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compositionComposition:PIROXICAM-40MG
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Prescription Medicine
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Doloforce Injection 4 x 2 ml contains piroxicam, which is an NSAID (Non-Steroidal Anti-Inflammatory Drugs) medicine. It is mainly used to relieve pain, swelling, and stiffness caused by osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis (inflammation of the joints). It is sometimes also used to reduce back pain. This medicine inhibits cyclo-oxygenase (COX) enzymes, and this helps reduce pain.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

PIROXICAM-40MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Doloforce Injection 4 x 2 ml

Doloforce Injection 4 x 2 ml is an injectable prescription medicine used to treat severe pain and swelling caused by joint and muscle conditions like rheumatoid arthritis and osteoarthritis. It belongs to a group of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs) that help lower pain and inflammation. This medication is typically used when quick relief is needed or when oral medications cannot be taken.

This injection is usually given once a day, and it is important to receive it consistently as directed by your healthcare provider to achieve the best results. Since it is injected directly into a muscle, food intake does not affect how it works, though drinking plenty of water helps protect your kidneys. Incorporating low-impact physical therapy and maintaining a healthy weight can also greatly support your joint health during treatment.

Some people may experience mild side effects like swelling at the injection site, stomach upset, or dizziness. However, if you notice serious symptoms such as severe stomach pain, black stools, shortness of breath, or sudden swelling, you must contact your doctor immediately.

Before you start treatment, tell your healthcare provider if you have a history of asthma, high blood pressure, heart disease, stomach ulcers, or kidney problems. Do not take this medicine if you have active stomach bleeding, severe heart failure, or if you have had a severe allergic reaction to aspirin or other NSAIDs.

Using this medicine with alcohol or tobacco increases your risk of stomach bleeding, while certain blood thinners or water pills can interact poorly with it. If you are pregnant, breastfeeding, or are an older adult, you should talk to your doctor or pharmacist to discuss the risks and benefits before starting treatment.

Uses of Doloforce Injection 4 x 2 ml

Doloforce Injection 4 x 2 ml is used to treat severe pain and swelling caused by joint and muscle conditions. The detailed uses of Doloforce Injection 4 x 2 ml are as follows:

  • Osteoarthritis: It helps reduce the persistent joint pain, swelling, and stiffness associated with wear-and-tear joint damage.
  • Rheumatoid arthritis: It relieves the painful inflammation, warmth, and swelling in the joints caused by this autoimmune condition.
  • Ankylosing spondylitis: It targets painful inflammation and stiffness in the spine and large joints, helping to improve flexibility.
  • Acute gout attacks: It provides rapid relief from the intense pain, redness, and swelling in joints during sudden gout flare-ups.
  • Moderate to severe acute pain: It is used for short-term relief of sudden, intense pain when oral medications are not suitable.

Key Benefits

Doloforce Injection 4 x 2 ml provides fast and effective relief from pain and inflammation through injectable administration. By acting quickly, it helps reduce pain, improve joint mobility, and offers a reliable treatment option when oral medicines are not suitable.

  • Provides Rapid Pain Relief: Because this medicine is administered by injection, it begins working quickly to relieve severe pain and discomfort, providing fast symptom relief.
  • Improves Mobility: By reducing swelling, stiffness, and inflammation in the joints and surrounding tissues, this medicine helps restore flexibility and makes everyday movements more comfortable.
  • Reduces Inflammation: This medicine targets the underlying inflammation, helping relieve pain, prevent further tissue irritation, and support the healing process.
  • Alternative to Oral Medicines: Injectable administration provides an effective option for patients who have difficulty swallowing tablets or cannot tolerate oral pain medicines due to stomach-related side effects.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Doloforce Injection 4 x 2 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Doloforce Injection 4 x 2 ml Works

Doloforce Injection 4 x 2 ml contains piroxicam, which works by stopping the body from producing certain natural chemicals called prostaglandins. These chemicals are responsible for causing pain, fever, and inflammation at the site of an injury or joint damage. By blocking the enzymes (known as COX enzymes) that make these chemicals, the injection successfully calms swelling, reduces heat in the affected joints, and eases painful sensations. Because it is given as an injection, the medicine is absorbed directly into the bloodstream, bypassing the digestive system initially to offer targeted relief.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Doloforce Injection 4 x 2 ml. Alcohol intake, along with Doloforce Injection 4 x 2 ml, may cause increased dizziness. It may also increase the risk of stomach/intestine ulcers and bleeding.

