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compositionComposition:GEMCITABINE-1GM
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Prescription Medicine
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CYTOGEM INJECTION 1GM is an anti-cancer medicine used in the treatment of breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. This medicine works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include nausea, hair loss, skin rash, vomiting, and oedema.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GEMCITABINE-1GM

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About CYTOGEM INJECTION 1GM

CYTOGEM INJECTION 1GM is a prescription chemotherapy medication used to treat several types of cancer, including pancreatic, non-small cell lung, ovarian, and breast cancer. It works by targeting and slowing the growth of cancer cells in your body. This helps manage the spread of the disease and can reduce the physical symptoms caused by tumors.

CYTOGEM INJECTION 1GM is given as an intravenous (IV) infusion in a clinic or hospital, usually on a specific weekly schedule determined by your doctor. Because it is injected directly into your vein, food does not affect how it works, though eating light meals before your appointment can help prevent nausea. Maintaining a balanced diet and staying well-hydrated during your treatment cycles will also support your body's recovery.

Like many cancer treatments, CYTOGEM INJECTION 1GM can cause side effects such as low blood cell counts, nausea, fatigue, and temporary liver changes. It is vital to consult your healthcare team immediately if you face specific serious side-effects, such as a high fever, unusual bruising, or sudden shortness of breath. Your doctor will monitor your blood levels regularly to ensure it is safe to continue your treatment.

Talk to your doctor before starting this medicine if you have kidney disease, liver disease, or a history of radiation therapy. Do not take this medicine if you have had a severe allergic reaction to it in the past, or if you are pregnant, as it can harm an unborn baby.

This medicine can interact with other drugs that affect your immune system, increasing your risk of infections. Combining your treatment with alcohol is not recommended as it can place extra stress on your liver. If you are breastfeeding, are an older adult, or are planning a family, you should consult your doctor or pharmacist to discuss your specific safety needs.

Uses of CYTOGEM INJECTION 1GM

This medicine is used to treat certain types of cancer by slowing or stopping the growth of cancer cells. The detailed uses of this medicine are as follows:

  • Pancreatic cancer: CYTOGEM INJECTION 1GM is used as a primary treatment for advanced or metastatic pancreatic cancer to help slow tumor growth and manage symptoms.
  • Non-small cell lung cancer: It is combined with other medications to treat advanced stages of this lung cancer to help shrink tumors.
  • Breast cancer: It is prescribed alongside other chemotherapy drugs after initial treatments have been tried, helping to control the spread of breast cancer cells.
  • Ovarian cancer: It is used in combination with other therapies for advanced ovarian cancer that has returned after previous treatments.
  • Bladder cancer: It is used to treat advanced bladder cancer, helping to target cancer cells in the urinary tract.

Key Benefits

This medicine helps slow the growth of cancer cells, reduce tumor progression, and improve overall quality of life. Its benefits include:

  • Helps slow or stop the growth of cancer cells.
  • May shrink tumors and reduce pressure on nearby organs and tissues.
  • Helps relieve cancer-related symptoms such as pain and discomfort.
  • Supports better disease control when used alone or with other anticancer medicines.
  • May help improve daily comfort and maintain physical activity.
  • Can help improve overall quality of life by slowing the progression of cancer.
Side effects of Cytogem Injection 1gm
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Your doctor may recommend regular liver function tests (LFT) to monitor liver enzyme levels.
  • To support your liver, eat a healthy diet with lots of fruits, vegetables, lean proteins, and healthy fats.
  • Avoid eating processed meats, sugary foods, and unhealthy fats.
  • Limit your alcohol consumption, since too much can worsen liver function and contribute to high levels of Alkaline Phosphatase (ALP).
  • Stay active with regular exercise, drink plenty of water, and try to avoid harmful chemicals that can damage your liver.
  • Quit smoking to lower the risk of elevated ALP levels.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Your doctor will decide the dosage and timing of CYTOGEM INJECTION 1GM based on the type of cancer and your body's response to the treatment.
  • CYTOGEM INJECTION 1GM will be administered by the doctor or nurse in a medical setting.
  • Do not self-administer it.

