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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Medistat-1.25 Nasal Spray 4 MDI is used to treat Seizure clusters (acute repetitive seizures). It contains Midazolam, which increases GABA activity (a chemical messenger in the brain). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls Seizures. Common side effects of Medistat-1.25 Nasal Spray 4 MDI are headache, drowsiness, runny nose, throat irritation, and nasal discomfort.

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Composition :

MIDAZOLAM-1.25%W/V

Manufacturer/Marketer :

Alteus Biogenics Pvt Ltd

Consume Type :

Nasal

Return Policy :

Not Returnable

About Medistat-1.25 Nasal Spray 4 MDI

Medistat-1.25 Nasal Spray 4 MDI belongs to a class of drugs called benzodiazepines used for the short-term treatment of seizure clusters. Seizure clusters are episodes of elevated seizure activity, defined as two or more seizures occurring within 24 hours. They are upsetting situations that can make you anxious, frustrated, or helpless.

Medistat-1.25 Nasal Spray 4 MDI contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain). Thus, Medistat-1.25 Nasal Spray 4 MDI suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Use Medistat-1.25 Nasal Spray 4 MDI as prescribed and for the duration as your doctor has prescribed it for you based on your medical condition. Sometimes, it may cause side effects such as headache, drowsiness, runny nose, throat irritation, and nasal discomfort. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Please tell your doctor if you are allergic to Midazolam or other medicines. If you are pregnant, planning for pregnancy or are breastfeeding, please inform your doctor before taking Medistat-1.25 Nasal Spray 4 MDI. Medistat-1.25 Nasal Spray 4 MDI is not recommended for children below 12 years as the safety and effectiveness have not been established. Avoid consumption of alcohol with Medistat-1.25 Nasal Spray 4 MDI as it may cause increased drowsiness. Avoid driving or operating machinery until you know how Medistat-1.25 Nasal Spray 4 MDI affects you. Avoid using Medistat-1.25 Nasal Spray 4 MDI if you have acute narrow-angle glaucoma (eye problem). Do not take Medistat-1.25 Nasal Spray 4 MDI with opioids unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma.

Uses of Medistat-1.25 Nasal Spray 4 MDI

Medistat-1.25 Nasal Spray 4 MDI is used in the treatment of seizure clusters (acute repetitive seizures). The detailed uses of Medistat-1.25 Nasal Spray 4 MDI are as follows:

  • Conscious Sedation: Medistat-1.25 Nasal Spray 4 MDI is used before diagnostic or therapeutic procedures to help patients feel relaxed and comfortable, and helps relieve anxiety and muscle tension before minor surgeries or dental procedures.
  • Treatment of Seizure Clusters: Medistat-1.25 Nasal Spray 4 MDI helps manage acute repetitive seizures, which involve multiple seizures within a short period and works by increasing GABA activity, a brain chemical that calms nerve cells and controls seizures.
  • Pre-Surgical Sedation: Medistat-1.25 Nasal Spray 4 MDI is administered before medical procedures to induce drowsiness and reduce discomfort, and helps patients remain calm without the need for general anaesthesia.

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Directions for Use

  • Follow your doctor's instructions regarding the dosage and duration.
  • Blow your nose to clear the nostrils before use. Insert the nozzle into one nostril while closing the other nostril. Spray the medicine while breathing in. Repeat for the other nostril if required.
  • Shake the nasal spray well before each use.

Key Benefits

Medistat-1.25 Nasal Spray 4 MDI contains Midazolam used to treat acute (sudden) repetitive fits. Medistat-1.25 Nasal Spray 4 MDI increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

How Medistat-1.25 Nasal Spray 4 MDI Works

Medistat-1.25 Nasal Spray 4 MDI contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain). Thus, Medistat-1.25 Nasal Spray 4 MDI suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Medistat-1.25 Nasal Spray 4 MDI

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Medistat-1.25 Nasal Spray 4 MDI may include agitation, changes in patterns and rhythms of speech, confusion, drowsiness, dullness, feeling of sluggishness, irritability, lack of coordination, loss of consciousness, loss of strength or energy, nervousness, nightmares, problems with muscle control or coordination, relaxed and calm feeling, restlessness, shakiness and unsteady walk, sleepiness, slurred speech, talkativeness, tiredness, trouble speaking, unsteadiness, unusual excitement, unusual weak feeling, and weakness. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant, planning for pregnancy, or breastfeeding, please inform your doctor before using Medistat-1.25 Nasal Spray 4 MDI. Medistat-1.25 Nasal Spray 4 MDI is not recommended for children below 12 years as the safety and effectiveness were not established. Avoid consumption of alcohol with Medistat-1.25 Nasal Spray 4 MDI as it may cause drowsiness. Avoid driving or operating machinery until you know how Medistat-1.25 Nasal Spray 4 MDI affects you. Avoid using Medistat-1.25 Nasal Spray 4 MDI if you have acute narrow-angle glaucoma (eye problem). Do not take Medistat-1.25 Nasal Spray 4 MDI with opioids until and unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma. Get medical help immediately if you experience unusually excessive sleepiness or shallow or slowed breathing while using Medistat-1.25 Nasal Spray 4 MDI.

