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compositionComposition:TRAMADOL-50MG
prescription
Prescription Medicine
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DOMADOL TABLET is used to prevent and treat moderate to severe pain. It contains Tramadol, which works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby inhibits the transmission of pain signals from nerves to the brain. Also, it improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. In some cases, you may experience side effects such as nausea, dizziness, headache, vomiting, dry mouth, drowsiness, constipation, sweating or tiredness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions. Avoid frequent or high doses as it may lead to addiction.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRAMADOL-50MG

Manufacturer/Marketer :

Unichem International

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About DOMADOL TABLET

DOMADOL TABLET is used to prevent and treat moderate to severe pain. Pain is an unpleasant sensation caused by an injury or illness. Pain may be acute (short term) or chronic (long term). It can be general (overall body pains) or localized (pain in a specific area of the body).

DOMADOL TABLET contains Tramadol, which works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby inhibits the transmission of pain signals from nerves to the brain. Also, DOMADOL TABLET improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain.

Take DOMADOL TABLET as prescribed. Your doctor will advise you how often you take DOMADOL TABLET based on your medical condition. In some cases, you may experience nausea, dizziness, headache, vomiting, dry mouth, drowsiness, constipation, sweating or tiredness. Most of these side effects of DOMADOL TABLET do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are known to be allergic to DOMADOL TABLET or any other medicines, please tell your doctor. DOMADOL TABLET is not recommended for children below 12 years of age. If you are pregnant or breastfeeding or have a history of fits, please inform your doctor before taking DOMADOL TABLET. Do not consume alcohol with DOMADOL TABLET as it may increase the risk of side effects. Avoid frequent or high doses as it may lead to addiction.

Uses of DOMADOL TABLET

DOMADOL TABLET is used to treat moderate to severe pain. The detailed uses of DOMADOL TABLET are as follows:

  • Pain Relief in Acute Pain Conditions: DOMADOL TABLET is primarily utilized to alleviate moderate to severe pain by enhancing combined pain relief in conditions such as injury pain, headaches, dental operations, and postoperative pain.
  • Chronic Pain Management: DOMADOL TABLET promotes pain treatment to people suffering from chronic illnesses such as osteoarthritis or lower back pain.
  • Postoperative Recovery Support: DOMADOL TABLET can be suggested to post-surgery patients to help them control their pain and recover more comfortably.
  • Adjunct Therapy for Fibromyalgia: It may also be utilized to manage fibromyalgia pain under a doctor's supervision.

Key Benefits

DOMADOL TABLET is a pain killer that works by mimicking the action of endorphins (pain-reducing chemicals) in the brain, thereby, inhibiting the transmission of pain signals from nerves to the brain. Thus, DOMADOL TABLET improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. DOMADOL TABLET is used to relieve pain after surgery, pain caused by an injury or illness.

Side effects of Domadol Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • DOMADOL TABLET can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow DOMADOL TABLET as a whole with a glass of water.
  • Do not chew, crush or break it.

How DOMADOL TABLET Works

DOMADOL TABLET contains Tramadol, which works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby inhibits the transmission of pain signals from nerves to the brain. Also, DOMADOL TABLET improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain.
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Alcohol

Unsafe

Avoid consumption of alcohol with DOMADOL TABLET as it may cause drowsiness or increase the risk of side effects.

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Pregnancy

Unsafe

DOMADOL TABLET is a Category C pregnancy drug and is considered unsafe for pregnant women as it may cause withdrawal symptoms in baby after birth.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking DOMADOL TABLET as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

DOMADOL TABLET may cause dizziness, blurred vision or drowsiness in some people. It is an offence to drive if DOMADOL TABLET affects you. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking DOMADOL TABLET.

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Liver

Caution

Take DOMADOL TABLET with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. However, the recommended dose of DOMADOL TABLET for adult patients with liver cirrhosis is 50 mg every 12 hours.

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Kidney

Caution

Take DOMADOL TABLET with caution, especially if you have a history of Kidney diseases/conditions. In patients with creatinine clearances of less than 30 mL/min, dosing reduction might be recommended.

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Children

Unsafe

DOMADOL TABLET is not recommended for children below 12 years of age.

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Heart

Consult your doctor

Please consult your doctor before using DOMADOL TABLET if you have pre-existing heart problems. Your doctor will prescribe DOMADOL TABLET if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before giving DOMADOL TABLET to geriatric patients. The doctor will prescribe DOMADOL TABLET if the benefits outweigh the risks.

What if I have taken an overdose of DOMADOL TABLET

Do not take more than the prescribed dose of DOMADOL TABLET as it may cause overdose. The symptoms of overdose include extreme sleepiness or drowsiness, difficulty breathing, slow or shallow breathing, decreased size of the pupil, slow heartbeat, muscle weakness and unable to respond or wake up. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Do regular exercise such as swimming or walking.
  • Drink plenty of water while taking DOMADOL TABLET to avoid dry mouth.
  • Maintain a fibre rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while taking DOMADOL TABLET.
  • Avoid consumption of alcohol and quit smoking.

