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  1. Home
  2. Medicine

  3. Endival ER 500 Tablet

Prescription drug
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Endival ER 500 Tablet, Pack of 1 Tablet
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Extra 15% Off with Bank Offers

Composition :

DIVALPROEX-500MG

Manufacturer/Marketer :

Medright Biogenics Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Endival ER 500 Tablet

Endival ER 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, Endival ER 500 Tablet is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain.

Endival ER 500 Tablet contains 'Divalproex', which reduces excessive, abnormal nerve activity in the brain. Thereby helping in controlling seizures.

Endival ER 500 Tablet increases the levels of the chemical substance GABA; this helps block nerve transmission in the brain and produces a calming effect. Thereby helping treat bipolar disorder.

In some cases, you may experience side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Talk to your doctor if you experience these side effects persistently.

Do not take Endival ER 500 Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Endival ER 500 Tablet. Consult your doctor if you are breastfeeding. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Endival ER 500 Tablet

Endival ER 500 Tablet is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of Endival ER 500 Tablet are as follows:

  • Seizure Management: Endival ER 500 Tablet is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.
  • Bipolar Disorder Treatment: Endival ER 500 Tablet can be utilised in the treatment of bipolar disorder, aiding in mood stabilisation and reducing the frequency of mood swings.
  • Migraine Prevention: Endival ER 500 Tablet may also be prescribed to prevent migraines, providing relief from recurrent headaches.

Have a query?

Directions for Use

  • Endival ER 500 Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Endival ER 500 Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Endival ER 500 Tablet is used to treat and prevent epilepsy, seizures, or fits by controlling abnormal electrical activity in the brain.
  • It helps manage various types of seizures, including simple partial, complex partial, and absence seizures.
  • Endival ER 500 Tablet may be used alone or in combination with other anti-epileptic medicines for better seizure control.
  • It is also prescribed to treat mood disorders, such as bipolar disorder, by enhancing GABA (gamma-aminobutyric acid) activity in the brain, which produces a calming and stabilising effect.
  • Endival ER 500 Tablet helps prevent migraine headaches by reducing abnormal nerve transmission and limiting the spread of pain signals.
  • By decreasing excessive nerve activity, Endival ER 500 Tablet restores normal brain function and helps maintain emotional balance.
  • Endival ER 500 Tablet provides broad neurological benefits by controlling seizures, stabilising mood, and reducing migraine frequency.

How Endival ER 500 Tablet Works

Endival ER 500 Tablet contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Endival ER 500 Tablet increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Endival ER 500 Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat eggs for zinc and other nutrients that support healthy vision.
  • Consume blueberries as antioxidants to combat eye strain.
  • Include broccoli in your diet for diverse eye-boosting nutrients.
  • Eat sweet potatoes as a natural source of vitamin A.
  • Snack on almonds for vitamin E and eye protection.
  • Add tomatoes to your diet for lycopene and vision protection.
  • Perform exercises that improve binocular vision, such as dot-to-dot cards, coloring within lines, and Brock string tests.
  • Wear an eye patch and perform tasks like playing games and solving puzzles.
  • Patching and eye exercises can improve symptoms.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Endival ER 500 Tablet

