-related symptoms: May reduce symptoms such as persistent cough, chest pain, and shortness of breath by controlling tumour growth.
  • Supports quality of life: By keeping the cancer under better control, it can help patients maintain their daily activities and overall well-being during treatment.
  • Offers convenient oral treatment: Comes as an oral capsule, allowing treatment to be taken at home without the need for regular intravenous infusions.
Side effects of Crizano-250 Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Crizano-250 Capsule 30's can be taken with or without food as advised by your doctor.
  • Crizano-250 Capsule 30's is usually taken twice a day, or as prescribed by your doctor.
  • Swallow Crizano-250 Capsule 30's as a whole with a glass of water.
  • Do not crush, chew, split, or open it.

How Crizano-250 Capsule 30's Works

Crizano-250 Capsule 30's contains Crizano-250 Capsule 30's, a targeted anticancer medicine that belongs to a class of medicines known as tyrosine kinase inhibitors. It is used to treat certain cancers that have abnormal proteins, such as ALK or ROS1, which promote the growth and spread of cancer cells. Crizano-250 Capsule 30's works by blocking the activity of these abnormal proteins. By switching off the signals that tell cancer cells to grow and divide uncontrollably, it helps slow or stop the growth of the cancer. In some cases, it may also help shrink existing tumours. Together, these actions help control the progression of ALK-positive or ROS1-positive cancers and slow the spread of cancer cells.
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Alcohol

Caution

Consuming alcohol while using Crizano-250 Capsule 30's is not recommended since it may produce side effects or make you more sensitive to the effects of alcohol.

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Pregnancy

Caution

Crizano-250 Capsule 30's is not typically recommended during the pregnancy. Please consult the healthcare professional if you have any concerns regarding this.

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Breast Feeding

Caution

Crizano-250 Capsule 30's is not typically recommended if you are a nursing woman. Please consult the healthcare professional if you have any concerns regarding this.

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Driving

Caution

Do not drive, or you should take special care when driving and using machines as patients taking Crizano-250 Capsule 30's may experience visual disturbances, dizziness, and tiredness.

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Liver

Caution

Caution should be taken while using Crizano-250 Capsule 30's in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Caution should be taken while using Crizano-250 Capsule 30's in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

It is not recommended for children as the safety and efficacy have not been established.

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Heart

Caution

Crizano-250 Capsule 30's should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using Crizano-250 Capsule 30's.

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Geriatrics

Consult your doctor

Crizano-250 Capsule 30's should be given to elderly patients only if prescribed by a doctor. If you have any concerns about using Crizano-250 Capsule 30's in geriatrics, please consult your doctor.

What if I have taken an overdose of Crizano-250 Capsule 30's

If you suspect an overdose, seek immediate emergency medical attention or contact a poison control centre right away. Do not wait for symptoms to develop.

Diet & Lifestyle Advise

  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine, as it can raise the level of the drug in your body to unsafe levels.
  • Stay hydrated: Drink plenty of fluids throughout the day to support your kidney function and manage mild side effects like diarrhoea.
  • Eat small, frequent meals: If you experience nausea, eating smaller portions more frequently throughout the day can help keep your stomach settled.
  • Protect your eyes: Because vision changes and light sensitivity are common, consider wearing sunglasses when outdoors or in bright environments.
  • Avoid smoking: Smoking can worsen lung symptoms and interfere with your overall cancer treatment plan.
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How Soon It Starts Working

The time required for Crizano-250 Capsule 30's to start to work: Crizano-250 Capsule 30's ideally shows its action within few hours after administration. The time for which the effects of Crizano-250 Capsule 30's last: The duration of action for Crizano-250 Capsule 30's is clinically unknown.

What if you forget to take Crizano-250 Capsule 30's

If you miss a dose of Crizano-250 Capsule 30's, take it as soon as you remember. However, if your next scheduled dose is less than 6 hours away, skip the missed dose and take your next dose at your regular time. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Crizano-250 Capsule 30's at room temperature between 20°C and 25°C (68°F to 77°F). •Keep the medicine in its original container to protect it from direct light and moisture, and do not store it in damp areas like the bathroom.

Drug Warnings

  • Avoid driving if affected: Do not drive, use tools, or operate heavy machinery if you experience blurred vision, dizziness, or tiredness while taking this medication.
  • Monitor your heart rate: Check your pulse regularly and contact your healthcare provider immediately if you notice your heart is beating much slower than normal.
  • Use effective contraception: Use highly effective birth control during treatment and for the recommended period after your final dose, as Crizano-250 Capsule 30's can cause serious harm to an unborn baby.
  • Keep all monitoring appointments: Attend all scheduled blood test appointments so your doctor can regularly monitor your liver function, blood cell counts, and overall response to treatment.
  • Handle damaged capsules safely: If a capsule accidentally breaks or leaks, avoid touching the powder directly. If contact occurs, wash the affected area thoroughly with soap and water immediately.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Crizano-250 Capsule 30's and affect its safety or effectiveness:

  • Strong CYP3A inhibitors (such as ketoconazole, itraconazole, clarithromycin, or ritonavir): These medicines can increase Crizano-250 Capsule 30's levels in the body, raising the risk of side effects.
  • Strong CYP3A inducers (such as rifampicin, carbamazepine, phenytoin, or St. John's wort): These medicines can reduce Crizano-250 Capsule 30's levels, making the treatment less effective.
  • QT-prolonging medicines: Medicines that affect heart rhythm, such as certain antiarrhythmics, antibiotics, antidepressants, or antipsychotics, may increase the risk of serious heart rhythm problems when taken with Crizano-250 Capsule 30's.
CrizotinibZiprasidone
Critical
CrizotinibAmitriptyline
Severe

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
How does the drug interact with Crizano-250 Capsule:
Coadministration of Crizano-250 Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Crizano-250 Capsule is not recommended,but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CrizotinibAmitriptyline
Severe
How does the drug interact with Crizano-250 Capsule:
Coadministration of Amitriptyline and Crizano-250 Capsule may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Crizano-250 Capsule may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
CrizotinibPromethazine
Severe
How does the drug interact with Crizano-250 Capsule:
Combining Promethazine with Crizano-250 Capsule can increase the risk of QTc prolongation.

