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compositionComposition:CYCLOPHOSPHAMIDE-1000MG
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Cyphos 1000 mg Injection is used to treat Cancer. It contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, It helps treat Cancer. Additionally, It is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients. It suppresses the body's immune system, thereby helping treat nephrotic syndrome. Common side effects of Cyphos 1000 mg Injection are nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss).

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYCLOPHOSPHAMIDE-1000MG

Manufacturer/Marketer :

Getwell Oncology Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cyphos 1000 mg Injection

Cyphos 1000 mg Injection is a prescription medicine given by injection or infusion to treat certain cancers, such as lymphomas and leukaemias, as well as severe autoimmune conditions like lupus nephritis. It works by slowing or stopping the growth of abnormal cells and reducing an overactive immune response.

Since this medicine is given as an injection or infusion, your healthcare team will administer it at scheduled intervals in a clinic or hospital. During treatment, staying well hydrated and following your doctor's dietary advice can help reduce certain side effects.

While Cyphos 1000 mg Injection is highly effective, it can cause common side effects like nausea, temporary hair thinning, or fatigue. It is important to watch for serious signs, such as blood in your urine or sudden fever, and tell your doctor immediately if they occur.

Do not take this if you have a severe active infection, severe bone marrow problems, or active bladder inflammation. Talk to your doctor if you have kidney or liver disease before starting this treatment.

This medication can interact with other drugs that affect your immune system, and you should avoid drinking alcohol during treatment to prevent additional liver stress. Pregnant or breastfeeding women, as well as elderly individuals, should discuss the risks and benefits thoroughly with their specialist.

Uses of Cyphos 1000 mg Injection

Cyphos 1000 mg Injection is used in the treatment of Cancer and nephrotic syndrome (kidney disease). The detailed uses of Cyphos 1000 mg Injection are as follows:

  • Certain Cancers: Cyphos 1000 mg Injection helps stop the growth and spread of cancer cells in conditions like lymphoma, leukaemia, breast cancer, and ovarian cancer.
  • Severe Autoimmune Conditions: It calms an overactive immune system to protect organs, which is especially helpful in treating severe kidney inflammation caused by lupus (lupus nephritis).
  • Kidney Disease in Children: It may be prescribed for children with certain types of kidney disease (nephrotic syndrome) when other treatments have not provided relief.

Key Benefits

Cyphos 1000 mg Injection brings real-world relief by managing aggressive conditions and helping you get back to a more comfortable, active life.
Benefits may include:

  • Helps treat certain cancers by slowing or stopping the growth of cancer cells.
  • Reduces harmful immune system activity in severe autoimmune diseases, such as lupus nephritis.
  • Helps protect important organs, including the kidneys, by controlling inflammation in selected autoimmune conditions.
  • May improve disease control and reduce the risk of complications when used as part of your prescribed treatment plan.
     
Side effects of Cyphos 1000 mg Injection
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Your doctor may adjust the dose of the suspected medication based on your immune health; however, do not stop taking it suddenly without consulting them first.
  • Wash your hands often and handle food safely to avoid germs.
  • Get enough sleep and manage your stress levels to help your immune system stay strong.
  • Eat a balanced diet with plenty of vegetables, fruits, whole grains, dairy, and proteins.
  • Do not eat raw eggs, meat, fruits, unpasteurized milk, or uncooked vegetables.
  • Stay away from crowded places and individuals who are sick.
  • Have regular blood tests to check your immune system’s health.
  • Keep your vaccines up-to-date and ask your doctor about which vaccines you need.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • Cyphos 1000 mg Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Cyphos 1000 mg Injection Works

Cyphos 1000 mg Injection belongs to a group of medicines known as alkylating agents. It works by interfering with the DNA inside rapidly multiplying cells. By damaging this DNA, the medicine prevents these abnormal cells, whether they are cancer cells or overactive immune cells, from growing, dividing, and spreading throughout your body. This helps control the disease and allows your healthy tissues to recover.
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Alcohol

Caution

You are recommended to avoid alcohol consumption as it may worsen the risk of cyclophosphamide-induced nausea and vomiting.

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Pregnancy

Caution

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Cyphos 1000 mg Injection. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Cyphos 1000 mg Injection. Avoid breastfeeding during treatment with Cyphos 1000 mg Injection and for one week after the last dose.

