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compositionComposition:MINOCYCLINE-50MG
prescription
Prescription Medicine
info
Divaine 50 Tablet 10's
Divaine 50 Tablet 10's
Divaine 50 Tablet 10's
Divaine 50 Tablet 10's
Divaine 50 Tablet 10's

Divaine 50 Tablet is used to treat bacterial infections. It contains Minocycline, which stops the growth of bacteria. It may cause side effects such as headache, photosensitivity, dizziness, vomiting, itching, nausea, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MINOCYCLINE-50MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Divaine 50 Tablet

Divaine 50 Tablet is used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, sexually transmitted infections, and skin infections. Besides this, Divaine 50 Tablet also treats acne-like lesions caused by rosacea.

Divaine 50 Tablet contains Minocycline, which inhibits the protein synthesis required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow.

You may experience headache, photosensitivity, dizziness, vomiting, itching, nausea, and diarrhoea. Most of these side effects of Divaine 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before using Divaine 50 Tablet , tell your doctor if you have ever had an allergy to Divaine 50 Tablet , have kidney problems, liver problems, or asthma. Use of Divaine 50 Tablet in pregnant and nursing mothers is not recommended.

Uses of Divaine 50 Tablet

Divaine 50 Tablet is used in the treatment of bacterial infections. The detailed uses of Divaine 50 Tablet are as follows:

  • Treatment of bacterial infections: Divaine 50 Tablet is primarily used to treat bacterial infections.
  • Skin Infections: Divaine 50 Tablet treats acne vulgaris, rosacea, and infected wounds.
  • Respiratory Infections: Divaine 50 Tablet is effective against bronchitis, pneumonia, and sinusitis.
  • Urinary Tract Infections (UTIs): Divaine 50 Tablet is used when other antibiotics are unsuitable.
  • Sexually Transmitted Infections (STIs): Divaine 50 Tablet treats chlamydia, gonorrhea, and syphilis (especially in penicillin-allergic patients).

Key Benefits

  • Divaine 50 Tablet , a tetracycline-class antibiotic, is effective against a wide variety of bacteria, including gram-positive, gram-negative, anaerobes, and certain parasites.
  • It helps manage infections such as bronchitis, pneumonia, and other bacterial respiratory illnesses.
  • Divaine 50 Tablet is used to treat urinary tract infections (UTIs) and gastrointestinal infections caused by susceptible bacteria and parasites.
  • It is prescribed for infections like gonorrhea and syphilis.
  • Divaine 50 Tablet helps manage bacterial skin infections and is also used off-label for acne treatment.
  • By inhibiting bacterial growth and multiplication, Divaine 50 Tablet helps control the infection and reduces the risk of complications.
  • Its broad activity ensures effective treatment of infections affecting multiple organ systems.
Side effects of Divaine 50 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Managing Medication-Triggered tinnitus (Ringing in the Ears): A Step-by-Step Guide:
  • Inform your doctor immediately if you experience ringing, buzzing, or other unusual sounds in your ears after taking medication.
  • Schedule an appointment to discuss symptoms and determine if the medication is the cause.
  • Your doctor may adjust your treatment plan by changing dosage, switching to a different medication, or stopping the medication.
  • Your doctor may recommend sound therapy or relaxation techniques to manage tinnitus symptoms.
  • Regularly track symptoms and report changes to your healthcare provider to ensure effective management.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.

Directions for Use

  • Take Divaine 50 Tablet with or without food or as advised by a doctor.
  • Recommended to take Divaine 50 Tablet twice a day or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Divaine 50 Tablet Works

Divaine 50 Tablet contains Minocycline (antibiotic) primarily used to treat a wide range of bacterial infections comprising gram-negative, gram-positive, anaerobic, and other bacteria. It is a derivative of the tetracycline class of antibiotics that inhibits the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow.
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Alcohol

Caution

Do not drink alcohol with Divaine 50 Tablet as it may increase the unpleasant side effects.

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Pregnancy

Unsafe

Divaine 50 Tablet is a Pregnancy Category D. There are no adequate and well-controlled studies on the use of Minocycline in pregnant women. In some cases, taking Divaine 50 Tablet during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy, contact the doctor before using Divaine 50 Tablet .

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Breast Feeding

Unsafe

Divaine 50 Tablet can pass into breast milk and may affect bone and tooth development in a nursing infant. The extent of absorption is unknown. Do not breastfeed while you are taking this medicine.

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Driving

Caution

Drive with caution, Divaine 50 Tablet usually causes blurry vision, dizziness and may affect driving ability.

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Liver

Caution

Divaine 50 Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Divaine 50 Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Children should not use this medicine. Divaine 50 Tablet can cause permanent yellowing or greying of the teeth in children younger than 8 years old.

