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compositionComposition:DORIPENEM-500MG
prescription
Prescription Medicine
info
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Doriplug 500mg Injection is used to treat bacterial infections, such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis). It contains doripenem, an antibacterial drug that works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, it treats bacterial infections.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DORIPENEM-500MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Doriplug 500mg Injection

Doriplug 500mg Injection is a prescription antibiotic injection used to treat severe bacterial infections in adults. It is commonly prescribed for complicated infections of the urinary tract, kidneys, and abdomen. By targeting the specific bacteria causing the illness, this medicine helps resolve serious infections and supports your recovery.

Because this medicine is given directly into a vein, it is typically given by a healthcare professional in a hospital or clinic setting. It is usually given at regular intervals throughout the day to keep a consistent level of the medicine in your body. While receiving this treatment, staying well-hydrated and getting plenty of rest can help your body heal more effectively.

While receiving Doriplug 500mg Injection, you may experience mild side effects like nausea, headache, or diarrhoea. However, you should contact your healthcare provider immediately if you experience severe watery diarrhoea, skin rash, or difficulty breathing, as these can be signs of a serious reaction.

Before starting this treatment, tell your doctor if you have a history of kidney disease or seizures, as these conditions may require special monitoring or dose adjustments. You should not receive this medicine if you have had a severe allergic reaction to similar antibiotics, such as penicillins or cephalosporins.

This medication can interact with other drugs, especially certain medicines used for epilepsy or gout, which can alter how your body processes them. If you are pregnant, breastfeeding, or an older adult, discuss the risks and benefits with your doctor before starting treatment. It is also wise to avoid alcohol during your recovery to help your body fight the infection and prevent additional stomach upset.

Uses of Doriplug 500mg Injection

Doriplug 500mg Injection is used to treat severe bacterial infections in adults. The detailed uses of Doriplug 500mg Injection are as follows:

  • Complicated intra-abdominal infections: Doriplug 500mg Injection helps clear deep-seated bacterial infections in the stomach and abdominal cavity, which often occur after surgery or organ rupture.
  • Complicated urinary tract infections: Doriplug 500mg Injection targets and eliminates the bacteria causing severe bladder and kidney infections, preventing further damage to the urinary system.
  • Severe kidney infections (pyelonephritis): Doriplug 500mg Injection penetrates the kidney tissues to destroy the bacteria responsible for painful, high-grade kidney infections.

Key Benefits

Doriplug 500mg Injection offers significant benefits for patients recovering from severe, deep-seated bacterial infections that do not respond to oral antibiotics.

  • Fast-acting relief: Because it is delivered directly into the bloodstream, the medicine begins fighting bacteria immediately, helping you start feeling better faster.
  • Broad protection: It works against a wide variety of difficult-to-treat bacteria, ensuring that complex, mixed infections are thoroughly cleared.
  • Prevents complication risks: By rapidly stopping bacterial growth, it reduces the risk of the infection spreading to other parts of your body or entering your bloodstream.
Side effects of Doriplug 500mg Injection
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Doriplug 500mg Injection will be administered in the hospital setting by a trained healthcare professional.
  • Do not self-administer.

How Doriplug 500mg Injection Works

Doriplug 500mg Injection contains doripenem, which belongs to a class of medicines known as carbapenem antibiotics. It works by interfering with the bacteria's ability to build their protective outer cell walls. Without a strong cell wall, the bacteria cannot survive the pressure within their own cells, causing them to burst and die. Because this medicine targets vital bacterial processes that human cells do not have, it specifically kills the invading bacteria without harming your body's healthy cells. This highly targeted action makes it an effective tool for resolving complex infections that have resisted other treatments.
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Alcohol

Caution

Consuming alcohol with Doriplug 500mg Injection is not advisable as it may cause unpleasant side effects.

