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compositionComposition:ADAPALENE-0.1%W/W
prescription
Prescription Medicine
info
Deriva MS Aqueous Gel 15 gm
Deriva MS Aqueous Gel 15 gm
Deriva MS Aqueous Gel 15 gm

Deriva MS Aqueous Gel is used to treat acne (pimples) in patients aged 12 years and older. It helps reduce pimples, blackheads, and whiteheads. Regular use helps maintain clear skin and prevents new breakouts. It also improves skin texture and appearance over time.

Read more
Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ADAPALENE-0.1%W/W

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Deriva MS Aqueous Gel

Deriva MS Aqueous Gel is a topical skin treatment used to clear up acne breakouts, blackheads, and whiteheads. It helps reduce the number and severity of pimples while promoting quicker healing of the skin. This medicine is designed for individuals dealing with mild to moderate acne lesions.

For the best results, you should apply Deriva MS Aqueous Gel consistently once a day, preferably at bedtime. It works best when applied to clean, dry skin on a regular daily schedule. Alongside using this medicine, adopting a gentle skincare routine, staying hydrated, and avoiding picking at your acne can greatly improve your treatment results.

While using this medicine, you may experience some mild skin dryness, redness, or peeling, especially during the first few weeks. These effects are usually normal as your skin adjusts, but you should contact your doctor if you experience severe burning, swelling, or signs of an allergic reaction.

Do not use this if you have extremely sensitive skin, severe eczema, or a bad sunburn on the areas you need to treat. You should also speak with your healthcare provider before starting this treatment if you have any other chronic skin conditions.

Avoid using other harsh skin products like abrasive soaps, strong chemical peelers, or drying cosmetics while using Deriva MS Aqueous Gel, as they can cause severe skin irritation. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor or pharmacist before using this medicine.

Uses of Deriva MS Aqueous Gel

Deriva MS Aqueous Gel is used to to clear up acne breakouts, blackheads, and whiteheads. The detailed uses of Deriva MS Aqueous Gel are as follows:

  • Acne Vulgaris: Deriva MS Aqueous Gel helps clear active acne pimples and prevents new breakouts from forming by keeping skin pores clear.
  • Blackheads and Whiteheads: It targets and dissolves the plugs of oil and dead skin cells that form stubborn blackheads and whiteheads.
     

Key Benefits

Deriva MS Aqueous Gel helps treat acne by targeting the underlying causes of breakouts and promoting healthier skin. By keeping pores clear and reducing inflammation, it helps improve skin appearance and supports long-term acne management.

  • Helps Clear Acne and Prevent New Breakouts: By preventing blocked pores and reducing the formation of acne lesions, Deriva MS Aqueous Gel helps treat existing pimples while lowering the risk of future breakouts.
  • Reduces Skin Inflammation: Deriva MS Aqueous Gel helps minimise redness, swelling, and irritation associated with acne, promoting clearer and healthier-looking skin.
  • Supports Long-Term Skin Health: With regular use, Deriva MS Aqueous Gel helps improve skin texture, reduce the likelihood of acne scarring, and maintain clearer skin by preventing the recurrence of acne lesions.
     
