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compositionComposition:DEXMEDETOMIDINE-100MCG
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Prescription Medicine
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Dexmedine Injection belongs to the class of sedative and hypnotic medicines used to sedate patients in acute settings such as the ICU, during surgical procedures and in those who require a mechanical ventilator. This medicine works by inhibiting the release of norepinephrine and subsequently blocks pain signals. Common side effects include slow heart rate, a change in blood pressure and an alteration in breathing pattern.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DEXMEDETOMIDINE-100MCG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Dexmedine Injection

Dexmedine Injection is a prescription sedative given as an injection or continuous drip into a vein. It is primarily used to keep patients calm, comfortable, and sleepy while they are in an intensive care unit (ICU) or undergoing certain medical and surgical procedures. By providing controlled sedation, it helps patients tolerate mechanical breathing tubes or medical examinations without feeling anxious or distressed.

Because this medication is given directly into a vein in a hospital setting, it is administered continuously or as a one-time dose by healthcare professionals, rather than on a set home schedule. It is injected directly into your bloodstream, meaning it does not need to be taken with food. While you are recovering, a light diet and avoiding strenuous physical activity can help support your body's healing process.

While receiving Dexmedine Injection , you may experience mild side effects such as temporary changes in blood pressure, a slower heart rate, or dry mouth. Your care team will monitor you constantly, but you should let them know immediately if you face specific serious side effects like severe dizziness, breathing difficulties, or chest pain.

Before starting Dexmedine Injection , tell your doctor if you have a history of severe heart rhythm problems, low blood pressure, or liver damage. Do not take this if you are highly sensitive to sedatives or have specific untreated heart blocks.

Dexmedine Injection can interact with other sedatives, strong pain relievers, and blood pressure medications, which may cause your heart rate or blood pressure to drop too low. If you are pregnant, breastfeeding, or an older adult, you should consult your healthcare provider to ensure this treatment is safe for your specific situation. Dexmedine Injection may also be used in children in specialized hospital settings, particularly in pediatric intensive care units. Dosing and monitoring requirements differ in children and are determined by a pediatric specialist.

Uses of Dexmedine Injection

Dexmedine Injection is used for Sedation. The detailed uses of Dexmedine Injection are as follows:

  • Sedation in the Intensive Care Unit (ICU): Helps patients who are on a breathing machine (ventilator) stay calm, relaxed, and cooperative without depressing their natural breathing.
  • Procedural Sedation: Keeps patients relaxed, comfortable, and cooperative during short surgical or diagnostic procedures while they remain awake and able to respond to verbal commands.

Key Benefits

Dexmedine Injection helps provide calm and controlled sedation in critically ill patients and during certain medical procedures. Promoting a cooperative, sleep-like state helps improve comfort while allowing appropriate medical monitoring and care.
Benefits may include:

  • Provides calm, controlled sedation while allowing patients to be more easily awakened when needed.
  • Helps reduce anxiety, agitation, and discomfort during intensive care or medical procedures.
  • Supports communication and neurological assessments when appropriate.
  • Helps maintain breathing function better than some other sedative medicines.
  • May assist in the transition away from ventilator support under close medical supervision.
  • Promotes patient comfort and supports a smoother recovery process in the hospital setting.
     
Side effects of Dexmedine Injection 0.5ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Your doctor will decide the dosage and timing of Dexmedine Injection , depending on the desired level of sedation and your response to treatment.
  • Dexmedine Injection will be administered by a healthcare professional in a hospital setting.
  • Do not self-administer this medication.

How Dexmedine Injection Works

Dexmedine Injection works by targeting specific docking sites in the brain called alpha-2 receptors. When it binds to these receptors, it decreases the release of a natural chemical messenger called norepinephrine, which is responsible for keeping the brain alert, active, and responsive to stress. By lowering the levels of this chemical, Dexmedine Injection naturally reduces brain activity, leading to calmness, sleepiness, and mild pain relief. Because it targets these specific brain pathways, it does not cause the deep, heavy respiratory suppression associated with some other classes of sedatives.
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Alcohol

Unsafe

There can be a reaction of alcohol with Dexmedine Injection . Use of Dexmedine Injection with alcohol is hence not recommended. Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Dexmedine Injection should be used with caution during pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Caution

Dexmedine Injection should be used with caution during breastfeeding. Please consult your doctor if you have any concerns.

