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compositionComposition:DULOXETINE-20MG+METHYLCOBALAMIN-1.5MG
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Prescription Medicine
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Duzela M 20 Capsule is used to treat neuropathic pain. It contains Duloxetine and Methylcobalamin, which work by increasing the levels of neurotransmitters (such as serotonin and noradrenaline) in the brain that are required to regulate pain. Also, it helps rejuvenate and protect damaged nerve cells. It may cause side effects such as drowsiness, nausea, constipation, headache, dry mouth, increased sweating, or loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DULOXETINE-20MG+METHYLCOBALAMIN-1.5MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Duzela M 20 Capsule

Duzela M 20 Capsule is a prescription oral medication used to treat chronic nerve pain, particularly diabetic neuropathy, which is nerve damage caused by diabetes. It helps relieve ongoing discomfort such as burning, stabbing, or tingling sensations in the hands and feet. By targeting pain signals in the brain and supporting nerve cell health, this medicine improves daily physical functioning.

You should take Duzela M 20 Capsule regularly at the same time every day to maintain steady levels of the medicine in your body. It can be taken with or without food, though taking it with food may help reduce initial stomach upset. Incorporating a balanced diet rich in B-vitamins and managing your blood sugar levels can further enhance your treatment outcomes.

While taking Duzela M 20 Capsule , you may experience mild side effects like dry mouth, nausea, sleepiness, or lightheadedness. These symptoms usually improve as your body adjusts to the medicine, but you must contact your doctor immediately if you experience severe mood changes, yellowing of your skin or eyes, or unusual bleeding.

Do not take this if you have severe kidney or liver disease, uncontrolled high blood pressure, or a history of heavy alcohol use. Talk to your doctor before starting Duzela M 20 Capsule if you have a history of glaucoma, seizures, bleeding disorders, or depression.

Avoid drinking alcohol while taking this medicine because it significantly increases the risk of serious liver damage and drowsiness. You should also consult your doctor if you are pregnant, breastfeeding, or planning a pregnancy, as well as if you are an older adult, to ensure this treatment is safe for your specific health needs.

Uses of Duzela M 20 Capsule

Duzela M 20 Capsule is used to treat chronic nerve pain. The detailed uses of Duzela M 20 Capsule are as follows:

  • Diabetic Peripheral Neuropathy: Duzela M 20 Capsule helps relieve chronic nerve pain, burning, tingling, and numbness in the hands and feet caused by nerve damage in diabetic patients.
  • Neuropathic Pain: It manages various types of long-term nerve pain resulting from injury or nerve dysfunction, helping to calm overactive pain signals in the nervous system.
  • Nutritional Support for Nerve Health: It provides essential nutrients that aid in the regeneration and protection of damaged nerve fibres, promoting healthier nerve conduction.
     

Key Benefits

Duzela M 20 Capsule helps relieve nerve pain while supporting healthy nerve function and repair. By reducing abnormal nerve signalling and promoting nerve health, it helps improve comfort, mobility, and overall quality of life.

  • Helps Relieve Nerve Pain: By calming overactive nerve signals, Duzela M 20 Capsule helps reduce burning, stabbing, tingling, and other painful sensations associated with nerve damage, making daily activities more comfortable.
  • Supports Nerve Repair and Recovery: Duzela M 20 Capsule helps nourish damaged nerves and supports the repair of their protective covering, promoting healthier nerve function and long-term recovery.
  • Improves Daily Comfort and Mobility: By reducing nerve pain and supporting nerve health, Duzela M 20 Capsule helps improve physical coordination, sensation, sleep quality, and the ability to carry out everyday activities with greater ease.
     
