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  3. Defrijet 500 Tablet 10's

Defrijet 500 Tablet 10's, Pack of 10 TABLETS
Defrijet 500 Tablet 10's, Pack of 10 TABLETS
Defrijet 500 Tablet 10's, Pack of 10 TABLETS
Defrijet 500 Tablet 10's, Pack of 10 TABLETS
Defrijet 500 Tablet 10's, Pack of 10 TABLETS
Defrijet 500 Tablet 10's, Pack of 10 TABLETS
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Defrijet 500 Tablet is used to treat iron overload due to transfusional hemosiderosis (the accumulation of iron in the body due to frequent blood transfusions) or non-transfusion-dependent thalassemia (patients who do not require lifelong regular transfusions for survival). It works by binding to the extra iron and facilitates its removal from the body through faeces. In some cases, this medicine may cause side effects like diarrhoea, vomiting, nausea, abdominal pain, and skin rashes.
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Composition :

DEFERASIROX-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Defrijet 500 Tablet

Defrijet 500 Tablet is used for treating chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients two years older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

The active ingredient in Defrijet 500 Tablet is deferasirox. It is a trivalent iron selective chelating agent. It binds the excess iron and eliminates it through faeces. The danger of organ damage is reduced as a result.

Defrijet 500 Tablet is available in the form of oral formulations. Please take Defrijet 500 Tablet in the dose and duration prescribed by your doctor based on specific medical conditions. In some cases, you may experience common side effects such as diarrhoea, vomiting, nausea, abdominal pain, skin rashes, and increased serum creatinine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue using Defrijet 500 Tablet for as long as your doctor has prescribed it. Do not use Defrijet 500 Tablet without a doctor's advice if you have a skin reaction or irritation to any medicine. Consult your doctor before using the Defrijet 500 Tablet if you are pregnant or breastfeeding. Do not use Defrijet 500 Tablet in more than prescribed doses or for a longer duration as it may cause adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking Defrijet 500 Tablet to rule out any side effects.

Uses of Defrijet 500 Tablet

Used for treating chronic iron overload that occurs due to blood transfusions (transfusional hemosiderosis) in patients two years of age and older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

Directions for Use

Swallow Defrijet 500 Tablet whole with water; do not crush, break, or chew it.

Medicinal Benefits

Deferasirox is the active component in Defrijet 500 Tablet . It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

How Defrijet 500 Tablet Works

The active ingredient in Defrijet 500 Tablet is deferasirox. It is a trivalent iron selective chelating agent. It binds the excess iron and eliminates it through faeces. The danger of organ damage is reduced as a result.

Storage

Store in a cool and dry place away from sunlight
Side effects of Defrijet 500 Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

What if I have taken an overdose of Defrijet 500 Tablet

Take Defrijet 500 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. Overdose symptoms may include nausea, abdominal pain, vomiting, diarrhoea, and kidney/liver problems that might be serious. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Defrijet 500 Tablet if you are allergic to Defrijet 500 Tablet or its ingredients. Defrijet 500 Tablet is not usually recommended if you are a pregnant or lactating woman; there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the medicine's benefits outweigh the risks. It is unknown whether Defrijet 500 Tablet alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react. Seek medical attention if the symptoms persist longer. Avoid consuming alcohol along with Defrijet 500 Tablet as it could lead to unpleasant side effects. Should monitor elderly and paediatric patients closely for toxicity.

Drug-Drug Interactions

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DeferasiroxNeomycin
Severe
DeferasiroxRuxolitinib
Severe

Drug-Drug Interactions

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DeferasiroxNeomycin
Severe
How does the drug interact with Defrijet 500 Tablet:
Defrijet 500 Tablet may cause kidney problems and combining it with neomycin may increase that risk.

How to manage the interaction:
Although taking Neomycin and Defrijet 500 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxRuxolitinib
Severe
How does the drug interact with Defrijet 500 Tablet:
Using Defrijet 500 Tablet together with Ruxolitinib may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although taking Defrijet 500 Tablet and Ruxolitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience abdominal pain, bloating, dizziness, lightheadedness, loss of hunger, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools call a doctor. Do not discontinue any medications without consulting a doctor.
DeferasiroxClozapine
Severe
How does the drug interact with Defrijet 500 Tablet:
Taking Defrijet 500 Tablet with Clozapine may increase the risk of infections.

How to manage the interaction:
Although taking Defrijet 500 Tablet and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor. They may be able to recommend other options for you that won't cause any problems. Do not stop using any medications without a doctor's advice.
DeferasiroxLomitapide
Severe
How does the drug interact with Defrijet 500 Tablet:
Lomitapide may cause liver problems and using it with Defrijet 500 Tablet may increase that risk.

