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compositionComposition:EPIRUBICIN-50MG
prescription
Prescription Medicine
info
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Epicin RD 50mg Injection is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer. It contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, it treats cancers.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

EPIRUBICIN-50MG

Manufacturer/Marketer :

Vhb Life Sciences Inc

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Epicin RD 50mg Injection

Epicin RD 50mg Injection is a prescription chemotherapy medication used primarily to treat breast cancer, often after surgery has been performed. It belongs to a group of medicines known as anthracyclines, which help stop cancer cells from multiplying. This medicine is designed to target and destroy rapidly dividing cells throughout the body to prevent the disease from spreading or returning.

Because this medicine is given as an injection directly into a vein, it is scheduled in cycles by your healthcare team, typically every few weeks. This structured schedule allows your healthy body cells time to recover between treatments. While receiving this therapy, eating a balanced diet, staying well-hydrated, and getting plenty of rest are highly recommended to support your body's natural recovery process.

Common side effects of this medicine include temporary hair loss, nausea, tiredness, and a harmless reddish colour in your urine for a day or two after injection. While many side effects can be managed at home, you must contact your doctor immediately if you face serious issues such as a fever, chills, or sudden shortness of breath.

Before starting this medicine, tell your doctor if you have a history of heart disease, liver problems, or low blood cell counts. Do not take this if you have severe heart muscle damage, very low bone marrow function, or severe liver damage. It is also not suitable for individuals who have already received the maximum safe lifetime dose of similar chemotherapy drugs.

This medicine can interact with other drugs that strain the heart or weaken the immune system, and it should not be taken alongside live vaccines. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider immediately, as this medicine can cause harm to a developing baby.

Uses of Epicin RD 50mg Injection

Epicin RD 50mg Injection is used to treat breast cancer. The detailed uses of Epicin RD 50mg Injection are as follows:

  • Breast cancer: Epicin RD 50mg Injection is widely used, often alongside other chemotherapy medicines, after surgery to remove a tumour. It helps destroy any remaining microscopic cancer cells and lowers the risk of the cancer coming back.
  • Other advanced cancers: In certain medical situations, doctors may prescribe this medicine to help treat advanced cancers of the stomach, ovaries, or lungs by slowing down tumour growth.

Key Benefits

Epicin RD 50mg Injection helps treat certain types of breast cancer by targeting the growth and spread of cancer cells. When used as prescribed, it supports effective cancer treatment, helps reduce the risk of recurrence, and improves disease control in advanced stages.

  • Reduces the Risk of Cancer Recurrence: When used after surgery for early-stage breast cancer, this medicine helps lower the risk of the cancer returning and supports long-term treatment outcomes.
  • Slows Cancer Growth: By interfering with the growth and spread of cancer cells, this medicine helps control the progression of advanced breast cancer and limits tumour growth.
  • Improves Quality of Life: By helping control the disease and reduce cancer-related symptoms, this medicine supports better daily functioning, greater physical comfort, and improved overall quality of life during treatment.
Side effects of Epicin RD 50mg Injection
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Epicin RD 50mg Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Epicin RD 50mg Injection Works

Epicin RD 50mg Injection is a parenteral medication, meaning it must be injected directly into your body. Because of the specialised care required, it is not something you take at home. Here is how it is administered: A trained doctor or nurse will inject the medicine slowly into a large vein, either through a temporary intravenous (IV) line or a semi-permanent venous access device (like a port). The injection is always given in a hospital, oncology clinic, or infusion centre where your health can be closely monitored. The medical team will check your injection site constantly during the infusion to ensure the medicine flows smoothly and does not leak into the surrounding tissues. Your medical team will determine your specific treatment schedule. Always follow your doctor's exact instructions and attend every scheduled appointment.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

Epicin RD 50mg Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Epicin RD 50mg Injection. Use reliable methods of birth control while on treatment with Epicin RD 50mg Injection.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Epicin RD 50mg Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Safe

Epicin RD 50mg Injection does not affect your ability to drive. However, drive only if you are alert.

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Liver

Caution

Epicin RD 50mg Injection should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

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Children

Unsafe

Epicin RD 50mg Injection is not recommended for use in children, as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF leading to serious side effects.

