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  1. Home
  2. Medicine

  3. Domisave R 20 mg/30 mg Capsule 10's

Prescription drug
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Domisave R 20 mg/30 mg Capsule 10's, Pack of 10
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Extra 15% Off with Bank Offers

Composition :

DOMPERIDONE-30MG + RABEPRAZOLE-20MG

Manufacturer/Marketer :

Cresha Lifesciences

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Domisave R 20 mg/30 mg Capsule

Domisave R 20 mg/30 mg Capsule belongs to the class of drugs known as Proton pump inhibitors, which reduce the amount of acid your stomach produces. It treats gastroesophageal reflux disease (GERD), stomach ulcers, Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour), duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.

Domisave R 20 mg/30 mg Capsule helps reduce stomach acid by blocking the action of an enzyme (H+/K+ ATPase, also known as the gastric proton pump), thus preventing the release of stomach acid and relieving symptoms of food pipe lining inflammation (esophagitis), gastroesophageal reflux disease (GERD), or heartburn.

Not everyone who is taking Domisave R 20 mg/30 mg Capsule will get these side effects. Domisave R 20 mg/30 mg Capsule may have common side effects, such as headache, diarrhoea, nausea, abdominal pain, vomiting, dizziness, and joint pain. These side effects are temporary and may resolve on their own over time. However, if these side effects persist, don't hesitate to contact your doctor.

Take Domisave R 20 mg/30 mg Capsule as advised. Your physician will decide the dosage based on your medical condition. You should take Domisave R 20 mg/30 mg Capsule 30 minutes before food. It is recommended not to exceed the recommended dose of Domisave R 20 mg/30 mg Capsule . Do not chew, crush, or break the medicine.

Inform your physician if you are allergic to Domisave R 20 mg/30 mg Capsule . Tell your doctor if you have stomach or intestinal cancer, liver problems, are allergic to Domisave R 20 mg/30 mg Capsule  or will have an endoscopy in the future. Prolonged intake of Domisave R 20 mg/30 mg Capsule may cause a deficiency of Vitamin B12 and low levels of calcium, magnesium and Vitamin D, leading to osteoporosis. Domisave R 20 mg/30 mg Capsule is not recommended for children below 5 years of age. Consult the doctor if you are pregnant or breastfeeding.

Uses of Domisave R 20 mg/30 mg Capsule

Domisave R 20 mg/30 mg Capsule is used in the treatment of acid reflux symptoms caused by peptic ulcer, Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour) and gastroesophageal reflux disease (GERD). The detailed uses of Domisave R 20 mg/30 mg Capsule are as follows:

  • Support Digestive Health: Domisave R 20 mg/30 mg Capsule helps alleviate digestive discomfort, promoting a balanced and regular digestive system.
  • Reduce Gastrointestinal Disorders: Domisave R 20 mg/30 mg Capsule provides relief from various gastrointestinal issues, such as gas, bloating, and irregular bowel movements.
  • Relieve Indigestion: Domisave R 20 mg/30 mg Capsule offers quick relief from indigestion and related symptoms, soothing the stomach and enhancing overall comfort.

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Directions for Use

  • Take Domisave R 20 mg/30 mg Capsule one hour before a meal or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Domisave R 20 mg/30 mg Capsule as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Domisave R 20 mg/30 mg Capsule is effective in healing erosive esophagitis (inflammation of the food pipe), heartburn, Zollinger-Ellison syndrome, duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.
  • Domisave R 20 mg/30 mg Capsule works by irreversibly blocking the proton pump gate, which secretes stomach acid. It can be prescribed to all age groups, including special populations like the elderly, pregnant, lactating mothers, and patients with kidney and liver disease.
  • Domisave R 20 mg/30 mg Capsule helps manage acidity-related conditions, promotes digestion, and provides relief from associated discomfort.