Side effects of Duzela M 20 Capsule
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Directions for Use

  • Take Duzela M 20 Capsule with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How Duzela M 20 Capsule Works

Duzela M 20 Capsule is a combination of two active components that work together to address nerve pain from different angles. The first component, duloxetine, is a nerve-pain reliever that works in the brain and spinal cord. It increases the levels of natural chemical messengers (serotonin and norepinephrine) that stop pain signals from travelling to the brain, effectively lowering the pain you feel. The second component, methylcobalamin, is an active form of vitamin B12. This vitamin is crucial for producing myelin, the protective sheath that wraps around and insulates your nerves. By promoting myelin production, it helps repair damaged nerves, restores normal nerve signalling, and protects nerve cells from further degeneration.
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Alcohol

Unsafe

Alcohol may worsen the condition by increasing the risk of side effects

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Pregnancy

Unsafe

Duzela M 20 Capsule is a category C medicine, so it is not recommended for use in pregnant women.

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Breast Feeding

Caution

Duzela M 20 Capsule should be used with caution in breastfeeding mothers.

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Driving

Unsafe

Duzela M 20 Capsule may cause drowsiness. So, avoid driving or operating heavy machinery while using Duzela M 20 Capsule .

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Liver

Caution

Duzela M 20 Capsule should be used with caution in patients with liver diseases.

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Kidney

Caution

Duzela M 20 Capsule should be used with caution in patients with kidney diseases.

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Children

Unsafe

Duzela M 20 Capsule is not recommended for children and anyone below 18 years. Please consult a medical professional for further information.

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Heart

Consult your doctor

Duzela M 20 Capsule can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Duzela M 20 Capsule should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Duzela M 20 Capsule .

What if I have taken an overdose of Duzela M 20 Capsule

In case of an accidental overdose, seek immediate medical attention. Symptoms of an overdose may include extreme sleepiness, severe dizziness, rapid heart rate, or vomiting.

Diet & Lifestyle Advise

  • Manage Blood Sugar Levels: Keep a close watch on your blood glucose levels, as stable blood sugar is key to preventing further nerve damage.
  • Eat a Balanced Diet: Focus on foods rich in B-complex vitamins, such as leafy greens, eggs, and lean meats, to support your nerve recovery.
  • Engage in Gentle Exercise: Regular, low-impact activities like walking or swimming can improve blood circulation to your hands and feet, easing neuropathic symptoms.
  • Protect Your Feet: Check your feet daily for cuts, blisters, or redness, as nerve pain can sometimes mask physical injuries.
  • Limit Alcohol Consumption: Restricting alcohol intake is crucial, as alcohol can worsen nerve damage and increase the risk of side effects.
     

Health Queries

What can my mother do right away to relieve the stomach acid, nausea, and burping she is experiencing after taking Duzela M 20 for nerve pain?

Veda Maddala

Veda Maddala

M Pharmacy

Duzela M 20 (which contains duloxetine and methylcobalamin) can sometimes cause temporary stomach upset, acid buildup, and nausea. To help her feel better right away, try having her take the medication with a meal or a light snack instead of on an empty stomach. She should also avoid lying down for at least 30 minutes after taking it and sip on cool water or ginger tea. Please consult her doctor before stopping the medication; they can safely suggest a temporary antacid or adjust her treatment plan to make her more comfortable.

left-hand pain at night for three days.

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Left-hand pain at night for a few days is often due to muscle strain or nerve compression, such as Carpal tunnel syndrome or cervical-related nerve irritation. Rest the hand, avoid repetitive use, and try a wrist splint at night if needed; warm compresses can help. You may take a mild pain reliever like Paracetamol for short-term relief. If pain persists, worsens, or is associated with numbness, tingling, or weakness, consult a doctor.

Right hand ache, slight from elbow to finger

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Mild pain from the elbow to fingers in the right hand is often due to muscle strain or nerve irritation, sometimes seen in conditions like Tennis elbow or minor nerve compression. Rest the hand, avoid repetitive activities, use a warm compress, and do gentle stretching. For relief, you can take Paracetamol or apply a topical pain gel. If the pain persists, worsens, or you develop numbness or weakness, consult a doctor.

Please recommend me since I suffer from cervical spondylosis and headaches.

