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  1. Home
  2. Medicine

  3. Despil 100 Tablet 10's

Prescription drug
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Despil 100 Tablet 10's, Pack of 10
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Composition :

DESVENLAFAXINE-100MG

Manufacturer/Marketer :

Zis Labs Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

About Despil 100 Tablet 10's

Despil 100 Tablet 10's is used to treat a major depressive disorder (depression). Major depressive disorder, also known as clinical depression, is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time.

Despil 100 Tablet 10's contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression.

In some cases, you may experience certain common side effects such as nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders. Talk to your doctor if you experience these side effects persistently.

Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself.

Uses of Despil 100 Tablet 10's

Despil 100 Tablet 10's is used to treat depression. The detailed uses of Despil 100 Tablet 10's are as follows:

  • Relieves Depression: Despil 100 Tablet 10's helps to improve mood, and reduce symptoms of depression, including sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty concentrating, making decisions, and thinking.
  • Supports Mental Health: Despil 100 Tablet 10's works by balancing brain chemicals, supporting overall mental well-being.

Have a query?

Directions for Use

  • Despil 100 Tablet 10's can be taken with or without food as advised by your doctor.
  • It is usually taken once a day or as directed by the doctor.
  • Swallow Despil 100 Tablet 10's as a whole with a glass of water.
  • Do not chew, crush, or break it.

Medicinal Benefits

  • Despil 100 Tablet 10's belongs to a group of antidepressant medicines indicated for the treatment of a major depressive disorder.
  • Despil 100 Tablet 10's works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain.
  • It maintains mental balance, helps in regulating mood, and treats depression.

How Despil 100 Tablet 10's Works

Despil 100 Tablet 10's contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Despil 100 Tablet
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Drink plenty of water to stay hydrated.
  • Eat smaller meals more frequently to help manage your condition.
  • Limit large carbohydrate-rich meals to avoid exacerbating your symptoms.
  • Before adding more salt to your diet, it's best to talk to your doctor to see if it's a good idea for you.
  • Rise slowly from a sitting or lying position to avoid feeling dizzy or lightheaded.
  • Avoid standing for long periods without moving around to reduce your risk of fainting.
  • Perform leg muscle exercises like ankle circles when standing for extended periods to improve blood flow.
  • Wear compression stockings to help improve blood flow in your legs and reduce swelling.
  • Engage in regular moderate exercise, avoiding strenuous activities in hot weather to prevent dehydration and worsening of symptoms.
  • Limit alcohol consumption and be mindful of caffeine intake as they can worsen symptoms and exacerbate your condition.
  • If you experience frequent or severe symptoms of dizziness, lightheadedness, or fainting upon standing, seek medical attention.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Despil 100 Tablet 10's

Do not take more than the prescribed dose of Despil 100 Tablet 10's as it may cause serious side effects. The symptoms of overdose include drowsiness, coma, seizures, vomiting, agitation, hallucinations, fever, sweating, severe muscle stiffness or twitching, confusion, fast heartbeat, shivering, loss of coordination, fast/slow/irregular heartbeat, nausea, vomiting, or diarrhoea. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Despil 100 Tablet 10's if you are allergic to any of its contents; if you are taking linezolid, intravenous methylene blue, other serotonergic agents, monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days.
  • Inform your doctor before taking Despil 100 Tablet 10's if you have heart problems, hypotension, bipolar disorder, glaucoma, epilepsy, lung or breathing problems, bleeding problems, or low sodium levels in the blood.
  • Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself.
  • Please inform your doctor if you are pregnant or breastfeeding.
  • Despil 100 Tablet 10's should not be given to children as safety and effectiveness have not been established.
  • Avoid consuming alcohol along with Despil 100 Tablet 10's as it could lead to increased sleepiness and dizziness.

Drug-Drug Interactions

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DesvenlafaxineSafinamide
Critical
DesvenlafaxineRasagiline
Critical

Drug-Drug Interactions

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DesvenlafaxineSafinamide
Critical
How does the drug interact with Despil 100 Tablet:
Taking Safinamide with Despil 100 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Despil 100 Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineRasagiline
Critical
How does the drug interact with Despil 100 Tablet:
Taking rasagiline with Despil 100 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Despil 100 Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineTranylcypromine
Critical
How does the drug interact with Despil 100 Tablet:
Taking tranylcypromine with Despil 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and Despil 100 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with Despil 100 Tablet:
Combining Isocarboxazid and Despil 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and Despil 100 Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with Despil 100 Tablet:
Combining Procarbazine and Despil 100 Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and Despil 100 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with Despil 100 Tablet and do not discontinue any medications without first consulting your doctor.
DesvenlafaxineDextromethorphan
Severe
How does the drug interact with Despil 100 Tablet:
Co-administration of Dextromethorphan and Despil 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although there is a possible interaction between Dextromethorphan and Despil 100 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as seizure (fits), confusion, hallucination, increased heart rate, fever, excessive sweating, shivering or shaking, tremors, incoordination, blurred vision, muscle spasms or stiffness, nausea, vomiting, stomach cramps, and diarrhea, contact a doctor immediately. Do not discontinue the medications without consulting a doctor.
DesvenlafaxineErgotamine
Severe
How does the drug interact with Despil 100 Tablet:
Co-administration of Ergotamine and Despil 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Ergotamine and Despil 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, in co-ordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineEscitalopram
Severe
How does the drug interact with Despil 100 Tablet:
Coadministration of Escitalopram and Despil 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although there is an interaction between escitalopram and Despil 100 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineImipramine
Severe
How does the drug interact with Despil 100 Tablet:
Although it is a rare adverse effect, Coadministration of Imipramine and Despil 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Co-administration of Imipramine and Despil 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineLithium succinate
Severe
How does the drug interact with Despil 100 Tablet:
Coadministration of Lithium with Despil 100 Tablet may increase the levels and side effects of Despil 100 Tablet.