How Domisave R 20 mg/30 mg Capsule Works

Domisave R 20 mg/30 mg Capsule contains two medicines, namely Rabeprazole and Domperidone. Rabeprazole helps reduce stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This gastric proton pump lies in the cells of the stomach wall. It is responsible for releasing gastric acid secretion and damaging tissues in the food pipe, stomach, and duodenum (uppermost part of the small intestine). On the other hand, Domperidone increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Domisave R 20 mg/30 mg Capsule
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

What if I have taken an overdose of Domisave R 20 mg/30 mg Capsule

Do not take more than the prescribed dose of Domisave R 20 mg/30 mg Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Avoid taking Domisave R 20 mg/30 mg Capsule if you are allergic to Domisave R 20 mg/30 mg Capsule or have any history of gastric cancer, liver disease, low magnesium levels, or low vitamin B1.
  • Prolonged intake of Domisave R 20 mg/30 mg Capsule may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), vitamin B12, and magnesium deficiency.
  • Domisave R 20 mg/30 mg Capsule may interact with blood thinners, antifungals, anti-HIV drugs, iron supplements, and anti-cancer medications. Please inform your doctor if you are taking any of these medications.
  • Intake of Domisave R 20 mg/30 mg Capsule may mask the symptoms of gastric cancer, so if you have any severe stomach pain or blood in stool, immediately consult the doctor.
  • It is advised to stop consuming alcohol and smoking, as it can cause serious side effects. This medicine is not recommended for use in children below 16 years of age.
  • Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes).
  • Although Domisave R 20 mg/30 mg Capsule is safe for use during pregnancy or breastfeeding, inform your doctor if you are pregnant or breastfeeding before starting treatment with Domisave R 20 mg/30 mg Capsule . Let your doctor know if you are taking any other medicines, including supplements and herbal products, to prevent any interactions.
  • Store Domisave R 20 mg/30 mg Capsule at room temperature. Keep the medicine out of reach of children. Do not take more than the recommended dose of medicine, as it can cause undesirable effects.
  • It is always important to check the expiry date of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

verifiedApollotooltip
EsomeprazoleRilpivirine
Critical
EsomeprazoleTacrolimus
Severe

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Domisave R 20 mg/30 mg Capsule may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Domisave R 20 mg/30 mg Capsule with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.
EsomeprazoleTacrolimus
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Taking tacrolimus with Domisave R 20 mg/30 mg Capsule may significantly increase the blood levels of tacrolimus, which can lead to an increased risk of side effects.

How to manage the interaction:
Although taking Domisave R 20 mg/30 mg Capsule with Tacrolimus can result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience irregular heartbeat, blurring of vision, fever, chills, or muscle spasms. Do not discontinue any medications without consulting a doctor.
EsomeprazoleAcalabrutinib
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Domisave R 20 mg/30 mg Capsule may interfere with the absorption of Acalabrutinib and reduce their efficacy.

How to manage the interaction:
Taking Domisave R 20 mg/30 mg Capsule with Acalabrutinib together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazoleMethotrexate
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Co-administration of methotrexate and Domisave R 20 mg/30 mg Capsule can increase the blood levels and side effects of methotrexate.

How to manage the interaction:
Although taking Domisave R 20 mg/30 mg Capsule with Methotrexate can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
EsomeprazoleGefitinib
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Taking gefitinib with Domisave R 20 mg/30 mg Capsule may reduce the effectiveness of gefitinib.

How to manage the interaction:
Although taking Domisave R 20 mg/30 mg Capsule and Gefitinib together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Gefitionib 12 hours before or after taking Domisave R 20 mg/30 mg Capsule. Do not stop taking any medications without consulting a doctor.
EsomeprazoleClopidogrel
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Coadministration of Clopidogrel with Domisave R 20 mg/30 mg Capsule may reduce the effectiveness of clopidogrel.

How to manage the interaction:
Taking clopidogrel and Domisave R 20 mg/30 mg Capsule together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazoleDacomitinib
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Domisave R 20 mg/30 mg Capsule can make Dacomitinib less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Domisave R 20 mg/30 mg Capsule with Dacomitinib can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazoleErlotinib
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Coadministration of erlotinib and Domisave R 20 mg/30 mg Capsule can reduce effects of erlotinib.

How to manage the interaction:
Taking Erlotinib and Domisave R 20 mg/30 mg Capsule together is generally avoided as it can possibly result in an interaction. It can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
EsomeprazoleNelfinavir
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Taking nelfinavir with Domisave R 20 mg/30 mg Capsule may decrease the effects of nelfinavir.

