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compositionComposition:DEGARELIX-120MG
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Prescription Medicine
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Degalix 120 Injection is used in the treatment of advanced prostate cancer. It contains Degarelix, a synthetic hormone blocker which works by decreasing the amount of testosterone and helps to stop or slow the spread of prostate cancer cells that require testosterone for their growth. This medicine is not intended for use in women. In some cases, Degalix 120 Injection may cause side effects such as injection site reaction and hot flushes.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DEGARELIX-120MG

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Degalix 120 Injection

Degalix 120 Injection is an injection primarily used to treat patients with advanced prostate cancer. This medicine serves as a hormone therapy, working to lower the amount of testosterone in your body. By reducing this hormone, it effectively helps slow down or stop the growth of cancer cells.

It is typically injected once a month by a healthcare provider after an initial starting dose. Because it is given as an injection under the skin, food intake does not affect how this medicine works in your system. Regular physical activity and dietary adjustments, like increasing your calcium intake, can help improve your overall results and maintain your strength.

While using this medicine, you may notice common side effects like hot flashes, weight gain, or redness and pain at the injection site. However, if you experience serious symptoms such as severe dizziness, shortness of breath, or signs of a severe allergic reaction, you must consult your doctor immediately.

Before starting this medicine, tell your doctor if you have a history of heart rhythm issues, liver damage, or kidney problems. You should not take this medicine if you have had a severe allergic reaction to it, or if you are a woman who is pregnant, planning to become pregnant, or breastfeeding.

This medicine can interact with other drugs that affect your heart rhythm, so it is important to inform your healthcare team of all medications you are taking. Additionally, while there is no direct interaction with alcohol, limiting alcohol and avoiding smoking is advised to protect your cardiovascular and liver health. Elderly individuals should discuss their complete medical history with their doctor to ensure safe use.

Uses of Degalix 120 Injection

Your doctor may prescribe Degalix 120 Injection to help manage the following conditions:

  • Advanced prostate cancer: Degalix 120 Injection helps by rapidly lowering the levels of testosterone, a hormone that prostate cancer cells need to grow and multiply. This helps slow the progression of the disease.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Rapid Hormone Control: This medicine helps manage advanced prostate cancer efficiently by offering quick hormone control. Because it lowers testosterone levels within days, it helps prevent a temporary worsening of symptoms like bone pain or urinary difficulty, which can sometimes happen with other therapies.
  • Helps Slow Prostate Cancer Progression: By keeping hormone levels consistently low, Degalix 120 Injection helps relieve discomfort, protect bone stability, and limit the spread of cancer. Since a healthcare provider administers this injection, you can feel reassured that you are receiving the exact dose you need on a reliable schedule.
Side effects of Degalix 120 Injection
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
  • Eat fiber-rich foods, fruits, and vegetables, and track your food intake to monitor calorie consumption.
  • Limit takeout and restaurant meals, and weigh yourself weekly to stay motivated.
  • Build balanced meals, allow yourself to enjoy treats in moderation, and prioritize sleep and stress management through exercise and relaxation techniques.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Degalix 120 Injection is given by the doctor or a trained nurse.
  • Do not self-administer.

How Degalix 120 Injection Works

Degalix 120 Injection contains degarelix, which works as a hormone blocker. It binds to specific receptors in the pituitary gland in the brain, blocking the signals that tell your testicles to produce testosterone. Since prostate cancer cells rely on testosterone to grow and spread, cutting off this hormonal supply helps shrink tumors and slows the progression of the disease. Unlike LHRH agonists such as leuprolide, Degalix 120 Injection lowers testosterone immediately and does not cause an initial temporary rise in testosterone, known as a 'testosterone flare.' This temporary flare can briefly worsen symptoms such as bone pain or difficulty passing urine before hormone levels fall.
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Alcohol

Consult your doctor

It is not known whether Degalix 120 Injection interacts with alcohol. Please consult your doctor.

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Pregnancy

Not applicable

-

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Breast Feeding

Not applicable

-

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Driving

Caution

In some cases, Degalix 120 Injection may cause dizziness or tiredness. So, drive or operate machinery only if you are alert.