How to manage the interaction:
Although there is a possible interaction between Promethazine and Crizano-250 Capsule, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
CrizotinibCeritinib
Severe
How does the drug interact with Crizano-250 Capsule:
Taking Crizano-250 Capsule with Ceritinib may significantly increase the blood levels and effects of Crizano-250 Capsule.

How to manage the interaction:
Co-administration of Ceritinib with Crizano-250 Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms like an irregular heart rhythm, dizziness, fainting, or a fast or pounding heartbeat, it is important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
CrizotinibGranisetron
Severe
How does the drug interact with Crizano-250 Capsule:
Taking granisetron with Crizano-250 Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Granisetron and Crizano-250 Capsule together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibNorfloxacin
Severe
How does the drug interact with Crizano-250 Capsule:
Coadministration of Norfloxacin with Crizano-250 Capsule can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin with Crizano-250 Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
CrizotinibGoserelin
Severe
How does the drug interact with Crizano-250 Capsule:
Taking Goserelin and Crizano-250 Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Goserelin and Crizano-250 Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibDoxepin
Severe
How does the drug interact with Crizano-250 Capsule:
Co-administration of Crizano-250 Capsule with Doxepin can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Crizano-250 Capsule with Doxepin together is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
CrizotinibOlaparib
Severe
How does the drug interact with Crizano-250 Capsule:
Using Crizano-250 Capsule and olaparib can increase the blood levels of olaparib. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Crizano-250 Capsule and olaparib can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
CrizotinibPosaconazole
Severe
How does the drug interact with Crizano-250 Capsule:
Taking Crizano-250 Capsule and posaconazole together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between posaconazole and Crizano-250 Capsule, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

The following foods and beverages may interact with Crizano-250 Capsule 30's:

  • Grapefruit and grapefruit juice: Avoid consuming grapefruit, grapefruit juice, or supplements containing grapefruit extracts, as they can increase Crizano-250 Capsule 30's levels in your body and raise the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Crizano-250 Capsule 30's belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults.
Crizotinib is the active ingredient in Crizano-250 Capsule 30's. It works by inhibiting an enzyme called tyrosine kinase and causing cancer cells to die. Crizano-250 Capsule 30's is only provided to individuals whose condition is caused by an ALK tyrosine kinase gene mutation.
In elderly patients, the risk of side effects is more if you take the Crizano-250 Capsule 30's. For the elderly, it might require dose adjustment, or your doctor might prescribe any other medication safe for the elderly.
No, avoid smoking before starting the treatment and while taking Crizano-250 Capsule 30's as smoking might alter the effectiveness of Crizano-250 Capsule 30's.
Take the missed dose as soon as you remember. Skip the missing dose and return to your regular dosing plan if it is time for the next dose. Do not take a double dose to make up for a missing dose.
Crizano-250 Capsule 30's may cause visual disturbances such as flashes of light, blurred vision, or double vision as a temporary side effect. If it continues or worsens your condition, seek medical advice immediately.
Crizano-250 Capsule 30's should be taken orally. Swallow it as a whole with a glass of water. Do not chew, crush or break it.
The side effects of Crizano-250 Capsule 30's include dizziness, diarrhoea, visual disturbances or stomach upset, including vomiting, nausea, and tiredness. Consult the doctor if any of these side effects persist or worsen.
Yes, you can take Crizano-250 Capsule 30's with or without food. The most important thing is to be consistent with how you take it each day. Talk to your doctor or pharmacist if you struggle with nausea when taking it on an empty stomach.
Vision changes, such as flashes of light or blurred vision, are common. Avoid driving or operating machinery if your vision is impaired, and report these changes to your healthcare provider as soon as possible. Talk to your doctor or pharmacist for further guidance.
No, Crizano-250 Capsule 30's can cause serious harm to an unborn baby. Both men and women should use reliable, highly effective methods of birth control during treatment and for a specified time after stopping the medication. Talk to your doctor or pharmacist about safe family planning options.
It is best to avoid or severely limit alcohol because both alcohol and Crizano-250 Capsule 30's are processed by your liver. Combining them can increase the risk of liver damage and worsen side effects like dizziness. Talk to your doctor or pharmacist before consuming alcohol.
Your doctor will monitor your blood to check your liver function and ensure your blood cell counts remain at a safe level. This helps catch potential side effects, like liver damage, before they become severe. Talk to your doctor or pharmacist if you want to understand your test results better.
No, you must swallow the capsules whole. Crushing or opening the capsules can cause the medicine to release too quickly into your body, which increases the risk of severe side effects. Talk to your doctor or pharmacist if you have difficulty swallowing pills.
If you vomit after taking your capsule, do not take an extra dose to replace it. Simply wait and take your next scheduled dose at your regular time. Talk to your doctor or pharmacist for advice on how to manage nausea during your treatment.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.2857 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Lung Cancer - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Crizotinib Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Crizotinib Crizotinib. 2011. [Accessed on 26 Mar. 2019]Check here
  6. Crizotinib Crizotinib. 2012. [Accessed on 26 Mar. 2019]Check here
  7. Crizotinib Crizotinib. 2022. [Accessed on 08 Jan. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Sco 84, Sector 5, Panchkula (Haryana) 134112 India.
Other Info - CRI0232
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