Side effects of Deriva MS Aqueous Gel 15 gm
  • After taking a shower or bath, apply a moisturizer to damp skin.
  • Use petroleum jelly or other thick emollients.
  • Use a hypoallergenic, fragrance-free moisturizer 2 to 3 times a day or as frequently as required.
  • Exfoliate your skin gently using a pumice stone or slightly abrasive sponge.
  • Do not scrub your skin.
  • Avoid hot showers or baths. Instead take short, warm showers or baths.
  • Use mild soap or skin cleansers with added moisturizer.
  • Drink lots of water.
  • Use sunscreen and wear protective clothing while going out to protect yourself from sun damage.
Here are the steps to manage medication-triggered Burning Or Stinging:
  • If you experience burning or stinging sensations and suspect that they may be related to medication, consult a doctor or healthcare expert to determine the cause and best course of treatment.
  • Avoid harsh products, extreme temperatures, and other potential irritants that may exacerbate burning or stinging.
  • Your healthcare professional may recommend applying a soothing or protective agent, such as a cream, gel, or ointment, to help alleviate burning or stinging.
  • Follow your healthcare professional's advice on how to care for the affected area, as gentle cleaning and care instructions may vary depending on the location and severity of the burning or stinging.
  • Schedule follow-up appointments with your doctor to monitor your symptoms and adjust your treatment plan as needed. If the burning or irritation persists or worsens, seek medical attention.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Avoid extreme heat or cold, like hot showers or cold winds, to prevent worsening skin discomfort.
  • Cool compresses: To reduce itch, redness, and swelling.
  • Avoid irritants like harsh chemicals or allergens to prevent worsening skin discomfort.
  • If you have severe itching, burning, or blistering seek medical attention.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Sunburns can occur commonly. Cover the area that is affected to avoid extended exposure.
  • Apply a clean, dampened towel to the affected skin for relief.
  • Take a cool bath by adding baking soda to water.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet that heals the allergy or burns.
  • Apply a skin-calming lotion, gel or moisturiser frequently.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Wash the affected area with water and dry it thoroughly. Apply a thin layer of Deriva MS Aqueous Gel to clean, dry skin at night, or as directed by your physician.
  • Deriva MS Aqueous Gel is for external use only.
  • Wash your hands before and after applying Deriva MS Aqueous Gel.

How Deriva MS Aqueous Gel Works

The active ingredient in Deriva MS Aqueous Gel is a topical retinoid called adapalene, which is a class of medications related to vitamin A. It works by regulating the growth of skin cells and preventing them from sticking together. When skin cells shed normally, they do not clog your pores, which prevents pimples from forming in the first place. Additionally, this medicine has natural anti-inflammatory properties. This helps reduce the swelling, redness, and soreness associated with active acne breakouts, allowing your skin to heal more quickly and evenly.
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Alcohol

Caution

The interaction of Deriva MS Aqueous Gel with alcohol is unknown. Please consult a doctor before consuming alcohol while using Deriva MS Aqueous Gel.

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Pregnancy

Caution

Deriva MS Aqueous Gel is a category C pregnancy drug and is usually not recommended for pregnant women. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

It is unknown whether Deriva MS Aqueous Gel is excreted in human milk. Therefore, Deriva MS Aqueous Gel is recommended for breastfeeding mothers only if the physician determines that the benefits outweigh the risks. However, do not apply Deriva MS Aqueous Gel on the chest area to avoid contact with the baby.

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Driving

Safe if prescribed

Deriva MS Aqueous Gel usually does not affect your ability to drive or operate machinery.

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Liver

Safe if prescribed

If you have any concerns regarding the use of Deriva MS Aqueous Gel in patients with liver problems, please consult a doctor.

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Kidney

Safe if prescribed

If you have any concerns regarding the use of Deriva MS Aqueous Gel in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Deriva MS Aqueous Gel is not recommended for children under 12 years of age, as its safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems.

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Geriatrics

Consult your doctor

Limited information available for use of Deriva MS Aqueous Gel in elderly patients. Please consult your doctor.

What if I have taken an overdose of Deriva MS Aqueous Gel

Using too much of this medicine will not make your acne clear up faster and may cause severe skin peeling and redness. If you apply too much, wash it off with cool water. If someone accidentally swallows the medicine, seek immediate medical attention.

Diet & Lifestyle Advise

  • Protect your skin from the sun: This medicine makes your skin highly sensitive to sunlight. Wear a broad-spectrum sunscreen with SPF 30 or higher daily, and wear protective clothing when outdoors.
  • Use a gentle moisturiser: To combat dryness and peeling, apply a gentle, oil-free (non-comedogenic) moisturiser regularly.
  • Avoid harsh skin products: Stay away from exfoliating scrubs, astringents, alcohol-based toners, and products containing alpha-hydroxy acids or salicylic acid unless advised by your doctor.
  • Do not pick or squeeze pimples: Squeezing or popping acne can worsen inflammation, delay healing, and increase the risk of permanent scarring.

