What is the use of Divazis-500 ER Tablet 10's?

Divazis-500 ER Tablet 10's belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Divazis-500 ER Tablet 10's is also used to treat manic episodes associated with bipolar disorder and to prevent migraine.

Is Divazis-500 ER Tablet 10's used to treat bipolar disorder?

Divazis-500 ER Tablet 10's helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

Does Divazis-500 ER Tablet 10's help in preventing migraine?

Divazis-500 ER Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.

Can I stop taking Divazis-500 ER Tablet 10's if I feel well?

Do not discontinue Divazis-500 ER Tablet 10's without consulting your doctor. To treat your condition effectively, continue taking Divazis-500 ER Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Divazis-500 ER Tablet 10's. Your doctor will reduce the dose gradually to avoid worsening of seizures.

Does Divazis-500 ER Tablet 10's cause weight gain?

Divazis-500 ER Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

I am planning for pregnancy, is it safe to take Divazis-500 ER Tablet 10's?

Use an effective method of contraception during the treatment with Divazis-500 ER Tablet 10's. Avoid getting pregnant while taking Divazis-500 ER Tablet 10's as it could lead to serious birth defects. Do not stop taking Divazis-500 ER Tablet 10's and consult your doctor immediately if you become pregnant.

Does Divazis-500 ER Tablet 10's increase the risk of bleeding?

Divazis-500 ER Tablet 10's may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Divazis-500 ER Tablet 10's.

Is it safe to take Divazis-500 ER Tablet 10's with topiramate?

Topiramate (anticonvulsant) should not be taken along with Divazis-500 ER Tablet 10's as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

What happens if I stop taking Divazis-500 ER Tablet 10's?

It is crucial to consult with your doctor before discontinuing Divazis-500 ER Tablet 10's. Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.

Is Divazis-500 ER Tablet 10's a mood stabilizer?

Divazis-500 ER Tablet 10's is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.

Does Divazis-500 ER Tablet 10's make you sleepy?

Divazis-500 ER Tablet 10's can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, please consult your doctor.

Does Divazis-500 ER Tablet 10's cause hair loss?

Yes, Divazis-500 ER Tablet 10's can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Divazis-500 ER Tablet 10's, it's essential to consult with your doctor.

Can Divazis-500 ER Tablet 10's damage my liver?

Yes, Divazis-500 ER Tablet 10's can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Divazis-500 ER Tablet 10's, seeking medical attention is crucial.

What should be done if I start experiencing abdominal pain, nausea and anorexia?

If you experience abdominal pain, nausea, and anorexia while taking Divazis-500 ER Tablet 10's, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.

Divazis-500 ER Tablet 10's

Prescription drug

MRP ₹152

(Inclusive of all Taxes)

₹22.8 Cashback (15%)

Extra 15% Off with Bank Offers

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Divazis-500 ER Tablet 10's is used to treat epilepsy, seizures or fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. It contains Divalproex sodium, which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. It helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder. In some cases, it may cause common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Divazis-500 ER Tablet 10's

Divazis-500 ER Tablet 10's is used to treat epilepsy, seizures or fits. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Divazis-500 ER Tablet 10's contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures.

In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Inform your doctor about your health, allergies, and medicines to avoid side effects. Do not take Divazis-500 ER Tablet 10's if you are pregnant, as it could cause severe birth defects. Consult your doctor before taking Divazis-500 ER Tablet 10's if you are breastfeeding. Use Divazis-500 ER Tablet 10's cautiously in children under 2 years, due to higher liver risk in the first 6 months.

Uses of Divazis-500 ER Tablet 10's

Divazis-500 ER Tablet 10's is used in the treatment of seizures, bipolar disorder, and migraine. The detailed uses of Divazis-500 ER Tablet 10's are as follows:

Bipolar Disorder: Divazis-500 ER Tablet 10's treats manic episodes associated with bipolar disorder, stabilizes mood, and reduces symptoms.
Seizure Treatment: Divazis-500 ER Tablet 10's is used for treating complex partial seizures, absence seizures, and multiple seizure types by stabilizing electrical activity in the brain.
Migraine Prevention: Divazis-500 ER Tablet 10's prevents migraine headaches by reducing frequency and severity.