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Driving

Unsafe

Dexmedine Injection is used only in hospitalised patients. Avoid driving or operating machinery as Dexmedine Injection causes sedation.

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Liver

Caution

Exercise caution before using Dexmedine Injection in case of liver conditions. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Dexmedine Injection in case of kidney problems. Please consult your doctor to address any concerns.

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Children

Unsafe

Dexmedine Injection is not recommended for use in children below 12 years of age. Please consult your physician if you have any concerns.

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Heart

Caution

Dexmedine Injection should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before receiving Dexmedine Injection .

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Geriatrics

Caution

Dexmedine Injection should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Dexmedine Injection

Because your dose is continuously controlled and monitored by medical professionals using specialized equipment, an overdose is extremely rare. However, if an excessive amount is given, it can lead to very low blood pressure or a dangerously slow heart rate. The medical team is trained to recognize these signs immediately and will stop the infusion or adjust the rate to treat any symptoms right away.

Diet & Lifestyle Advise

  • Avoid alcohol and sleep aids: Do not consume alcohol or use over-the-counter sleep medications for at least 24 hours after receiving this medicine, as they can increase drowsiness and sedation.
  • Avoid activities requiring alertness: Do not drive, operate heavy machinery, or perform tasks that require full mental concentration for at least 24 hours after your procedure, as the effects of sedation may persist.
  • Eat light meals after sedation: Begin with light, easily digestible foods such as clear broths, crackers, or toast when you resume eating to help prevent stomach discomfort.
  • Change positions slowly: Stand up gradually from a sitting or lying position during your recovery period to help reduce the risk of dizziness or lightheadedness caused by sudden drops in blood pressure.
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How Soon It Starts Working

The time required for Dexmedine Injection to start to work: Dexmedine Injection ideally shows its action within 5 to 10 minutes after administration. The time for which the effects of Dexmedine Injection last: The effect of Dexmedine Injection lasts for 2 to 3 hours.

What if you forget to take Dexmedine Injection

Since this medication is given in a hospital or clinical setting under the direct supervision of healthcare providers, it is highly unlikely that you will miss a dose. Your medical team will manage and monitor the timing of your infusion.

Storage

•It should be kept at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the vials in their original packaging to protect them from direct light.

Drug Warnings

  • Inspect the solution before use: Ensure the healthcare provider checks the vial before administration. The solution should be clear, colorless, and free of visible particles.
  • Inform your doctor about heart conditions: Tell your healthcare provider if you have a history of chronic heart failure, severe heart rhythm disorders, or significant cardiovascular instability, as Dexmedine Injection can slow the heart rate and may require close monitoring.
  • Discuss recent medications with your care team: Inform your doctor or nurse about all medicines you have taken in the 24 hours before your procedure, especially blood pressure medicines and other sedatives.
  • Report unusual symptoms during treatment: Tell your nurse immediately if you experience sudden shivering, significant changes in body temperature, or any unexpected symptoms during or after the infusion.
  • Arrange support after treatment: If you are discharged on the same day, ensure a responsible adult is available to drive you home and stay with you until the effects of the sedative have worn off.
  • Advanced heart block: Do not use Dexmedine Injection if you have advanced heart block (a severe delay in the heart's electrical signals) unless you have a functioning pacemaker.
  • Allergy to Dexmedine Injection : Do not receive Dexmedine Injection if you are allergic to Dexmedine Injection or any of its ingredients.
  • Severe low blood pressure or unstable circulation: Dexmedine Injection should not be used in patients with severe untreated low blood pressure or unstable circulation unless the healthcare team determines that the benefits outweigh the risks.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Anesthetics and other sedatives: Taking these medicines alongside Dexmedine Injection may cause excessive sedation and slow breathing.
  • Strong pain relievers (e.g., opioids): Combining these with Dexmedine Injection may increase the risk of severe drowsiness, low blood pressure, and breathing difficulties.
  • Blood pressure medicines (e.g., beta-blockers): Taking these alongside Dexmedine Injection may cause a dangerously slow heart rate or a significant drop in blood pressure.
  • Herbal supplements with sedative effects (e.g., valerian, kava, melatonin): These products may increase drowsiness and sedation. Inform your healthcare team about any supplements or over-the-counter products you use before receiving Dexmedine Injection .
DexmedetomidineTizanidine
Severe