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Pregnancy

Consult your doctor

Please visit your doctor. There are no adequate and well-controlled studies in pregnant women. Your doctor will only provide a prescription if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor; there has been no significant research on the use of Doriplug 500mg Injection in breastfeeding women.

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Driving

Caution

It is unclear whether Doriplug 500mg Injection affects driving abilities, so don't drive or operate machinery if you're having trouble concentrating or reacting.

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Liver

Caution

Limited information was available about using Doriplug 500mg Injection in patients with liver disease. Inform your doctor before receiving Doriplug 500mg Injection if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Doriplug 500mg Injection if you have had a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

It is not recommended for use in children below 18 years.

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Heart

Consult your doctor

Doriplug 500mg Injection should be avoided in individuals with heart problems due to potential risks and complications. Always consult your doctor for safer alternatives tailored to your cardiac condition.

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Geriatrics

Caution

Doriplug 500mg Injection can be used in geriatric patients, but caution is advised due to age-related kidney issues. Dose adjustments may be necessary, and close monitoring is recommended to ensure safety and effectiveness.

What if I have taken an overdose of Doriplug 500mg Injection

Since this medicine is given by healthcare professionals, an overdose is highly unlikely. However, if you suspect you have received too much or experience severe dizziness, confusion, or seizures, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water during your treatment to help your kidneys flush out the medication and support your body's natural healing process.
  • Take probiotics: Consider taking a probiotic supplement or eating yoghurt with active cultures a few hours after your treatment to help maintain a healthy balance of gut bacteria and reduce the risk of antibiotic-related diarrhoea.
  • Get adequate rest: Your body requires extra energy to fight off a severe infection, so prioritise sleep and avoid strenuous activities during your recovery.
  • Eat simple, bland foods: If you experience mild nausea, eat small, frequent meals consisting of plain foods like crackers, rice, or toast.
health query

Have a query?

How Soon It Starts Working

The time required for Doriplug 500mg Injection to start to work: The onset of time for Doriplug 500mg Injection is unknown. The time for which the effects of Doriplug 500mg Injection last: The duration of Doriplug 500mg Injection effect is unknown.

What if you forget to take Doriplug 500mg Injection

If you miss an appointment for your injection or miss a scheduled dose at home, contact your doctor or healthcare provider immediately for instructions. Do not double the dose to make up for a missed one.

Storage

•Store the dry powder vials at a controlled room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution: If you are injecting this at home, always check the mixed liquid before use; it should be clear and free of particles. Do not use it if it is cloudy or discoloured.
  • Report bowel changes: Contact your doctor immediately if you develop severe watery diarrhoea, even if it occurs several weeks after finishing your treatment.
  • Monitor the injection site: Keep a close eye on where the needle enters your skin and notify a nurse or doctor if you notice worsening pain, warmth, or redness.
  • Complete the course: Never stop your treatment early, as doing so can allow the remaining bacteria to multiply and become resistant to antibiotics.
  • Share your history: Ensure your medical team knows if you have ever had a seizure, as this medicine must be used with extra caution in individuals prone to seizures.

Drug-Drug Interactions

verifiedApollotooltip
  • Valproic acid or Sodium valproate: Taking Doriplug 500mg Injection with these seizure medications can significantly lower their levels in your blood, increasing your risk of experiencing a seizure.
  • Probenecid: This medication, often used for gout, can slow down how quickly your kidneys remove Doriplug 500mg Injection from your body, leading to higher levels of the antibiotic in your blood.
DoripenemDivalproex
Severe
DoripenemSodium Valproate
Severe

Drug-Drug Interactions

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DoripenemDivalproex
Severe
How does the drug interact with Doriplug 500mg Injection:
Co-administration of Divalproex and Doriplug 500mg Injection can reduce the blood levels of divalproex sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Divalproex with Doriplug 500mg Injection can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DoripenemSodium Valproate
Severe
How does the drug interact with Doriplug 500mg Injection:
Co-administration of sodium valproate with Doriplug 500mg Injection can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and sodium valproate can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Doriplug 500mg Injection when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