Have a query?

Directions for Use

Divazis-500 ER Tablet 10's can be taken with or without food, or as advised by the doctor.
It is usually taken once daily; however, your doctor may adjust the dose and frequency based on your medical condition.
Swallow Divazis-500 ER Tablet 10's as a whole with a glass of water.
Do not crush, chew, break, or open it.

Medicinal Benefits

Divazis-500 ER Tablet 10's belongs to a group of medicines called anticonvulsants or anti-epileptics.
Divazis-500 ER Tablet 10's is used to treat epilepsy/seizures/fits. Additionally, Divazis-500 ER Tablet 10's is also used to treat mood disorders and to prevent migraine headaches.
Divazis-500 ER Tablet 10's decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
Divazis-500 ER Tablet 10's treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect.
Divazis-500 ER Tablet 10's prevents migraine headaches by limiting the transmission of nerve pain.
Divazis-500 ER Tablet 10's is used alone or in combination to treat simple seizures, complex partial seizures, and complex absence seizures.
Divazis-500 ER Tablet 10's is used in combination to treat multiple seizures, such as absence seizures.

How Divazis-500 ER Tablet 10's Works

Divazis-500 ER Tablet 10's contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping in controlling seizures. Divazis-500 ER Tablet 10's increases the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Divazis-500 Er Tab

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Flu syndrome (Flu Symptoms)

Get plenty of rest and sleep.
Keep your body warm.
Drink plenty of fluids to stay hydrated.
Avoid strenuous activities.
Maintain good hygiene to prevent flu from spreading.

Black or tarry stools

Bleeding Gums

Eat a balanced diet high in nutrients and low in sugar.
Include fruits, vegetables, and leafy greens rich in vitamins C and K.
Brush and floss regularly twice a day with fluoride toothpaste and once a day with floss.
Use a soft or extra-soft toothbrush.
Reduce stress to minimize inflammation and gum bleeding.
Avoid tobacco products as smoking can worsen gum disease.
Stay hydrated by drinking water to flush bacteria and food particles.
Consider vitamin supplements if deficient to support gum health.
Use an antimicrobial mouthwash to reduce bacteria and prevent bleeding.
Swish with coconut oil for its antibacterial properties to reduce plaque.
Drink green tea rich in catechin to reduce inflammation from oral bacteria.
Consult your dentist if gums bleed consistently.

Facial Swelling

Apply a cold compress to the affected area for 10 to 15 minutes multiple times a day.
Elevate your head while resting or sleeping to reduce fluid accumulation.
Drink lots of water to eliminate excess fluids.
Limit salty foods as they can cause water retention.
To stimulate lymphatic drainage, gently massage the swollen area.

Presence of blood in urine

What if I have taken an overdose of Divazis-500 ER Tablet 10's

Please do not take more than the prescribed dose of Divazis-500 ER Tablet 10's, as it may lead to serious side effects. The symptoms of an overdose may include heart block, excess sleepiness, and deep coma. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Divazis-500 ER Tablet 10's if you are allergic to any of its contents, have/had liver problems, or urea cycle disorders.
Inform your doctor before taking Divazis-500 ER Tablet 10's if you have pancreatitis, blood problems, or multi-organ hypersensitivity.
Consult your doctor immediately if you experience suicidal tendencies while taking Divazis-500 ER Tablet 10's.
Divazis-500 ER Tablet 10's may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature), and liver problems.
Please do not stop taking Divazis-500 ER Tablet 10's without consulting your doctor to avoid worsening of seizures.
Do not take Divazis-500 ER Tablet 10's if you are pregnant, as it could cause serious birth defects.
If you are of child-bearing age, use effective contraception while taking Divazis-500 ER Tablet 10's.
Avoid driving or operating machinery, as Divazis-500 ER Tablet 10's can cause dizziness and may affect thinking and motor skills.
Avoid consuming alcohol along with Divazis-500 ER Tablet 10's as it could lead to increased dizziness.
Care should be taken while giving Divazis-500 ER Tablet 10's to children below 2 years, as there is a higher risk of liver intoxication during the first 6 months of treatment.