How to manage the interaction:
Although taking Domisave R 20 mg/30 mg Capsule and Nelfinavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.
EsomeprazoleDasatinib
Severe
How does the drug interact with Domisave R 20 mg/30 mg Capsule:
Using Dasatinib together with Domisave R 20 mg/30 mg Capsule may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Domisave R 20 mg/30 mg Capsule together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
  • Avoid taking alcohol and smoking cigarette. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.
  • Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a break of 5 minutes in 1 hour by brisk walking or stretching.
  • Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
  • Include high fibre containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine.
  • Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess stomach acid production. Cranberry juice can be beneficial in the peptic ulcer and H Pylori infection.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Domisave R 20 mg/30 mg Capsule Substitute

Substitutes safety advice
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Alcohol

Unsafe

Drinking alcohol with Domisave R 20 mg/30 mg Capsule may cause dehydration and elevate the level of stomach acid, thereby decreasing its efficiency. So try to avoid, limit alcohol or contact a doctor before intake of Domisave R 20 mg/30 mg Capsule .

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Pregnancy

Consult your doctor

It is not known whether the Domisave R 20 mg/30 mg Capsule affects the baby or not. So, contact a doctor before intake of Domisave R 20 mg/30 mg Capsule . Your doctor will weigh the benefits and potential risks before prescribing them.

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Breast Feeding

Consult your doctor

Domperidone present in Domisave R 20 mg/30 mg Capsule passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of Domisave R 20 mg/30 mg Capsule . Your doctor will weigh the benefits and potential risks before prescribing them.

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Driving

Caution

In some cases, Domisave R 20 mg/30 mg Capsule may cause dizziness, sleepy, or blur vision. If you observe these symptoms do not drive or operate heavy machinery until you feel better.

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Liver

Consult your doctor

If u have or had history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Consult your doctor

If u have or had history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

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Children

Unsafe

Domisave R 20 mg/30 mg Capsule is not recommended for use in children due to a lack of data on safety and efficacy. Please consult your doctor.

FAQs

Domisave R 20 mg/30 mg Capsule is used to treat Gastro-Esophagal Reflux Disease (GERD), acid reflux, heartburn, peptic ulcer, stomach ulcers, and dyspepsia (stomach discomfort due to indigestion). It works by blocking the actions of the gastric proton pump, increasing the motility of the upper gastrointestinal tract and blocking the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).

No. Domisave R 20 mg/30 mg Capsule prevents excess production of stomach acid causing acid reflux and heartburn. If blood is coming in your stool or mucous immediately contact the doctor.

Yes, Domisave R 20 mg/30 mg Capsule can cause dry mouth and it is due to domperidone. In case you fell excessive thirsty, please increase your fluid intake and do frequent mouth rinses.

Diarrhoea might be a side-effect of Domisave R 20 mg/30 mg Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or any other discomfort.

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting on a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Domisave R 20 mg/30 mg Capsule is contraindicated in patients with a known hypersensitivity to domperidone or rabeprazole or any other inactive ingredients of Domisave R 20 mg/30 mg Capsule . Domisave R 20 mg/30 mg Capsule should be used with caution in patients with underlying liver or kidney disease.

Store Domisave R 20 mg/30 mg Capsule at room temperature in a cool and dry place protected from light. Keep it out of reach of children.

Yes, Domisave R 20 mg/30 mg Capsule is safe for most of the patients. However, in some patients it may cause common side effects such as stomach pain, diarrhea, flatulence (gas), dryness in mouth, headache, dizziness, and other uncommon and rare side effects. If these side effects persist or worsen, please consult your doctor.

It is preferable to take Domisave R 20 mg/30 mg Capsule on an empty stomach or before the first meal of the day.

Yes, Domisave R 20 mg/30 mg Capsule may increase the risk of developing irregular heartbeat (serious arrhythmias). Although, it is a serious side effect, it is extremely unlikely to occur. Patients aged above 60 years are at higher risk.

Country of origin

India

Manufacturer/Marketer address

No 498,Nirman Layout, Bagur-Koppa Road, Jigani Hubli, Anekal Taluk, Bangalore-562106
Other Info - DOM0219

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 3, 2025 | 8:11 AM IST

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Reference

  1. https://www.ciplamed.com/content/rabicip-d-capsules

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