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Liver

Caution

If you have a history of liver disease, please inform the doctor before receiving Degalix 120 Injection. Liver function may need to be monitored in patients with liver disease.

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Kidney

Caution

If you have a history of kidney disease, please inform the doctor before receiving Degalix 120 Injection.

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Children

Unsafe

Degalix 120 Injection is not recommended for children as the safety and effectiveness have not been established.

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Heart

Caution

If you have a history of heart disease, please inform the doctor before receiving Degalix 120 Injection.

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Geriatrics

Consult your doctor

Limited information available about the use of Degalix 120 Injection in geriatric patients. Please consult your physician.

What if I have taken an overdose of Degalix 120 Injection

Because a trained healthcare professional injects this medicine, an overdose is highly unlikely. However, if you suspect an error or experience severe chest discomfort, breathing difficulties, or severe dizziness after an injection, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Support your bones: Lowering testosterone can weaken your bones over time. Eat a diet rich in calcium and vitamin D, including foods like leafy greens, dairy, and fortified cereals, or ask your doctor about supplements.
  • Bone Health Monitoring: Ask your doctor whether you need periodic bone density (DEXA) scans during long-term treatment. These scans help detect early bone loss so steps can be taken to reduce your risk of osteoporosis and fractures.
  • Stay active: Engage in regular, gentle weight-bearing exercises like walking or light strength training to help protect your bones, maintain muscle mass, and combat fatigue.
  • Eat a heart-healthy diet: Hormone therapy can affect your cholesterol and blood sugar. Focus on whole grains, lean proteins, fruits, vegetables, and healthy fats while limiting processed foods.
  • Manage hot flashes: Wear layers of breathable cotton clothing, keep your living space cool, and avoid known triggers like hot drinks, spicy foods, caffeine, and alcohol.
     
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How Soon It Starts Working

The time required for Degalix 120 Injection to start to work: The time required for Degalix 120 Injection to show its action is not clinically established. The time for which the effects of Degalix 120 Injection last: The duration of action for Degalix 120 Injection is not clinically established.

What if you forget to take Degalix 120 Injection

Since this medicine is given in a clinical setting, missing a dose is uncommon. If you miss or have to cancel an appointment for your injection, contact your healthcare provider's office immediately to reschedule. Keeping your injections on a regular schedule is vital for managing your condition.

Storage

• Store the unmixed powder vials at room temperature, between 20°C to 25°C (68°F to 77°F). Keep the medication in its original packaging to protect it from light and moisture.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Do not massage the injection area: Avoid pressing, rubbing, or wearing tight waistbands directly over the injection site on your stomach to prevent skin irritation.
  • Rotate your injection sites: Make sure your healthcare provider uses a different spot on your abdomen for each injection to help keep your skin healthy.
  • Monitor your heart rhythm: This medicine can alter your heart's electrical activity. Contact your doctor immediately if you feel lightheaded, dizzy, or experience a fluttering heartbeat.
  • Keep up with regular lab work: You will need routine blood tests to check your testosterone levels, prostate-specific antigen (PSA), and liver function.
  • Metabolic Health Monitoring: Your doctor may also periodically check your blood sugar and cholesterol levels because long-term hormone therapy can increase the risk of diabetes and metabolic changes.
  • Inspect the mixture: If you are assisting in preparing the medicine under medical guidance, verify that the liquid is clear and free of floating particles before it is injected.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart rhythm medicines: Combining Degalix 120 Injection with drugs used to treat irregular heartbeats (such as amiodarone, sotalol, or quinidine) can increase the risk of serious heart rhythm abnormalities.
  • Certain antibiotics and antipsychotics: Some medications used to treat infections or mental health conditions can also affect your heart rhythm and should be used with caution while taking this medicine.