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Pregnancy

Consult your doctor

Avoid taking Doloforce Injection 4 x 2 ml if you are pregnant unless prescribed by the doctor. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe Doloforce Injection 4 x 2 ml only if the benefits outweigh the risks. Do not take Doloforce Injection 4 x 2 ml in the last 20 weeks of pregnancy as it may cause serious kidney and heart problems in the unborn baby and complications with the pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Doloforce Injection 4 x 2 ml. Please consult your doctor if you have any concerns.

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Driving

Caution

Doloforce Injection 4 x 2 ml may cause dizziness. Do not drive or operate heavy machinery if you experience dizziness.

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Liver

Caution

Dose adjustment may be needed. Doloforce Injection 4 x 2 ml should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Doloforce Injection 4 x 2 ml should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Doloforce Injection 4 x 2 ml is not recommended for children, as the efficacy and safety have not been established.

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Heart

Caution

Doloforce Injection 4 x 2 ml should be used with caution in patients with heart problems. Therefore, please consult your doctor before using Doloforce Injection 4 x 2 ml.

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Geriatrics

Consult your doctor

Doloforce Injection 4 x 2 ml should be used with caution and may require dose adjustment in elderly patients. Please consult your doctor if you have any concerns.

What if I have taken an overdose of Doloforce Injection 4 x 2 ml

If you suspect an overdose or experience severe symptoms like extreme stomach pain, slow breathing, or loss of consciousness, seek immediate medical attention or call emergency services right away.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water throughout the day to help your kidneys flush out waste and stay healthy while using this medication.
  • Eat an anti-inflammatory diet: Focus on foods rich in omega-3 fatty acids, such as salmon, walnuts, and flaxseeds, and plenty of colourful vegetables to help naturally manage joint inflammation.
  • Engage in low-impact exercise: Gently move your joints with activities like swimming, cycling, or walking to maintain flexibility and strengthen the muscles around your joints.
  • Protect your stomach: Avoid consuming alcohol and limit spicy or highly acidic foods, as these can irritate your stomach lining and increase the risk of ulcers.
  • Manage your weight: Maintaining a healthy weight reduces the physical stress and pressure on your weight-bearing joints, like your knees and hips.
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How Soon It Starts Working

  • The time required for Doloforce Injection 4 x 2 ml to start to work: Doloforce Injection 4 x 2 ml shows its action within 30 minutes to 1 hour of administration.
  • The time for which the effects of Doloforce Injection 4 x 2 ml last: Doloforce Injection 4 x 2 ml effect lasts for a few hours.

What if you forget to take Doloforce Injection 4 x 2 ml

If you miss a scheduled injection, contact your doctor or healthcare clinic right away for instructions. Do not receive a double dose to make up for a missed one.

Storage

• Store this medicine at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the liquid before use: Always check the injection vial or syringe before use; the solution should be clear and free of particles or discolouration. Do not use it if it looks cloudy or contains floating specks.
  • Rotate your injection sites: If you receive multiple injections over time, ensure the injection site is changed each time to prevent muscle damage, hardness, or pain.
  • Practice safe needle disposal: If injecting at home under medical guidance, always discard used needles and syringes immediately in a puncture-resistant sharps container. Never reuse needles.
  • Watch your blood pressure: Since this class of medicine can cause your body to hold onto extra fluid, monitor your blood pressure regularly and report any sudden increases to your doctor.
  • Avoid other pain relievers: Do not take other oral NSAIDs (like ibuprofen or naproxen) while receiving this injection unless specifically advised by your doctor, as this greatly increases your risk of side effects.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (like warfarin): May increase the risk of severe stomach bleeding.
  • Water pills (diuretics) and blood pressure medicines: May lower the effectiveness of these medications and increase the risk of kidney damage.
  • Other NSAIDs or aspirin: May significantly increase the risk of stomach ulcers and bleeding.
  • Lithium: May increase the levels of lithium in your body, raising the risk of toxicity.

Drug-Drug Interactions

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How does the drug interact with Doloforce Injection 4 x 2 ml:
Co-administration of Cidofovir with Doloforce Injection 4 x 2 ml can increase the risk of kidney problems.