Health Queries

I have been taking Tramadol 100 mg for back pain for the past 15 days. How long should I continue taking this medication, and what is the safest way to taper off and withdraw from it?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

For back pain, tramadol is typically prescribed for the shortest duration possible, usually not exceeding a few weeks. Since you have been taking it for 15 days, it is an ideal time to discuss stopping with your doctor. To prevent mild discontinuation symptoms like restlessness or sweating, you should avoid stopping abruptly. The safest approach is a gradual taper. Under your doctor's guidance, this might involve reducing your daily dose (for example, to 50 mg) for a few days before stopping completely. Always consult your prescribing physician to design a personalized and comfortable tapering plan.

I have successfully reduced my daily Tramadol dosage from 300 mg to 75 mg after using it to recover from opium addiction; how can I safely taper off and completely quit taking Tramadol?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Congratulations on successfully reducing your dosage to 75 mg; this is a significant achievement. To safely taper off completely, you should consult your supervising doctor to design a personalized schedule. Typically, a gradual reduction is best such as decreasing your daily dose by 12.5 mg to 25 mg every one to two weeks, depending on your comfort level. Because tramadol affects both opioid receptors and serotonin levels, a slow taper helps minimize mild withdrawal symptoms like anxiety or insomnia. Avoid stopping suddenly. Keep in close contact with your healthcare provider for guidance and support during this final step.
health query

Have a query?

How Soon It Starts Working

The time required for DOMADOL TABLET to start to work: The time required for DOMADOL TABLET to start to work is 1 to 2 hours after administration. The time for which the effects of DOMADOL TABLET last: The effect of DOMADOL TABLET lasts for 6 to 7 hours.

What if you forget to take DOMADOL TABLET

If you miss a dose of DOMADOL TABLET, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not stop taking DOMADOL TABLET suddenly as it may cause withdrawal symptoms. Avoid frequent or high doses as it may lead to addiction. If you are known to be allergic to DOMADOL TABLET or any other medicines, please tell your doctor. DOMADOL TABLET is not recommended for children below 12 years of age and for children suffering from breathing problems as it may worsen the symptoms of DOMADOL TABLET toxicity. If you are pregnant or breastfeeding or have a history of epilepsy (fits), please inform your doctor before taking DOMADOL TABLET. Do not consume alcohol with DOMADOL TABLET as it may increase the risk of side effects. DOMADOL TABLET should be taken with caution by the patients taking sleeping pills, tranquillizers, hypnotics or other opiate containing pain killers.

Drug-Drug Interactions

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Drug-Drug Interaction: DOMADOL TABLET may have interaction with pain killers (pentazocine, buprenorphine, nalbuphine), blood thinners (warfarin), anti-anxiety drugs (alprazolam), fits related medicines (carbamazepine), medicines used to prevent nausea (ondansetron), antifungal drugs (ketoconazole), antibiotic (ciprofloxacin, erythromycin), anticancer drugs (ceritinib, lapatinib), immunosuppressants (fingolimod), antidepressants (fluoxetine, doxepin), antipsychotics (droperidol), and HIV/AIDS drugs (saquinavir).

Drug-Food Interaction: DOMADOL TABLET may interact with grapefruit juice. Therefore, avoid intake of grapefruit juice with DOMADOL TABLET as it may increase DOMADOL TABLET levels in the body. Also, avoid alcohol consumption while taking DOMADOL TABLET as it may increase the risk of adverse effects such as drowsiness, dizziness and difficulty in concentrating.

Drug-Disease Interaction: People with severe kidney or liver problems, fits and breathing problems should consult a doctor before taking DOMADOL TABLET.

 

TramadolLinezolid
Critical
TramadolRasagiline
Critical

Drug-Drug Interactions

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TramadolLinezolid
Critical
How does the drug interact with Domadol Tablet:
Co-administration of Linezolid with Domadol Tablet can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Linezolid with Domadol Tablet is not recommended, consult a doctor before taking it. Consult a doctor if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not stop using any medications without talking to a doctor.
TramadolRasagiline
Critical
How does the drug interact with Domadol Tablet:
Taking rasagiline with Domadol Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Domadol Tablet with Rasagiline is not recommended, as it can lead to an interaction, but can be taken if advised by your doctor. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TramadolTranylcypromine
Critical
How does the drug interact with Domadol Tablet:
Combining Tranylcypromine with Domadol Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Domadol Tablet is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
TramadolPhenelzine
Critical
How does the drug interact with Domadol Tablet:
Combining Phenelzine with Domadol Tablet can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Domadol Tablet with Phenelzine is not recommended, please consult your doctor before taking it.
TramadolAlvimopan
Critical
How does the drug interact with Domadol Tablet:
Co-administration of Domadol Tablet with Alvimopan can make the side effects worse or more dangerous.

