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  3. Endoxan Tablet 10's

Endoxan Tablet 10's, Pack of 10 TABLETS
Endoxan Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Endoxan Tablet is used to treat cancer and nephrotic syndrome (kidney disease). It contains Cyclophosphamide that stops the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

CYCLOPHOSPHAMIDE-50MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Endoxan Tablet

Endoxan Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia,  nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Endoxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Endoxan Tablet contains ‘Cyclophosphamide’, an alkylating agent that damages the genetic material of cancer cells to stop their growth and multiplication. Thus, Endoxan Tablet helps treat cancer by killing the cancer cells.
 
You are advised to take Endoxan Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Do not be reluctant to talk with your doctor if you experience any of these side effects persistently.
 
Do not take Endoxan Tablet if you are allergic to any of its components; or if you have bladder obstruction or other urination problems. Avoid taking Endoxan Tablet if you are pregnant or breastfeeding. Endoxan Tablet may cause dizziness, so drive only if you are alert. Endoxan Tablet should be given to children only if prescribed by the doctor. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Endoxan Tablet

Endoxan Tablet is used for the treatment of cancer and nephrotic syndrome (kidney disease). The detailed uses of Endoxan Tablet are as follows:

  • Cancer treatment: Endoxan Tablet is used to treat various cancers, including lymphomas, leukaemia, and breast cancer, by slowing or stopping cancer cell growth.
  • Autoimmune disorders: Endoxan Tablet helps manage autoimmune diseases like lupus and rheumatoid arthritis by suppressing the immune response and reducing inflammation.
  • Organ Transplantation: Endoxan Tablet is used in organ transplant patients to prevent rejection by suppressing the immune system.
  • Nephrotic Syndrome: Endoxan Tablet is used to treat nephrotic syndrome, especially in cases resistant to standard treatments, by reducing proteinuria and improving kidney function.
  • Scleroderma Treatment: Endoxan Tablet is involved in managing scleroderma by alleviating symptoms and slowing disease progression through immune system suppression.

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Directions for Use

• It is generally recommended to take Endoxan Tablet with food to prevent stomach upset or as advised by the doctor. • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety. • Swallow Endoxan Tablet as a whole with a glass of water. • Do not chew, crush or break it.

Medicinal Benefits

Endoxan Tablet belongs to the group of anti-cancer medicines used to treat malignant diseases such as Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma(cancer of plasma cells), Burkitt’s lymphoma, leukaemia (blood cancer), neuroblastoma (nerve tissue cancer), retinoblastoma (eye cancer), adenocarcinoma of the ovary (ovarian cancer), mycosis fungoides (T-cell lymphoma), rhabdomyosarcoma (soft tissue cancer), osteosarcoma (bone cancer), and breast carcinoma. Additionally, Endoxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Endoxan Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet helps to treat cancer by killing the cancer cells.

How Endoxan Tablet Works

Endoxan Tablet contains ‘Cyclophosphamide’, an alkylating agent that damages the genetic material of cancer cells to stop their growth and multiplication. Thus, Endoxan Tablet helps treat cancer by killing the cancer cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Endoxan Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Endoxan Tablet
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • If you are concerned about impaired spermatogenesis, talk to your doctor. They may adjust the dose if necessary or prescribe alternative medication.
  • Limit exposure to environmental toxins, smoking, and excessive alcohol consumption.
  • Regularly monitor hormone levels, such as testosterone and follicle-stimulating hormone (FSH), to detect any changes.
  • Ensure adequate zinc and folate intake, as these nutrients are essential for spermatogenesis.
  • Consume omega-3 fatty acid-rich foods or supplements, such as fish oil, to support reproductive health.

What if I have taken an overdose of Endoxan Tablet

Take Endoxan Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include black/tarry stools, red urine, unusual bleeding/bruising, unusual tiredness/weakness, signs of infection (sore throat, cough, fever), chest pain, and swelling in the ankles, feet or legs. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Endoxan Tablet if you are allergic to any of its contents; or have urinary flow obstruction, bone marrow suppression, or infections. Talk to your doctor if you have myelosuppression, immunosuppression, infections, diabetes, heart, lung, liver, or kidney problems. Inform your doctor if you are receiving any radiotherapy or chemotherapy. Avoid taking Endoxan Tablet if you are pregnant or breastfeeding. Endoxan Tablet may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with Endoxan Tablet:
Co-administration of Nalidixic acid with Endoxan Tablet may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Endoxan Tablet and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideGolimumab
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Golimumab with Endoxan Tablet may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Endoxan Tablet with Golimumab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideDeferiprone
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet and Deferiprone may increase the risk of serious and potential infections.

