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compositionComposition:MIDAZOLAM-1.25%W/V
prescription
Prescription Medicine
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₹461 with coupons & bank offers*

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Da Plus 1.25% w/v Nasal Spray 4 MDI is used to treat Seizure clusters (acute repetitive seizures). It contains Midazolam, which increases GABA activity (a chemical messenger in the brain). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls Seizures. Common side effects of Da Plus 1.25% w/v Nasal Spray 4 MDI are headache, drowsiness, runny nose, throat irritation, and nasal discomfort.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MIDAZOLAM-1.25%W/V

Manufacturer/Marketer :

Allan Labs

Consume Type :

Nasal

Return Policy :

Not Returnable

About Da Plus 1.25% w/v Nasal Spray 4 MDI

Da Plus 1.25% w/v Nasal Spray 4 MDI is a prescription nasal spray used for the emergency treatment of sudden, repeated seizure episodes, often called seizure clusters. This medicine is designed to stop these active seizures quickly before they can progress into longer, more dangerous events. It is a critical rescue treatment that helps bring rapid control during a medical emergency.

Unlike daily seizure preventatives, this medicine is only used as-needed when a seizure cluster actually occurs. Because it is sprayed directly into the nose, you can use it regardless of whether the patient has eaten. Implementing a consistent sleep schedule and reducing daily stress are key lifestyle adjustments that can also help improve overall seizure control.

While using this medicine, some people may experience mild side effects like nasal discomfort, a runny nose, throat irritation, or minor sleepiness. However, if you notice serious issues like extremely slow breathing, severe dizziness, or signs of an allergic reaction, you must seek medical help immediately. Always keep your doctor informed of any unusual symptoms that develop after use.

Before keeping this rescue medicine on hand, talk to your doctor if you have a history of breathing problems, sleep apnea, or liver damage. Do not take this if you have narrow-angle glaucoma or are allergic to any of the ingredients in the spray. It is vital to discuss your complete health history with your doctor to ensure this medicine is safe for your specific situation.

Using this medicine with alcohol, pain relievers, or sleeping pills can cause dangerous slow breathing and extreme drowsiness. Additionally, smoking can alter how your body processes certain medications, so notify your doctor if you smoke. If you are pregnant, breastfeeding, or are caring for an elderly patient, consult your healthcare provider before using this medicine, as they may require special monitoring.

Uses of Da Plus 1.25% w/v Nasal Spray 4 MDI

Da Plus 1.25% w/v Nasal Spray 4 MDI is used in the treatment of seizure clusters (acute repetitive seizure episodes). The detailed uses of Da Plus 1.25% w/v Nasal Spray 4 MDI are as follows:

  • Seizure clusters: Da Plus 1.25% w/v Nasal Spray 4 MDI helps by rapidly interrupting brief, intense episodes of repeated seizures that occur over a short period.
  • Prevention of continuous seizures: By stopping clusters early, this medicine helps prevent the situation from turning into a continuous, life-threatening seizure state.

Key Benefits

Da Plus 1.25% w/v Nasal Spray 4 MDI helps quickly stop seizure clusters, providing rapid relief during seizure emergencies. The following are the benefits of this medication:

  • Acts rapidly to help stop ongoing seizure clusters.
  • Reduces the physical strain and potential complications associated with prolonged seizures.
  • Can be easily administered as a nasal spray without the need for injections or swallowing tablets during a seizure.
  • Enables caregivers to provide prompt treatment outside of a hospital setting.
  • May reduce the need for emergency medical visits when used as prescribed.
     

Directions for Use

  • Follow your doctor's instructions regarding the dosage and duration.
  • Blow your nose to clear the nostrils before use. Insert the nozzle into one nostril while closing the other nostril. Spray the medicine while breathing in. Repeat for the other nostril if required.
  • Shake the nasal spray well before each use.