How to manage the interaction:
Although taking Defrijet 500 Tablet and Lomitapide together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor right away: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, weakness, nausea, vomiting, bleeding, abdominal pain, or dark urine. Do not stop using any medications without a doctor's advice.
DeferasiroxCortisone
Severe
How does the drug interact with Defrijet 500 Tablet:
Using Defrijet 500 Tablet together with cortisone may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Co-administration of Cortisone with Defrijet 500 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts. If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxEtidronic acid
Severe
How does the drug interact with Defrijet 500 Tablet:
Combining Etidronic acid (oral form) with Defrijet 500 Tablet can increase the risk of bleeding and ulcers in the stomach and intestines.

How to manage the interaction:
Co-administration of Etidronic acid with Defrijet 500 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxUrokinase
Severe
How does the drug interact with Defrijet 500 Tablet:
Using Defrijet 500 Tablet together with Urokinase may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Urokinase with Defrijet 500 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxGentamicin
Severe
How does the drug interact with Defrijet 500 Tablet:
Taking Defrijet 500 Tablet may cause kidney problems and combining it with gentamicin may increase that risk.

How to manage the interaction:
Although there is a possible interaction, gentamicin can be taken with Defrijet 500 Tablet if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Dehydration can also harm the kidney, therefore drink plenty of fluids if you develop diarrhoea or vomiting during treatment with these medications.
DeferasiroxVancomycin
Severe
How does the drug interact with Defrijet 500 Tablet:
Coadministration of Vancomycin with Defrijet 500 Tablet can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Vancomycin with Defrijet 500 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
DeferasiroxAmphotericin b
Severe
How does the drug interact with Defrijet 500 Tablet:
Defrijet 500 Tablet can cause kidney issues, and mixing it with amphotericin B, can enhance that risk.

How to manage the interaction:
Taking Amphotericin b with Defrijet 500 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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DEFERASIROX-500MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEFERASIROX-500MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
The blood levels and effects of caffeine may be enhanced by Defrijet 500 Tablet. Avoid consumption of caffeinated drinks during the treatment with Defrijet 500 Tablet. If you experience any unusual symptoms call a doctor.

Diet & Lifestyle Advise

  • Choose foods high in nutrients, such as fruits, vegetables, and whole grains.

  • Replace fatty protein sources with lean alternatives and consume modest quantities of healthy fat sources for improved well-being.

  • Create a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.

  • Instead of saturated and trans fats, choose monounsaturated and polyunsaturated fats (fish, nuts, and vegetable oils).

  • Select/prepare foods and beverages with fewer added sugars/caloric sweeteners.

  • Be mindful of salt; consume no more than 2,300 mg each day.

  • Limit or avoid alcohol and caffeine consumption.

Habit Forming

No

Therapeutic Class

CHELATING AGENTS

Defrijet 500 Tablet Substitute

Substitutes safety advice

  • Desirox 500 mg Tablet 30's

    by Others

    ₹58.58per tablet

  • Deferataj 500mg Tablet DT

    by Others

    ₹43.92per tablet

  • Deferglob 500mg Tablet

    by Others

    ₹37.80per tablet

Product Substitutes

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Alcohol

Caution

Consume alcohol along with Defrijet 500 Tablet is not advisable as it may cause unpleasant side effects, or you also may become more sensitive to the effects of alcohol.

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Pregnancy

Caution

Defrijet 500 Tablet is not usually recommended if you are pregnant. This is because there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks. Please consult the doctor.

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Breast Feeding

Caution

Defrijet 500 Tablet is not usually recommended if you are a lactating woman. This is because there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks.

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Driving

Caution

It is not known whether Defrijet 500 Tablet alters the ability to drive, so do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react.

bannner image

Liver

Caution

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Caution

Should be used under the supervision of healthcare provider

Have a query?

FAQs

Defrijet 500 Tablet is used to treat chronic iron overload due to blood transfusions (transfusional hemosiderosis).

Deferasirox is the active component in Defrijet 500 Tablet . It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.

Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose. Do not take a double dose to make up for the dose that you missed.

Defrijet 500 Tablet is safe if used in the dose and duration recommended by your doctor. Take it precisely as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.

The extra iron due to iron overload is stored in pancreas. This damages the pancreas and it does not produce insulin properly. Insulin is required by the body to utilise sugar/glucose efficiently. As insulin is not produced properly, it affects blood sugar levels.

Yes, iron overload is the same as haemochromatosis. Hemochromatosis, or iron overload, is a condition in which your body stores too much iron.

Yes, Defrijet 500 Tablet can be used in children above 2 years if prescribed by the doctor. Talk to the doctor if you have any concerns regarding this.

Defrijet 500 Tablet may cause side effects like diarrhoea, vomiting, nausea, abdominal pain, skin rashes, and increased serum creatinine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - DEF0068

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:46 PM IST

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Reference

  1. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=207968
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/207968s009lbl.pdf
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