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Driving

Caution

Cyphos 1000 mg Injection may cause dizziness. Do not drive or operate heavy machinery until you are alert.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Cyphos 1000 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a history of kidney diseases, inform your doctor before receiving Cyphos 1000 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will with the benefits and risks before prescribing this medicine based on your child's medical condition.

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Heart

Consult your doctor

Please inform your doctor before taking this medicine if you have a heart problem or any concerns regarding this.

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Geriatrics

Caution

Cyphos 1000 mg Injection should be used in the elderly only if advised by a doctor, as dose adjustment may be required.

What if I have taken an overdose of Cyphos 1000 mg Injection

Since this medication is given by a medical professional in a clinical setting, an accidental overdose is highly unlikely. However, if you suspect an issue or experience severe symptoms after your treatment, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Try to drink 8 to 12 cups of water daily, unless your doctor tells you otherwise, to help flush your bladder and prevent irritation.
  • Empty your bladder frequently: Urinate often, especially in the hours immediately following your injection and right before you go to sleep at night.
  • Practice infection prevention: Avoid contact with people who are sick with colds, flu, or other contagious infections, as your body's defence system will be weaker during treatment.
  • Eat small, frequent meals: Consuming small, nutritious meals throughout the day can help manage nausea and keep your energy levels steady.
health query

Have a query?

How Soon It Starts Working

The time required for Cyphos 1000 mg Injection to start to work: The time required for Cyphos 1000 mg Injection to show its action is unknown. The time for which the effects of Cyphos 1000 mg Injection last: The duration of action for Cyphos 1000 mg Injection is unknown.

What if you forget to take Cyphos 1000 mg Injection

If you miss an appointment for your injection, contact your doctor or clinic right away to reschedule. Do not try to make up for it without medical advice.

Storage

•Unopened vials of this medicine are typically stored at controlled room temperature between 20°C to 25°C (68°F to 77°F) in a secure place.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Inspect the medicine before use: Check the infusion bag or vial before your treatment begins; do not use it if you see any particles floating in it or if the liquid is discoloured.
  • Use effective contraception: Use reliable, non-hormonal birth control during your treatment and for several months after your last dose, as this medicine can cause harm to an unborn baby.
  • Attend regular monitoring: Get your blood tests and urine tests done exactly as scheduled so your doctor can monitor your blood cell counts, kidney function, liver function, and check for early signs of bladder irritation.
  • Inform your healthcare providers: Inform your dentist or any other doctor you see that you are receiving this treatment before scheduling any dental work or surgical procedures.

Drug-Drug Interactions

verifiedApollotooltip

  • Immunosuppressants: May further weaken your immune system when taken with cyclophosphamide, increasing the risk of serious or opportunistic infections.
  • Heart medicines: May affect the heart and increase the risk of heart-related side effects, including inflammation or weakening of the heart muscle, particularly at high doses.
  • Blood thinners: May increase or decrease the effect of blood thinners, which can raise the risk of bleeding or reduce protection against blood clots. Your doctor may monitor your blood clotting tests more closely.
  • Liver-affecting medicines: May increase the risk of liver injury. Your doctor may monitor your liver function with regular blood tests during treatment.
CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with Cyphos 1000 mg Injection:
Co-administration of Cyphos 1000 mg Injection and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with Cyphos 1000 mg Injection:
Co-administration of Nalidixic acid with Cyphos 1000 mg Injection may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Cyphos 1000 mg Injection and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideDeferiprone
Severe
How does the drug interact with Cyphos 1000 mg Injection:
Co-administration of Cyphos 1000 mg Injection and Deferiprone may increase the risk of serious and potential infections.

How to manage the interaction:
Co-administration of Cyphos 1000 mg Injection with Deferiprone can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CyclophosphamideVoclosporin
Severe
How does the drug interact with Cyphos 1000 mg Injection:
Co-administration of Cyphos 1000 mg Injection with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Cyphos 1000 mg Injection and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.
CyclophosphamideLidocaine
Severe
How does the drug interact with Cyphos 1000 mg Injection:
Taking Lidocaine with Cyphos 1000 mg Injection may increase the risk of methemoglobinemia (a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Although there is a possible interaction, Cyphos 1000 mg Injection can be taken with lidocaine if prescribed by the doctor. However, consult the doctor if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue the medication without consulting a doctor.
CyclophosphamideThalidomide
Severe
How does the drug interact with Cyphos 1000 mg Injection:
Taking Cyphos 1000 mg Injection with Thalidomide may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Cyphos 1000 mg Injection can be taken with Thalidomide if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
CyclophosphamideClozapine
Severe
How does the drug interact with Cyphos 1000 mg Injection:
Taking Clozapine and Cyphos 1000 mg Injection may increase the risk of infection.