How CYTOGEM INJECTION 1GM Works

CYTOGEM INJECTION 1GM belongs to a group of medicines called antimetabolites. Cancer cells need to copy their DNA in order to grow and divide. CYTOGEM INJECTION 1GM is designed to mimic the natural building blocks that these cells use to make DNA. Once the cancer cells absorb this medicine, it gets incorporated into their genetic material and stops them from making new DNA. This prevents the cells from multiplying, eventually causing them to die. Because it targets rapidly dividing cells, it is highly effective at slowing down or stopping the spread of cancer throughout the body.
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Alcohol

Unsafe

It is not recommended to use alcohol with CYTOGEM INJECTION 1GM as it might lead to increased drowsiness.

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Pregnancy

Unsafe

CYTOGEM INJECTION 1GM should be avoided during pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

CYTOGEM INJECTION 1GM is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

CYTOGEM INJECTION 1GM may cause drowsiness and sleepiness, which may affect your ability to drive. Do not drive if you experience any side effects after using CYTOGEM INJECTION 1GM.

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Liver

Caution

Exercise caution before using CYTOGEM INJECTION 1GM in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using CYTOGEM INJECTION 1GM in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

CYTOGEM INJECTION 1GM is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

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Heart

Caution

CYTOGEM INJECTION 1GM should be administered with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before receiving CYTOGEM INJECTION 1GM.

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Geriatrics

Caution

CYTOGEM INJECTION 1GM should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of CYTOGEM INJECTION 1GM

Because this medicine is given by healthcare professionals in a controlled clinical environment, an overdose is highly unlikely. However, if you suspect an error or experience severe side effects shortly after an infusion, tell your medical team or seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of fluids, especially water, clear broths, or herbal teas, starting the day before your infusion and for several days after. This helps protect your kidneys and flushes the medicine through your system.
  • Eat small, frequent meals: If you experience nausea, eat five or six small meals a day instead of three large ones. Stick to bland foods like crackers, toast, or rice, and avoid greasy or highly spiced dishes.
  • Prioritize rest: Fatigue is common during chemotherapy. Listen to your body and rest when needed, but try to incorporate short, gentle walks into your day to keep your strength up and improve your mood.
  • Practice strict hygiene: Because CYTOGEM INJECTION 1GM can lower your white blood cell count and weaken your immune system, wash your hands frequently with soap and water, avoid crowds, and stay away from people who are sick.
health query

Have a query?

How Soon It Starts Working

The time required for CYTOGEM INJECTION 1GM to start to work: CYTOGEM INJECTION 1GM ideally shows its action within 15 to 30 minutes after administration. The time for which the effects of CYTOGEM INJECTION 1GM last: The effect of CYTOGEM INJECTION 1GM lasts for 2 to 5 hours.

What if you forget to take CYTOGEM INJECTION 1GM

If you miss an appointment for your infusion, contact your doctor or cancer clinic immediately to reschedule. Keeping your treatment on schedule is very important for the medication to work effectively.

Storage

•The undiluted vials of CYTOGEM INJECTION 1GM are stored at room temperature between 20°C to 25°C (68°F to 77°F) in a secure place.

Drug Warnings

  • Check the injection site: During and after the infusion, monitor the injection area closely. If you feel pain, burning, stinging, or notice redness or swelling at the IV site, tell your nurse immediately, as the medicine could be leaking out of the vein.
  • Monitor your temperature daily: Keep a thermometer at home and check your temperature if you feel unwell. A fever during chemotherapy is a medical emergency that requires immediate clinical evaluation.
  • Use reliable birth control: Both men and women should use effective birth control during treatment and for several months after the last dose to prevent pregnancy, as CYTOGEM INJECTION 1GM can cause severe birth defects.
  • Keep up with blood tests: You will need regular blood tests before each infusion to check your blood cell counts, liver function, and kidney function. Do not skip these appointments, as your doctor uses these results to ensure it is safe to give your next dose.

