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compositionComposition:DOXEPIN-25MG
prescription
Prescription Medicine
info
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Doxin-25 Capsule is used to treat depression and anxiety when patients become intolerant to other medicines. In addition, it is also given as a medication to treat insomnia (difficulty in sleeping) in some people. It contains Doxepin, which increases the level of chemicals in the brain responsible for mood changes and causing depression. As a result, your mood is enhanced, and you feel better. If it is prescribed for insomnia, it helps us sleep for more time and treats sleeping difficulty. In some cases, you may experience side effects such as drowsiness, dry mouth, increased heart rate, constipation, weight gain, difficulty in urination, and sudden blood pressure lowering on standing up (orthostatic hypotension). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DOXEPIN-25MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Doxin-25 Capsule

Doxin-25 Capsule is an oral prescription medication used to manage depression, anxiety, and sleep maintenance difficulties, which involve trouble staying asleep. It belongs to a class of drugs that help restore the balance of certain natural chemicals in the brain to improve your mood, relieve tension, and promote restful sleep.

To achieve the best results, you must take Doxin-25 Capsule consistently every day exactly as directed by your doctor. This medicine can be taken with or without food, but keeping your routine the same each day helps maintain steady levels of the medication in your body. Combining this treatment with healthy sleep habits or regular counselling can significantly support your overall progress.

While taking Doxin-25 Capsule , some patients experience mild side effects like drowsiness or dry mouth. However, you should contact your doctor immediately if you notice serious changes in your health, such as severe mood swings, confusion, or a rapid or irregular heartbeat.

Talk to your doctor before starting this medication if you have a history of heart problems, glaucoma, or difficulty urinating. Do not take this if you are recovering from a recent heart attack, have untreated narrow-angle glaucoma, or suffer from severe urinary retention.

This medicine can interact with alcohol, smoking, and other medications like certain allergy or pain relievers, which can significantly increase drowsiness. If you are pregnant, breastfeeding, or an older adult, talk to your doctor or pharmacist to discuss whether this medication is appropriate for you.

Uses of Doxin-25 Capsule

Doxin-25 Capsule is used to manage depression, anxiety, and sleep maintenance difficulties. The detailed uses of Doxin-25 Capsule are as follows:

  • Depression: Doxin-25 Capsule helps relieve persistent feelings of sadness, low energy, and loss of interest by balancing chemical messengers in the brain.
  • Anxiety: It reduces excessive worry, fear, and physical tension, helping you feel more relaxed during your daily routine.
    Insomnia: When prescribed for sleep difficulties, it helps you stay asleep longer throughout the night and reduces the number of times you wake up.

 

Key Benefits

Doxin-25 Capsule helps support mental wellbeing by improving symptoms of depression, anxiety, and sleep disturbances. By helping restore the balance of certain brain chemicals, it promotes emotional stability, better daily functioning, and improved quality of life.

  • Helps Improve Mood and Emotional Wellbeing: By addressing chemical imbalances in the brain, Doxin-25 Capsule helps reduce symptoms of depression and anxiety. This can contribute to a calmer mind, improved emotional balance, and a greater ability to cope with everyday challenges.
  • Supports Better Energy and Daily Functioning: As symptoms become better controlled, Doxin-25 Capsule may help improve motivation, concentration, and overall energy levels, making it easier to participate in work, social activities, and daily routines.
  • Promotes Restful Sleep: For individuals experiencing sleep difficulties, Doxin-25 Capsule helps support longer and more restful sleep. Improved sleep quality can help you feel refreshed during the day and support overall mental and physical wellbeing.
     
Side effects of Doxin-25 Capsule
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.

Directions for Use

  • Doxin-25 Capsule can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Doxin-25 Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Doxin-25 Capsule Works

Doxin-25 Capsule contains doxepin. It works by preventing your brain cells from reabsorbing two key natural chemical messengers: serotonin and norepinephrine. By keeping more of these chemicals active in your brain, the medication helps elevate your mood, relieve feelings of anxiety, and calm your nervous system. When taken in much lower doses for sleep issues, the medication acts primarily as a potent blocker of histamine, a natural substance in the body that promotes wakefulness. By blocking these histamine receptors, Doxin-25 Capsule helps quiet brain activity, making it easier for you to stay asleep throughout the night.
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Alcohol

Unsafe

Doxin-25 Capsule should not be taken along with alcohol as it can affect you much more and may make you feel more depressed.

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Pregnancy

Caution

Doxin-25 Capsule is a pregnancy category C drug. It is not known whether it will harm the baby or not. So, it should be only taken when prescribed by a doctor.

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Breast Feeding

Unsafe

Doxin-25 Capsule is not recommended for breastfeeding women.

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Driving

Unsafe

Doxin-25 Capsule may impair your concentration and lead to drowsiness, so do not drive after taking Doxin-25 Capsule .

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Liver

Caution

Inform your doctor before receiving the Doxin-25 Capsule if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Inform your doctor before receiving the Doxin-25 Capsule if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Children

Caution

Doxin-25 Capsule is not recommended for children below the age of 12 years.

