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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Endoblock T Kit Combipack

Endoblock T Kit Combipack is used to treat pulmonary arterial hypertension (high blood pressure affecting arteries in the lungs). Pulmonary hypertension is defined as high blood pressure in the blood veins that supply the blood to the lungs (pulmonary arteries). It can affect the arteries of the lungs and the right side of the heart. The common symptoms of pulmonary hypertension are shortness of breath, dizziness, palpitations, and chest pressure.

Endoblock T Kit Combipack is a combination of two medications: ambrisentan and tadalafil. Tadalafil belongs to a class of drugs known as phosphodiesterase-5 (PDE5) inhibitors. It aids in treating pulmonary hypertension by relaxing blood vessels in the chest. This increases blood supply to the lungs while decreasing the workload on the heart. Ambrisentan belongs to a class of drugs known as 'endothelin receptor antagonists.' Ambrisentan prevents endothelin, a naturally occurring substance that constricts blood vessels and raises blood pressure. It relaxes the constricted pulmonary arteries and increases blood supply to the lungs, lowering blood pressure.

Endoblock T Kit Combipack can be taken with or without food. Swallow the tablet whole with a glass of water; do not crush, chew or break it. You are advised to take Endoblock T Kit Combipack for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Endoblock T Kit Combipack can cause side effects like headache, flushing, blocked nose, palpitations, diarrhoea, nausea, indigestion, muscle aches and pain. These side effects are unfamiliar to everyone and vary from person to person. Please get in touch with your doctor if you experience any of the side effects persistently.

If you are allergic to any of the ingredients of Endoblock T Kit Combipack, please do not take it. Stopping Endoblock T Kit Combipack without consulting your doctor may aggravate your condition and increase your chances of future cardiac problems. Consult your doctor if you are pregnant or breastfeeding. Endoblock T Kit Combipack causes drowsiness and dizziness, so drive only if you are alert. Endoblock T Kit Combipack should not be given to children as safety and effectiveness have not been established. Alcohol should not be consumed with Endoblock T Kit Combipack since it may raise the risk of low blood pressure. Keep your doctor up to date on your medical condition and medications to rule out any potential side effects.

Uses of Endoblock T Kit Combipack

Treatment of Pulmonary arterial hypertension (PAH)

Directions for Use

• Endoblock T Kit Combipack can be taken with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Endoblock T Kit Combipack as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Endoblock T Kit Combipack is an antihypertensive drug used to treat pulmonary arterial hypertension (PAH). Endoblock T Kit Combipack contains tadalafil (PDE-5 inhibitor) and ambrisentan (endothelin receptor antagonist). Tadalafil aids in treating pulmonary hypertension by relaxing blood vessels in the chest. This increases blood supply to the lungs while decreasing the workload on the heart. Ambrisentan prevents endothelin, a naturally occurring substance that constricts blood vessels and raises blood pressure. It relaxes the constricted pulmonary arteries and increases blood supply to the lungs, lowering blood pressure.

How Endoblock T Kit Combipack Works

Endoblock T Kit Combipack is a combination of two medications: ambrisentan and tadalafil. Tadalafil belongs to a class of drugs known as phosphodiesterase-5 (PDE5) inhibitors. It aids in treating pulmonary hypertension by relaxing blood vessels in the chest. This increases blood supply to the lungs while decreasing the workload on the heart. Ambrisentan belongs to a class of drugs known as 'endothelin receptor antagonists.' Ambrisentan prevents endothelin, a naturally occurring substance that constricts blood vessels and raises blood pressure. It relaxes the constricted pulmonary arteries and increases blood supply to the lungs, lowering blood pressure.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Endoblock T Kit Combipack

Take Endoblock T Kit Combipack only as prescribed by the physician. Do not exceed the recommended dose as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to any of the ingredients of Endoblock T Kit Combipack, please do not take it. Stopping Endoblock T Kit Combipack without consulting your doctor may aggravate your condition and increase your chances of future cardiac problems. Endoblock T Kit Combipack is not recommended during pregnancy because it is harmful to the foetus. Before using Endoblock T Kit Combipack, you should definitely get a negative pregnancy test. Also, if you are undergoing treatment with Endoblock T Kit Combipack, please use reliable forms of birth control to avoid pregnancy. Brief your medical history to the doctor if you have heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure). Endoblock T Kit Combipack causes drowsiness and dizziness, so drive if you are alert. Avoid consuming alcohol with Endoblock T Kit Combipack as it may raise the chance of developing low blood pressure. Endoblock T Kit Combipack is not suggested for patients under the age of 18.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Endoblock T Kit Combipack:
Coadministration of Endoblock T Kit Combipack with Isosorbide mononitrate can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Isosorbide mononitrate with Endoblock T Kit Combipack is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Endoblock T Kit Combipack:
Taking Endoblock T Kit Combipack with Riociguat may increase the risk or severity of lower the blood pressure.