How to manage the interaction:
Although there is a possible interaction between Despil 100 Tablet and Lithium succinate, you can take these medicines together if prescribed by your doctor. However, if you experience Headache, nausea, vomiting, diarrhea, constipation, dry mouth, increased sweating, decreased appetite, tremor, feeling nervous, restless, fatigue, or having trouble sleeping (insomnia), contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly, as it helps in improving overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega-3 fatty acids, such as fish, nuts, fresh fruits, vegetables, and olive oil.
  • Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters.
  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps relieve stress, improve mood, boost self-esteem, and promote restful sleep.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

Despil 100 Tablet 10's Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Despil 100 Tablet 10's as it may cause increased sleepiness and dizziness.

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Pregnancy

Caution

Despil 100 Tablet 10's belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning a pregnancy; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Despil 100 Tablet 10's may pass into breastmilk. Consult your doctor before taking Despil 100 Tablet 10's your doctor will decide whether Despil 100 Tablet 10's can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Despil 100 Tablet 10's causes sleepiness and dizziness. Do not drive or operate machinery.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Despil 100 Tablet 10's should not be given to children as safety and effectiveness have not been established.

FAQs

Despil 100 Tablet 10's is used to treat a major depressive disorder (depression).

Despil 100 Tablet 10's works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain, which help maintain mental balance and regulate mood, thereby treating depression.

Do not discontinue Despil 100 Tablet 10's without consulting your doctor, as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking Despil 100 Tablet 10's for as long as prescribed. Do not hesitate to consult your doctor if you experience any difficulties while taking Despil 100 Tablet 10's.

Despil 100 Tablet 10's may cause decreased sex drive (libido) and problems with ejaculation and orgasm. Consult your doctor if you have any concerns regarding this.

Hypertension should be controlled before starting treatment with Despil 100 Tablet 10's. Therefore, consult your doctor if you have high blood pressure. Regular monitoring of blood pressure levels is advised while taking Despil 100 Tablet 10's.

Despil 100 Tablet 10's may increase the chances of bleeding and bruising. The risk increases when Despil 100 Tablet 10's is taken along with painkillers and blood thinners. Consult your doctor if you notice unusual bleeding or bruising.

When taken along with other medicines, Despil 100 Tablet 10's may cause a rare but potentially life-threatening condition called serotonin syndrome. This condition causes changes in how the brain, blood vessels, muscles and digestive system work. Avoid taking Despil 100 Tablet 10's along with MAOIs (used to treat depression), linezolid, intravenous methylene blue and other serotonergic agents.

Despil 100 Tablet 10's may dilate your pupils (widen the dark centre's of your eyes). This can trigger a glaucoma attack. Before taking Despil 100 Tablet 10's, consult your doctor if you have glaucoma.

Despil 100 Tablet 10's may cause seizures. If you have ever had a seizure, tell your doctor before taking Despil 100 Tablet 10's.

Many people have sexual side effects when using antidepressants. Working together with your doctor will help you find a solution that addresses both your mental and sexual wellness.

You may have to take Despil 100 Tablet 10's for several weeks before you begin to feel better.

Despil 100 Tablet 10's can begin lowering anxiety symptoms in as little as one week, according to one clinical study. Generally, you'll start to feel the full effects after taking it for eight weeks.

Although Despil 100 Tablet 10's is only officially allowed to treat depression, doctors frequently prescribe it to treat anxiety as well.

Take Despil 100 Tablet 10's exactly as prescribed by your healthcare practitioner. Take Despil 100 Tablet 10's once a day, about the same time every day. Despil 100 Tablet 10's can be taken with or without food. Swallow Despil 100 Tablet 10's pills whole and with a drink.

It should be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.

Despil 100 Tablet 10's works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance. Thus, it helps to treat depression.

Despil 100 Tablet 10's typically does not cause weight gain for most people. In very rare cases, people taking it experience weight changes (gain or loss) of less than 2 kgs.

Despil 100 Tablet 10's may cause sexual dysfunction; however, men are more affected than women. If it happens to you, please seek medical attention from your doctor.

Common side effects of Despil 100 Tablet 10's may include nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders.

Country of origin

India

Manufacturer/Marketer address

Raza Hyder Street, Mount Road, Chennai 600002, Tamil Nadu, India.
Other Info - DES0275

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 25, 2025 | 11:10 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204150s005lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a608022.html#:~:text=Desvenlafaxine%20is%20used%20to%20treat,that%20help%20maintain%20mental%20balance
  3. https://www.drugs.com/mtm/desvenlafaxine.html
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