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  3. Domstal NP-500 mg Tablet 10's

Prescription drug
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Domstal NP-500 mg Tablet 10's, Pack of 10 TABLETS
Domstal NP-500 mg Tablet 10's, Pack of 10 TABLETS
Domstal NP-500 mg Tablet 10's, Pack of 10 TABLETS
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Composition :

DOMPERIDONE-10MG + NAPROXEN-500MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Domstal NP-500 mg Tablet

Domstal NP-500 mg Tablet is used to treat migraine headaches. Migraine is a condition characterised by intense headaches. Pain is a symptom that occurs due to various underlying conditions.

Domstal NP-500 mg Tablet is a combination of two drugs: Naproxen and Domperidone. Naproxen blocks COX enzymes that produce chemicals causing pain and swelling. Domperidone stops nausea and vomiting by blocking signals in the brain that cause vomiting.

Take Domstal NP-500 mg Tablet as prescribed by your doctor. Common side effects of Domstal NP-500 mg Tablet are dry mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems, and headache. Consult your doctor if you feel any discomfort.

If you are known to be allergic to any of the components in Domstal NP-500 mg Tablet , please inform your doctor. Consult your doctor before taking Domstal NP-500 mg Tablet if you are pregnant or breastfeeding. Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to painkillers.

Uses of Domstal NP-500 mg Tablet

Domstal NP-500 mg Tablet is used in the treatment of migraine headache, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). The detailed uses of Domstal NP-500 mg Tablet are as follows:

  • Effective Pain Relief: Domstal NP-500 mg Tablet is commonly prescribed to alleviate moderate to severe pain, including headaches, dental pain, menstrual cramps, and postoperative discomfort. It works by blocking the production of chemicals responsible for inflammation and pain.
  • Powerful Anti-inflammatory Action: Domstal NP-500 mg Tablet helps reduce inflammation associated with conditions like rheumatoid arthritis, providing relief from joint pain and swelling.
  • Relief for Muscle Pain: Whether caused by exercise, strains, or injuries, Domstal NP-500 mg Tablet can help alleviate muscle pain, improving comfort and mobility.
  • Nausea and vomiting: It also controls nausea and vomiting associated with migraine headaches.

Have a query?

Directions for Use

  • Domstal NP-500 mg Tablet can be taken with meals to avoid stomach ulcers and irritation.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow the whole tablet with a glass of water.
  • Do not crush, chew or break it.

Medicinal Benefits

  • Domstal NP-500 mg Tablet is a combination of naproxen and domperidone used to treat migraine headaches.
  • Naproxen is an anti-inflammatory (reduces inflammation) and analgesic (reduces pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation.
  • Domperidone acts by enhancing gastric peristalsis (movements) to empty the stomach. It blocks the dopamine receptors present in the chemoreceptor trigger zone, which is responsible for regulating nausea and vomiting.
  • Domstal NP-500 mg Tablet can also be used to reduce pain associated with rheumatoid arthritis, gout, and dysmenorrhea (menstrual pain).
  • Domstal NP-500 mg Tablet also controls nausea and vomiting associated with migraine.

How Domstal NP-500 mg Tablet Works

Domstal NP-500 mg Tablet is a combination of two drugs: Naproxen and Domperidone. Naproxen works by inhibiting the cyclooxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins that induce pain and swelling. Domperidone is an antiemetic that blocks specific receptors, such as dopamine and serotonin receptors, that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Domstal NP-500 mg Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

What if I have taken an overdose of Domstal NP-500 mg Tablet

Do not take more than the prescribed dose of Domstal NP-500 mg Tablet as it may cause serious side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are taking any of the anticoagulants (warfarin), other NSAIDS (ibuprofen, ketorolac), corticosteroids (prednisolone), antidepressants (citalopram, fluoxetine, paroxetine, duloxetine, venlafaxine), or any other dietary or herbal supplements.
  • Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDS) (other than aspirin), such as naproxen, may increase the risk of heart attack or stroke and stomach ulcers.
  • The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, are older in age, are an alcoholic or have multiple diseases.
  • The risk of having a heart attack increases if you smoke or if you or your family has a history of heart failure, stroke, or hypertension.
  • Call for medical help immediately if you experience chest pain, shortness of breath, blood in the stool or dark stools, heartburn, or any other abnormal signs.
  • Patients above 65 years of age, with pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases or bleeding disorders should use Domstal NP-500 mg Tablet only when prescribed by a doctor.