Drug-Drug Interactions

verifiedApollotooltip
  • Live vaccines: Taking CYTOGEM INJECTION 1GM alongside live vaccines (such as the yellow fever or MMR vaccine) can increase the risk of severe, life-threatening infections because your immune system is weakened.
  • Blood thinners: Combining this medicine with blood thinners like warfarin can increase your risk of serious bruising and bleeding.
  • Other bone marrow suppressants: Using this medicine with other drugs that suppress bone marrow can further lower your blood counts, raising the risk of severe infections and anemia.
GemcitabineNatalizumab
Severe
GemcitabineDeferiprone
Severe

Drug-Drug Interactions

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GemcitabineNatalizumab
Severe
How does the drug interact with Cytogem Injection 1gm:
Combining Cytogem Injection 1gm with Natalizumab can increase the risk of side effects.

How to manage the interaction:
Co-administration of Cytogem Injection 1gm with Natalizumab can result in an interaction, but it can be taken if your doctor has advised it. If you experience any symptoms such as fever, diarrhea, sore throat, muscle aches, or vision changes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
GemcitabineDeferiprone
Severe
How does the drug interact with Cytogem Injection 1gm:
Cytogem Injection 1gm can cause higher levels of Deferiprone in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Cytogem Injection 1gm and Deferiprone, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain while urinating contact a doctor right away. Do not stop using any medications without a doctor's advice.
GemcitabineTofacitinib
Severe
How does the drug interact with Cytogem Injection 1gm:
Coadministration of Tofacitinib and Cytogem Injection 1gm can lead to or increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Tofacitinib and Cytogem Injection 1gm, but it can be taken if advised by a doctor. Contact your doctor immediately if you develop symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
GemcitabineAdalimumab
Severe
How does the drug interact with Cytogem Injection 1gm:
Combining Adalimumab with Cytogem Injection 1gm can increase the risk of side effects like developing serious infections.

How to manage the interaction:
Although taking Cytogem Injection 1gm and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like feeling sick, having a fever, diarrhea, a sore throat, muscle aches, weight loss, pain when you pee, or having trouble breathing it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
GemcitabineGolimumab
Severe
How does the drug interact with Cytogem Injection 1gm:
Combining Cytogem Injection 1gm with Golimumab can increase the risk of infections.

How to manage the interaction:
Taking Cytogem Injection 1gm with Golimumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain/burning when you urinate. Do not stop using any medications without a doctor's advice.
GemcitabineVoclosporin
Severe
How does the drug interact with Cytogem Injection 1gm:
When Cytogem Injection 1gm is taken with Voclosporin, the amount of Cytogem Injection 1gm in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Cytogem Injection 1gm and Voclosporin, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination contact a doctor right away. Do not stop using any medications without talking to a doctor.
GemcitabineCladribine
Severe
How does the drug interact with Cytogem Injection 1gm:
Taking Cladribine with Cytogem Injection 1gm can increase the risk and severity of developing serious infections.

How to manage the interaction:
Co-administration of Cytogem Injection 1gm with Cladribine can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning urination, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
GemcitabineEtanercept
Severe
How does the drug interact with Cytogem Injection 1gm:
Taking Etanercept with Cytogem Injection 1gm can increase the risk of infections.

How to manage the interaction:
Taking Etanercept with Cytogem Injection 1gm together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
GemcitabineClozapine
Severe
How does the drug interact with Cytogem Injection 1gm:
Co-administration of Cytogem Injection 1gm with Clozapine can increase the risk or severity of serious infections.

