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compositionComposition:VALPROIC ACID-500MG
prescription
Prescription Medicine
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Divat XR 500 Tablet is used to treat seizures and manage manic episodes in bipolar disorder. It also helps prevent migraine attacks. It supports better brain stability and reduces symptom frequency. This helps improve daily functioning and overall quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VALPROIC ACID-500MG

Manufacturer/Marketer :

Atlanta Biological Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Divat XR 500 Tablet

Divat XR 500 Tablet is an oral prescription medication used to control various types of seizures in people with epilepsy. It is also prescribed to treat the manic phase of bipolar disorder and to prevent migraine headaches from occurring. This medicine works by calming overactive nerve activity in the brain to help stabilise your mood and prevent abnormal brain signals.

To get the best results, you must take Divat XR 500 Tablet consistently every day at the same time as directed by your doctor. You can take this medicine with or without food, but taking it with meals can help prevent an upset stomach. Incorporating a regular sleep schedule, managing stress levels, and avoiding known seizure or migraine triggers can also support the effectiveness of your treatment.

While taking Divat XR 500 Tablet , you may experience some common side effects such as mild sleepiness, nausea, or temporary hair thinning. However, you must seek medical help immediately if you notice serious symptoms like severe abdominal pain, dark urine, yellowing of your skin or eyes, or unusual mood changes.

Before starting this medication, tell your doctor if you have a history of liver problems, kidney disease, or pancreatic disorders. Do not take this if you have a family history of severe liver damage or genetic mitochondrial disorders. Pregnant women, or those planning to become pregnant, should not take this medicine for migraine prevention, and should only use it for epilepsy or bipolar disorder if no other treatments are suitable, due to a high risk of birth defects.

Divat XR 500 Tablet can interact with alcohol, which can worsen drowsiness, and with other medicines like aspirin or certain antidepressants by changing how your body processes them. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss the risks and benefits before starting this medicine.

Uses of Divat XR 500 Tablet

Divat XR 500 Tablet is used for the treatment of epilepsy (seizures), bipolar disorder, and migraine. The detailed uses of Divat XR 500 Tablet are as follows:

  • Epilepsy and Seizure Control: Divat XR 500 Tablet helps prevent and control various types of seizures, including absence seizures, complex partial seizures, and generalised tonic-clonic seizures, by reducing abnormal electrical activity in the brain.
  • Bipolar Disorder (Manic Episodes): Divat XR 500 Tablet helps stabilise mood swings and manage manic episodes, which are periods of overly high, excited, or irritable mood.
  • Migraine Prevention: Divat XR 500 Tablet reduces the frequency and severity of migraine headaches when taken daily as a preventive treatment.

Key Benefits

Divat XR 500 Tablet helps manage seizures, stabilise mood in bipolar disorder, and prevent migraine headaches, helping you lead a more active and balanced life.

The following are the benefits of Divat XR 500 Tablet :

  • Helps reduce the frequency and severity of seizures.
  • Improves mood stability in people with bipolar disorder.
  • Reduces the occurrence of migraine headaches.
  • Supports better concentration and emotional well-being.
  • Promotes greater confidence in carrying out everyday activities.
  • Provides long-term control of symptoms with regular treatment.
Side effects of Divat XR 500 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Eat a balanced diet high in nutrients and low in sugar.
  • Include fruits, vegetables, and leafy greens rich in vitamins C and K.
  • Brush and floss regularly twice a day with fluoride toothpaste and once a day with floss.
  • Use a soft or extra-soft toothbrush.
  • Reduce stress to minimize inflammation and gum bleeding.
  • Avoid tobacco products as smoking can worsen gum disease.
  • Stay hydrated by drinking water to flush bacteria and food particles.
  • Consider vitamin supplements if deficient to support gum health.
  • Use an antimicrobial mouthwash to reduce bacteria and prevent bleeding.
  • Swish with coconut oil for its antibacterial properties to reduce plaque.
  • Drink green tea rich in catechin to reduce inflammation from oral bacteria.
  • Consult your dentist if gums bleed consistently.
  • Apply a cold compress to the affected area for 10 to 15 minutes multiple times a day.
  • Elevate your head while resting or sleeping to reduce fluid accumulation.
  • Drink lots of water to eliminate excess fluids.
  • Limit salty foods as they can cause water retention.
  • To stimulate lymphatic drainage, gently massage the swollen area.