How to manage the interaction:
Taking Alvimopan with Domadol Tablet is not recommended, please consult your doctor before taking it.
TramadolZiprasidone
Critical
How does the drug interact with Domadol Tablet:
Co-administration of Ziprasidone with Domadol Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Domadol Tablet with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TramadolSafinamide
Critical
How does the drug interact with Domadol Tablet:
Taking Safinamide with Domadol Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Domadol Tablet is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
TramadolCitalopram
Severe
How does the drug interact with Domadol Tablet:
Co-administration of citalopram with Domadol Tablet may increase the risk and severity of the seizure.

How to manage the interaction:
Taking citalopram with Domadol Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TramadolRisperidone
Severe
How does the drug interact with Domadol Tablet:
Co-administration of risperidone with Domadol Tablet can increase the risk of irregular heart rhythms.

How to manage the interaction:
Although there is a possible interaction between Domadol Tablet and Risperidone, you can take these medicines together if prescribed by your doctor. However, if you notice any symptoms like feeling tired, dizzy, or having trouble focusing, make sure to contact a doctor. Do not stop using any medications without a doctor's advice.
TramadolOxamniquine
Severe
How does the drug interact with Domadol Tablet:
Co-administration of Domadol Tablet with oxamniquine can increase the effect of Domadol Tablet.

How to manage the interaction:
There may be a possibility of interaction between Oxamniquine and Domadol Tablet, but it can be taken if prescribed by a doctor. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[NARCOTIC (OPIOID) ANALGESIC]

FAQs

DOMADOL TABLET belongs to a class of drugs called opioid analgesics (pain killers). DOMADOL TABLET is primarily used to prevent and treat moderate to severe pain.
Yes, DOMADOL TABLET may cause withdrawal symptoms such as irritability, anxiety, restlessness, difficulty in sleeping, palpitations (feeling your heartbeat), feeling sick, shivering, sweating, high blood pressure and shaking when you stop taking DOMADOL TABLET suddenly. Therefore, if you experience any difficulty while taking DOMADOL TABLET, do not stop taking suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.
No, DOMADOL TABLET is not recommended for use during pregnancy as baby may develop dependence on DOMADOL TABLET and lead to withdrawal symptoms after birth. Therefore, if you are pregnant or planning for pregnancy, please inform your doctor before taking DOMADOL TABLET.
Yes, DOMADOL TABLET may cause dry mouth as a common side effect. It is not necessary for everyone taking DOMADOL TABLET to experience this side effect. However, drink plenty of water, suck on sugar candy or chew sugar free gum to prevent such side effects while taking DOMADOL TABLET. If the condition worsens or persist, please consult a doctor.
Yes, DOMADOL TABLET may cause fits especially when taken in high doses or if you have a history of fits. Therefore, it is recommended to inform your doctor if you ever had fits as it may increase the chance of getting fits and take DOMADOL TABLET only in doses as prescribed by a doctor.
No, you are not recommended to take DOMADOL TABLET with antidepressants (medicines used to treat depression) and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with DOMADOL TABLET may increase the risk of fits. However, please consult a doctor before taking DOMADOL TABLET with other medicines.
Yes, DOMADOL TABLET may cause addiction especially if taken for prolonged time. Therefore, DOMADOL TABLET should be given only for a short duration under strict medical supervision particularly to patients who are susceptible to drug abuse. Take DOMADOL TABLET only as advised by a doctor as overuse or misuse of DOMADOL TABLET can lead to overdose or death.
DOMADOL TABLET contains Tramadol as its active ingredient.
Do not consume alcohol while taking DOMADOL TABLET. Inform your doctor if you are allergic to DOMADOL TABLET, if you have kidney or liver disease, epilepsy, asthma, recent head injuries or if you are taking other medications. And also let your doctor know if you are breastfeeding, pregnancy or planning to pregnancy to avoid possible interactions.
The common side effects of DOMADOL TABLET are nausea, dizziness, headache, vomiting, dry mouth, drowsiness, constipation, sweating or tiredness. If any of these side effects persist or worsen, please consult your doctor.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.6116 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.4648 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.1625 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. U.S. Food and Drug Administration (FDA). 021692S015Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  5. Drugs.com Clinical Review Team. Tramadol Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  6. National Health Service (NHS). Tramadol - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  7. ScienceDirect ScienceDirect. [Accessed on 02 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Unichem Laboratories Ltd., Unichem Bhavan, Prabhat Estate, Off S.V.Road, Jogeshwari (West), Mumbai – 400 102
Other Info - DOM0049

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