Diet & Lifestyle Advise

  • Do regular exercise and maintain a healthy body weight.
  • Maintain a diet rich in fruits, vegetables and whole grains. Avoid fried foods, high-fat dairy products, pastries and processed foods, as they may worsen anxiety.
  • Follow a regular sleep pattern. Do not take a nap during the daytime.
  • Avoid watching tv and using mobiles or laptops just before bedtime.
  • Avoid the consumption of alcohol as it may increase drowsiness.

Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

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Alcohol

Safe if prescribed

Avoid consumption of alcohol with Medistat-1.25 Nasal Spray 4 MDI as it may increase drowsiness.

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Pregnancy

Consult your doctor

If you are pregnant or planning for pregnancy, inform your doctor before using Medistat-1.25 Nasal Spray 4 MDI. Babies born to mothers receiving Medistat-1.25 Nasal Spray 4 MDI late in pregnancy may be at risk of feeding or breathing problems, withdrawal symptoms or dangerously low body temperature.

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Breast Feeding

Consult your doctor

Medistat-1.25 Nasal Spray 4 MDI may be excreted in breast milk and may harm your baby. Therefore, discuss with your doctor the best way to feed your baby if you use Medistat-1.25 Nasal Spray 4 MDI.

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Driving

Safe if prescribed

Avoid driving or operating machinery until you know how Medistat-1.25 Nasal Spray 4 MDI affects you.

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Liver

Consult your doctor

If you have liver problems, consult your doctor before using Medistat-1.25 Nasal Spray 4 MDI.

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Kidney

Consult your doctor

If you have kidney diseases/conditions, consult your doctor before using Medistat-1.25 Nasal Spray 4 MDI.

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Children

Safe if prescribed

Medistat-1.25 Nasal Spray 4 MDI is not recommended for children below 12 years as the safety and effectiveness were not established.

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Heart

Medistat-1.25 Nasal Spray 4 MDI is generally safe for heart patients due to its rapid, localized action and low systemic absorption. However, it may cause sedation or breathing issues, so medical supervision is essential.

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Geriatrics

Consult your doctor

Geriatric patients can use Medistat-1.25 Nasal Spray 4 MDI, but with caution. Older adults are more sensitive to sedative effects, which may increase the risk of drowsiness, confusion, or slowed breathing. It's important that a healthcare provider supervises its use, especially if there are other medications or health conditions involved.

FAQs

Medistat-1.25 Nasal Spray 4 MDI is used to treat Seizure clusters (acute repetitive seizures).

Medistat-1.25 Nasal Spray 4 MDI contains Midazolam, which works by increasing the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thereby preventing fits by stabilizing the electrical activity of nerve cells in the brain.

If the seizure cluster continues after 10 minutes of the first dose, you can use the second dose of Medistat-1.25 Nasal Spray 4 MDI if advised by your doctor. However, the second dose should be given in the other nostril. Do not use more than two doses to treat a seizure cluster.

You are not recommended to take Medistat-1.25 Nasal Spray 4 MDI with opioids, alcohol or other central nervous system depressants as it may cause breathing problems, severe drowsiness or coma. Therefore, please consult your doctor before taking Medistat-1.25 Nasal Spray 4 MDI with any other medicines.

You are not recommended to stop using Medistat-1.25 Nasal Spray 4 MDI suddenly without consulting your doctor as it may cause withdrawal symptoms such as hallucinations, nervousness, shaking, muscle pain or cramps. Therefore, use Medistat-1.25 Nasal Spray 4 MDI for as long as your doctor has prescribed it, and if you experience any difficulty while using Medistat-1.25 Nasal Spray 4 MDI, please consult your doctor so that the dose may be reduced gradually.

Yes, Medistat-1.25 Nasal Spray 4 MDI may cause physical dependence if used for prolonged periods. Therefore, use Medistat-1.25 Nasal Spray 4 MDI only in the dose and for the duration as advised by your doctor.

Country of origin

India

Manufacturer/Marketer address

14-B Dover Lane, Kolkata - 700029, Wb, India.
Other Info - MED1729

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