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Heart

Consult your doctor

Limited information available for use of Doxin-25 Capsule in heart patients. Please consult your doctor.

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Geriatrics

Caution

Exercise caution while giving Doxin-25 Capsule in geriatric patients. Close monitoring of the individual is required.

What if I have taken an overdose of Doxin-25 Capsule

If you suspect an overdose, seek immediate medical attention or contact your local poison control centre. Symptoms of an overdose can be severe and may include extreme drowsiness, rapid or irregular heartbeat, dilated pupils, confusion, or fainting.

Diet & Lifestyle Advise

  • Manage dry mouth: Drink plenty of water throughout the day, suck on ice chips, or chew sugar-free gum to keep your mouth moist.
  • Prevent constipation: Eat a diet rich in fibre, including whole grains, fruits, and vegetables, and stay physically active if possible.
  • Stand up slowly: To prevent dizziness or fainting, take your time when rising from a lying or sitting position.
  • Keep a consistent sleep schedule: If you are treating sleep issues, go to bed and wake up at the same time every day to reinforce your body's natural sleep cycle.
  • Limit late-day stimulants: Avoid caffeine, chocolate, and heavy meals close to bedtime, as they can interfere with both sleep quality and anxiety management.
     
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How Soon It Starts Working

The time required for Doxin-25 Capsule to start to work: The time required for Doxin-25 Capsule to show its action is not clinically established. The time for which the effects of Doxin-25 Capsule last: The duration of action for Doxin-25 Capsule is not clinically established.

What if you forget to take Doxin-25 Capsule

If you take this medicine once daily at bedtime and miss a dose, skip the missed dose and take your next dose at the regular time the following night. Do not take a double dose to make up for a missed one. If you take it multiple times a day, take the missed dose as soon as you remember, unless it is almost time for your next dose.

Storage

•Store Doxin-25 Capsule at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the medication in its original container, tightly closed, to protect it from moisture and direct light.

Drug Warnings

  • Do not drive, operate machinery, or perform dangerous activities until you know how this medication affects your alertness and coordination.
  • Never stop taking this medication suddenly, as doing so can cause unpleasant withdrawal symptoms like nausea, headache, and sleep problems. Your doctor will help you taper off safely.
  • Avoid consuming alcohol while taking this medicine, as it can dangerously increase drowsiness and slow your breathing.
  • Protect your skin from direct sunlight; this medicine can make your skin more sensitive to sunburn. Wear sunscreen and protective clothing when outdoors.
  • Inform your doctor or dentist that you are taking this medication before undergoing any scheduled surgery or dental procedures.
     

Drug-Drug Interactions

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Drug-Drug Interactions

  • Monoamine Oxidase Inhibitors (MAOIs): Do not take this medicine within 14 days of taking an MAOI, as this can lead to a dangerously high, life-threatening spike in blood pressure.
  • Central Nervous System Depressants: Combining this medication with pain relievers, sleeping pills, muscle relaxers, or other anxiety medicines can cause severe drowsiness and slow your breathing.
  • Anticholinergic Drugs: Taking this with certain allergy medicines or overactive bladder treatments can increase the risk of dry mouth, severe constipation, and difficulty urinating.

Drug-Food Interactions

  • Alcohol: Avoid alcohol completely, as it can worsen side effects like dizziness, drowsiness, and confusion.
  • Grapefruit Juice: Avoid consuming large amounts of grapefruit juice, as it may raise the levels of this medicine in your body and increase the risk of side effects.

Drug-Disease Interactions

  • Glaucoma: Do not take this medicine if you have untreated narrow-angle glaucoma, as it can increase fluid pressure in your eyes.
  • Urinary Retention: Avoid this medication if you have severe trouble emptying your bladder, as it can worsen urinary blockage.
  • Heart Conditions: Use with caution if you have a history of irregular heartbeats or heart disease, as this medication can affect your heart rhythm.

 

DoxepinPotassium citrate
Critical
DoxepinSaquinavir
Critical

Drug-Drug Interactions

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DoxepinPotassium citrate
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Doxin-25 Capsule and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Doxin-25 Capsule with Potassium citrate is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, consult the doctor immediately if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), loss of appetite, or dark, tarry stools. Do not discontinue any medications without a doctor's advice.
DoxepinSaquinavir
Critical
How does the drug interact with Doxin-25 Capsule:
Combining Doxin-25 Capsule with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxin-25 Capsule with Saquinavir is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DoxepinPotassium chloride
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Doxin-25 Capsule with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Doxin-25 Capsule with Potassium chloride is not recommended, as it can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), loss of appetite, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
DoxepinProcarbazine
Critical
How does the drug interact with Doxin-25 Capsule:
Combining Procarbazine and Doxin-25 Capsule can increase the risk of a rare but serious condition called the serotonin syndrome(build up high levels of serotonin in the body).