How to manage the interaction:
Taking Riociguat with Endoblock T Kit Combipack is generally not recommended as it can lead to an interaction, but it can be taken together if prescribed by a doctor. However, if you experience dizziness, headache, and nasal congestion consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Endoblock T Kit Combipack:
Taking Endoblock T Kit Combipack with Isosorbide dinitrate can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Isosorbide dinitrate with Endoblock T Kit Combipack is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TadalafilNitroprusside
Critical
How does the drug interact with Endoblock T Kit Combipack:
Taking Endoblock T Kit Combipack with Nitroprusside can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Endoblock T Kit Combipack with Nitroprusside is generally avoided as it can lead to an interaction, but it can be taken if prescribed by a doctor. If you experience dizziness, or heart palpitations, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
TadalafilAmyl nitrite
Critical
How does the drug interact with Endoblock T Kit Combipack:
Taking Endoblock T Kit Combipack with Amyl Nitrite can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Endoblock T Kit Combipack with Amyl nitrite is generally avoided as it can lead to interaction. They can be taken only when advised by a doctor. Seek immediate medical attention if you experience symptoms like dizziness, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Endoblock T Kit Combipack:
When Endoblock T Kit Combipack is taken with cyclosporine, this increases the blood levels of Endoblock T Kit Combipack. This can increase the risk of serious side effects such as liver problems, anemia, and fluid accumulation (particularly in the lungs).

How to manage the interaction:
Co-administration of ciclosporin with Endoblock T Kit Combipack can result in an interaction, but it can be taken if a doctor has advised it. If you experience any of these symptoms such as fever with shivering, pain in your joints, swelling, bleeding or bruising easily, a rash or itchy skin, not feeling hungry, feeling tired, dark color urine, looking pale, dizziness, gaining weight suddenly, or breathing problem, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Endoblock T Kit Combipack:
Coadministration of Tizanidine with Endoblock T Kit Combipack may increase the risk or severity of developing low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Endoblock T Kit Combipack and Tizanidine, you can take these medicines together if your doctor advises. If you notice any symptoms like headache, dizziness, shortness of breath, chest pain, or sweating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Endoblock T Kit Combipack:
When Endoblock T Kit Combipack and Teriflunomide are taken together, the risk or severity of developing liver injury increases.

How to manage the interaction:
Although taking Endoblock T Kit Combipack and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmbrisentanMipomersen
Severe
How does the drug interact with Endoblock T Kit Combipack:
Taking Endoblock T Kit Combipack with Mipomersen can increase the risk or severity of liver problems.

How to manage the interaction:
Taking Endoblock T Kit Combipack with Mipomersen together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AmbrisentanLomitapide
Severe
How does the drug interact with Endoblock T Kit Combipack:
Taking Endoblock T Kit Combipack with Lomitapide can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is a possible interaction, Endoblock T Kit Combipack can be taken with Lomitapide if prescribed by the doctor. Consult the prescriber if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your heart healthy by exercising on a regular basis.

  • Consume natural and nutritious foods while avoiding high-sodium processed foods.

  • Reduce your salt intake in your diet to keep your blood pressure stable.

  • Obesity is a risk factor for hypertension, so reduce those excess pounds.

  • Avoid smoking and drinking alcohol.

  • High blood pressure can also be caused by chronic stress. As a result, avoid stress and make time for yourself to relax and engage in things that you enjoy.

  • Include heart-healthy omega 3 fatty acid-containing foods and beverages in your daily diet.

  • To lower your blood pressure (BP), you can also use low-fat cooking oils such as olive oil, coconut oil, soybean oil and canola oil.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Endoblock T Kit Combipack Substitute

Substitutes safety advice
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Alcohol

Caution

It is advised to limit or quit the consumption of alcohol as it may increase the risk of low blood pressure.

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Pregnancy

Unsafe

Endoblock T Kit Combipack is not recommended in pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Endoblock T Kit Combipack in breastfeeding/nursing mothers. Endoblock T Kit Combipack should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Endoblock T Kit Combipack causes drowsiness and dizziness, so drive only if you are alert.