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Heart

Consult your doctor

Epicin RD 50mg Injection should be avoided if you have heart problems, especially cardiomyopathy, heart failure, or arrhythmias. It carries a high risk of heart damage, including congestive heart failure, which can occur during or even years after treatment. Always consult your oncologist for safer alternatives tailored to your cardiac condition.

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Geriatrics

Caution

Geriatric patients can receive Epicin RD 50mg Injection, but with extra caution and close monitoring.

What if I have taken an overdose of Epicin RD 50mg Injection

Because this medication is prepared and given by trained medical staff, an overdose is highly unlikely. However, if you suspect an administration mistake has occurred, or if you experience severe side effects immediately after an infusion, notify your clinical team or seek emergency medical care right away.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water and clear fluids (such as broths or decaffeinated teas) in the days following your treatment to help your kidneys flush the medicine out of your system.
  • Practice food safety: Since this medicine lowers your white blood cell count, your body cannot fight infections easily. Avoid raw or undercooked meats, seafood, and eggs, and thoroughly wash all raw fruits and vegetables before eating.
  • Eat small, frequent meals: To manage nausea and maintain your strength, eat five or six small, bland meals throughout the day instead of three large ones.
  • Gentle mouth care: Use a very soft-bristled toothbrush and a mild, alcohol-free mouthwash to clean your teeth. This helps prevent painful mouth sores and reduces the risk of bleeding gums.
health query

Have a query?

How Soon It Starts Working

The time required for Epicin RD 50mg Injection to start to work: The peak effect of Epicin RD 50mg Injection starts immediately after the IV administration. The time for which the effects of Epicin RD 50mg Injection last: The peak effect of Epicin RD 50mg Injection lasts for 3-4 days.

What if you forget to take Epicin RD 50mg Injection

Since this medicine is given on a strict schedule by healthcare professionals at a clinic, missing a dose means missing a scheduled appointment. If you miss or need to delay an appointment, call your oncology clinic immediately to reschedule your treatment. Do not wait until your next scheduled cycle to address a missed appointment.

Storage

• Epicin RD 50mg Injection is stored and handled almost exclusively by the hospital or clinic pharmacy.

Drug Warnings

  • Speak up during injection: Tell your nurse immediately if you feel any burning, stinging, coldness, or pain at the injection site. This is a critical safety check to prevent skin and tissue damage.
  • Avoid live vaccines: Do not receive live vaccines (such as the shingles, yellow fever, or nasal spray flu vaccine) during your treatment, as your weakened immune system may not be able to protect you against the virus.
  • Use reliable birth control: Both men and women must use highly effective birth control during treatment and for several months afterwards, as this medicine can cause severe birth defects.
  • Monitor your heart health: Keep all appointments for heart monitoring tests, such as echocardiograms or MUGA scans, which your doctor will order to ensure your heart muscle remains healthy during treatment.
  • Protect your skin from the sun: This medicine can make your skin highly sensitive to sunlight. Wear protective clothing, hats, and a broad-spectrum sunscreen with a high SPF when outdoors.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart-damaging medicines: Taking this medicine with other drugs that can affect the heart (such as trastuzumab or other chemotherapy agents) can increase your risk of heart strain.
  • Bone marrow suppressants: Other treatments that lower your blood cell counts can worsen your risk of severe infections and bleeding when combined with this medicine.
  • Live vaccines: Combining this medicine with live vaccines can lead to serious, potentially life-threatening infections.
EpirubicinZiprasidone
Critical
EpirubicinChloroquine
Severe

