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compositionComposition:DORIPENEM-500MG
prescription
Prescription Medicine
info
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DORIPIK 500MG INJECTION is used to treat bacterial infections, such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis). It contains doripenem, an antibacterial drug that works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, it treats bacterial infections.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DORIPENEM-500MG

Manufacturer/Marketer :

Bion Mj Health Care Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About DORIPIK 500MG INJECTION

DORIPIK 500MG INJECTION is a prescription antibiotic injection used to treat severe bacterial infections in adults. It is commonly prescribed for complicated infections of the urinary tract, kidneys, and abdomen. By targeting the specific bacteria causing the illness, this medicine helps resolve serious infections and supports your recovery.

Because this medicine is given directly into a vein, it is typically given by a healthcare professional in a hospital or clinic setting. It is usually given at regular intervals throughout the day to keep a consistent level of the medicine in your body. While receiving this treatment, staying well-hydrated and getting plenty of rest can help your body heal more effectively.

While receiving DORIPIK 500MG INJECTION, you may experience mild side effects like nausea, headache, or diarrhoea. However, you should contact your healthcare provider immediately if you experience severe watery diarrhoea, skin rash, or difficulty breathing, as these can be signs of a serious reaction.

Before starting this treatment, tell your doctor if you have a history of kidney disease or seizures, as these conditions may require special monitoring or dose adjustments. You should not receive this medicine if you have had a severe allergic reaction to similar antibiotics, such as penicillins or cephalosporins.

This medication can interact with other drugs, especially certain medicines used for epilepsy or gout, which can alter how your body processes them. If you are pregnant, breastfeeding, or an older adult, discuss the risks and benefits with your doctor before starting treatment. It is also wise to avoid alcohol during your recovery to help your body fight the infection and prevent additional stomach upset.

Uses of DORIPIK 500MG INJECTION

DORIPIK 500MG INJECTION is used to treat severe bacterial infections in adults. The detailed uses of DORIPIK 500MG INJECTION are as follows:

  • Complicated intra-abdominal infections: DORIPIK 500MG INJECTION helps clear deep-seated bacterial infections in the stomach and abdominal cavity, which often occur after surgery or organ rupture.
  • Complicated urinary tract infections: DORIPIK 500MG INJECTION targets and eliminates the bacteria causing severe bladder and kidney infections, preventing further damage to the urinary system.
  • Severe kidney infections (pyelonephritis): DORIPIK 500MG INJECTION penetrates the kidney tissues to destroy the bacteria responsible for painful, high-grade kidney infections.

Key Benefits

DORIPIK 500MG INJECTION offers significant benefits for patients recovering from severe, deep-seated bacterial infections that do not respond to oral antibiotics.

  • Fast-acting relief: Because it is delivered directly into the bloodstream, the medicine begins fighting bacteria immediately, helping you start feeling better faster.
  • Broad protection: It works against a wide variety of difficult-to-treat bacteria, ensuring that complex, mixed infections are thoroughly cleared.
  • Prevents complication risks: By rapidly stopping bacterial growth, it reduces the risk of the infection spreading to other parts of your body or entering your bloodstream.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • DORIPIK 500MG INJECTION will be administered in the hospital setting by a trained healthcare professional.
  • Do not self-administer.

How DORIPIK 500MG INJECTION Works

DORIPIK 500MG INJECTION contains doripenem, which belongs to a class of medicines known as carbapenem antibiotics. It works by interfering with the bacteria's ability to build their protective outer cell walls. Without a strong cell wall, the bacteria cannot survive the pressure within their own cells, causing them to burst and die. Because this medicine targets vital bacterial processes that human cells do not have, it specifically kills the invading bacteria without harming your body's healthy cells. This highly targeted action makes it an effective tool for resolving complex infections that have resisted other treatments.
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Alcohol

Caution

Consuming alcohol with DORIPIK 500MG INJECTION is not advisable as it may cause unpleasant side effects.