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Heart

Consult your doctor

Limited studies available for the use of Divaine 50 Tablet in heart patients. Consult your physician.

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Geriatrics

Caution

Divaine 50 Tablet should be used in elderly patients with proper monitoring and individualised care.

What if I have taken an overdose of Divaine 50 Tablet

Do not take more than the prescribed dose of Divaine 50 Tablet as it may cause overdose. The symptoms of overdose include nausea, dizziness or vomiting. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet.
  • Eating grapefruit during antibiotic treatment can prevent the body from utilising Divaine 50 Tablet properly. So, avoid consuming grapefruit or grapefruit juice while taking the antibiotic.
  • Avoid taking too much calcium, iron-enriched foods, and drinks, as it might affect the working of Divaine 50 Tablet . 
  • Avoid intake of alcoholic beverages with Divaine 50 Tablet as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Divaine 50 Tablet in fighting off infections.
  • Probiotics should be taken after taking the full course of Divaine 50 Tablet in order to restore some of the healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help restore the good bacteria of the intestine.

Health Queries

Have a query?

How Soon It Starts Working

The time required for Divaine 50 Tablet to start to work: Divaine 50 Tablet ideally shows its action within 1 to 3 hours after administration.

The time for which the effects of Divaine 50 Tablet last: The duration of action for Divaine 50 Tablet is not clinically established.

What if you forget to take Divaine 50 Tablet

If you miss a dose of Divaine 50 Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Iron and antacids (like magnesium hydroxide and aluminium hydroxide) may bind to Divaine 50 Tablet in the gastrointestinal tract, lowering its efficiency. So, a gap of at least 2 hours should be maintained between the intake of Divaine 50 Tablet and iron supplements and antacids.
  • Prolonged use of Divaine 50 Tablet during tooth development (pregnancy, infancy, and childhood to the age of 8 years) may cause permanent discolouration of the teeth (yellow-grey-brown).
  • Do not consume alcohol as it may cause excessive drowsiness when taken along with Divaine 50 Tablet .
  • Before using Divaine 50 Tablet , tell your doctor if you have ever had an allergy to Divaine 50 Tablet , have kidney problems, liver problems, or asthma.
  • Use efficient birth control to prevent pregnancy while you are using Divaine 50 Tablet .
  • The use of Divaine 50 Tablet causes antibiotic-associated diarrhoea. Consult your doctor if you have diarrhoea while taking Divaine 50 Tablet .
  • Divaine 50 Tablet may cause sensitive skin to sunlight and ultraviolet rays, causing exaggerated sunburn reactions. Hence, it is advisable to apply sunscreen before going outside.

Drug-Drug Interactions

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Drug-Drug Interaction: Divaine 50 Tablet may interact with medicines used for infections (phenoxymethylpenicillin), medicines for acne (isotretinoin), medicines for heart disease (quinapril), medicines for migraine (ergotamine), medicines for inducing labour pain (ergometrine), diuretics/ water tablets (furosemide), medicines for diarrhoea (kaolin), antacids (like aluminium, calcium, or magnesium, bismuth subsalicylate), iron supplements.

Drug-Food Interaction: Food containing calcium and iron should be avoided as it may affect the effectiveness of the drug. Also, avoid consuming grapefruit or grapefruit juice with Divaine 50 Tablet .

Drug-Disease Interaction: Divaine 50 Tablet should not be given to people with colitis (inflammation in the gastrointestinal tract), liver, or kidney disease.

MinocyclineTretinoin
Critical
MinocyclineEtretinate
Critical

Drug-Drug Interactions

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MinocyclineTretinoin
Critical
How does the drug interact with Divaine 50 Tablet:
Co-administration of Tretinoin with Divaine 50 Tablet can increase the risk of side effects like pseudotumor cerebri (increased pressure in the brain)

How to manage the interaction:
Taking Tretinoin with Divaine 50 Tablet is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MinocyclineEtretinate
Critical
How does the drug interact with Divaine 50 Tablet:
Co-administration of Etretinate with Divaine 50 Tablet may raise the chance of developing pseudotumor cerebri, an uncommon but serious illness brought on by elevated brain pressure.

How to manage the interaction:
Taking Divaine 50 Tablet with Etretinate is generally avoided as it can result in an interaction. However, if you experience headache, nausea, vomiting, or visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MinocyclineAcitretin
Critical
How does the drug interact with Divaine 50 Tablet:
Co-administration of Acitretin with Divaine 50 Tablet may increase the risk of a serious condition called pseudomotor cerebral (false brain tumour).

