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compositionComposition:DESVENLAFAXINE-50MG
prescriptionPrescription Medicine
Desnri-ER 50 Tablet 10's

Desnri-ER 50 Tablet is used in the treatment of major depressive disorder (depression). It helps improve mood, restore emotional balance, and reduce symptoms such as persistent sadness, loss of interest in daily activities, fatigue, and anxiety. This medicine supports mental well-being by enhancing energy levels, concentration, and overall motivation, thereby improving daily functioning and quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DESVENLAFAXINE-50MG

Manufacturer/Marketer :

Lupichem Healthcare

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Desnri-ER 50 Tablet

Desnri-ER 50 Tablet is used to treat a major depressive disorder (depression). Major depressive disorder, also known as clinical depression, is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time.

Desnri-ER 50 Tablet contains desvenlafaxine, which increases the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. Thereby, it helps improve mood.

Take Desnri-ER 50 Tablet as prescribed by your doctor. In some cases, you may experience side effects such as nausea, dizziness, sleep problems, constipation, sleepiness, loss of appetite, and anxiety. Talk to your doctor if you experience these side effects persistently.

Before taking Desnri-ER 50 Tablet , you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself.

Uses of Desnri-ER 50 Tablet

Desnri-ER 50 Tablet is used to treat depression. The detailed uses of Desnri-ER 50 Tablet are as follows:

  • Depression: Desnri-ER 50 Tablet helps to improve mood and reduce symptoms of depression, including sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty concentrating, making decisions, and thinking.

Key Benefits

  • Desnri-ER 50 Tablet belongs to a group of antidepressant medicines indicated for the treatment of a major depressive disorder.
  • Helps treat depression by improving mood, energy, and interest in daily activities.
  • Reduces anxiety symptoms such as excessive worry and tension.
  • Improves focus and concentration by balancing serotonin and norepinephrine levels.
  • Helps relieve physical symptoms linked to depression, like body aches and fatigue.
Side effects of Desnri-ER 50 Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Desnri-ER 50 Tablet can be taken with or without food as advised by your doctor.
  • It is usually taken once a day or as directed by the doctor.
  • Swallow Desnri-ER 50 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Desnri-ER 50 Tablet Works

Desnri-ER 50 Tablet contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Desnri-ER 50 Tablet as it may cause increased sleepiness and dizziness.

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Pregnancy

Caution

Desnri-ER 50 Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning a pregnancy; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Desnri-ER 50 Tablet may pass into breastmilk. Consult your doctor before taking Desnri-ER 50 Tablet your doctor will decide whether Desnri-ER 50 Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Desnri-ER 50 Tablet causes sleepiness and dizziness. Do not drive or operate machinery.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Desnri-ER 50 Tablet should not be given to children as safety and effectiveness have not been established.

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Heart

Caution

Desnri-ER 50 Tablet is used with caution in cardiac patients and regular monitoring is required.

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Geriatrics

Caution

Desnri-ER 50 Tablet should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Desnri-ER 50 Tablet

Do not take more than the prescribed dose of Desnri-ER 50 Tablet as it may cause serious side effects. The symptoms of overdose include drowsiness, coma, seizures, vomiting, agitation, hallucinations, fever, sweating, severe muscle stiffness or twitching, confusion, fast heartbeat, shivering, loss of coordination, fast/slow/irregular heartbeat, nausea, vomiting, or diarrhoea. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Healthy eating habits:

  • To promote general mental health, eat a balanced diet rich in fruits, vegetables, whole grains, and lean meats.
  • To avoid constipation and dry mouth, which might happen after taking desvenlafaxine, drink plenty of water.
  • Limit alcohol and caffeine since they can exacerbate side effects, anxiety, or sleep issues.
  • Desvenlafaxine can slightly increase blood pressure, so cut back on processed and salty meals to help control it.

Lifestyle changes:

  • To elevate your mood and lessen exhaustion, keep your sleep and wake times consistent.
  • To maximise the benefits of antidepressants, engage in regular exercise (walking, yoga, mild workouts).
  • Use relaxation methods, such as deep breathing or meditation, to reduce tension.
  • Steer clear of alcohol and smoke in moderation since they can exacerbate depression and other negative effects.

Follow-up:

  • Attend routine follow-up appointments to evaluate daily functioning, anxiety levels, and mood improvement
  • Keep an eye out for adverse effects such as headaches, nausea, altered sleep patterns, or elevated blood pressure.
  • Regularly check your blood pressure, especially in the initial weeks of medication.
  • Any agitation, suicidal thoughts, or deepening depression should be reported right away.
  • Do not stop taking the medication or alter the dosage without first talking to your doctor.

Have a query?