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
How does the drug interact with Epicin RD 50mg Injection:
Using ziprasidone together with Epicin RD 50mg Injection can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Ziprasidone with Epicin RD 50mg Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinChloroquine
Severe
How does the drug interact with Epicin RD 50mg Injection:
Using chloroquine together with Epicin RD 50mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Chloroquine and Epicin RD 50mg Injection, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinInfliximab
Severe
How does the drug interact with Epicin RD 50mg Injection:
Combining Infliximab with Epicin RD 50mg Injection can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Epicin RD 50mg Injection together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, contact a doctor right away. Do not stop using any medications without a doctor's advice.
EpirubicinNilotinib
Severe
How does the drug interact with Epicin RD 50mg Injection:
Coadministration of Epicin RD 50mg Injection and nilotinib can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Epicin RD 50mg Injection and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
EpirubicinTofacitinib
Severe
How does the drug interact with Epicin RD 50mg Injection:
Taking Tofacitinib with Epicin RD 50mg Injection may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Epicin RD 50mg Injection with Tofacitinib can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - make sure to call your doctor right away. Do not discontinue any medications without first consulting your doctor.
EpirubicinBaricitinib
Severe
How does the drug interact with Epicin RD 50mg Injection:
Coadministration of baricitinib and Epicin RD 50mg Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Epicin RD 50mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
EpirubicinMoxifloxacin
Severe
How does the drug interact with Epicin RD 50mg Injection:
Using Moxifloxacin together with Epicin RD 50mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Epicin RD 50mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heart rhythm, vomiting, dizziness, difficulty breathing, or irregular heartbeat call a doctor right away. Do not discontinue any medications without consulting a doctor.
EpirubicinMifepristone
Severe
How does the drug interact with Epicin RD 50mg Injection:
Co-administration of Epicin RD 50mg Injection with mifepristone can increase the risk of irregular heart rhythms. Prolonged treatment with Mifepristone may result in low potassium levels.

How to manage the interaction:
Taking Epicin RD 50mg Injection with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
EpirubicinHaloperidol
Severe
How does the drug interact with Epicin RD 50mg Injection:
Co-administration of Epicin RD 50mg Injection and Haloperidol can affect the rhythm of the heart.

How to manage the interaction:
Co-administration of Epicin RD 50mg Injection and Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EpirubicinDisopyramide
Severe
How does the drug interact with Epicin RD 50mg Injection:
The combined use of Efavirenz and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Efavirenz and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Epicin RD 50mg Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Epicin RD 50mg Injection may temporarily or permanently affect fertility by disrupting menstrual cycles in women and reducing sperm production in men. However, you should not assume you cannot become pregnant or father a child. Because this medicine can seriously harm an unborn baby, both men and women should use effective contraception during treatment and for the period recommended by their doctor. Talk to your healthcare provider about family planning and fertility preservation before starting treatment.
Epicin RD 50mg Injection is a vesicant, meaning it can cause severe tissue damage if it leaks out of the vein during administration. If you notice burning, pain, stinging, swelling, or redness at the injection site during your infusion, tell your nurse or doctor immediately so the infusion can be stopped and appropriate treatment started. This medicine should always be administered by trained healthcare professionals.
It is completely normal for your urine to take on a reddish colour for 1 to 2 days after an injection. This is simply the natural colour of the medicine passing safely out of your body and is not a cause for alarm. Talk to your doctor if the red colour lasts longer than 48 hours or if you experience pain while urinating.
Yes, temporary hair loss is a very common side effect. It usually begins a few weeks after your first treatment cycle and can affect your scalp, eyebrows, and eyelashes. Your hair will typically start to grow back a few months after your treatment cycles are completely finished.
This medicine is given as an injection directly into a vein (intravenously). This is performed by a trained nurse or doctor in a clinic or hospital setting over a period of several minutes to an hour. Talk to your doctor if you have questions about your specific infusion setup.
This class of medicine can occasionally weaken the heart muscle, especially when given in large total amounts over time. Your medical team will perform regular heart scans before and during your treatment to make sure your heart remains strong and healthy.
It is highly recommended to avoid or limit alcohol during your treatment. Alcohol can dehydrate you, put extra strain on your liver, and worsen common side effects like nausea and stomach upset. Talk to your doctor or pharmacist for personalised advice.
Your treatment schedule is determined by your oncologist based on your specific type of cancer and health status. Typically, it is given in cycles every 3 to 4 weeks, allowing your body a rest period between injections. Talk to your doctor to understand your exact schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Mayo Clinic Staff. Drg 20063685 Inhalation and Dosage Monograph. Rochester, MN: Mayo Foundation for Medical Education; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A603003 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 050778S021Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Epirubicin hydrochloride. 2008. [Accessed on 26 Mar. 2019]Check here
  5. Epirubicin hydrochloride 2 mg/ml solution for injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 9 Oct 2025]Check here
  6. Epirubicin. Drug information (DrugBank ID: DB00445). Go.DrugBank.com [Internet]. [Accessed on 2025 Dec 12]Check here

Country of origin

India

Manufacturer/Marketer address

Plot No. 28/6, Industrial Area,Phase 2, Chandigarh (India)
Other Info - EP79663
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