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compositionComposition:VALPROIC ACID-500MG
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Prescription Medicine
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Divalsha-500 mg SR Tablet 10's is used to treat seizures and manage manic episodes in bipolar disorder. It also helps prevent migraine attacks. It supports better brain stability and reduces symptom frequency. This helps improve daily functioning and overall quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VALPROIC ACID-500MG

Manufacturer/Marketer :

Suraksha Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Divalsha-500 mg SR Tablet 10's

Divalsha-500 mg SR Tablet 10's is an oral prescription medication used to control various types of seizures in people with epilepsy. It is also prescribed to treat the manic phase of bipolar disorder and to prevent migraine headaches from occurring. This medicine works by calming overactive nerve activity in the brain to help stabilise your mood and prevent abnormal brain signals.

To get the best results, you must take Divalsha-500 mg SR Tablet 10's consistently every day at the same time as directed by your doctor. You can take this medicine with or without food, but taking it with meals can help prevent an upset stomach. Incorporating a regular sleep schedule, managing stress levels, and avoiding known seizure or migraine triggers can also support the effectiveness of your treatment.

While taking Divalsha-500 mg SR Tablet 10's, you may experience some common side effects such as mild sleepiness, nausea, or temporary hair thinning. However, you must seek medical help immediately if you notice serious symptoms like severe abdominal pain, dark urine, yellowing of your skin or eyes, or unusual mood changes.

Before starting this medication, tell your doctor if you have a history of liver problems, kidney disease, or pancreatic disorders. Do not take this if you have a family history of severe liver damage or genetic mitochondrial disorders. Pregnant women, or those planning to become pregnant, should not take this medicine for migraine prevention, and should only use it for epilepsy or bipolar disorder if no other treatments are suitable, due to a high risk of birth defects.

Divalsha-500 mg SR Tablet 10's can interact with alcohol, which can worsen drowsiness, and with other medicines like aspirin or certain antidepressants by changing how your body processes them. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss the risks and benefits before starting this medicine.

Uses of Divalsha-500 mg SR Tablet 10's

Divalsha-500 mg SR Tablet 10's is used for the treatment of epilepsy (seizures), bipolar disorder, and migraine. The detailed uses of Divalsha-500 mg SR Tablet 10's are as follows:

  • Epilepsy and Seizure Control: Divalsha-500 mg SR Tablet 10's helps prevent and control various types of seizures, including absence seizures, complex partial seizures, and generalised tonic-clonic seizures, by reducing abnormal electrical activity in the brain.
  • Bipolar Disorder (Manic Episodes): Divalsha-500 mg SR Tablet 10's helps stabilise mood swings and manage manic episodes, which are periods of overly high, excited, or irritable mood.
  • Migraine Prevention: Divalsha-500 mg SR Tablet 10's reduces the frequency and severity of migraine headaches when taken daily as a preventive treatment.

Key Benefits

Divalsha-500 mg SR Tablet 10's helps manage seizures, stabilise mood in bipolar disorder, and prevent migraine headaches, helping you lead a more active and balanced life.

The following are the benefits of Divalsha-500 mg SR Tablet 10's:

  • Helps reduce the frequency and severity of seizures.
  • Improves mood stability in people with bipolar disorder.
  • Reduces the occurrence of migraine headaches.
  • Supports better concentration and emotional well-being.
  • Promotes greater confidence in carrying out everyday activities.
  • Provides long-term control of symptoms with regular treatment.

Directions for Use

  • Swallow the tablets or capsules whole with a full glass of water. Do not crush, chew, or break it.
  • Take this medicine with food if it causes an upset stomach.
  • Never change your dose or stop taking this medication suddenly without talking to your doctor first. Stopping abruptly can cause your seizures to return or worsen.
  • Always follow your doctor's exact instructions regarding your dosing schedule.

How Divalsha-500 mg SR Tablet 10's Works

Divalsha-500 mg SR Tablet 10's contains valproic acid, which works by stabilising electrical activity in the brain. In conditions like epilepsy, bipolar disorder, and migraines, brain cells can become overactive and send rapid, uncontrolled signals. To help restore balance, Divalsha-500 mg SR Tablet 10's increases the levels of a natural calming chemical in the brain called gamma-aminobutyric acid (GABA), which helps slow excessive nerve activity. It also reduces abnormal electrical signalling by blocking certain sodium channels and T-type calcium channels in nerve cells. Together, these actions help keep nerve signals stable, thereby preventing seizures, managing mood shifts, and reducing processes that can trigger migraines.
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Alcohol

Unsafe

Do not consume alcohol while taking Divalsha-500 mg SR Tablet 10's as alcohol can worsen the side effects of the Divalsha-500 mg SR Tablet 10's, including sleepiness and dizziness.