How to manage the interaction:
Taking Cytogem Injection 1gm with Clozapine together can result in an interaction, but it can be taken if a doctor has advised it. If you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination it is important to contact a doctor. Do not stop using any medications without talking to a doctor.
GemcitabineBaricitinib
Severe
How does the drug interact with Cytogem Injection 1gm:
Using baricitinib together with Cytogem Injection 1gm may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Cytogem Injection 1gm if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with CYTOGEM INJECTION 1GM when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

CYTOGEM INJECTION 1GM belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer.
CYTOGEM INJECTION 1GM works blocking DNA synthesis and causing cell death, thereby preventing the cells from proliferating beyond normal.
Men taking CYTOGEM INJECTION 1GM are advised not to father a child during the treatment with CYTOGEM INJECTION 1GM and for 6months after the treatment. Consult your doctor before starting CYTOGEM INJECTION 1GM if you are planning to father a child. Your doctor may advise you regarding sperm storage.
If you suffer from CKD, please consult with your doctor before using CYTOGEM INJECTION 1GM and discuss any concerns with them. CYTOGEM INJECTION 1GM is to be used with caution in those suffering from kidney and liver problems.
CYTOGEM INJECTION 1GM might cause low white blood cell count leading to increased risk of infections. Consult your doctor if you have a fever, sweating, and any signs of infections.
CYTOGEM INJECTION 1GM may cause bleeding and bruising due to less platelet count. Consult a doctor if you notice unexpected bruising, pinkish or reddish urine, bleeding from gums, mouth, or nose.
CYTOGEM INJECTION 1GM contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. It is very effective in controlling cancer cells from multiplying and is used for the treatment of various types of cancers.
The side effects of CYTOGEM INJECTION 1GM include hair loss, vomiting, nausea, skin rash and oedema. Consult the doctor if any of these symptoms persist or worsen.
CYTOGEM INJECTION 1GM is given as an intravenous (IV) infusion directly into a vein. This process is done by a healthcare professional in a clinic or hospital setting and usually takes about 30 minutes. Talk to your doctor if you have questions about your infusion schedule.
Some people may experience mild thinning of the hair or temporary hair loss while receiving CYTOGEM INJECTION 1GM. This is usually temporary, and your hair should grow back after the treatment is completed. Talk to your doctor or nurse for tips on managing hair changes.
It is highly recommended to avoid alcohol during your treatment. Both alcohol and CYTOGEM INJECTION 1GM are processed by your liver, and combining them can increase the risk of liver damage. Talk to your doctor before consuming any alcohol.
CYTOGEM INJECTION 1GM can temporarily lower your white blood cells, red blood cells, and platelets, which can increase your risk of infections or bleeding. Blood tests ensure your body has recovered enough from the previous dose to safely receive the next one. Talk to your doctor about your test results.
No, CYTOGEM INJECTION 1GM can cause serious harm to an unborn baby. You must use effective birth control while receiving this medicine and for a specified time after your last dose. If you suspect you are pregnant, contact your healthcare provider immediately. Talk to your doctor about safe family planning options.
Because CYTOGEM INJECTION 1GM lowers your white blood cells, you are at a higher risk of getting sick. Watch closely for a fever, chills, sore throat, cough, or painful urination, and seek emergency medical care immediately if these occur. Talk to your doctor about when to go to the hospital.
You should avoid receiving live vaccines while undergoing treatment with CYTOGEM INJECTION 1GM because your immune system is weakened and the vaccine could make you sick. Always consult your oncologist before receiving any vaccine. Talk to your doctor or pharmacist about safe vaccination schedules.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.2839 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Gemcitabine Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Pmc6649805 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Ema.Gemcitabine 200 mg, powder for solution for infusion. [[Accessed on 12 Sept].2019]Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Gemcitabine. [Updated 2019 Jul 20]Check here
  7. El Karak F, Flechon A. Gemcitabine in bladder cancer. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. December 2007. [Accessed on 8th November 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - CYT0024
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