Drug-Drug Interactions

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How does the drug interact with Degalix 120 Injection:
Taking Degalix 120 Injection with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Degalix 120 Injection with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Degalix 120 Injection:
Using amisulpride together with Degalix 120 Injection can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although taking Degalix 120 Injection and Amisulpride together can cause an interaction, it can be taken if a doctor has suggested it. If you experience symptoms like irregular heart rhythm, dizziness, fainting, or shortness of breath, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Degalix 120 Injection:
Using sotalol together with Degalix 120 Injection can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Degalix 120 Injection, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Degalix 120 Injection:
Combining Degalix 120 Injection with Clozapine can increase the risk of QTc prolongation.

How to manage the interaction:
Co-administration of Degalix 120 Injection with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like changes in your heart rhythm, feeling dizzy or lightheaded, or having trouble breathing, it's important to call your doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Degalix 120 Injection:
Coadministration of Degalix 120 Injection with amiodarone may increase the risk of abnormal cardiac rhythms.

How to manage the interaction:
Although taking Degalix 120 Injection with amiodarone may cause an interaction, it is safe to do so if your doctor has prescribed it. If you have a cardiac problem or electrolyte imbalances, you may be more vulnerable. If you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, consult a doctor . Do not stop taking any medications without visiting a doctor.
How does the drug interact with Degalix 120 Injection:
Taking Degalix 120 Injection and Efavirenz can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Degalix 120 Injection and Efavirenz together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Degalix 120 Injection:
Combining Degalix 120 Injection with Escitalopram can increase the risk of QTc prolongation.

How to manage the interaction:
Taking Degalix 120 Injection with Escitalopram together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any symptoms like dizziness, fainting, or abnormal heart rhythm, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Degalix 120 Injection:
Using Moxifloxacin together with Degalix 120 Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Degalix 120 Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, or irregular heartbeat, contact a doctor right away. Do not discontinue any medications without consulting a doctor,
How does the drug interact with Degalix 120 Injection:
Taking Degalix 120 Injection with Ceritinib can increase the risk of irregular heart rhythm and other side effects.

How to manage the interaction:
There may be a possibility of interaction between Degalix 120 Injection and Ceritinib, but it can be taken if prescribed by a doctor. If you experience any symptoms like dizziness, fainting, or difficulty breathing, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Degalix 120 Injection:
Co-administration of Degalix 120 Injection with Haloperidol can increase the risk of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Degalix 120 Injection with Haloperidol together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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  • No clinically significant food interactions are known with Degalix 120 Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Degalix 120 Injection is used to treat Prostate cancer.
Degalix 120 Injection works by decreasing the amount of testosterone and helps to stop or slow the spread of prostate cancer cells.
Degalix 120 Injection may decrease fertility. If you have any concerns regarding this, please consult the doctor.
Worsening or onset of diabetes may occur. Therefore, if you have diabetes, inform the doctor. You may need to check your blood glucose levels more regularly if you have diabetes.
This medicine is not a cure for prostate cancer, but it is highly effective at controlling the disease and slowing down the growth of cancer cells by blocking the hormones they need. Talk to your doctor for more information on long-term management.
If you have a mild cold, it is generally safe to receive your injection. If you have a high fever or a serious infection, call your doctor's office before your appointment to see if you should reschedule. Talk to your doctor if you are unwell.
The length of your treatment depends on how your prostate cancer responds and your overall health. Your doctor will regularly evaluate your condition to decide the best duration of therapy. Talk to your doctor for personalised advice.
While less common than with traditional chemotherapy, the hormone changes caused by this medicine can sometimes cause thinning hair or mild hair loss. Talk to your doctor or pharmacist if you notice changes in your hair.
If you stop your injections, your testosterone levels will rise again, which can cause your prostate cancer to start growing or spreading. Always talk to your doctor before stopping or delaying your treatment.
Yes, this medicine can cause temporary increases in liver enzymes. Your healthcare team will monitor your liver health with routine blood tests. Talk to your doctor if you experience signs of liver issues, such as yellowing of your skin or eyes.
Most people can drive safely after their injection, but some may feel unusually tired or dizzy. If you experience these symptoms, avoid driving or operating machinery until you feel fully alert. Talk to your doctor if you have concerns.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Engineering Center 6Th Floor, 9Th Matthew Road, Opera House, Mumbai – 400 00
Other Info - DEG0029
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