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compositionComposition:AMBRISENTAN-5MG
prescription
Prescription Medicine
info
Endobloc 5 Tablet 10's
Endobloc 5 Tablet 10's
Endobloc 5 Tablet 10's
Endobloc 5 Tablet 10's
Endobloc 5 Tablet 10's

Endobloc 5 Tablet is used to treat pulmonary arterial hypertension (high blood pressure in the lungs). It contains Ambrisentan, which works by widening the blood vessels and improving blood flow. In some cases, this medicine may cause side effects such as headache, dizziness, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMBRISENTAN-5MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Endobloc 5 Tablet

Endobloc 5 Tablet is used to treat high blood pressure in the arteries of the lungs (pulmonary arterial hypertension). Pulmonary hypertension affects the arteries in the lungs and the right side of the heart.

Endobloc 5 Tablet contains Ambrisentan, which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure.

In some cases, Endobloc 5 Tablet can cause side effects like headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Please inform your doctor if you are using any prescription or non-prescription drugs, including vitamins and herbal products. It is advised to consult a doctor if you are a pregnant or breastfeeding mother. Do not stop taking Endobloc 5 Tablet without consulting your doctor, since it may worsen your condition.

Uses of Endobloc 5 Tablet

Endobloc 5 Tablet is used in the treatment of Pulmonary arterial hypertension. The detailed uses of Endobloc 5 Tablet are as follows:

  • Treatment of Pulmonary Arterial Hypertension: Endobloc 5 Tablet is used to treat Pulmonary Arterial Hypertension (PAH) by increasing blood supply to the lungs, thus lowering the blood pressure.
  • Decreases High Blood Pressure in Lung Arteries: Endobloc 5 Tablet helps reduce high pressure in the arteries between the heart and lungs.
  • Improves Exercise Tolerance: Endobloc 5 Tablet improves stamina and physical activity capacity in PAH patients.
  • Lowers Disease Progression: Endobloc 5 Tablet slows the advancement of symptoms linked to PAH.
  • Reduces Heart Strain: Endobloc 5 Tablet reduces the workload on the heart by widening blood vessels in the lungs.

Key Benefits

  • Endobloc 5 Tablet is an anti-hypertensive medicine that treats high blood pressure in the arteries of the lungs (pulmonary arterial hypertension (PAH)).
  • Endobloc 5 Tablet works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure.
  • Relaxes and widens blood vessels in the lungs.
  • Improves blood flow from the heart to the lungs.
  • Reduces strain on the heart caused by high lung pressure.
  • Lowers pulmonary blood pressure.
Side effects of Endobloc 5 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Avoid diet rich in salt and carbohydrates
  • Drink plenty of water and stay hydrated.
  • Exercise regularly and maintain a healthy lifestyle.
  • Take potassium rich foods like potatoes, spinach, tomatoes, sea food and dairy products.
  • Take beverages containing caffeine like coffee and tea.
  • Red rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Take Endobloc 5 Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to improve effectiveness.
  • Swallow Endobloc 5 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Endobloc 5 Tablet Works

Endobloc 5 Tablet contains Ambrisentan, which belongs to the class of endothelin receptor blockers. Ambrisentan works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. Endobloc 5 Tablet widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply to the lungs, thus lowering the blood pressure.
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Alcohol

Caution

It is advised to limit alcohol intake, since alcohol consumption may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Unsafe

Endobloc 5 Tablet is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting Endobloc 5 Tablet . You should get a negative pregnancy test for sure before using Endobloc 5 Tablet . Also, please use reliable forms of birth control if you are undergoing treatment with Endobloc 5 Tablet to avoid pregnancy.

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Breast Feeding

Consult your doctor

It is not known if Endobloc 5 Tablet is excreted into the breast milk. Please talk to your doctor for more information before taking Endobloc 5 Tablet if you are a nursing mother.

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Driving

Caution

Endobloc 5 Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert.

