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compositionComposition:DESVENLAFAXINE-50MG
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Prescription Medicine
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Desnri-ER 50 Tablet is used in the treatment of major depressive disorder (depression). It helps improve mood, restore emotional balance, and reduce symptoms such as persistent sadness, loss of interest in daily activities, fatigue, and anxiety. This medicine supports mental well-being by enhancing energy levels, concentration, and overall motivation, thereby improving daily functioning and quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DESVENLAFAXINE-50MG

Manufacturer/Marketer :

Lupichem Healthcare

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Desnri-ER 50 Tablet

Desnri-ER 50 Tablet is an oral prescription medication used to treat depression, specifically major depressive disorder in adults. It belongs to a group of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs), which help balance certain natural chemicals in the brain. By restoring this balance, it helps improve mood, sleep, appetite, and energy levels.

Take Desnri-ER 50 Tablet once daily, at the same time each day, to maintain a consistent level of the medicine in your body. You can take this tablet with or without food, but swallowing it whole is essential. Combining this treatment with regular physical activity, balanced meals, and proper sleep hygiene can significantly support your overall progress.

While taking Desnri-ER 50 Tablet , you may experience mild side effects like nausea, dry mouth, or excessive sweating, which often improve over time. However, you must contact your doctor immediately if you experience severe symptoms such as high blood pressure, unusual bleeding, or sudden changes in vision.

Do not take this if you are allergic to any of its ingredients or if you are currently taking monoamine oxidase inhibitors (MAOIs). Before starting, talk to your doctor if you have a history of high blood pressure, heart problems, kidney disease, liver damage, or seizures.

Desnri-ER 50 Tablet can interact with other medicines, especially blood thinners and other antidepressants, which can increase your risk of bleeding or a rare condition called serotonin syndrome. It is highly recommended to avoid alcohol while taking this medicine, as it can worsen drowsiness. If you are pregnant, breastfeeding, or an elderly patient, consult your healthcare provider to discuss the risks and benefits.

Uses of Desnri-ER 50 Tablet

Desnri-ER 50 Tablet is used to treat depression, specifically major depressive disorder in adults. The detailed uses of Desnri-ER 50 Tablet are as follows:

  • Major Depressive Disorder (MDD): Desnri-ER 50 Tablet helps relieve persistent feelings of sadness, loss of interest in daily activities, and emotional exhaustion by regulating chemical messengers in the brain.
     

Key Benefits

Desnri-ER 50 Tablet helps manage depression by restoring the balance of chemical messengers in the brain. By improving mood and reducing depressive symptoms, it supports emotional wellbeing, daily functioning, and overall quality of life.

  • Helps Improve Mood and Emotional Wellbeing: By balancing brain chemicals involved in mood regulation, Desnri-ER 50 Tablet helps reduce symptoms of depression, such as persistent sadness, loss of interest, and emotional distress.
  • Supports Better Energy and Sleep: As depressive symptoms improve, Desnri-ER 50 Tablet may help restore energy levels and promote healthier sleep patterns, allowing you to feel more refreshed and alert during the day.
  • Enhances Daily Functioning: By reducing the emotional and physical effects of depression, Desnri-ER 50 Tablet helps you manage daily responsibilities, participate in social activities, and maintain a more stable and productive routine.
     
Side effects of Desnri-ER 50 Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Desnri-ER 50 Tablet can be taken with or without food as advised by your doctor.
  • It is usually taken once a day or as directed by the doctor.
  • Swallow Desnri-ER 50 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Desnri-ER 50 Tablet Works

Desnri-ER 50 Tablet contains desvenlafaxine. It works as a serotonin-norepinephrine reuptake inhibitor (SNRI). In the brain, nerve cells release natural chemical messengers called serotonin and norepinephrine to transmit signals. After sending the signal, the cells normally reabsorb these chemicals. Desnri-ER 50 Tablet works by blocking this reabsorption process, which keeps more serotonin and norepinephrine active in the spaces between brain cells. This increased activity enhances communication between nerve pathways, helping to elevate and stabilise mood.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Desnri-ER 50 Tablet as it may cause increased sleepiness and dizziness.