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Pregnancy

Unsafe

Divalsha-500 mg SR Tablet 10's is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Divalsha-500 mg SR Tablet 10's.

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Breast Feeding

Caution

Divalsha-500 mg SR Tablet 10's passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Divalsha-500 mg SR Tablet 10's. Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Unsafe

Divalsha-500 mg SR Tablet 10's may cause dizziness, drowsiness, or fatigue in some individuals. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Divalsha-500 mg SR Tablet 10's.

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Liver

Caution

Inform your doctor before taking the Divalsha-500 mg SR Tablet 10's if you have a history of liver diseases. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Divalsha-500 mg SR Tablet 10's.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

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Children

Caution

Use is not recommended for children under 10 years old. Your doctor will decide the dose based on your child's condition if they are more than ten years old.

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Heart

Caution

Divalsha-500 mg SR Tablet 10's can be used cautiously in patients with heart disease if prescribed by a physician.

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Geriatrics

Caution

Divalsha-500 mg SR Tablet 10's can be given to elderly patients with extreme caution if prescribed by a physician.

What if I have taken an overdose of Divalsha-500 mg SR Tablet 10's

If you suspect an overdose, seek immediate emergency medical attention or call your local poison control centre. Symptoms of an overdose may include severe drowsiness, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol while taking this medicine, as it can increase drowsiness, dizziness, and the risk of liver problems.
  • Maintain a healthy diet: Eat a balanced diet and check your weight regularly, as this medicine may increase your appetite and lead to weight gain.
  • Stay well hydrated: Drink plenty of water throughout the day to support kidney function and your overall health.
  • Care for your hair and skin: Use gentle hair care products and moisturising skin creams if you notice temporary hair thinning or dry skin while taking this medicine.
  • Keep a symptom diary: Record your seizures, mood changes, or migraine episodes to help your doctor monitor your progress and adjust your treatment if needed.
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How Soon It Starts Working

  • The time required for Divalsha-500 mg SR Tablet 10's to start to work: Divalsha-500 mg SR Tablet 10's ideally shows its action within 1 to 4 hours after administration.
  • The time for which the effects of Divalsha-500 mg SR Tablet 10's last: The effect of Divalsha-500 mg SR Tablet 10's lasts for 13 to 19 hours.

What if you forget to take Divalsha-500 mg SR Tablet 10's

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Divalsha-500 mg SR Tablet 10's out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Attend regular blood tests: Get the blood tests your doctor recommends to check your liver, pancreas, and the amount of medicine in your body. This helps ensure the medicine is working safely.
  • Use effective birth control: If you can become pregnant, use reliable birth control while taking this medicine. Divalsha-500 mg SR Tablet 10's can seriously harm an unborn baby.
  • Watch for mood changes: Contact your doctor right away if you notice unusual changes in your mood, behaviour, or thoughts, including feelings of depression or thoughts of self-harm.
  • Tell healthcare providers about this medicine: Inform your doctor, dentist, or surgeon that you are taking this medicine before any procedure. It can affect how your blood clots.
  • Be careful with activities requiring alertness: Do not drive, operate heavy machinery, or do other dangerous activities until you know how this medicine affects you. It may cause drowsiness or reduce alertness.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., phenytoin, carbamazepine): Taking these medicines alongside Divalsha-500 mg SR Tablet 10's may affect how either medicine works and may increase the risk of side effects or reduce seizure control.
  • Blood thinners (e.g., warfarin): Taking these medicines with Divalsha-500 mg SR Tablet 10's may increase the risk of bleeding and may require closer monitoring.
  • Certain antibiotics (e.g., meropenem, imipenem): These antibiotics may greatly reduce the amount of Divalsha-500 mg SR Tablet 10's in the body, increasing the risk of breakthrough seizures.
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateLithium
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Divalsha-500 mg SR Tablet:
Combining Sodium phenylbutyrate and Divalsha-500 mg SR Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Divalsha-500 mg SR Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
Co-administration of Lithium with Divalsha-500 mg SR Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Divalsha-500 mg SR Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
Co-administration of Meropenam and Divalsha-500 mg SR Tablet together can reduce the effect of Divalsha-500 mg SR Tablet.