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Pregnancy

Consult your doctor

Please visit your doctor. There are no adequate and well-controlled studies in pregnant women. Your doctor will only provide a prescription if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor; there has been no significant research on the use of DORIPIK 500MG INJECTION in breastfeeding women.

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Driving

Caution

It is unclear whether DORIPIK 500MG INJECTION affects driving abilities, so don't drive or operate machinery if you're having trouble concentrating or reacting.

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Liver

Caution

Limited information was available about using DORIPIK 500MG INJECTION in patients with liver disease. Inform your doctor before receiving DORIPIK 500MG INJECTION if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving DORIPIK 500MG INJECTION if you have had a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

It is not recommended for use in children below 18 years.

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Heart

Consult your doctor

DORIPIK 500MG INJECTION should be avoided in individuals with heart problems due to potential risks and complications. Always consult your doctor for safer alternatives tailored to your cardiac condition.

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Geriatrics

Caution

DORIPIK 500MG INJECTION can be used in geriatric patients, but caution is advised due to age-related kidney issues. Dose adjustments may be necessary, and close monitoring is recommended to ensure safety and effectiveness.

What if I have taken an overdose of DORIPIK 500MG INJECTION

Since this medicine is given by healthcare professionals, an overdose is highly unlikely. However, if you suspect you have received too much or experience severe dizziness, confusion, or seizures, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water during your treatment to help your kidneys flush out the medication and support your body's natural healing process.
  • Take probiotics: Consider taking a probiotic supplement or eating yoghurt with active cultures a few hours after your treatment to help maintain a healthy balance of gut bacteria and reduce the risk of antibiotic-related diarrhoea.
  • Get adequate rest: Your body requires extra energy to fight off a severe infection, so prioritise sleep and avoid strenuous activities during your recovery.
  • Eat simple, bland foods: If you experience mild nausea, eat small, frequent meals consisting of plain foods like crackers, rice, or toast.
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How Soon It Starts Working

The time required for DORIPIK 500MG INJECTION to start to work: The onset of time for DORIPIK 500MG INJECTION is unknown. The time for which the effects of DORIPIK 500MG INJECTION last: The duration of DORIPIK 500MG INJECTION effect is unknown.

What if you forget to take DORIPIK 500MG INJECTION

If you miss an appointment for your injection or miss a scheduled dose at home, contact your doctor or healthcare provider immediately for instructions. Do not double the dose to make up for a missed one.

Storage

•Store the dry powder vials at a controlled room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution: If you are injecting this at home, always check the mixed liquid before use; it should be clear and free of particles. Do not use it if it is cloudy or discoloured.
  • Report bowel changes: Contact your doctor immediately if you develop severe watery diarrhoea, even if it occurs several weeks after finishing your treatment.
  • Monitor the injection site: Keep a close eye on where the needle enters your skin and notify a nurse or doctor if you notice worsening pain, warmth, or redness.
  • Complete the course: Never stop your treatment early, as doing so can allow the remaining bacteria to multiply and become resistant to antibiotics.
  • Share your history: Ensure your medical team knows if you have ever had a seizure, as this medicine must be used with extra caution in individuals prone to seizures.

Drug-Drug Interactions

verifiedApollotooltip
  • Valproic acid or Sodium valproate: Taking DORIPIK 500MG INJECTION with these seizure medications can significantly lower their levels in your blood, increasing your risk of experiencing a seizure.
  • Probenecid: This medication, often used for gout, can slow down how quickly your kidneys remove DORIPIK 500MG INJECTION from your body, leading to higher levels of the antibiotic in your blood.
DoripenemSodium Valproate
Severe
DoripenemDivalproex
Severe

Drug-Drug Interactions

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DoripenemSodium Valproate
Severe
How does the drug interact with Doripik 500mg Injection:
Co-administration of sodium valproate with Doripik 500mg Injection can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and sodium valproate can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DoripenemDivalproex
Severe
How does the drug interact with Doripik 500mg Injection:
Co-administration of Divalproex and Doripik 500mg Injection can reduce the blood levels of divalproex sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Divalproex with Doripik 500mg Injection can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with DORIPIK 500MG INJECTION when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