How Da Plus 1.25% w/v Nasal Spray 4 MDI Works

During a seizure cluster, the nerve cells in the brain experience a sudden storm of excessive, chaotic electrical activity. This medicine belongs to a class of drugs that work directly on the central nervous system to quiet this electrical storm. It works by boosting the effects of a natural calming chemical in the brain known as gamma-aminobutyric acid (GABA). When GABA activity is enhanced, it acts like a brake system, slowing down the overactive nerve signals and quickly restoring normal, calm brain activity to stop the seizure.
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Alcohol

Unsafe

Avoid consumption of alcohol with Da Plus 1.25% w/v Nasal Spray 4 MDI as it may increase drowsiness.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, inform your doctor before using Da Plus 1.25% w/v Nasal Spray 4 MDI. Babies born to mothers receiving Da Plus 1.25% w/v Nasal Spray 4 MDI late in pregnancy may be at risk of feeding or breathing problems, withdrawal symptoms or dangerously low body temperature.

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Breast Feeding

Caution

Da Plus 1.25% w/v Nasal Spray 4 MDI may be excreted in breast milk and may harm your baby. Therefore, discuss with your doctor the best way to feed your baby if you use Da Plus 1.25% w/v Nasal Spray 4 MDI.

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Driving

Caution

Avoid driving or operating machinery until you know how Da Plus 1.25% w/v Nasal Spray 4 MDI affects you.

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Liver

Consult your doctor

If you have liver problems, consult your doctor before using Da Plus 1.25% w/v Nasal Spray 4 MDI.

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Kidney

Consult your doctor

If you have kidney diseases/conditions, consult your doctor before using Da Plus 1.25% w/v Nasal Spray 4 MDI.

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Children

Unsafe

Da Plus 1.25% w/v Nasal Spray 4 MDI is not recommended for children below 12 years as the safety and effectiveness were not established.

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Heart

Caution

Da Plus 1.25% w/v Nasal Spray 4 MDI is generally safe for heart patients due to its rapid, localized action and low systemic absorption. However, it may cause sedation or breathing issues, so medical supervision is essential.

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Geriatrics

Caution

Geriatric patients can use Da Plus 1.25% w/v Nasal Spray 4 MDI, but with caution. Older adults are more sensitive to sedative effects, which may increase the risk of drowsiness, confusion, or slowed breathing. It's important that a healthcare provider supervises its use, especially if there are other medications or health conditions involved.

What if I have taken an overdose of Da Plus 1.25% w/v Nasal Spray 4 MDI

If you suspect an overdose, such as if someone is showing signs of extreme sleepiness, slow reflexes, confusion, or very shallow breathing, seek emergency medical attention or contact a poison control centre immediately.

Diet & Lifestyle Advise

  • Prioritise consistent sleep: Lack of sleep is a well-known trigger for seizures. Aim for 7 to 9 hours of quality sleep every night.
  • Avoid alcohol and recreational substances: Alcohol can interfere with your daily seizure medications, lower your seizure threshold, and cause dangerous interactions when combined with Da Plus 1.25% w/v Nasal Spray 4 MDI.
  • Manage daily stress: High stress can trigger seizure activity. Practice relaxation techniques like deep breathing, meditation, or gentle yoga.
  • Stay hydrated and eat regular meals: Dehydration and sudden drops in blood sugar can sometimes trigger seizures. Keep water on hand and eat balanced meals.
  • Keep a detailed seizure log: Record the date, time, duration, and triggers of any seizure clusters, along with when you used Da Plus 1.25% w/v Nasal Spray 4 MDI. Share this log with your doctor to help them optimise your care.
     
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How Soon It Starts Working

The time required for Da Plus 1.25% w/v Nasal Spray 4 MDI to start to work: Da Plus 1.25% w/v Nasal Spray 4 MDI shows its action rapidly, its complete effect can be achieved within 10 minutes of administration. The time for which the effects of Da Plus 1.25% w/v Nasal Spray 4 MDI last: The duration of Da Plus 1.25% w/v Nasal Spray 4 MDI’s effect is clinically not established.

What if you forget to take Da Plus 1.25% w/v Nasal Spray 4 MDI

Since this medicine is a rescue treatment used only during an active seizure cluster, there is no daily schedule. Only use it when a seizure cluster occurs, as directed by your doctor.