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Pregnancy

Caution

Desnri-ER 50 Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning a pregnancy; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Desnri-ER 50 Tablet may pass into breastmilk. Consult your doctor before taking Desnri-ER 50 Tablet your doctor will decide whether Desnri-ER 50 Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Desnri-ER 50 Tablet causes sleepiness and dizziness. Do not drive or operate machinery.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Desnri-ER 50 Tablet should not be given to children as safety and effectiveness have not been established.

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Heart

Caution

Desnri-ER 50 Tablet is used with caution in cardiac patients and regular monitoring is required.

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Geriatrics

Caution

Desnri-ER 50 Tablet should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Desnri-ER 50 Tablet

In case of an accidental overdose, seek immediate emergency medical attention or contact your local hospital right away.

Diet & Lifestyle Advise

  • Avoid drinking alcohol while taking this medicine, as it can worsen drowsiness, impair coordination, and decrease the effectiveness of your treatment.
  • Stay well-hydrated throughout the day, especially if you experience dry mouth or increased sweating as side effects.
  • Maintain a consistent daily routine that includes gentle physical exercise, such as walking, and a regular sleep schedule to complement the therapeutic effects of Desnri-ER 50 Tablet .
  • Monitor your blood pressure regularly at home, as this class of medication can occasionally cause mild increases in blood pressure.

 

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How Soon It Starts Working

The time required for Desnri-ER 50 Tablet to start to work: The time required for Desnri-ER 50 Tablet to show its action is unknown.

The time for which the effects of Desnri-ER 50 Tablet last: The effect of Desnri-ER 50 Tablet lasts for 20 to 25 days.

What if you forget to take Desnri-ER 50 Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Desnri-ER 50 Tablet at controlled room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Always inspect your tablet packaging before use to ensure the blister strip or bottle seal is completely intact.
  • You may occasionally notice the empty shell of the tablet in your stool; this is normal for extended-release tablets and does not mean the medicine did not work.
  • Avoid driving, riding a bicycle, or operating machinery until you know how Desnri-ER 50 Tablet affects you, as it may cause initial dizziness or drowsiness.
  • Do not stop taking Desnri-ER 50 Tablet abruptly. If you need to discontinue the medicine, your doctor will provide instructions on gradually decreasing your dose to prevent withdrawal symptoms.
  • Inform laboratory technicians and doctors that you take Desnri-ER 50 Tablet before any urine screenings, as it can sometimes cause false-positive results on certain drug tests.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Do not take Desnri-ER 50 Tablet if you are taking an MAOI or have stopped taking one within the last 14 days. This combination can cause high blood pressure, tremors, and severe mental changes.
  • Serotonergic Medicines: Taking this drug with other antidepressants, triptans or tramadol can increase the risk of a rare, serious condition called serotonin syndrome.
  • Blood Thinners and NSAIDs: Combining this medicine with aspirin, warfarin, ibuprofen, or other nonsteroidal anti-inflammatory drugs can increase your risk of bruising and bleeding.
     
DesvenlafaxineRasagiline
Critical
DesvenlafaxineIsocarboxazid
Critical

Drug-Drug Interactions

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DesvenlafaxineRasagiline
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Taking rasagiline with Desnri-ER 50 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desnri-ER 50 Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Combining Isocarboxazid and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and Desnri-ER 50 Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineSafinamide
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Taking Safinamide with Desnri-ER 50 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desnri-ER 50 Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineTranylcypromine
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Taking tranylcypromine with Desnri-ER 50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and Desnri-ER 50 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with Desnri-ER 50 Tablet:
Combining Procarbazine and Desnri-ER 50 Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and Desnri-ER 50 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with Desnri-ER 50 Tablet and do not discontinue any medications without first consulting your doctor.
DesvenlafaxineNefazodone
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Co-administration of Nefazodone and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Nefazodone and Desnri-ER 50 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineLinezolid
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Co-administration of linezolid with Desnri-ER 50 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of linezolid along with Desnri-ER 50 Tablet can lead to an interaction, it can be taken if recommended by a doctor. While taking these medications if you experience, confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineImipramine
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Although it is a rare adverse effect, Coadministration of Imipramine and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Co-administration of Imipramine and Desnri-ER 50 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxinePhentermine
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Co-administration of Phentermine and Desnri-ER 50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of phentermine and Desnri-ER 50 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineBupropion
Severe
How does the drug interact with Desnri-ER 50 Tablet:
Co-administration of Bupropion with Desnri-ER 50 Tablet may increase the risk or severity of seizures.