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Liver

Caution

Let your doctor know if you have any history of liver disease before taking Endobloc 5 Tablet . Endobloc 5 Tablet may cause an increase in liver enzymes. If you are using Endobloc 5 Tablet and experience any nausea, vomiting, loss of appetite, dark-coloured urine and yellowing of the skin, please see your doctor immediately.

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Kidney

Caution

Endobloc 5 Tablet should be used with caution in cases of renal impairment. It is recommended to seek a doctor's advice before starting Endobloc 5 Tablet if you have any kidney problems.

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Children

Unsafe

Safety and effectiveness of Endobloc 5 Tablet have not been established in patients below 18 years of age.

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Heart

Safe if prescribed

Endobloc 5 Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Endobloc 5 Tablet should be taken with caution in geriatric patients. Please inform your doctor before using Endobloc 5 Tablet .

What if I have taken an overdose of Endobloc 5 Tablet

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include sweating, confusion, blurred vision, dizziness, light-headedness when getting up suddenly from a sitting/lying position, or faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Reduce sodium intake in your diet to maintain your blood pressure.
  • Eat natural and healthy foods by cutting down on high-sodium processed foods.
  • Lose those extra pounds, since being obese can be a risk factor for hypertension.
  • Exercise regularly to maintain good heart health.
  • Avoid smoking and alcohol intake.
  • Chronic stress may also cause high blood pressure. Therefore, avoid stress triggers and make time for yourself to relax and do activities that you enjoy.
  • Try to include heart-healthy omega-3 fatty acids in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

Health Queries

Have a query?

How Soon It Starts Working

The time required for Endobloc 5 Tablet to start to work: The time required for Endobloc 5 Tablet to show its action is not clinically established.

The time for which the effects of Endobloc 5 Tablet last: The duration of action for Endobloc 5 Tablet is not clinically established.

What if you forget to take Endobloc 5 Tablet

If you miss a dose of Endobloc 5 Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take an extra dose to make up for a missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Inform your doctor if you have low blood pressure, lung, heart, kidney or liver problems, and anaemia (lack of blood cells).
  • Endobloc 5 Tablet is contraindicated during pregnancy since it has harmful effects on the foetus.
  • Consult your doctor before using Endobloc 5 Tablet if you are a breastfeeding mother.
  • Do not stop taking Endobloc 5 Tablet without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems.
  • Endobloc 5 Tablet is not recommended in patients younger than 18 years of age.
  • Do not drive or operate machinery since Endobloc 5 Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive.
  • Avoid consumption of alcohol with Endobloc 5 Tablet as it may increase the risk of low blood pressure.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Endobloc 5 Tablet may interact with other PAH treating medicines (iloprost, epoprostenol), impotence-treating drugs (sildenafil), antibiotics (rifampicin) and immunosuppressants (cyclosporine).

Drug-Food Interaction: Alcohol may increase the side effects of Endobloc 5 Tablet . Hence, it is advised to limit the intake of alcohol while using Endobloc 5 Tablet .

Drug-Disease Interaction: People with heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention), low blood pressure and severe dehydration should consult the doctor before taking Endobloc 5 Tablet .

AmbrisentanTeriflunomide
Severe
AmbrisentanLeflunomide
Severe

Drug-Drug Interactions

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AmbrisentanTeriflunomide
Severe
How does the drug interact with Endobloc 5 Tablet:
When Endobloc 5 Tablet and Teriflunomide are taken together, the risk or severity of developing liver injury increases.

How to manage the interaction:
Although taking Endobloc 5 Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmbrisentanLeflunomide
Severe
How does the drug interact with Endobloc 5 Tablet:
Taking leflunomide and Endobloc 5 Tablet can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Endobloc 5 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmbrisentanMipomersen
Severe
How does the drug interact with Endobloc 5 Tablet:
Taking Endobloc 5 Tablet with Mipomersen can increase the risk or severity of liver problems.