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

For Cervical spondylosis with headaches, focus on posture correction (avoid long phone/laptop use, keep screen at eye level), use a firm pillow, and do regular neck stretching/physiotherapy. Apply warm compresses and take a pain reliever like Paracetamol for short-term relief; muscle relaxants or other medicines may be prescribed if needed. Regular exercise and stress control help prevent headaches. If pain is persistent, severe, or associated with numbness or weakness, consult a doctor for further evaluation.

Pressure pain and headache in the right forearm (over elbow)

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Pain around the elbow and forearm with headache may be due to overuse strain or conditions like Tennis elbow causing local pain, sometimes along with tension-type headache from muscle strain. Rest the arm, avoid repetitive activities, use a warm compress, and gentle stretching. For relief, you can take Paracetamol or apply a topical pain gel. If pain persists, worsens, or affects movement, consult a doctor for proper evaluation.
health query

Have a query?

How Soon It Starts Working

The time required for Duzela M 20 Capsule to start to work: Duzela M 20 Capsule ideally shows its action within 4 hours after administration. The time for which the effects of Duzela M 20 Capsule last: The duration of action for Duzela M 20 Capsule is unknown.

What if you forget to take Duzela M 20 Capsule

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Duzela M 20 Capsule at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the medication in its original container to protect it from direct light, moisture, and excess heat.

Drug Warnings

  • Avoid Sudden Discontinuation: Stopping this medicine abruptly can lead to withdrawal symptoms like dizziness, nausea, headache, and irritability.Always consult your doctor for a plan to gradually decrease the dose.
  • Monitor Mood Changes: Pay close attention to any sudden changes in mood, behaviour, or thoughts of self-harm, especially during the first few weeks of treatment.
  • Be Careful Driving: This medication can cause dizziness and drowsiness. Avoid driving or operating heavy machinery until you know how Duzela M 20 Capsule affects you.
  • Limit Alcohol Intake: Combining this medicine with alcohol increases the risk of liver damage and severe drowsiness.
  • Check Blood Pressure Regularly: Since this medication can sometimes raise blood pressure, it is wise to monitor your readings periodically.

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Taking Duzela M 20 Capsule with MAOIs can cause a dangerous, life-threatening interaction. Allow at least 14 days between stopping an MAOI and starting Duzela M 20 Capsule .
  • Blood Thinners: Combining this medicine with aspirin or other blood thinners can increase your risk of bleeding or bruising.
  • Other Serotonergic Drugs: Using other antidepressants or migraine medications alongside Duzela M 20 Capsule can lead to a serious condition called serotonin syndrome.
     
Duloxetine + MecobalaminSafinamide
Critical
Duloxetine + MecobalaminSelegiline
Critical

Drug-Drug Interactions

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Duloxetine + MecobalaminSafinamide
Critical
How does the drug interact with Duzela M 20 Capsule:
Co-administration of safinamide with Duzela M 20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with Safinamide is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminSelegiline
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Duzela M 20 Capsule with selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with Selegiline is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminEliglustat
Critical
How does the drug interact with Duzela M 20 Capsule:
Co-administration of eliglustat and Duzela M 20 Capsule can significantly increase the blood levels of eliglustat.

How to manage the interaction:
Taking Duzela M 20 Capsule with Eliglustat is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain, or tiredness. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminPhenelzine
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking phenelzine with duloxetine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Duloxetine with Phenelzine is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminProcarbazine
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Duzela M 20 Capsule with procarbazine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with Procarbazine is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminTranylcypromine
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Tranylcypromine with Duzela M 20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with tranylcypromine is not recommended, they can be taken if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminLinezolid
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Duzela M 20 Capsule with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with Linezolid is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminRasagiline
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Rasagiline with Duloxetine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with Rasagiline is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminAlfentanil
Severe
How does the drug interact with Duzela M 20 Capsule:
Taking Duzela M 20 Capsule with Alfentanil can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with Alfentanil is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Duloxetine + MecobalaminVilazodone
Severe
How does the drug interact with Duzela M 20 Capsule:
Taking Duzela M 20 Capsule with Vilazodone can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with Vilazodone is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid alcohol as it increases drowsiness and the risk of severe liver damage.