Doriplug 500mg Injection is used to treat Bacterial infections (Complicated intra-abdominal infections and complicated urinary tract infections including pyelonephritis).
Doriplug 500mg Injection contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, Doriplug 500mg Injection helps treat bacterial infections.
Caution should be exercised. Patients with seizure disorders who are being treated with valproic acid or sodium valproate are at a higher risk of having a seizure. It has been demonstrated that administering Doriplug 500mg Injection together with valproic acid lowers its (valproic acid) serum levels.
In some cases, Doriplug 500mg Injection may lead to Clostridium difficile-associated diarrhoea (ranging from mild to fatal colitis): in major cases, it gradually resolves over time. In case this condition persists, consult your doctor immediately.
Inform your doctor if you do not feel better even after finishing the full course of treatment. If the symptoms worsen while using this medicine, consult your doctor.
To reduce the development of antibiotic resistance and maintain the effectiveness of Doriplug 500mg Injection, it should only be used to treat or prevent infections that are proven or highly suspected to be caused by bacteria.
Usually, Doriplug 500mg Injection starts working soon after taking it. However, it may take a few days to kill all the harmful bacteria and make you feel better.
A healthcare professional will administer Doriplug 500mg Injection through an intravenous (IV) infusion. It is given over a specific duration, depending on the infection being treated and the patient's condition. Do not self-administer it.
Yes, Doriplug 500mg Injection is an antibiotic medication. It belongs to the carbapenem class of antibiotics and is used to treat a variety of bacterial infections (such as complicated intra-abdominal infections and urinary tract infections) by inhibiting the growth of bacteria.
No, Doriplug 500mg Injection is an antibiotic used to treat bacterial infections, not viral infections. It does not directly targets the SARS-CoV-2 virus that causes COVID-19.
Doriplug 500mg Injection is not available as an over-the-counter medication. It is a prescription medication used to treat serious bacterial infections and must be prescribed by a healthcare provider.
Taking too much of Doriplug 500mg Injection may lead to an overdose, potentially causing serious side effects such as seizures, difficulty breathing, and severe allergic reactions (like itching, rash, or blisters on the skin, mouth, nose, and eyes). If an overdose is suspected, seek immediate medical help.
While taking Doriplug 500mg Injection, you should avoid certain medications that may interact with it, such as vaccines (e.g., BCG vaccine, live cholera vaccine, live typhoid vaccine) and anticonvulsants (e.g., valproic acid, divalproex sodium). Always consult your doctor before taking Doriplug 500mg Injection with other medications.
Doriplug 500mg Injection should be stored in a cool and dry place, away from direct sunlight. Do not freeze the medication. Keep it out of reach of children.
You must tell your doctor if you have a penicillin allergy. While many people with mild penicillin allergies can safely receive Doriplug 500mg Injection, there is a small risk of cross-allergic reactions, so your doctor will carefully evaluate your medical history. Talk to your doctor if you have concerns.
There is limited information on the safety of this medicine during pregnancy or breastfeeding. It should only be used if clearly needed and prescribed by your doctor. Talk to your doctor to weigh the benefits against potential risks.
It is highly recommended to avoid alcohol during your treatment. Alcohol can dehydrate your body, weaken your immune system, and worsen side effects like nausea or dizziness. Talk to your doctor or pharmacist for personalised advice.
Mild irritation at the injection site can occur. However, if you notice increasing pain, swelling, warmth, or redness, you should inform your nurse or doctor right away, as this could indicate an infection or irritation of the vein. Talk to your doctor or nurse if you notice these signs.
This medicine generally does not affect your ability to drive. However, if you experience side effects like dizziness or a headache, you should avoid driving or operating machinery until you feel fully alert. Talk to your doctor if you feel unwell.

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Country of origin

India

Manufacturer/Marketer address

20Th Km, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - DO57374
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