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compositionComposition:CRIZOTINIB-250MG
prescriptionPrescription Medicine
Crizenta 250 mg Capsule 60's
Crizenta 250 mg Capsule 60's
Crizenta 250 mg Capsule 60's
Crizenta 250 mg Capsule 60's is an anti-cancer medicine used in the treatment of Non-small cell lung cancer (NSCLC). This medicine contains crizotinib which works by stopping the tyrosine kinase enzyme and stops the cancerous cell growth. Common side effects include visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

CRIZOTINIB-250MG

Manufacturer/Marketer :

Adley Oncology

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Crizenta 250 mg Capsule 60's

Crizenta 250 mg Capsule 60's belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

Crizenta 250 mg Capsule 60's contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. Crizenta 250 mg Capsule 60's is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine exactly as your doctor has told you. You must keep to your doctor's instructions to get the maximum benefit. Sometimes, you may experience specific common side effects, such as visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Crizenta 250 mg Capsule 60's if you are allergic to Crizenta 250 mg Capsule 60's or any of its ingredients. Crizenta 250 mg Capsule 60's may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Crizenta 250 mg Capsule 60's as it could lead to increased dizziness. Crizenta 250 mg Capsule 60's is not recommended for children as safety and effectiveness have not been established. Inform your healthcare professional if you are a pregnant or breastfeeding woman so that your doctor decides whether Crizenta 250 mg Capsule 60's can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. While on Crizenta 250 mg Capsule 60's treatment, you should avoid eating grapefruit or consuming grapefruit juice since they may alter the amount of Crizenta 250 mg Capsule 60's in your body.

Uses of Crizenta 250 mg Capsule 60's

Crizenta 250 mg Capsule 60's is used in the treatment of non-small cell lung cancer (NSCLC). The detailed uses of Crizenta 250 mg Capsule 60's are as follows:

  • Treats Non-Small Cell Lung Cancer (NSCLC): Crizenta 250 mg Capsule 60's is used in adults to treat NSCLC that is locally advanced or metastatic (spread to other body parts). It slows down or stops cancer cell growth by inhibiting a type of enzyme called tyrosine kinase.
  • Effective in Anaplastic Large Cell Lymphoma (ALCL): Crizenta 250 mg Capsule 60's may be prescribed for children and adolescents to treat anaplastic lymphoma kinase (ALK)-positive tumors when previous treatments have failed to control the disease.

Key Benefits

Crizenta 250 mg Capsule 60's contains the active substance Crizotinib, a medicine used to treat adults with non-small cell lung cancer (NSCLC). Crizenta 250 mg Capsule 60's is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth.

Side effects of Crizenta 250 mg Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Crizenta 250 mg Capsule 60's can be taken with or without food as advised by your doctor.
  • Crizenta 250 mg Capsule 60's is usually taken twice a day, or as prescribed by your doctor.
  • Swallow Crizenta 250 mg Capsule 60's as a whole with a glass of water.
  • Do not crush, chew, split, or open it.

How Crizenta 250 mg Capsule 60's Works

Crizenta 250 mg Capsule 60's contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. Crizenta 250 mg Capsule 60's is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.
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Alcohol

Caution

Consuming alcohol while using Crizenta 250 mg Capsule 60's is not recommended since it may produce side effects or make you more sensitive to the effects of alcohol.

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Pregnancy

Caution

Crizenta 250 mg Capsule 60's is not typically recommended during the pregnancy. Please consult the healthcare professional if you have any concerns regarding this.

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Breast Feeding

Caution

Crizenta 250 mg Capsule 60's is not typically recommended if you are a nursing woman. Please consult the healthcare professional if you have any concerns regarding this.

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Driving

Caution

Do not drive, or you should take special care when driving and using machines as patients taking Crizenta 250 mg Capsule 60's may experience visual disturbances, dizziness, and tiredness.

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Liver

Caution

Caution should be taken while using Crizenta 250 mg Capsule 60's in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Caution should be taken while using Crizenta 250 mg Capsule 60's in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

It is not recommended for children as the safety and efficacy have not been established.

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Heart

Caution

Crizenta 250 mg Capsule 60's should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using Crizenta 250 mg Capsule 60's.

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Geriatrics

Consult your doctor

Crizenta 250 mg Capsule 60's should be given to elderly patients only if prescribed by a doctor. If you have any concerns about using Crizenta 250 mg Capsule 60's in geriatrics, please consult your doctor.

What if I have taken an overdose of Crizenta 250 mg Capsule 60's

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow a pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Have a query?

How Soon It Starts Working

The time required for Crizenta 250 mg Capsule 60's to start to work: Crizenta 250 mg Capsule 60's ideally shows its action within few hours after administration. The time for which the effects of Crizenta 250 mg Capsule 60's last: The duration of action for Crizenta 250 mg Capsule 60's is clinically unknown.

What if you forget to take Crizenta 250 mg Capsule 60's

If you miss a dose, take it as soon as you remember. However, if it’s less than 6 hours before your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.