Do not take more than the prescribed dose of Endival ER 500 Tablet as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Endival ER 500 Tablet if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders.
  • Inform your doctor before taking Endival ER 500 Tablet if you have pancreatitis, blood problems or multi-organ hypersensitivity.
  • Consult your doctor immediately if you experience suicidal tendencies while taking Endival ER 500 Tablet.
  • Endival ER 500 Tablet may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems.
  • Please do not stop taking Endival ER 500 Tablet without consulting your doctor to avoid worsening of seizures.
  • Do not take Endival ER 500 Tablet if you are pregnant, as it could cause serious birth defects.
  • If you are of childbearing age, use effective contraception while taking Endival ER 500 Tablet.
  • Consult your doctor before taking Endival ER 500 Tablet if you are breastfeeding.
  • Avoid driving or operating machinery as Endival ER 500 Tablet causes dizziness and may affect thinking and motor skills.
  • Avoid consuming alcohol along with Endival ER 500 Tablet as it could lead to increased dizziness.
  • Care should be taken while giving Endival ER 500 Tablet to children below 2 years, as there is a higher risk of liver intoxication during the first six months of treatment.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
DivalproexGlycerol phenylbutyrate
Critical
DivalproexSodium oxybate
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Endival ER 500 Tablet:
Coadministration of Glycerol phenylbutyrate and Endival ER 500 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Endival ER 500 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexSodium oxybate
Severe
How does the drug interact with Endival ER 500 Tablet:
Co-administration of Sodium oxybate and Endival ER 500 Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Endival ER 500 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexLeflunomide
Severe
How does the drug interact with Endival ER 500 Tablet:
Co-administration of Endival ER 500 Tablet and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Endival ER 500 Tablet and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DivalproexKetoconazole
Severe
How does the drug interact with Endival ER 500 Tablet:
Coadministration of Ketoconazole and Endival ER 500 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Endival ER 500 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexErtapenem
Severe
How does the drug interact with Endival ER 500 Tablet:
Coadministration of Ertapenem with Endival ER 500 Tablet may reduce the blood levels of Endival ER 500 Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Endival ER 500 Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexMipomersen
Severe
How does the drug interact with Endival ER 500 Tablet:
Co-administration of Endival ER 500 Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Endival ER 500 Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexLomitapide
Severe
How does the drug interact with Endival ER 500 Tablet:
Co-administration of Endival ER 500 Tablet and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Endival ER 500 Tablet and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.
DivalproexDoripenem
Severe
How does the drug interact with Endival ER 500 Tablet:
Co-administration of Endival ER 500 Tablet and Doripenem can reduce the blood levels of Endival ER 500 Tablet sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Endival ER 500 Tablet with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DivalproexBexarotene
Severe
How does the drug interact with Endival ER 500 Tablet:
Co-administration of Endival ER 500 Tablet and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Endival ER 500 Tablet and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Endival ER 500 Tablet:
Co-administration of Endival ER 500 Tablet and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Endival ER 500 Tablet and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • The Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan, help those around you know what to do.
  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Endival ER 500 Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Endival ER 500 Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Endival ER 500 Tablet belongs to pregnancy category D. Avoid taking Endival ER 500 Tablet if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Endival ER 500 Tablet may pass into breastmilk. Consult your doctor before taking Endival ER 500 Tablet if you are breastfeeding.

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Driving

Unsafe

Endival ER 500 Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

Endival ER 500 Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Endival ER 500 Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years, as they are at a higher risk of liver toxicity.

FAQs

Endival ER 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.

Endival ER 500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

Endival ER 500 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

Endival ER 500 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.

Endival ER 500 Tablet may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Endival ER 500 Tablet only after consulting a doctor.

Endival ER 500 Tablet may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.

Do not discontinue Endival ER 500 Tablet without consulting your doctor. To treat your condition effectually, continue taking Endival ER 500 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Endival ER 500 Tablet; your doctor will gradually reduce the dose to avoid worsening seizures.

Before taking Endival ER 500 Tablet, certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.

Endival ER 500 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Endival ER 500 Tablet.

Topiramate (anticonvulsant) should not be taken along with Endival ER 500 Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

It's crucial to consult with your doctor before discontinuing Endival ER 500 Tablet. Abruptly stopping this medication can lead to severe consequences, especially if it's prescribed to treat conditions like epilepsy.

Endival ER 500 Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.

Endival ER 500 Tablet can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.

Yes, Endival ER 500 Tablet can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Endival ER 500 Tablet, it's essential to consult with your doctor.

Yes, Endival ER 500 Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Endival ER 500 Tablet, seeking medical attention is crucial.

Avoid consumption of alcohol while taking Endival ER 500 Tablet as it may cause increased dizziness.

If you experience abdominal pain, nausea, and anorexia while taking Endival ER 500 Tablet, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.

An overdose of Endival ER 500 Tablet can be a severe medical emergency. If you or someone you know has taken an overdose of Endival ER 500 Tablet, it's crucial to seek immediate medical attention.

Endival ER 500 Tablet can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.

Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Country of origin

India
Other Info - EN28454

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Nov 4, 2025 | 9:20 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018723s037lbl.pdf
  2. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e26005ef-77f0-4393-a2dc-b5fe460cead8&type=display
  3. https://www.drugs.com/mtm/divalproex-sodium.html
  4. https://www.depakote.com/depakote-formulations
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