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Liver

Caution

Endoblock T Kit Combipack may increase liver enzymes. Before taking Endoblock T Kit Combipack, inform your doctor if you have/had liver illness.

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Kidney

Caution

In cases of renal impairment, take Endoblock T Kit Combipack with caution. If you have kidney problems, you should consult a doctor before beginning Endoblock T Kit Combipack. Your doctor will prescribe if the benefits outweigh the risks.

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Children

Unsafe

Safety and effectiveness of Endoblock T Kit Combipack have not been established in patients below 18 years of age.

Have a query?

FAQs

Endoblock T Kit Combipack is used to treat pulmonary arterial hypertension (high blood pressure affecting arteries in the lungs).

Endoblock T Kit Combipack contains Ambrisentan and tadalafil. Tadalafil aids in treating pulmonary hypertension by relaxing blood vessels in the chest. This increases blood supply to the lungs while decreasing the workload on the heart. Ambrisentan prevents endothelin, a naturally occurring substance that constricts blood vessels and raises blood pressure. It relaxes the constricted pulmonary arteries and increases blood supply to the lungs, lowering blood pressure.

Yes, Endoblock T Kit Combipack can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve dizziness. If the side effect persists longer, please seek medical help.

Even if you feel better, do not stop using Endoblock T Kit Combipack. It should be used exactly as prescribed by your doctor to minimise the recurrence of symptoms and worsening of the disease.

No, it is a medication recommended by a doctor to treat or prevent specific medical issues. Taking it on your own can result in unfavourable side effects.

Endoblock T Kit Combipack is safe if taken in the dose and for the term prescribed by your doctor. Take it exactly as directed and do not miss any doses. Follow your doctor's instructions carefully and notify the doctor if any of the adverse effects bother you.

Endoblock T Kit Combipack should be used with caution if you have any allergic reactions, heart failure, liver or renal disease, lung problems (pulmonary fibrosis), anaemia, oedema (fluid retention), or hypotension (low blood pressure).

It is recommended not to take Endoblock T Kit Combipack along with mediations used to relieve chest pain (nitrates). Please consult your doctor if you have concerns.

Endoblock T Kit Combipack should be swallowed as a whole with a glass of water with or without food or taken as directed by the physician. Do not crush or chew the tablet.

Don't stop taking Endoblock T Kit Combipack without completing the prescribed course. Stopping abruptly may lead to adverse side effects, withdrawal symptoms, or the condition returning. Consult your doctor if you have concerns.

Endoblock T Kit Combipack should be used with caution in patients with kidney problems. If you have renal impairment, inform your doctor before taking Endoblock T Kit Combipack. They will assess the benefits and risks and guide safe usage.

Taking more Endoblock T Kit Combipack than prescribed can lead to an overdose, which may cause serious side effects. Always follow your doctor's prescribed dosage and never take more than recommended.

Endoblock T Kit Combipack is not recommended for children under 18 years old, as its safety and effectiveness in this age group have not been established. If you have concerns about your child's health, please consult your doctor for personalized advice.

Endoblock T Kit Combipack should not be taken during pregnancy, as it may harm the fetus. Women who can become pregnant should have a negative pregnancy test before starting Endoblock T Kit Combipack and use two reliable birth control methods during treatment and for one month after stopping. If you miss a menstrual period or suspect pregnancy, contact your doctor immediately.

Follow your doctor's advice and take the right amount of medicine. Be aware of side effects and take care of yourself. If you're pregnant while on treatment, inform your doctor immediately. Don't take other medications unless instructed by the doctor. Alcohol consumption should be avoided. By following these precautions, you'll benefit most from your medicine and stay safe.

Endoblock T Kit Combipack causes dizziness and drowsiness that may affect your ability to drive. So, do not drive or operate machinery if you experience these.

Endoblock T Kit Combipack can lower blood pressure, specifically in the pulmonary arteries, which helps treat pulmonary arterial hypertension (PAH). However, it typically does not significantly lower systemic blood pressure in most individuals. If you have concerns about hypertension, consult your healthcare professional for a personalized treatment plan.

Common side effects of Endoblock T Kit Combipack may include headache, flushing, blocked nose, palpitations, diarrhoea, nausea, indigestion, muscle aches, and pain. Not everyone experiences side effects, and their severity can vary from person to person. Consult your doctor for guidance if you encounter persistent or troubling side effects.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - END0447

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