 

Health Queries

I have painful acne that develops under the skin and does not fully come to the surface. What treatment can help remove these and prevent new ones from forming?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Painful acne that stays under the skin (often called cystic or nodular acne) usually needs a slightly stronger and consistent treatment approach, so avoid squeezing or picking as it can worsen inflammation and cause scars, and start with proven treatments like Benzoyl Peroxide or a retinoid-based gel to reduce bacteria and unclog pores, while using a gentle cleanser, oil-free moisturizer, and sunscreen daily. However, because these deeper pimples often do not respond fully to creams alone, it is best to consult a dermatologist who may prescribe oral medicines such as antibiotics or, in more severe cases, isotretinoin to control the condition and prevent new breakouts, and with proper treatment and patience over several weeks, you can achieve good improvement.

Have a query?

How Soon It Starts Working

  • The time required for Deriva MS Aqueous Gel to start to work: The time required for Deriva MS Aqueous Gel to show its action is not clinically established.
  • The time for which the effects of Deriva MS Aqueous Gel last: The duration of action for Deriva MS Aqueous Gel is not clinically established.

What if you forget to take Deriva MS Aqueous Gel

If you miss an application, apply it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed application and continue with your regular schedule. Do not apply extra medicine to make up for a missed dose.

Storage

•Store Deriva MS Aqueous Gel at room temperature, ideally between 20°C to 25°C. •Keep the tube tightly closed when not in use to protect the medicine from moisture and air.