How to manage the interaction:
Co-administration of Meropenam and Divalsha-500 mg SR Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
Co-administration of Divalsha-500 mg SR Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Divalsha-500 mg SR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
Co-administration of Vorinostat with Divalsha-500 mg SR Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Divalsha-500 mg SR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
Using buprenorphine together with Divalsha-500 mg SR Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Divalsha-500 mg SR Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
The combined use of Ertapenem and Divalsha-500 mg SR Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Divalsha-500 mg SR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
Co-administration of Teriflunomide and Divalsha-500 mg SR Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Divalsha-500 mg SR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
Co-administration of Leflunomide and Divalsha-500 mg SR Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Divalsha-500 mg SR Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Divalsha-500 mg SR Tablet:
Co-administration of Ketamine and Divalsha-500 mg SR Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Divalsha-500 mg SR Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Carbonated beverages (e.g., soda, sparkling water): Consuming these drinks while taking Divalsha-500 mg SR Tablet 10's may increase the risk of irritation to the mouth and throat.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Divalsha-500 mg SR Tablet 10's is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).
Divalsha-500 mg SR Tablet 10's decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.
Divalsha-500 mg SR Tablet 10's helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.
Divalsha-500 mg SR Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.
Divalsha-500 mg SR Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Use an effective method of contraception during the treatment with Divalsha-500 mg SR Tablet 10's. Avoid getting pregnant while taking Divalsha-500 mg SR Tablet 10's as it could lead to serious birth defects. Do not stop taking Divalsha-500 mg SR Tablet 10's and consult your doctor immediately if you become pregnant.
Divalsha-500 mg SR Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Divalsha-500 mg SR Tablet 10's may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.
Divalsha-500 mg SR Tablet 10's contains Valproic acid as its active ingredient.
Take Divalsha-500 mg SR Tablet 10's with food to avoid stomach upset or as advised by your doctor.
You are recommended to avoid alcohol consumption while taking Divalsha-500 mg SR Tablet 10's as it may worsen the side effects of the Divalsha-500 mg SR Tablet 10's, including sleepiness and dizziness.
No, Divalsha-500 mg SR Tablet 10's does not cause addiction. However, Divalsha-500 mg SR Tablet 10's should be used as per the dose and duration prescribed by your doctor. Do not self-medicate.
Divalsha-500 mg SR Tablet 10's does not cure epilepsy; it only helps prevent seizures. However, you must take Divalsha-500 mg SR Tablet 10's for as long as your doctor advises. If you face any difficulty while taking Divalsha-500 mg SR Tablet 10's, consult your doctor.
If you stop taking Divalsha-500 mg SR Tablet 10's suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to discontinue Divalsha-500 mg SR Tablet 10's, please consult your physician.
Some birth control pills (oestrogen-containing birth control pills) may lower the levels of Divalsha-500 mg SR Tablet 10's in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about a suitable method of contraception.
Divalsha-500 mg SR Tablet 10's is safe for long-term use in many patients when prescribed by a physician. In rare cases, prolonged use of Divalsha-500 mg SR Tablet 10's may weaken bones, thereby increasing the risk of fractures (osteopenia and osteoporosis). Get regular checkups for bone health if you have been taking Divalsha-500 mg SR Tablet 10's for a long time.
Divalsha-500 mg SR Tablet 10's may cause hair thinning, hair colour changes and even hair loss. If you have any concerns about this, please ask your doctor whether it is possible to reduce the dose of Divalsha-500 mg SR Tablet 10's. Your hair may regrow after either lowering your dose or changing medication.
Your doctor will order regular blood tests to check the levels of Divalsha-500 mg SR Tablet 10's in your body and to monitor how well your liver and blood cells are working. This ensures the medicine is working safely and effectively. Talk to your doctor if you have questions about your tests.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Valproic Acid Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.6102 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 018081S065 018082S048Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Valproic Acid - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Valporic acid. 1978. [Accessed on 19 Mar 2019]Check here
  6. Valproic acid. 2026. [Accessed on 21 Apr. 2026]Check here
  7. Sodium valproate: medicine to treat epilepsy and bipolar disorder [Internet]. nhs.uk. 2025 [Accessed on 10 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

33, Jadugar Road, Niti Nagar, Civil Lines, Roorkee, Uttarakhand 247667
Other Info - DIV0195

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