How to manage the interaction:
Co-administration of Endoxan Tablet with Deferiprone can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CyclophosphamideThalidomide
Severe
How does the drug interact with Endoxan Tablet:
Taking Endoxan Tablet with Thalidomide may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Endoxan Tablet can be taken with Thalidomide if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
CyclophosphamideThiotepa
Severe
How does the drug interact with Endoxan Tablet:
When Thiotepa is taken with Endoxan Tablet, can increase the blood levels or add to the medication side effects of Endoxan Tablet.

How to manage the interaction:
Although taking Thiotepa and Endoxan Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
CyclophosphamideClozapine
Severe
How does the drug interact with Endoxan Tablet:
Taking Clozapine and Endoxan Tablet may increase the risk of infection.

How to manage the interaction:
Taking Endoxan Tablet with Clozapine can possibly lead to an interaction. However, they can be taken together if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Ropivacaine with Endoxan Tablet can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Endoxan Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
CyclophosphamideLevobupivacaine
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet with Levobupivacaine can increase the risk of methemoglobinemia (low level of oxygen in the blood).

How to manage the interaction:
Co-administration of Levobupivacaine with Endoxan Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. Keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray skin, feeling sick, headaches, dizziness, tiredness, or trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
CyclophosphamideBusulfan
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet with Busulfan can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busulfan and Endoxan Tablet, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Stay protected from the sun. Avoid tanning beds and cover up with clothing, sunscreen, and sunglasses.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Endoxan Tablet Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

It is not known if alcohol affects Endoxan Tablet . Please consult your doctor.

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Pregnancy

Unsafe

Cyclophosphamide belongs to pregnancy category D. Endoxan Tablet should not be taken during pregnancy as it might cause fetal harm. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnant.

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Breast Feeding

Unsafe

Endoxan Tablet passes into breastmilk. Avoid breastfeeding while taking Endoxan Tablet .

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Driving

Caution

Endoxan Tablet may cause dizziness. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Endoxan Tablet should be used with caution in patients with renal impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Endoxan Tablet should be given to children only if prescribed by a doctor.

FAQs

Endoxan Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia, nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Endoxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.

Endoxan Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet helps to treat cancer by killing the cancer cells.

Do not stop taking Endoxan Tablet on your own. You are advised to take Endoxan Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Endoxan Tablet .

Endoxan Tablet might interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm) and could impair fertility. Before starting treatment with Endoxan Tablet , talk to your doctor regarding cryopreservation/freezing of eggs/sperm if you consider becoming parents.

Endoxan Tablet might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding, or bruising or if the wounds do not heal properly.

No, it is not safe to father a child while taking Endoxan Tablet . Use effective contraception while taking Endoxan Tablet and for at least four months after treatment. Women of childbearing age taking Endoxan Tablet should use highly effective contraceptives while taking Endoxan Tablet up to 1 year after the treatment.

Endoxan Tablet might cause myelosuppression/bone marrow suppression leading to a decrease in white blood cells. This could lead to an increased risk of infections. Regular blood tests while taking Endoxan Tablet are advised.

During treatment with Endoxan Tablet , stay protected from sun and avoid excessive sun exposure. It’s best to use sunscreen, sunglasses and protective clothing to prevent skin damage, if your immune system is weakened.

Cancer treatments like chemotherapy and radiation therapy can increase the chance of developing other cancers, which may appear years after treatment with Endoxan Tablet . The use of Endoxan Tablet is associated with a higher risk of bladder cancer. Rarely, it may also increase the risk of other cancers like acute leukaemia, and ureter cancer.

Endoxan Tablet is a chemotherapy medicine which belongs to the class of alkylating agents. It works by destroying cancer cells.

Yes, Endoxan Tablet may be used to treat nephrotic syndrome in children, especially in cases where the condition has not improved, or has recurred after using other medications. It is also an option for children who have experienced severe side effects from other treatments. However, its safety and effectiveness for nephrotic syndrome in adults have not been established.

Endoxan Tablet may cause weight loss due to decreased appetite and may be due to underlying cancer. Consult a doctor if you experience significant weight loss.

Endoxan Tablet may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. However, if these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad – 380015, Gujarat, India.
Other Info - END0101

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 10:26 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/012141s090,012142s112lbl.pdf
  2. https://www.medicines.org.uk/emc/medicine/30161#gref
  3. https://www.drugs.com/mtm/cyclophosphamide-oral-and-injection.html
  4. https://mri.cts-mrp.eu/human/downloads/NL_H_2814_002_FinalPL.pdf

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