Drug Warnings

  • Check the packaging before use to ensure the safety seal is intact and the gel or cream appears uniform.
  • Expect a temporary increase in acne breakouts (known as skin purging) during the first few weeks of treatment; this is a sign that the medicine is working to clear deep blockages.
  • Do not apply this medicine to broken, cut, scraped, or sunburnt skin.
  • Avoid wax depilation (waxing) on any areas of the skin where you are applying this medicine, as it can cause skin tearing.
  • Be careful not to let the medicine build up in the creases of your nose or mouth, where irritation is more likely to occur.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Peeling or abrasive agents: Combining Deriva MS Aqueous Gel with products containing sulphur, resorcinol, or salicylic acid can cause severe skin irritation.
  • Drying cosmetics or soaps: Using medicated soaps, astringents, or alcohol-rich cosmetics alongside this medicine can severely dry and irritate your skin.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Deriva MS Aqueous Gel when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Deriva MS Aqueous Gel is used to treat acne, a common skin condition that occurs when hair follicles are blocked with dead skin cells and oil.
Deriva MS Aqueous Gel works by loosening cells on the skin's surface and unblocking pores by reducing the production of sebum. Thereby, decreases pimples, spots, whiteheads and blackheads. Also, adapalene increases the production of new skin cells and supports natural exfoliation (removal of dead skin cells) in the outer layers of the skin.
Deriva MS Aqueous Gel may cause photosensitivity (increased skin sensitivity to sunlight) in the treated areas. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen (SPF 30 or more) and wear protective clothing while going out to prevent sunburn.
No, Deriva MS Aqueous Gel is not recommended for patients with eczema (itchy, cracked, swollen, or rough skin) because it may cause severe irritation. Therefore, if you have eczema, inform your physician before using Deriva MS Aqueous Gel.
Yes, Deriva MS Aqueous Gel may cause skin irritation as a side effect. However, if the irritation persists or worsens, discontinue use of Deriva MS Aqueous Gel and consult a physician.
You are advised not to use other acne products containing erythromycin, benzoyl peroxide or clindamycin with Deriva MS Aqueous Gel at the same time, as it may cause excessive irritation or dry skin. Therefore, it is recommended to use Deriva MS Aqueous Gel at night and other products in the morning. However, please consult a doctor before using any other medicines or products with Deriva MS Aqueous Gel.
Yes, Deriva MS Aqueous Gel may cause skin dryness. You can use a moisturiser while using Deriva MS Aqueous Gel to prevent dry skin. However, do not apply Deriva MS Aqueous Gel and the moisturiser simultaneously, as this may reduce the effectiveness of Deriva MS Aqueous Gel. Please consult a doctor before using other products with Deriva MS Aqueous Gel.
Deriva MS Aqueous Gel may cause side effects such as skin irritation, skin redness, a burning sensation, sunburn, peeling, or dry skin. If these side effects persist or worsen, please consult your doctor.
Yes, Deriva MS Aqueous Gel helps reduce scars after acne.
Blackheads are a type of acne. Thus, Deriva MS Aqueous Gel can be used to manage and treat acne. However, it is advisable to use Deriva MS Aqueous Gel only after a doctor's advice. The doctor will prescribe the same after a proper skin diagnosis. Do not self-medicate.
Deriva MS Aqueous Gel is usually not recommended for pregnant women. Please consult a doctor if you are pregnant.
It is advisable to avoid cosmetic procedures while using Deriva MS Aqueous Gel. Cosmetic products with abrasive, peeling, or drying actions may increase irritant effects. Please consult your doctor if you have any concerns regarding this.
Yes, Deriva MS Aqueous Gel may cause a burning sensation as a common side effect. Additionally, during the first 4 weeks of treatment, you may experience dryness, redness, and scaling, which usually improve as you continue to use Deriva MS Aqueous Gel. If the side effects persist or worsen, inform your doctor.
If necessary, moisturisers may be used; however, products containing glycolic or alpha hydroxy acids should be avoided.
Deriva MS Aqueous Gel should be applied at night before bedtime or should be used as advised by your doctor. Clean the affected area with water and ensure it is dry before applying Deriva MS Aqueous Gel. Apply it as a thin layer over the entire face and any other affected areas by taking a small amount onto your fingertips. It is important to clean your hands after applying Deriva MS Aqueous Gel.
You are advised to limit your time outdoors in the sun, as Deriva MS Aqueous Gel can make your skin sensitive. If you must be in direct sunlight, wear sunscreen, a hat, and clothing that covers the treated areas. You should avoid exposure to extreme weather, such as cold and wind, as this may irritate your skin. Avoid using certain skin products, such as astringents, harsh soaps, and cosmetics with strong skin-drying effects. In addition, products with high alcohol levels should be avoided, as they may further irritate or dry your skin.
Mild peeling is a common reaction when starting this medicine. You can manage this by applying a gentle, oil-free moisturiser or talking to your doctor about gradually increasing how often you apply it to give your skin time to adapt.
Yes, you can wear makeup, but it is best to apply Deriva MS Aqueous Gel at night on clean skin. If you wear makeup during the day, choose non-comedogenic (pore-clearing) products so they do not block the medicine's effects. Talk to your doctor or pharmacist for product recommendations.
Skin purging is a temporary phase where your acne may seem to get worse before it gets better, as deep-seated clogs are pushed to the surface. This is normal and usually subsides within a few weeks. Talk to your doctor if the breakout remains severe or painful.
No, you should never apply this medicine to broken, cut, or scraped skin, as it can cause intense burning and irritation. Wait until your skin has fully healed before applying. Talk to your doctor if you have concerns about skin healing.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.920 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Adapalene Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. Adapalene [EMC SmPC. 2022. [Accessed on 16 Jan. 2026] Check here
  4. Adapalene [Prescribing Information]. 2012. [Accessed on 20 Feb. 2024] Check here
  5. Piskin S, Uzunali E. A review of the use of adapalene for the treatment of acne vulgaris. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. 2007. [Accessed on 7th May 2026] Check here
  6. Galderma (U.K.) Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022]. [Accessed on 7th May 2026] Check here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 03 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - DER0046

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