Directions for Use

  • Swallow the tablets or capsules whole with a full glass of water. Do not crush, chew, or break it.
  • Take this medicine with food if it causes an upset stomach.
  • Never change your dose or stop taking this medication suddenly without talking to your doctor first. Stopping abruptly can cause your seizures to return or worsen.
  • Always follow your doctor's exact instructions regarding your dosing schedule.

How Divat XR 500 Tablet Works

Divat XR 500 Tablet contains valproic acid, which works by stabilising electrical activity in the brain. In conditions like epilepsy, bipolar disorder, and migraines, brain cells can become overactive and send rapid, uncontrolled signals. To help restore balance, Divat XR 500 Tablet increases the levels of a natural calming chemical in the brain called gamma-aminobutyric acid (GABA), which helps slow excessive nerve activity. It also reduces abnormal electrical signalling by blocking certain sodium channels and T-type calcium channels in nerve cells. Together, these actions help keep nerve signals stable, thereby preventing seizures, managing mood shifts, and reducing processes that can trigger migraines.
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Alcohol

Unsafe

Do not consume alcohol while taking Divat XR 500 Tablet as alcohol can worsen the side effects of the Divat XR 500 Tablet , including sleepiness and dizziness.

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Pregnancy

Unsafe

Divat XR 500 Tablet is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Divat XR 500 Tablet .

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Breast Feeding

Caution

Divat XR 500 Tablet passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Divat XR 500 Tablet . Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Unsafe

Divat XR 500 Tablet may cause dizziness, drowsiness, or fatigue in some individuals. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Divat XR 500 Tablet .

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Liver

Caution

Inform your doctor before taking the Divat XR 500 Tablet if you have a history of liver diseases. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Divat XR 500 Tablet .

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

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Children

Caution

Use is not recommended for children under 10 years old. Your doctor will decide the dose based on your child's condition if they are more than ten years old.

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Heart

Caution

Divat XR 500 Tablet can be used cautiously in patients with heart disease if prescribed by a physician.

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Geriatrics

Caution

Divat XR 500 Tablet can be given to elderly patients with extreme caution if prescribed by a physician.

What if I have taken an overdose of Divat XR 500 Tablet

If you suspect an overdose, seek immediate emergency medical attention or call your local poison control centre. Symptoms of an overdose may include severe drowsiness, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol while taking this medicine, as it can increase drowsiness, dizziness, and the risk of liver problems.
  • Maintain a healthy diet: Eat a balanced diet and check your weight regularly, as this medicine may increase your appetite and lead to weight gain.
  • Stay well hydrated: Drink plenty of water throughout the day to support kidney function and your overall health.
  • Care for your hair and skin: Use gentle hair care products and moisturising skin creams if you notice temporary hair thinning or dry skin while taking this medicine.
  • Keep a symptom diary: Record your seizures, mood changes, or migraine episodes to help your doctor monitor your progress and adjust your treatment if needed.
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Have a query?

How Soon It Starts Working

  • The time required for Divat XR 500 Tablet to start to work: Divat XR 500 Tablet ideally shows its action within 1 to 4 hours after administration.
  • The time for which the effects of Divat XR 500 Tablet last: The effect of Divat XR 500 Tablet lasts for 13 to 19 hours.

What if you forget to take Divat XR 500 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Divat XR 500 Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Attend regular blood tests: Get the blood tests your doctor recommends to check your liver, pancreas, and the amount of medicine in your body. This helps ensure the medicine is working safely.
  • Use effective birth control: If you can become pregnant, use reliable birth control while taking this medicine. Divat XR 500 Tablet can seriously harm an unborn baby.
  • Watch for mood changes: Contact your doctor right away if you notice unusual changes in your mood, behaviour, or thoughts, including feelings of depression or thoughts of self-harm.
  • Tell healthcare providers about this medicine: Inform your doctor, dentist, or surgeon that you are taking this medicine before any procedure. It can affect how your blood clots.
  • Be careful with activities requiring alertness: Do not drive, operate heavy machinery, or do other dangerous activities until you know how this medicine affects you. It may cause drowsiness or reduce alertness.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., phenytoin, carbamazepine): Taking these medicines alongside Divat XR 500 Tablet may affect how either medicine works and may increase the risk of side effects or reduce seizure control.
  • Blood thinners (e.g., warfarin): Taking these medicines with Divat XR 500 Tablet may increase the risk of bleeding and may require closer monitoring.
  • Certain antibiotics (e.g., meropenem, imipenem): These antibiotics may greatly reduce the amount of Divat XR 500 Tablet in the body, increasing the risk of breakthrough seizures.
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateLithium
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Divat XR 500 Tablet:
Combining Sodium phenylbutyrate and Divat XR 500 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Divat XR 500 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Divat XR 500 Tablet:
Co-administration of Lithium with Divat XR 500 Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Divat XR 500 Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Divat XR 500 Tablet:
Co-administration of Meropenam and Divat XR 500 Tablet together can reduce the effect of Divat XR 500 Tablet.