Drug-Drug Interactions

verifiedApollotooltip
DomperidoneMethadone
Severe
DomperidoneToremifene
Severe

Drug-Drug Interactions

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DomperidoneMethadone
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Coadministration of Domstal NP-500 mg Tablet with Methadone can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domstal NP-500 mg Tablet and Methadone together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneToremifene
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Coadministration of Domstal NP-500 mg Tablet with Toremifene can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domstal NP-500 mg Tablet and Toremifene together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneMizolastine
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Combining Mizolastine with Domstal NP-500 mg Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although taking Domstal NP-500 mg Tablet and Mizolastine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DomperidoneCitalopram
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Coadministration of Domstal NP-500 mg Tablet with Citalopram can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domstal NP-500 mg Tablet and Citalopram together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneBepridil
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Co-administration of Domeperidone and Bepridil can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domstal NP-500 mg Tablet and Bepridil together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneNefazodone
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Coadministration of Domstal NP-500 mg Tablet with Nefazodone can increase the blood levels of Domstal NP-500 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Domstal NP-500 mg Tablet and Nefazodone, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneRitonavir
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Coadministration of Domstal NP-500 mg Tablet with Ritonavir can increase the blood levels of Domstal NP-500 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Domstal NP-500 mg Tablet and Ritonavir, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneHalofantrine
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Coadministration of Domstal NP-500 mg Tablet with Halofantrine can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domstal NP-500 mg Tablet and Halofantrine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneClarithromycin
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Coadministration of Domstal NP-500 mg Tablet with Clarithromycin can increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Domstal NP-500 mg Tablet and Clarithromycin, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
DomperidoneKetoconazole
Severe
How does the drug interact with Domstal NP-500 mg Tablet:
Coadministration of Domstal NP-500 mg Tablet with Ketoconazole can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domstal NP-500 mg Tablet and Ketoconazole together can cause an interaction, it can be taken if a doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Drink plenty of fluids to avoid gastrointestinal problems.
  • Avoid triggers that can increase your migraine headaches.
  • Take enough rest.
  • Acupuncture, massage and physical therapy may also be helpful.
  • De-stress yourself by meditating, reading a book, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Practising yoga may also help improve joint flexibility and manage pain.
  • Get adequate sleep, as rest can help reduce inflammation and swelling.
  • Taking meals at the same time every day and getting sufficient sleep may help prevent migraine attacks.
  • You are recommended to avoid loud music, noisy places, extreme temperatures and bright light.
  • Avoid consumption of chocolates, cheese, processed food, smoking and alcohol.

Habit Forming

No

Therapeutic Class

ANALGESICS

Domstal NP-500 mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

It is advised not to take alcohol as Domstal NP-500 mg Tablet can cause dizziness or drowsiness.

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Pregnancy

Consult your doctor

Domstal NP-500 mg Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Domstal NP-500 mg Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Domstal NP-500 mg Tablet can cause dizziness or drowsiness. Drive only if you are alert.

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Liver

Consult your doctor

Limited information was available for the use of Domstal NP-500 mg Tablet in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Domstal NP-500 mg Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Limited information was available regarding the use of Domstal NP-500 mg Tablet in patients with kidney impairment. Please consult your doctor if you have any concerns regarding using Domstal NP-500 mg Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Domstal NP-500 mg Tablet should be used in children below 12 years of age only when prescribed by a child specialist.

FAQs

Domstal NP-500 mg Tablet is used to treat migraine headaches, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). It also controls nausea and vomiting associated with migraines.

Domstal NP-500 mg Tablet contains Naproxen and Domperidone. Naproxen works by inhibiting the cyclooxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins that induce pain and swelling. Domperidone is an antiemetic that blocks specific receptors, such as dopamine and serotonin receptors, that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).

Domstal NP-500 mg Tablet cannot permanently cure migraine. It can provide relief from pain and headache.