Drug-Drug Interactions

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DexmedetomidineTizanidine
Severe
How does the drug interact with Dexmedine Injection 0.5ml:
Combining Tizanidine and Dexmedine Injection 0.5ml can increase the risk of low blood pressure.

How to manage the interaction:
Taking Tizanidine and Dexmedine Injection 0.5ml together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, palpitations, chest pain, or excessive sweating, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Dexmedine Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[SEDATIVES AND HYPNOTICS]

FAQs

Dexmedine Injection belongs to the group of sedatives used to sedate patients in acute settings such as the ICU, during surgical procedures and in those who require a mechanical ventilator. Sedation is defined as a state of relaxation, drowsiness or sleep.
Dexmedine Injection works by inhibiting the release of an active neurotransmitter (nerve substance) called norepinephrine and subsequently blocks pain signals.
Inform your doctor if you have high blood pressure or if you are taking blood pressure-lowering medicines as Dexmedine Injection may cause alterations in blood pressure.
No, Dexmedine Injection is not a controlled substance. It is a sedative for patients in acute settings such as the ICU, during surgical procedures, and in those who require a mechanical ventilator.
Yes, Dexmedine Injection is approved by the FDA in the year 1999.
The common side effects of Dexmedine Injection , which may occur in some individuals, include a slow heart rate, blood pressure changes, and breathing patterns. If these side effects persist, you are advised to consult your doctor.
No, Dexmedine Injection is a sterile solution that must only be administered by qualified healthcare professionals in a hospital or clinic where continuous monitoring equipment is available. Talk to your doctor.
The sedative effects of Dexmedine Injection typically wear off within a few hours after the infusion is stopped, but you may still feel slightly sleepy or relaxed for up to 24 hours. Talk to your doctor.
While Dexmedine Injection is not designed to cause complete memory loss, many patients experience a relaxed, sleepy state and may have little to no memory of the medical procedure. Talk to your doctor.
Yes, a slower heart rate is a known effect of Dexmedine Injection . Your medical team will constantly monitor your heart rhythm during the infusion to keep you safe. Talk to your doctor.
Yes, but older adults may be more sensitive to its effects, particularly blood pressure and heart rate changes. Doctors often adjust the delivery rate and monitor elderly patients more closely. Talk to your doctor.
Since this medication is given for procedures or in intensive care, your medical team will provide specific fasting instructions based on the procedure you are undergoing. Always follow their guidance. Talk to your doctor.
No, you should not drive or operate machinery for at least 24 hours after receiving this medication, as it can temporarily impair your reflexes and judgment. Arrange for a family member or friend to drive you home. Talk to your doctor.
You must tell your healthcare team about all your medical conditions, especially heart, liver, or kidney problems, and all medications you are currently taking, including over-the-counter drugs and supplements. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.4783 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 021038S021Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Pmc1291306 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. ScienceDirect Topics. Dexmedetomidine - Research & Medical Applications Summary. Amsterdam, Netherlands: Elsevier; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Dexmedetomidine hydrochloride. 1999. [Accessed on 12 Feb. 2019]Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 20 Feb. 2020]Check here
  7. Manpreet Kaur and P. M. Singh1. Current role of dexmedetomidine in clinical anesthesia and intensive care. NIH, National Library of Medicine, National center for biotechnology information. PubMed Central. Jul-Dec 2011. [Accessed on 1st December 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - DEX0332

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