How to manage the interaction:
There's a possible interaction between Acitretin and Divaine 50 Tablet should be used together only if prescribed by a doctor. However, if you develop symptoms such as nausea, vomiting, headache, or visual disturbances during treatment with either medication, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
MinocyclineKetoconazole
Severe
How does the drug interact with Divaine 50 Tablet:
Co-administration of ketoconazole with Divaine 50 Tablet can increase the risk of liver damage.

How to manage the interaction:
Although taking ketoconazole and Divaine 50 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, light-coloured stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MinocyclineMipomersen
Severe
How does the drug interact with Divaine 50 Tablet:
Co-administration of mipomersen with Divaine 50 Tablet can cause liver damage.

How to manage the interaction:
Although taking mipomersen and Divaine 50 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, light-coloured stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MinocyclineIsotretinoin
Severe
How does the drug interact with Divaine 50 Tablet:
Taking isotretinoin with Divaine 50 Tablet may increase the risk of a rare and serious condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking isotretinoin and Divaine 50 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting a doctor.
MinocyclineMethoxyflurane
Severe
How does the drug interact with Divaine 50 Tablet:
Taking methoxyflurane with Divaine 50 Tablet may increase the risk of kidney damage.

How to manage the interaction:
Although taking methoxyflurane and Divaine 50 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as swelling, weight gain, feeling short of breath, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, pain in your lower back, and urinating, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MinocyclineAminolevulinic acid
Severe
How does the drug interact with Divaine 50 Tablet:
Co-administration of aminolevulinic acid with Divaine 50 Tablet can increase the risk of severe sunburn.

How to manage the interaction:
Although taking aminolevulinic acid and Divaine 50 Tablet together can result in an interaction, it can be taken if your doctor has advised it. Avoid exposure of the eyes and skin to sunlight or bright indoor lights for 48 hours, after taking the medication. Do not discontinue any medications without consulting a doctor.
MinocyclineBCG vaccine
Severe
How does the drug interact with Divaine 50 Tablet:
Co-administration of the BCG vaccine with Divaine 50 Tablet may reduce the activity of the BCG vaccine.

How to manage the interaction:
Although taking BCG vaccine and Divaine 50 Tablet together can result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MinocyclineRetinol
Severe
How does the drug interact with Divaine 50 Tablet:
Taking retinol (vitamin A) with Divaine 50 Tablet may increase the risk of pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking retinol (vitamin A) and Divaine 50 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor immediately if you experience headaches, nausea, vomiting, and visual disturbances. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

Divaine 50 Tablet is used to treat bacterial infections. It inhibits the protein synthesis process required for the growth of the bacterial cell.
No, Divaine 50 Tablet should not be stopped even if you feel better, as it is an antibiotic medication and completing the full course is very necessary. Otherwise, the infection might reappear in a more severe form.
Divaine 50 Tablet can make birth control pills less effective. Please ask your doctor about using non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.
You should avoid taking iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking Divaine 50 Tablet . Avoid taking any other antibiotics containing Divaine 50 Tablet unless your doctor has prescribed you.
Use of Divaine 50 Tablet during tooth development (pregnancy, infancy, and childhood to the age of 8 years) may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for pregnant women, breastfeeding mothers, and children below 8 years of age.
Yes, Divaine 50 Tablet is an antibiotic used to treat bacterial infections.
Do not discontinue Divaine 50 Tablet without consulting your doctor. To treat your condition effectively, keep taking Divaine 50 Tablet for the prescribed duration.
Divaine 50 Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.
Divaine 50 Tablet kills acne-causing bacteria, thereby helps treat acne.
There are no adequate and well-controlled studies on the use of Minocycline in pregnant women. In some cases, taking Divaine 50 Tablet during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy contact the doctor before using Divaine 50 Tablet .
Divaine 50 Tablet does not cause addiction or dependence; therefore, it does not make you high.
Yes, Divaine 50 Tablet may cause dizziness as a side effect. Drive or operate machinery only if you are alert.
Divaine 50 Tablet should be swallowed as a whole with water; do not crush or chew it.
Side effects of Divaine 50 Tablet are headache, photosensitivity (extreme sensitivity to ultraviolet (UV) rays from the sun and other light sources), dizziness, vomiting, itching, nausea, and diarrhoea. Most of these side effects of Divaine 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Minocycline Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Pil.5971 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. U.S. Food and Drug Administration (FDA). 050808S014Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  4. Minocycline [Prescribing Information]. 2019. [Accessed on 19 Sept. 2025] Check here
  5. EMA. minocycline. [Accessed on 10 Sep 2019] Check here
  6. Webmd. minocycline. [Accessed on 10 Sep 2019] Check here
  7. N Garrido-Mesa, A Zarzuelo, and J Gálvez. Minocycline: far beyond an antibiotic. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2013. [Accessed on 1st June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - DIV0023

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