Drug Warnings

  • Do not take Desnri-ER 50 Tablet if you are allergic to any of its contents; if you are taking linezolid, intravenous methylene blue, other serotonergic agents, monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days.
  • Inform your doctor before taking Desnri-ER 50 Tablet if you have heart problems, hypotension, bipolar disorder, glaucoma, epilepsy, lung or breathing problems, bleeding problems, or low sodium levels in the blood.
  • Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself.
  • Please inform your doctor if you are pregnant or breastfeeding.
  • Desnri-ER 50 Tablet should not be given to children as safety and effectiveness have not been established.
  • Avoid consuming alcohol along with Desnri-ER 50 Tablet as it could lead to increased sleepiness and dizziness.
  • Let your doctor know if you are taking any other medicines.

Drug-Drug Interactions

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DesvenlafaxineTranylcypromine
Critical
DesvenlafaxineRasagiline
Critical

Drug-Drug Interactions

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DesvenlafaxineTranylcypromine
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Taking tranylcypromine with Desnri-ER 50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and Desnri-ER 50 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineRasagiline
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Taking rasagiline with Desnri-ER 50 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desnri-ER 50 Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineSafinamide
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Taking Safinamide with Desnri-ER 50 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desnri-ER 50 Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Combining Isocarboxazid and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and Desnri-ER 50 Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Combining Procarbazine and Desnri-ER 50 Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and Desnri-ER 50 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with Desnri-ER 50 Tablet and do not discontinue any medications without first consulting your doctor.
DesvenlafaxineDesipramine
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Co-administration of Desipramine and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Desipramine and Desnri-ER 50 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineImipramine
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Although it is a rare adverse effect, Coadministration of Imipramine and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Co-administration of Imipramine and Desnri-ER 50 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxinePhenelzine
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Co-administration of Phenelzine and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Phenelzine and Desnri-ER 50 Tablet can lead to interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineSufentanil
Severe
How does the drug interact with Desnri-ER 50 Tablet:
The combined use of Sufentanil and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Sufentanil and Desnri-ER 50 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineLithium
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Taking Lithium with Desnri-ER 50 Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Desnri-ER 50 Tablet and Lithium, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[PSYCHOTHERAPEUTICS]

FAQs

Desnri-ER 50 Tablet is used to treat a major depressive disorder (depression).

Desnri-ER 50 Tablet works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain, which help maintain mental balance and regulate mood, thereby treating depression.

Do not discontinue Desnri-ER 50 Tablet without consulting your doctor, as it could lead to withdrawal symptoms. To treat your condition effectively, continue taking Desnri-ER 50 Tablet for as long as prescribed. Do not hesitate to consult your doctor if you experience any difficulties while taking Desnri-ER 50 Tablet .

Desnri-ER 50 Tablet may cause decreased sex drive (libido) and problems with ejaculation and orgasm. Consult your doctor if you have any concerns regarding this.

Hypertension should be controlled before starting treatment with Desnri-ER 50 Tablet . Therefore, consult your doctor if you have high blood pressure. Regular monitoring of blood pressure levels is advised while taking Desnri-ER 50 Tablet .

Desnri-ER 50 Tablet may increase the chances of bleeding and bruising. The risk increases when Desnri-ER 50 Tablet is taken along with painkillers and blood thinners. Consult your doctor if you notice unusual bleeding or bruising.

When taken along with other medicines, Desnri-ER 50 Tablet may cause a rare but potentially life-threatening condition called serotonin syndrome. This condition causes changes in how the brain, blood vessels, muscles and digestive system work. Avoid taking Desnri-ER 50 Tablet along with MAOIs (used to treat depression), linezolid, intravenous methylene blue and other serotonergic agents.

Desnri-ER 50 Tablet may dilate your pupils (widen the dark centres of your eyes). This can trigger a glaucoma attack. Before taking Desnri-ER 50 Tablet , consult your doctor if you have glaucoma.

Desnri-ER 50 Tablet may cause seizures. If you have ever had a seizure, tell your doctor before taking Desnri-ER 50 Tablet .

Many people have sexual side effects when using antidepressants. Working together with your doctor will help you find a solution that addresses both your mental and sexual wellness.

You may have to take Desnri-ER 50 Tablet for several weeks before you begin to feel better.

Desnri-ER 50 Tablet can begin lowering symptoms in as little as one week, according to one clinical study. Generally, you'll start to feel the full effects after taking it for eight weeks.

Take Desnri-ER 50 Tablet exactly as prescribed by your healthcare practitioner. Take Desnri-ER 50 Tablet once a day, about the same time every day. Desnri-ER 50 Tablet can be taken with or without food. Swallow the medicine as a whole with water.

It should be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.

Desnri-ER 50 Tablet typically does not cause weight gain for most people. In very rare cases, people taking it experience weight changes (gain or loss) of less than 2 kgs.

Desnri-ER 50 Tablet may cause sexual dysfunction; however, men are more affected than women. If it happens to you, please seek medical attention from your doctor.

Common side effects of Desnri-ER 50 Tablet may include nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders.

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Country of origin

India

Manufacturer/Marketer address

311/B Shreyas Complex, Vejalpur Bus Stand, Nr. Prahlad Nagar Main Road, Satellite, Ahmedabad-380051
Other Info - DES0260
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