DORIPIK 500MG INJECTION is used to treat Bacterial infections (Complicated intra-abdominal infections and complicated urinary tract infections including pyelonephritis).
DORIPIK 500MG INJECTION contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, DORIPIK 500MG INJECTION helps treat bacterial infections.
Caution should be exercised. Patients with seizure disorders who are being treated with valproic acid or sodium valproate are at a higher risk of having a seizure. It has been demonstrated that administering DORIPIK 500MG INJECTION together with valproic acid lowers its (valproic acid) serum levels.
In some cases, DORIPIK 500MG INJECTION may lead to Clostridium difficile-associated diarrhoea (ranging from mild to fatal colitis): in major cases, it gradually resolves over time. In case this condition persists, consult your doctor immediately.
Inform your doctor if you do not feel better even after finishing the full course of treatment. If the symptoms worsen while using this medicine, consult your doctor.
To reduce the development of antibiotic resistance and maintain the effectiveness of DORIPIK 500MG INJECTION, it should only be used to treat or prevent infections that are proven or highly suspected to be caused by bacteria.
Usually, DORIPIK 500MG INJECTION starts working soon after taking it. However, it may take a few days to kill all the harmful bacteria and make you feel better.
A healthcare professional will administer DORIPIK 500MG INJECTION through an intravenous (IV) infusion. It is given over a specific duration, depending on the infection being treated and the patient's condition. Do not self-administer it.
Yes, DORIPIK 500MG INJECTION is an antibiotic medication. It belongs to the carbapenem class of antibiotics and is used to treat a variety of bacterial infections (such as complicated intra-abdominal infections and urinary tract infections) by inhibiting the growth of bacteria.
No, DORIPIK 500MG INJECTION is an antibiotic used to treat bacterial infections, not viral infections. It does not directly targets the SARS-CoV-2 virus that causes COVID-19.
DORIPIK 500MG INJECTION is not available as an over-the-counter medication. It is a prescription medication used to treat serious bacterial infections and must be prescribed by a healthcare provider.
Taking too much of DORIPIK 500MG INJECTION may lead to an overdose, potentially causing serious side effects such as seizures, difficulty breathing, and severe allergic reactions (like itching, rash, or blisters on the skin, mouth, nose, and eyes). If an overdose is suspected, seek immediate medical help.
While taking DORIPIK 500MG INJECTION, you should avoid certain medications that may interact with it, such as vaccines (e.g., BCG vaccine, live cholera vaccine, live typhoid vaccine) and anticonvulsants (e.g., valproic acid, divalproex sodium). Always consult your doctor before taking DORIPIK 500MG INJECTION with other medications.
DORIPIK 500MG INJECTION should be stored in a cool and dry place, away from direct sunlight. Do not freeze the medication. Keep it out of reach of children.
You must tell your doctor if you have a penicillin allergy. While many people with mild penicillin allergies can safely receive DORIPIK 500MG INJECTION, there is a small risk of cross-allergic reactions, so your doctor will carefully evaluate your medical history. Talk to your doctor if you have concerns.
There is limited information on the safety of this medicine during pregnancy or breastfeeding. It should only be used if clearly needed and prescribed by your doctor. Talk to your doctor to weigh the benefits against potential risks.
It is highly recommended to avoid alcohol during your treatment. Alcohol can dehydrate your body, weaken your immune system, and worsen side effects like nausea or dizziness. Talk to your doctor or pharmacist for personalised advice.
Mild irritation at the injection site can occur. However, if you notice increasing pain, swelling, warmth, or redness, you should inform your nurse or doctor right away, as this could indicate an infection or irritation of the vein. Talk to your doctor or nurse if you notice these signs.
This medicine generally does not affect your ability to drive. However, if you experience side effects like dizziness or a headache, you should avoid driving or operating machinery until you feel fully alert. Talk to your doctor if you feel unwell.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

313-Neelkanth Palace-B, 100ft Anand Nagar Road, Satellite Ahmedabad ? 380015, Gujarat, India
Other Info - DOR0078
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