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

FAQs

Duzela M 20 Capsule is used to treat neuropathic pain.
Duzela M 20 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine increases the number of neurotransmitters like serotonin and noradrenaline in the brain that can regulate pain. On the other hand, methylcobalamin (vitamin B12) can protect the nerve cells from further damage. Thus, Duzela M 20 Capsule prevents nerve damage due to various conditions like injury or diabetic neuropathy and ensures smooth conduction of nerve signals throughout the body.
Duzela M 20 Capsule should be taken either in the morning or evening. If you feel drowsy after taking Duzela M 20 Capsule , consider taking it in the evening. Also, it is recommended to take Duzela M 20 Capsule every day at the same time for the best results.
Duzela M 20 Capsule should not be used with antidepressants, especially antidepressants like monoamine oxidase (MAO) inhibitors (moclobemide, linezolid) as they cause serious side-effects. It is advised to wait at least 14 days after stopping MAO inhibitors before taking Duzela M 20 Capsule also wait at least 5 days after stopping Duzela M 20 Capsule before taking any MAO inhibitors.
Seek medical attention immediately if you notice any depressive thoughts while using Duzela M 20 Capsule . Your doctor may change the dose or medicine to treat your condition.
The common side effects of Duzela M 20 Capsule include drowsiness, nausea, constipation, headache, dry mouth, increased sweating, anorexia (loss of appetite), and hot sensation (burning pain). Please inform your doctor if any of these side effects persist or worsen.
No, do not stop taking Duzela M 20 Capsule , even if you start to feel better. Stopping the medication suddenly may cause withdrawal symptoms. If you need to stop the medication, your doctor will guide you on how to gradually reduce the dose safely.
Yes, you can take Duzela M 20 Capsule with or without food. However, if you experience nausea or stomach upset, taking it with a meal can help reduce these side effects. Talk to your doctor if stomach issues persist.
Duzela M 20 Capsule is designed to manage and significantly reduce nerve pain while supporting the repair of damaged nerve fibres. While it helps restore nerve function, it may not completely cure the underlying cause of the nerve damage. Talk to your doctor about your long-term treatment plan.
Dry mouth is a common side effect of Duzela M 20 Capsule . You can manage this by sipping water frequently, chewing sugar-free gum, or sucking on sugar-free hard candies. If dry mouth becomes severe or causes dental issues, talk to your doctor or pharmacist.
Moderate intake of caffeine is generally fine, but excessive caffeine might increase anxiety or interfere with sleep, especially when starting Duzela M 20 Capsule . Keep your caffeine intake moderate and talk to your doctor if you experience jitteriness or trouble sleeping.
The safety of Duzela M 20 Capsule during pregnancy has not been fully established. It should only be used if the potential benefits outweigh the risks to the unborn baby. Talk to your doctor to discuss safer alternatives if you are pregnant or planning to become pregnant.
Some people may experience changes in weight or appetite while taking this medicine. These changes can vary, with some experiencing weight loss and others weight gain. Talk to your doctor if you notice significant, unexpected changes in your weight.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.8650 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Duloxetine hydrochloride. 2004. [Accessed on 23 Apr. 2019]Check here
  3. MedlinePlus MedlinePlus. [Accessed on 23 Apr. 2019]Check here
  4. Chetna Sharma, Inderpal Kaur, Harpreet Singh, Inderpal Singh Grover and Jatinder Singh. Uses of methylcobalamin plus duloxetine. Indian Journal of Pharmacology. September 2021. [Accessed on 14th June 2022]Check here
  5. Jaberpreet S. Dhaliwal, Benjamin C. Spurling, Mohammed Molla. Mechanism of duloxetine. National Institute of Health. NLM. National Centre for Biotechnology Information. Pubmed.gov. May 2022. [Accessed on 14th June 2022]Check here
  6. Eli Lilly and Company. U.S. Food & Drug Administration. [Revised in October 2010] [Accessed on 14th June 2022] docs/label/2010/022516lbl.pdfCheck here
  7. Eli Lilly and Company Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 14th June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - DUZ0006

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