How to manage the interaction:
Co-administration of Meropenam and Divat XR 500 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Divat XR 500 Tablet:
Co-administration of Divat XR 500 Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Divat XR 500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Divat XR 500 Tablet:
Co-administration of Vorinostat with Divat XR 500 Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Divat XR 500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Divat XR 500 Tablet:
Using buprenorphine together with Divat XR 500 Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Divat XR 500 Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Divat XR 500 Tablet:
The combined use of Ertapenem and Divat XR 500 Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Divat XR 500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Divat XR 500 Tablet:
Co-administration of Teriflunomide and Divat XR 500 Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Divat XR 500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Divat XR 500 Tablet:
Co-administration of Leflunomide and Divat XR 500 Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Divat XR 500 Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Divat XR 500 Tablet:
Co-administration of Ketamine and Divat XR 500 Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Divat XR 500 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Carbonated beverages (e.g., soda, sparkling water): Consuming these drinks while taking Divat XR 500 Tablet may increase the risk of irritation to the mouth and throat.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Divat XR 500 Tablet is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).
Divat XR 500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.
Divat XR 500 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.
Divat XR 500 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.
Divat XR 500 Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Use an effective method of contraception during the treatment with Divat XR 500 Tablet . Avoid getting pregnant while taking Divat XR 500 Tablet as it could lead to serious birth defects. Do not stop taking Divat XR 500 Tablet and consult your doctor immediately if you become pregnant.
Divat XR 500 Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Divat XR 500 Tablet may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.
Divat XR 500 Tablet contains Valproic acid as its active ingredient.
Take Divat XR 500 Tablet with food to avoid stomach upset or as advised by your doctor.
You are recommended to avoid alcohol consumption while taking Divat XR 500 Tablet as it may worsen the side effects of the Divat XR 500 Tablet , including sleepiness and dizziness.
No, Divat XR 500 Tablet does not cause addiction. However, Divat XR 500 Tablet should be used as per the dose and duration prescribed by your doctor. Do not self-medicate.
Divat XR 500 Tablet does not cure epilepsy; it only helps prevent seizures. However, you must take Divat XR 500 Tablet for as long as your doctor advises. If you face any difficulty while taking Divat XR 500 Tablet , consult your doctor.
If you stop taking Divat XR 500 Tablet suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to discontinue Divat XR 500 Tablet , please consult your physician.
Some birth control pills (oestrogen-containing birth control pills) may lower the levels of Divat XR 500 Tablet in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about a suitable method of contraception.
Divat XR 500 Tablet is safe for long-term use in many patients when prescribed by a physician. In rare cases, prolonged use of Divat XR 500 Tablet may weaken bones, thereby increasing the risk of fractures (osteopenia and osteoporosis). Get regular checkups for bone health if you have been taking Divat XR 500 Tablet for a long time.
Divat XR 500 Tablet may cause hair thinning, hair colour changes and even hair loss. If you have any concerns about this, please ask your doctor whether it is possible to reduce the dose of Divat XR 500 Tablet . Your hair may regrow after either lowering your dose or changing medication.
Your doctor will order regular blood tests to check the levels of Divat XR 500 Tablet in your body and to monitor how well your liver and blood cells are working. This ensures the medicine is working safely and effectively. Talk to your doctor if you have questions about your tests.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Valproic Acid Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.6102 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 018081S065 018082S048Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Valproic Acid - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Valporic acid. 1978. [Accessed on 19 Mar 2019]Check here
  6. Valproic acid. 2026. [Accessed on 21 Apr. 2026]Check here
  7. Sodium valproate: medicine to treat epilepsy and bipolar disorder [Internet]. nhs.uk. 2025 [Accessed on 10 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

1307, 11Th St, Yelareddyguda Hyderabad Tg 500073 In
Other Info - DIV0301

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