How to manage the interaction:
Co-administration of bupropion along with Desnri-ER 50 Tablet can lead to an interaction, it can be taken if recommended by a doctor. Avoid or limit tasks that need mental attention, such as driving or operating dangerous machinery while taking them. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, involuntary movements, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: May increase drowsiness, impair mental alertness, and worsen the underlying symptoms of depression.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[PSYCHOTHERAPEUTICS]

FAQs

Desnri-ER 50 Tablet is used to treat a major depressive disorder (depression).
Desnri-ER 50 Tablet works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain, which help maintain mental balance and regulate mood, thereby treating depression.
Do not discontinue Desnri-ER 50 Tablet without consulting your doctor, as it could lead to withdrawal symptoms. To treat your condition effectively, continue taking Desnri-ER 50 Tablet for as long as prescribed. Do not hesitate to consult your doctor if you experience any difficulties while taking Desnri-ER 50 Tablet .
Hypertension should be controlled before starting treatment with Desnri-ER 50 Tablet . Therefore, consult your doctor if you have high blood pressure. Regular monitoring of blood pressure levels is advised while taking Desnri-ER 50 Tablet .
Desnri-ER 50 Tablet may increase the chances of bleeding and bruising. The risk increases when Desnri-ER 50 Tablet is taken along with painkillers and blood thinners. Consult your doctor if you notice unusual bleeding or bruising.
When taken along with other medicines, Desnri-ER 50 Tablet may cause a rare but potentially life-threatening condition called serotonin syndrome. This condition causes changes in how the brain, blood vessels, muscles and digestive system work. Avoid taking Desnri-ER 50 Tablet along with MAOIs (used to treat depression), linezolid, intravenous methylene blue and other serotonergic agents.
Desnri-ER 50 Tablet may dilate your pupils (widen the dark centres of your eyes). This can trigger a glaucoma attack. Before taking Desnri-ER 50 Tablet , consult your doctor if you have glaucoma.
Desnri-ER 50 Tablet may cause seizures. If you have ever had a seizure, tell your doctor before taking Desnri-ER 50 Tablet .
Yes. Desnri-ER 50 Tablet may cause sexual side effects such as reduced sex drive (libido), difficulty achieving orgasm, delayed ejaculation, or erectile dysfunction in some people. Do not stop taking the medicine on your own if you experience these effects. Talk to your doctor, who may recommend ways to manage these symptoms while continuing treatment for your depression.
Take Desnri-ER 50 Tablet exactly as prescribed by your healthcare practitioner. Take Desnri-ER 50 Tablet once a day, about the same time every day. Desnri-ER 50 Tablet can be taken with or without food. Swallow the medicine as a whole with water.
It should be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.
Desnri-ER 50 Tablet typically does not cause weight gain for most people. In very rare cases, people taking it experience weight changes (gain or loss) of less than 2 kgs.
Common side effects of Desnri-ER 50 Tablet may include nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders.
Clinical studies indicate that weight changes with Desnri-ER 50 Tablet are typically minimal; some patients may experience a slight loss of appetite and weight, while others may notice minor weight gain. Talk to your doctor or pharmacist if you have concerns about weight changes.
Taking this class of medicine during the third trimester may cause temporary breathing or feeding difficulties in newborns. However, untreated depression also carries health risks, so talk to your doctor to weigh the benefits and risks.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can increase drowsiness, reduce the effectiveness of the drug, and worsen depression symptoms. Talk to your doctor if you have questions about alcohol use.
Take the missed dose as soon as you remember. If it is close to your next scheduled dose, skip it and continue with your normal daily routine. Do not double the dose. Talk to your doctor or pharmacist if you frequently miss doses.
Yes, Desnri-ER 50 Tablet can raise blood pressure in some patients, so your doctor will likely monitor your blood pressure regularly while you are taking it. Talk to your doctor if you notice consistently high readings.
Certain pain relievers like ibuprofen, naproxen, or aspirin can increase your risk of bleeding when taken with this medicine. Acetaminophen is usually a safer alternative, but you should talk to your doctor or pharmacist before taking any new over-the-counter product.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

311/B Shreyas Complex, Vejalpur Bus Stand, Nr. Prahlad Nagar Main Road, Satellite, Ahmedabad-380051
Other Info - DES0260

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