How to manage the interaction:
Taking Endobloc 5 Tablet with Mipomersen together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AmbrisentanTizanidine
Severe
How does the drug interact with Endobloc 5 Tablet:
Coadministration of Tizanidine with Endobloc 5 Tablet may increase the risk or severity of developing low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Endobloc 5 Tablet and Tizanidine, you can take these medicines together if your doctor advises. If you notice any symptoms like headache, dizziness, shortness of breath, chest pain, or sweating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AmbrisentanLomitapide
Severe
How does the drug interact with Endobloc 5 Tablet:
Taking Endobloc 5 Tablet with Lomitapide can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is a possible interaction, Endobloc 5 Tablet can be taken with Lomitapide if prescribed by the doctor. Consult the prescriber if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmbrisentanCiclosporin
Severe
How does the drug interact with Endobloc 5 Tablet:
When Endobloc 5 Tablet is taken with cyclosporine, this increases the blood levels of Endobloc 5 Tablet. This can increase the risk of serious side effects such as liver problems, anemia, and fluid accumulation (particularly in the lungs).

How to manage the interaction:
Co-administration of ciclosporin with Endobloc 5 Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience any of these symptoms such as fever with shivering, pain in your joints, swelling, bleeding or bruising easily, a rash or itchy skin, not feeling hungry, feeling tired, dark color urine, looking pale, dizziness, gaining weight suddenly, or breathing problem, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Endobloc 5 Tablet is used to treat Pulmonary arterial hypertension.
Endobloc 5 Tablet consists of Ambrisentan. It is an anti-hypertensive medicine that lowers blood pressure by widening the pulmonary arteries and making the heart pump blood efficiently.
Yes, Endobloc 5 Tablet can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve dizziness. If the side effect persists longer, please seek medical help.
Do not stop using Endobloc 5 Tablet even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.
Endobloc 5 Tablet should be used with caution in cases of any allergic reactions, heart failure, liver, kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure).
Store Endobloc 5 Tablet away from direct sunlight and at a temperature not exceeding 30°C. Keep this medicine out of the sight and reach of children.
Endobloc 5 Tablet may rarely cause liver problems. Your doctor will monitor your liver function while you're taking Endobloc 5 Tablet . If you experience symptoms like yellowing skin, dark urine, or abdominal pain, seek medical attention. Discuss any concerns with your doctor.
Take Endobloc 5 Tablet exactly as your doctor tells you to. Typically, it's one tablet once a day. Swallow the tablet whole with water, and take it at the same time each day. Don't crush, chew, or break it.
Don't stop taking Endobloc 5 Tablet without talking to your doctor first. Stopping suddenly can worsen your condition and increase the risk of heart problems. Your doctor will advise you on how to safely stop taking Endobloc 5 Tablet if needed. Follow their instructions carefully.
Endobloc 5 Tablet is used to treat high blood pressure in the lungs, but have risks and limitations. They can cause serious side effects and may not be suitable for everyone, including pregnant women and those with certain medical conditions. Always follow your doctor's instructions and ask questions if needed.
Endobloc 5 Tablet can be effective in treating certain conditions, but in some cases, it can cause serious side effects. Watch out for severe swelling, difficulty breathing or swallowing, and sudden weight gain. Additionally, be aware of extreme tiredness, yellowing of the skin or eyes, dark urine, and severe itching. If you experience any of these symptoms, call your doctor right away or seek emergency medical help. Don't delay; these side effects can be serious and require prompt attention. Discussing the potential risks and benefits with your doctor before starting treatment is essential.
You have been prescribed Endobloc 5 Tablet to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the lungs.
Avoid exceeding the recommended dose, as it could lead to an overdose. Symptoms of overdose may include sweating, confusion, blurred vision, dizziness, light-headedness when getting up suddenly from a sitting/lying position, or faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Common side effects of Endobloc 5 Tablet may include headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.
No, you should not take Endobloc 5 Tablet on your own without consulting a doctor. This medication is prescribed for specific medical conditions and requires a doctor's supervision to ensure safe and effective use.
Safety and effectiveness of Endobloc 5 Tablet have not been established in patients below 18 years of age.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - END0270

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