How to manage the interaction:
Taking Doloforce Injection 4 x 2 ml with Cidofovir is not recommended as it can cause an interaction, it can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Using ketorolac tromethamine together with Doloforce Injection 4 x 2 ml may increase the risk of side effects.

How to manage the interaction:
Taking Doloforce Injection 4 x 2 ml with Ketorolac tromethamine is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without talking to a doctor.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Using Doloforce Injection 4 x 2 ml together with flurbiprofen may increase the risk of side effects such as inflammation(swelling with redness and pain), bleeding and ulceration.

How to manage the interaction:
Although there is a possible interaction between Flurbiprofen and Doloforce Injection 4 x 2 ml, it can be taken if your doctor has advised it. However, if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Taking Doloforce Injection 4 x 2 ml with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Fondaparinux and Doloforce Injection 4 x 2 ml, you can take these medicines together if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Using panobinostat together with Doloforce Injection 4 x 2 ml may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Doloforce Injection 4 x 2 ml and Panobinostat, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Co-administration of Sirolimus with Doloforce Injection 4 x 2 ml can increase the risk or severity of kidney damage.

How to manage the interaction:
Co-administration of Sirolimus with Doloforce Injection 4 x 2 ml can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not stop using any medication without consulting your doctor.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Coadministration of Warfarin with Doloforce Injection 4 x 2 ml can increase the risk of bleeding.

How to manage the interaction:
Although taking Doloforce Injection 4 x 2 ml with Warfarin together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness consult a doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Using regorafenib together with Doloforce Injection 4 x 2 ml may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Doloforce Injection 4 x 2 ml and Regorafenib, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Coadministration of Doloforce Injection 4 x 2 ml with Etodolac can increase the risk of side effects such as inflammation(swelling with redness), bleeding, ulceration.

How to manage the interaction:
Although taking Etodolac and Doloforce Injection 4 x 2 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Doloforce Injection 4 x 2 ml:
Coadministration of Mefenamic acid with Doloforce Injection 4 x 2 ml can increase the risk side effects such as inflammation(swelling with redness and pain), bleeding, ulceration, and perforation leading to serious blood loss.

How to manage the interaction:
Taking Mefenamic acid with Doloforce Injection 4 x 2 ml together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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  • Alcohol: Consuming alcohol while using this medicine significantly increases your risk of stomach bleeding and irritation.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

Doloforce Injection 4 x 2 ml belongs to the group of medications known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to relieve symptoms like pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and musculoskeletal disorders.
Doloforce Injection 4 x 2 ml works by blocking the effect of chemical messengers (prostaglandin), thereby reducing pain, stiffness, swelling, and inflammation.
Diarrhoea might be a side-effect of Doloforce Injection 4 x 2 ml. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Do not use Doloforce Injection 4 x 2 ml immediately before or after bypass surgery. Doloforce Injection 4 x 2 ml may increase the risk of heart attack or stroke. Therefore, inform your doctor if you have heart problems.
Doloforce Injection 4 x 2 ml may be used to treat musculoskeletal pain. Musculoskeletal pain refers to the pain in the bones, muscles, ligaments, and tendon.
It is generally not recommended if you have active or recurrent stomach ulcers, as it can increase the risk of severe stomach bleeding. Talk to your doctor to find a safer alternative.
Some people may feel dizzy, drowsy, or experience blurred vision after receiving this injection. If you experience these side effects, avoid driving or operating machinery and talk to your doctor.
This medicine is generally not recommended during pregnancy, especially during the last three months, as it may harm the unborn baby or cause complications during delivery. Talk to your doctor.
This medicine is given as an injection deep into a large muscle, usually by a doctor, nurse, or trained healthcare professional. Talk to your doctor if you have questions about how it is administered.
No, you should avoid taking other nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or aspirin while receiving this medication, as doing so increases your risk of severe stomach irritation and bleeding. Talk to your doctor or pharmacist.
Prolonged use of this class of medication can affect kidney function, especially in people who are dehydrated or already have kidney issues. Ensure you drink plenty of fluids and talk to your doctor.
Mild pain or redness at the injection site is common and usually goes away on its own. However, if the pain worsens, or if you notice severe swelling, warmth, or pus, talk to your doctor immediately.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase III, New Delhi - 110020.
Other Info - DOL0094
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