Drug-Drug Interactions

Sodium ValproateSodium phenylbutyrate

Critical

Sodium ValproateErtapenem

Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate

Critical

How does the drug interact with Divazis-500 Er Tab:
Combining Sodium phenylbutyrate and Divazis-500 Er Tab can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Divazis-500 Er Tab is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Sodium ValproateErtapenem

Severe

How does the drug interact with Divazis-500 Er Tab:
The combined use of Ertapenem and Divazis-500 Er Tab can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Divazis-500 Er Tab can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.

Sodium ValproateDoripenem

Severe

How does the drug interact with Divazis-500 Er Tab:
Co-administration of Divazis-500 Er Tab with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Divazis-500 Er Tab can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Sodium ValproateVorinostat

Severe

How does the drug interact with Divazis-500 Er Tab:
Co-administration of Vorinostat with Divazis-500 Er Tab can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Divazis-500 Er Tab can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.

Sodium ValproateTeriflunomide

Severe

How does the drug interact with Divazis-500 Er Tab:
Co-administration of Teriflunomide and Divazis-500 Er Tab can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Divazis-500 Er Tab can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.

Sodium ValproateBuprenorphine

Severe

How does the drug interact with Divazis-500 Er Tab:
Using buprenorphine together with Divazis-500 Er Tab may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Divazis-500 Er Tab can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Sodium ValproateLeflunomide

Severe

How does the drug interact with Divazis-500 Er Tab:
Co-administration of Leflunomide and Divazis-500 Er Tab can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Divazis-500 Er Tab can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Sodium ValproateMeropenem

Severe

How does the drug interact with Divazis-500 Er Tab:
Co-administration of Meropenam and Divazis-500 Er Tab together can reduce the effect of Divazis-500 Er Tab.

How to manage the interaction:
Co-administration of Meropenam and Divazis-500 Er Tab can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Sodium ValproateLithium

Severe

How does the drug interact with Divazis-500 Er Tab:
Co-administration of Lithium with Divazis-500 Er Tab can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Divazis-500 Er Tab can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.

Sodium ValproateKetamine

Severe

How does the drug interact with Divazis-500 Er Tab:
Co-administration of Ketamine and Divazis-500 Er Tab can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Divazis-500 Er Tab can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for energy generation.
The Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
Exercising regularly helps maintain weight and improve overall health.
Rest well, get plenty of sleep.
Avoid smoking and alcohol consumption.
Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.
Have a seizure response plan, and help those around you know what to do.
Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
Understand what triggers seizures and try reducing or avoiding them.
Please pay attention to overall health, as it can help in reducing seizure activity.
Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Divazis-500 ER Tablet 10's, as it may cause increased dizziness.

Pregnancy

Unsafe

Divazis-500 ER Tablet 10's belongs to pregnancy category D. Avoid taking Divazis-500 ER Tablet 10's if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

Breast Feeding

Consult your doctor

Divazis-500 ER Tablet 10's may pass into breastmilk. Consult your doctor before taking Divazis-500 ER Tablet 10's if you are breastfeeding.

Driving

Unsafe

Divazis-500 ER Tablet 10's causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery until you are mentally alert.

Liver

Unsafe

Divazis-500 ER Tablet 10's should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this. Dose adjustment may be needed in patients with kidney impairment.

Children

Caution

Divazis-500 ER Tablet 10's can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below 2 years as they are at a higher risk of liver toxicity.

Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

Geriatrics

Caution

Divazis-500 ER Tablet 10's can be given in elderly patients with extreme caution due to the serious adverse effects.

FAQs

Country of origin

India

Manufacturer/Marketer address

Raza Hyder Street, Mount Road, Chennai 600002, Tamil Nadu, India.

Other Info - DIV0236

Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Dec 3, 2025 | 7:33 AM IST

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