How to manage the interaction:
Taking Cyphos 1000 mg Injection with Clozapine can possibly lead to an interaction. However, they can be taken together if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideCertolizumab
Severe
How does the drug interact with Cyphos 1000 mg Injection:
When Cyphos 1000 mg Injection is taken with Certolizumab, may increase the risk or severity of infections.

How to manage the interaction:
There may be a possibility of interaction between Cyphos 1000 mg Injection and Certolizumab, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
CyclophosphamideCladribine
Severe
How does the drug interact with Cyphos 1000 mg Injection:
The combined use of Cladribine with Cyphos 1000 mg Injection can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Cladribine with Cyphos 1000 mg Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, contact a doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not discontinue any medications without consulting a doctor.
CyclophosphamideFingolimod
Severe
How does the drug interact with Cyphos 1000 mg Injection:
Taking Fingolimod's ability to suppress the immune system may be enhanced by Cyphos 1000 mg Injection.

How to manage the interaction:
Although taking Cyphos 1000 mg Injection and Fingolimod together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away - a serious infection, problems, high body temperature, feeling cold, loose stools, a painful throat, body discomfort, difficulty breathing, losing weight, or experiencing pain or discomfort while urinating. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit: Avoid eating grapefruit or drinking grapefruit juice, as it can change how your body processes this medicine.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Cyphos 1000 mg Injection is used to treat Cancer and nephrotic syndrome (kidney disease).
Cyphos 1000 mg Injection works by stopping or slowing down the growth of cancer cells in the body. Thereby, Cyphos 1000 mg Injection helps treat cancer. Cyphos 1000 mg Injection suppresses the body's immune system and helps treat nephrotic syndrome.
Cyphos 1000 mg Injection might impair fertility and interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm). Please consult your doctor if you have any concerns.
Men should avoid fathering a child during the treatment and for six months following discontinuation of therapy.
Cyphos 1000 mg Injection might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding or bruising or if the wounds do not heal properly.
Cyphos 1000 mg Injection is given as an injection or a slow intravenous (IV) infusion by a trained healthcare professional in a hospital or clinic.
Yes. Temporary hair thinning or hair loss is a common side effect. Hair usually begins to grow back after treatment ends, although the timing and texture of regrowth can vary from person to person.
Drinking plenty of fluids helps your body remove the medicine through the urine and lowers the risk of bladder irritation or bleeding. Your healthcare team may also recommend emptying your bladder frequently and, in some cases, prescribe medicines such as mesna to help protect your bladder.
Live vaccines should generally be avoided during treatment because your immune system may not be able to respond safely. Some non-live vaccines may still be recommended, but the timing may need to be adjusted. Ask your healthcare provider before receiving any vaccination.
Cyclophosphamide is broken down in the liver, and its active by-products are gradually removed from the body, mainly through the kidneys. Although the medicine is cleared within a few days, some of its effects on blood cells and the immune system can last longer.
Some people feel tired, dizzy, or unwell after treatment. If this happens, avoid driving or operating machinery until you feel fully alert. Consider arranging for someone to take you home after your infusion.
Blood in your urine can be a sign of serious bladder irritation or bleeding caused by cyclophosphamide. Do not ignore this symptom. Go to the nearest emergency department or seek immediate medical attention, even if the bleeding seems mild.

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Reference

  1. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 012142S109Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Cyclophosphamide Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Cyclophosphamide monohydrate. 2014. [Accessed on 26 Mar. 2019]Check here
  5. Cyclophosphamide Cyclophosphamide. 1959. [Accessed on 26 Mar. 2019]Check here
  6. Baxter Healthcare Corporation. U.S. Food & Drug Administration. [Revised on May 2013] [Accessed on 28th May 2022] docs/label/2013/012141s090,012142s112lbl.pdfCheck here
  7. Baxter Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised on June 2016] [Accessed on 28th May 2022]Check here

Country of origin

India

Manufacturer/Marketer address

464, Udyog Vihar, Phase-V Sector 19, Gurugram Haryana 122016
Other Info - CYP0053
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