Storage

• Store in a cool and dry place away from sunlight. • Keep Crizenta 250 mg Capsule 60's out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not take Crizenta 250 mg Capsule 60's if you are allergic to Crizenta 250 mg Capsule 60's or any of its ingredients. Crizenta 250 mg Capsule 60's may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol along with Crizenta 250 mg Capsule 60's as it could lead to increased dizziness. Crizenta 250 mg Capsule 60's is not recommended for children as safety and effectiveness have not been established. Consult your doctor if you are a pregnant or breastfeeding woman; your doctor will decide whether the Crizenta 250 mg Capsule 60's can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. It is essential to take Crizenta 250 mg Capsule 60's every day, as long as your doctor prescribes it. Contact your doctor immediately if you cannot take medicine as your doctor prescribed or feel you do not need it anymore. Do not stop taking this medicine on your own. People with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders should consult the doctor before taking the Crizenta 250 mg Capsule 60's.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Crizenta 250 mg Capsule 60's may interact with various medications, including medicines used to treat fungal infections (e.g. ketoconazole, itraconazole, posaconazole, and voriconazole), medicines used to treat bacterial infections (e.g. clarithromycin, telithromycin, and erythromycin), medicines used to treat AIDS/HIV (e.g. atazanavir, ritonavir, and cobicistat), medicines used to treat seizures or fits (e.g. phenytoin, carbamazepine or phenobarbital), medications used to treat tuberculosis (e.g. rifabutin, rifampicin), and a herbal product used to treat depression (e.g. St. John's wort).

Drug-Food Interactions: You must not drink alcohol or grapefruit juice or eat grapefruit while on treatment.

Drug-Disease Interactions: Crizenta 250 mg Capsule 60's should be used with caution in patients with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders.

CrizotinibZiprasidone
Critical
CrizotinibDisopyramide
Severe

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
How does the drug interact with Crizenta 250 mg Capsule:
Coadministration of Crizenta 250 mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Crizenta 250 mg Capsule is not recommended,but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CrizotinibDisopyramide
Severe
How does the drug interact with Crizenta 250 mg Capsule:
The combined use of Crizenta 250 mg Capsule and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Crizenta 250 mg Capsule and Disopyramide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
CrizotinibGranisetron
Severe
How does the drug interact with Crizenta 250 mg Capsule:
Taking granisetron with Crizenta 250 mg Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Granisetron and Crizenta 250 mg Capsule together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibSotalol
Severe
How does the drug interact with Crizenta 250 mg Capsule:
Coadministration of Crizenta 250 mg Capsule with Sotalol can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Crizenta 250 mg Capsule, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
CrizotinibPazopanib
Severe
How does the drug interact with Crizenta 250 mg Capsule:
When Pazopanib is taken with Crizenta 250 mg Capsule, the amount of Pazopanib in the blood can go up.

How to manage the interaction:
Although taking Pazopanib and Crizenta 250 mg Capsule together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
CrizotinibVenlafaxine
Severe
How does the drug interact with Crizenta 250 mg Capsule:
Taking Venlafaxine with Crizenta 250 mg Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Crizenta 250 mg Capsule, you can take these medicines together if prescribed by a doctor. However, consult your doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
CrizotinibDasatinib
Severe
How does the drug interact with Crizenta 250 mg Capsule:
Using Crizenta 250 mg Capsule together with Dasatinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Crizenta 250 mg Capsule with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. Consult a doctor if you experience dizziness, fainting, breathlessness, or heart palpitations. Do not stop using any medications without talking to a doctor.
CrizotinibCiprofloxacin
Severe
How does the drug interact with Crizenta 250 mg Capsule:
Taking ciprofloxacin and Crizenta 250 mg Capsule together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking ciprofloxacin and Crizenta 250 mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibIbrutinib
Severe
How does the drug interact with Crizenta 250 mg Capsule:
Taking Ibrutinib with Crizenta 250 mg Capsule may increase the levels of Ibrutinib.

How to manage the interaction:
Although there is a possible interaction between Ibrutinib and Crizenta 250 mg Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CrizotinibIdarubicin
Severe
How does the drug interact with Crizenta 250 mg Capsule:
Taking Idarubicin and Crizenta 250 mg Capsule together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Idarubicin and Crizenta 250 mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Crizenta 250 mg Capsule 60's belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults.

Crizotinib is the active ingredient in Crizenta 250 mg Capsule 60's. It works by inhibiting an enzyme called tyrosine kinase and causing cancer cells to die. Crizenta 250 mg Capsule 60's is only provided to individuals whose condition is caused by an ALK tyrosine kinase gene mutation.

In elderly patients, the risk of side effects is more if you take the Crizenta 250 mg Capsule 60's. For the elderly, it might require dose adjustment, or your doctor might prescribe any other medication safe for the elderly.

No, avoid smoking before starting the treatment and while taking Crizenta 250 mg Capsule 60's as smoking might alter the effectiveness of Crizenta 250 mg Capsule 60's.

Take the missed dose as soon as you remember. Skip the missing dose and return to your regular dosing plan if it is time for the next dose. Do not take a double dose to make up for a missing dose.

Crizenta 250 mg Capsule 60's may cause visual disturbances such as flashes of light, blurred vision, or double vision as a temporary side effect. If it continues or worsens your condition, seek medical advice immediately.

Crizenta 250 mg Capsule 60's should be taken orally. Swallow it as a whole with a glass of water. Do not chew, crush or break it.

The side effects of Crizenta 250 mg Capsule 60's include dizziness, diarrhoea, visual disturbances or stomach upset, including vomiting, nausea, and tiredness. Consult the doctor if any of these side effects persist or worsen.

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

  • Bayyarapu Mahesh Kumar

    M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

  • Veda Maddala

    M Pharmacy

Last Updated

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Country of origin

India

Manufacturer/Marketer address

SCO-184, Sector - 5, Panchkula -134114 Haryana (INDIA)
Other Info - CRI0233
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