Storage

.•Store Da Plus 1.25% w/v Nasal Spray 4 MDI at room temperature, ideally between 20°C to 25°C (68°F to 77°F). Do not freeze this medication

Drug Warnings

  • Do not test-spray the device: The nasal spray contains only one pre-measured dose. If you press the plunger to test it, the medicine will be lost, and the device cannot be reused.
  • Check the expiration date: Regularly check the expiration date on your rescue spray package and replace it before it expires so it is ready when you need it.
  • Monitor the patient's breathing: After using the spray, watch the patient's breathing closely. Call for emergency medical help immediately if their breathing becomes unusually slow or shallow.
  • Inform close contacts: Make sure your family, friends, coworkers, or school staff know where your rescue medicine is stored and how to use it in an emergency.
  • Avoid driving after use: This medicine causes significant drowsiness. Do not drive, ride a bike, or operate any machinery for at least 24 hours after using it.

verifiedApollotooltip
  • Opioid pain relievers, sleeping pills, or other muscle relaxants(e.g., morphine, zolpidem, baclofen): Taking these medicines alongside Da Plus 1.25% w/v Nasal Spray 4 MDI may cause extreme drowsiness, severe breathing problems, coma, or even death.
  • Certain antifungals and antibiotics (e.g., ketoconazole, clarithromycin): These medications can slow down how your body breaks down Da Plus 1.25% w/v Nasal Spray 4 MDI, which may increase the risk and severity of side effects.

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verifiedApollotooltip
  • Alcohol: Avoid alcohol entirely, as combining it with this medication significantly increases the risk of dangerous, life-threatening breathing suppression and severe drowsiness.
  • Grapefruit: Avoid eating grapefruit or drinking grapefruit juice, as it can raise the levels of this medicine in your body, increasing the risk of side effects.

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

FAQs

Da Plus 1.25% w/v Nasal Spray 4 MDI is used to treat Seizure clusters (acute repetitive seizures).
Da Plus 1.25% w/v Nasal Spray 4 MDI contains Midazolam, which works by increasing the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thereby preventing fits by stabilizing the electrical activity of nerve cells in the brain.
You are not recommended to take Da Plus 1.25% w/v Nasal Spray 4 MDI with opioids, alcohol or other central nervous system depressants as it may cause breathing problems, severe drowsiness or coma. Therefore, please consult your doctor before taking Da Plus 1.25% w/v Nasal Spray 4 MDI with any other medicines.
You are not recommended to stop using Da Plus 1.25% w/v Nasal Spray 4 MDI suddenly without consulting your doctor as it may cause withdrawal symptoms such as hallucinations, nervousness, shaking, muscle pain or cramps. Therefore, use Da Plus 1.25% w/v Nasal Spray 4 MDI for as long as your doctor has prescribed it, and if you experience any difficulty while using Da Plus 1.25% w/v Nasal Spray 4 MDI, please consult your doctor so that the dose may be reduced gradually.
Yes, Da Plus 1.25% w/v Nasal Spray 4 MDI may cause physical dependence if used for prolonged periods. Therefore, use Da Plus 1.25% w/v Nasal Spray 4 MDI only in the dose and for the duration as advised by your doctor.
You should only use a second dose if your doctor has explicitly written this step into your personalised rescue plan. If the seizure does not stop after using the recommended dose, call for emergency medical help immediately. Talk to your doctor to ensure you have a clear plan.
No, you should never test-spray or prime the device. Each spray device contains only one single dose of medicine. If you spray it into the air, the medicine will be gone, and the device will be empty when you try to use it. Talk to your pharmacist if you are unsure how the device works.
Yes, drowsiness is a very common effect of this medicine. It is important to rest safely after using it, and you should avoid driving or doing anything that requires alertness for at least 24 hours. Talk to your doctor if you experience severe drowsiness that does not improve.
A blocked or runny nose can sometimes affect how well the medicine is absorbed into your body. If you are experiencing nasal congestion or a cold, talk to your doctor or pharmacist for guidance on how to manage your rescue treatment.
This medicine may pose risks to an unborn baby. However, untreated seizure clusters are also highly dangerous for both the mother and the baby. Talk to your doctor to discuss the risks and benefits of keeping this rescue medicine on hand during pregnancy.
No, you must strictly avoid drinking alcohol after using this medicine. Mixing alcohol with this medication can lead to dangerous, life-threatening breathing difficulties and severe drowsiness. Talk to your doctor if you have any questions.
No, this medicine is not a daily preventative treatment. It is an emergency rescue medicine used only to stop sudden, repeated seizure clusters when they happen. Talk to your doctor about your daily seizure medications to ensure your regular treatment plan is optimised.

Disclaimer

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Country of origin

India
Other Info - DAP1259
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