Domstal NP-500 mg Tablet on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be used only for a duration as prescribed by the doctor.

Arthritis is a chronic condition affecting the joints, characterised by pain and inflammation. Domstal NP-500 mg Tablet does not cure arthritis, but it relieves symptoms of arthritis-like joint pain, swelling, and stiffness.

Yes, Domstal NP-500 mg Tablet may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the Domstal NP-500 mg Tablet .

Dry mouth may be caused by Domperidone in Domstal NP-500 mg Tablet . Chew a sugar-free sweet or sugar-free gum.

Yes, Domstal NP-500 mg Tablet is a painkiller. It contains Naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain and inflammation, while Domperidone helps manage nausea, which is common in migraines. Additionally, it can also be used to alleviate pain associated with gout, rheumatoid arthritis, and dysmenorrhea (menstrual pain).

Domstal NP-500 mg Tablet usually starts working within 30-60 minutes after oral intake. However, the exact time may vary depending on the individual's response and medical condition. Always consult your doctor for personalised guidance and proper usage.

To ensure safe and effective treatment, it's helpful to know that Domstal NP-500 mg Tablet may have a potential impact on blood pressure, but with proper monitoring, you can minimise risks. By working closely with your healthcare provider, you can enjoy the benefits of Domstal NP-500 mg Tablet while maintaining healthy blood pressure. Open communication with your doctor is key to a successful treatment plan.

Domstal NP-500 mg Tablet is a combination medication that pairs a nonsteroidal anti-inflammatory drug (NSAID) with an antiemetic and prokinetic agent. This combination helps alleviate pain and reduce nausea, thereby improving overall comfort.

The side effects of Domstal NP-500 mg Tablet include dry mouth, constipation, abdominal pain, drowsiness, dizziness, visual disturbances, hearing problems, and headache. Most of these side effects do not require medical attention and typically resolve on their own over time. However, please consult your doctor if any symptoms persist or worsen.

You should consult your doctor before stopping Domstal NP-500 mg Tablet , even if your migraine is relieved. It is generally used as needed for migraine attacks, but stopping suddenly without medical advice may not be ideal. Follow the dosage instructions provided by your doctor and complete the entire treatment course to effectively treat your medical condition.

Yes, Domstal NP-500 mg Tablet may cause diarrhoea, a common side effect. If you experience this symptom, drink plenty of water to stay hydrated, take probiotics, avoid spicy, fatty, or dairy foods, and limit caffeine intake to manage diarrhoea.

To ensure a safe and effective treatment experience with Domstal NP-500 mg Tablet , it's essential to be aware of certain contraindications. By knowing these guidelines, you can minimise risks and maximise benefits. Domstal NP-500 mg Tablet is not recommended for individuals with NSAID hypersensitivity, NSAID-induced asthma, or severe allergic reactions, as well as during pregnancy, especially after 30 weeks, and in cases of severe liver impairment, heart conditions, or significant electrolyte disturbances. Additionally, caution is advised for patients with gastrointestinal bleeding, obstruction, or prolactin-releasing pituitary tumours and when taking QT-prolonging drugs or potent CYP3A4 inhibitors. By working closely with your healthcare provider, you can navigate these guidelines and enjoy a successful treatment outcome.

Yes, prolonged or frequent use of Domstal NP-500 mg Tablet may cause kidney damage as it contains Naproxen, an NSAID, which can affect kidney function, especially with long-term use. Therefore, it should only be used as a doctor prescribes to minimize the risk.

No, you should not take a higher than the recommended dose of Domstal NP-500 mg Tablet , as it may cause serious side effects like irregular heartbeat, drowsiness, extreme tiredness, nausea, stomach pain, and breathing difficulties. If you accidentally take more than the prescribed dose, seek immediate medical attention.

Domstal NP-500 mg Tablet should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India.
Other Info - DOM0225

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Author Details

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Sep 24, 2025 | 7:39 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a681029.html
  2. https://www.drugs.com/uk/domperidone-10mg-film-coated-tablets-leaflet.html
  3. https://www.nhs.uk/medicines/naproxen/
  4. https://www.nhs.uk/medicines/domperidone/

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