How to manage the interaction:
Taking Doxin-25 Capsule with Procarbazine is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping procarbazine before you start treatment with Doxin-25 Capsule and do not discontinue any medications without consulting your doctor.
DoxepinZiprasidone
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Doxin-25 Capsule with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Doxin-25 Capsule with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxepinSafinamide
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Safinamide with Amitriptyline can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Doxin-25 Capsule with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DoxepinTranylcypromine
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Doxin-25 Capsule with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Doxin-25 Capsule with Tranylcypromine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
DoxepinRasagiline
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Rasagiline with Doxin-25 Capsule can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Doxin-25 Capsule with rasagiline is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms, like confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms, stomach cramps, nausea, vomiting, and loose stools, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxepinDronedarone
Critical
How does the drug interact with Doxin-25 Capsule:
Combining Doxin-25 Capsule with Dronedarone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxin-25 Capsule with Dronedarone is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DoxepinVilazodone
Severe
How does the drug interact with Doxin-25 Capsule:
The combined use of vilazodone and Doxin-25 Capsule can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of vilazodone and Doxin-25 Capsule can lead to an interaction, but it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDEPRESSANT]

FAQs

Doxin-25 Capsule is used to treat depression and anxiety when patients become intolerant to other medicines. In addition, it is also used to treat insomnia (difficulty in sleeping) in some people.
Doxin-25 Capsule contains Doxepin, a tricyclic antidepressant. It works by increasing the levels of certain brain chemicals involved in regulating mood, helping reduce symptoms of depression and anxiety. When prescribed at low doses for insomnia, it helps improve sleep by promoting longer and better-quality sleep.
Take Doxin-25 Capsule exactly as prescribed by your doctor. If it is prescribed for insomnia, take it within 30 minutes before bedtime and avoid taking it during the day, as it can cause significant drowsiness. If it is prescribed for depression or anxiety, take it at the same time each day, following your doctor's instructions.
Yes. Some people may experience increased appetite or weight gain while taking Doxin-25 Capsule , particularly at higher doses used for depression or anxiety. Maintaining a healthy diet and regular physical activity may help. Contact your doctor if you notice significant or persistent weight gain.
If you have allergies to any of its ingredients or are pregnant, you are advised to avoid using Doxin-25 Capsule . Do not take the Doxin-25 Capsule if you have glaucoma (increased eye pressure), severe liver or kidney issues, or trouble urinating. Take Doxin-25 Capsule only as recommended by a doctor and with under medical care if you are pregnant or nursing. If you have taken an MAO inhibitor within the last 15 days, avoid taking Doxin-25 Capsule .
Yes, Doxin-25 Capsule can be used to treat insomnia, especially in people who do not fall asleep or have difficulty staying asleep.
No, do not drive while taking Doxin-25 Capsule , as it may cause drowsiness and impair your concentration. If you feel sleepy or dizzy, avoid driving until you are sure it is safe.
Overdose symptoms of Doxin-25 Capsule can include irregular heartbeat, feeling agitated or confused, drowsiness, trouble concentrating, vomiting, seizures, muscle stiffness, increase in pupil size, hallucination (seeing or hearing things that aren't there), fever, low body temperature, and even coma (loss of consciousness for some time). If you suspect an overdose, seek immediate medical help from your doctor.
Yes, Doxin-25 Capsule , like other antidepressants, may increase the risk of suicidal thoughts or behaviours, particularly in children, adolescents, and young adults. This risk is higher when starting the medication or adjusting the dosage. If you notice any changes in your mental health while using Doxin-25 Capsule , please contact your doctor immediately.
The common side effects of Doxin-25 Capsule include drowsiness, dry mouth, increased heart rate, constipation, weight gain, difficulty urinating, and a sudden drop in blood pressure upon standing (orthostatic hypotension). Most of these side effects may resolve gradually over time, but if they persist or worsen, please consult your doctor.
No. Doxin-25 Capsule is generally not considered habit-forming or addictive. However, stopping it suddenly after long-term use may cause withdrawal symptoms. Always consult your doctor before reducing or stopping your medication.
Dry mouth is a common side effect. You can manage it by sipping water throughout the day, sucking on ice chips, or chewing sugar-free gum. If the dryness is severe, painful, or does not go away, talk to your doctor or pharmacist.
No. Avoid drinking alcohol while taking Doxin-25 Capsule . Alcohol can increase drowsiness, dizziness, impaired coordination, and other side effects, making activities such as driving more dangerous.
No. Do not stop taking Doxin-25 Capsule suddenly, even if you feel better. Abrupt discontinuation may cause withdrawal symptoms such as nausea, headache, sleep disturbances, irritability, and recurrence or worsening of your symptoms. Your doctor may gradually reduce your dose before stopping treatment. Always consult your doctor before making any changes to your medication.
Yes, many over-the-counter cold, allergy, and cough medicines contain ingredients that can cause severe drowsiness or interact poorly with this medication. Always talk to your doctor or pharmacist before taking any new over-the-counter products.

Disclaimer

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Reference

  1. MedlinePlus. A682390 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.8133 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 070791S027Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Doxepin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Doxepin Doxepin. 1969. [Accessed on 22 Mar. 2019]Check here
  6. Anasheh Almasi; Carlos E. Meza. Doxepin. NIH National Library of Medicine, National center for biotechnology information. Statpearls. January 2022. [Accessed on 27th May 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - DOX0108

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