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compositionComposition:DIVALPROEX-300MG
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Prescription Medicine
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Epilex Chrono 300 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

DIVALPROEX-300MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Epilex Chrono 300 Tablet

Epilex Chrono 300 Tablet is a prescription medication primarily used to treat and control various types of seizures. It is also prescribed to manage the manic phases of bipolar disorder and to prevent migraine headaches from occurring. This medication works by stabilising electrical activity in the brain to help manage these conditions.

Divalproex is available in different formulations, including delayed-release and extended-release products. These formulations are not always interchangeable on a milligram-for-milligram basis. Do not switch between different brands or release forms unless specifically instructed by your doctor.

To get the best results, you must take Epilex Chrono 300 Tablet consistently every day at the same times as directed by your doctor. You can take this medicine with or without food, but taking it with meals can help prevent an upset stomach. Eating a balanced diet and keeping a regular sleep schedule can also support your treatment and improve how you feel.

While taking this medication, you may experience mild side effects such as sleepiness, dizziness, or temporary hair thinning. However, you must contact your doctor immediately if you notice serious signs like severe abdominal pain, persistent nausea, or yellowing of your skin or eyes.

Before starting Epilex Chrono 300 Tablet , tell your doctor if you have a history of liver disease, kidney problems, or mitochondrial disorders. Do not take this if you have active liver damage or a family history of severe liver issues, as this medication can worsen these conditions.

This medicine can interact with alcohol and certain other medications, which may cause extreme drowsiness or increase the risk of liver damage. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor, as special precautions are required for these groups.

Uses of Epilex Chrono 300 Tablet

Epilex Chrono 300 Tablet is used to treat and control various types of seizures. The detailed uses of Epilex Chrono 300 Tablet are as follows:

  • Seizure disorders: Helps control and prevent various types of fits or seizures by calming overactive nerve signals in the brain.
  • Bipolar disorder: Manages manic episodes, helping to stabilise extreme mood swings, hyperactivity, and racing thoughts.
  • Migraine prevention: Reduces the frequency and severity of painful migraine headaches when taken daily as a preventive measure.
     

Key Benefits

Epilex Chrono 300 Tablet helps manage certain neurological and mood-related conditions by stabilising abnormal electrical activity in the brain. By supporting seizure control, emotional stability, and migraine prevention, it can improve daily functioning and overall quality of life. This medicine offers several key benefits:

  • Helps Control Seizure Episodes: Epilex Chrono 300 Tablet helps reduce the frequency and severity of seizures in people with epilepsy. By stabilising nerve activity in the brain, it lowers the likelihood of unexpected seizure episodes, helping improve safety, confidence, and independence in everyday life.
  • Supports Emotional and Mood Stability: For people with bipolar disorder, Epilex Chrono 300 Tablet helps regulate mood fluctuations and reduce the occurrence of mood episodes. This can support more stable relationships, improved concentration, and better participation in daily activities and responsibilities.
  • Helps Prevent Migraine Attacks: Epilex Chrono 300 Tablet can help reduce the number of migraine attacks and headache days experienced over time. By lowering the frequency of migraines, it helps minimise disruptions to work, social activities, and overall quality of life.
     
Side effects of Epilex Chrono 300 Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.

Directions for Use

Always follow your doctor's exact instructions regarding your dose and schedule. Below are standard guidelines for taking this medication:

  • Swallow the tablet or capsule whole with a full glass of water.
  • Do not crush, chew, or break the medicine, as this can affect how it is released into your body and may irritate your mouth or throat.
  • Take this medicine at the exact times prescribed by your doctor to keep a steady amount in your bloodstream.
  • If you experience stomach upset, try taking your dose with food to help protect your stomach.
     

How Epilex Chrono 300 Tablet Works

Epilex Chrono 300 Tablet works by balancing certain natural chemicals in your brain that transmit nerve signals. When brain cells become overactive, they can trigger seizures, severe mood shifts, or migraine pain. This medicine increases the levels of a calming chemical messenger called gamma-aminobutyric acid (GABA). By boosting GABA levels, Epilex Chrono 300 Tablet helps soothe hyperactive nerve pathways. This action stabilises electrical activity in the brain and prevents the sudden bursts that lead to medical symptoms.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Epilex Chrono 300 Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Epilex Chrono 300 Tablet belongs to pregnancy category D. Avoid taking Epilex Chrono 300 Tablet if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Epilex Chrono 300 Tablet may pass into breastmilk. Consult your doctor before taking Epilex Chrono 300 Tablet if you are breastfeeding.

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Driving

Unsafe

Epilex Chrono 300 Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

Epilex Chrono 300 Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Epilex Chrono 300 Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years, as they are at a higher risk of liver toxicity.

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Heart

Caution

Epilex Chrono 300 Tablet can be used in cardiac patients, but requires careful monitoring.

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Geriatrics

Caution

Epilex Chrono 300 Tablet should be used under caution in geriatric patients for conditions like bipolar mania and seizures. Please consult your physician.

What if I have taken an overdose of Epilex Chrono 300 Tablet

Do not take more than the prescribed dose of Epilex Chrono 300 Tablet as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Keep a consistent sleep schedule: Lack of sleep can trigger seizures and mood episodes, so aim for 7 to 8 hours of restful sleep every night.
  • Track your triggers: Keep a daily diary to log your meals, stress levels, and activities to identify what triggers your migraines or seizures.
  • Stay well-hydrated: Drink plenty of water throughout the day, as dehydration can worsen headaches and affect how your body processes medication.
  • Avoid alcohol entirely: Alcohol can dangerously increase sleepiness and dizziness caused by this medication and elevates the risk of liver damage.
     

Health Queries

Are Epilex Chrono 300 mg and Mazetol 200 mg outdated medications for treating seizures, and are there newer treatments available for someone who has been on these drugs for a long time?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Please be reassured that Epilex Chrono (sodium valproate) and Mazetol (carbamazepine) are not outdated. While they are older medications, they remain highly effective, reliable, and widely used gold standards for seizure control. Yes, newer medications exist with different side-effect profiles, but if your current treatment is keeping you seizure-free and comfortable, staying on them is often the safest path. Please do not make any changes on your own. I highly recommend discussing your options with your neurologist, who can safely guide you if any adjustment is needed.
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Have a query?

How Soon It Starts Working

The time required for Epilex Chrono 300 Tablet to start to work: The time required for Epilex Chrono 300 Tablet to show its action is not clinically established.

The time for which the effects of Epilex Chrono 300 Tablet last: The duration of action for Epilex Chrono 300 Tablet is not clinically established.

What if you forget to take Epilex Chrono 300 Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

•Store Epilex Chrono 300 Tablet tablets or capsules at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the bottle tightly closed in a dry place, away from direct sunlight, high heat, and moisture. Avoid storing it in bathroom cabinets where humid

Drug Warnings

  • Monitor your mental health: Pay close attention to sudden changes in mood, anxiety, or depressive feelings, and report them to your doctor immediately.
  • Check your blood tests regularly: Your doctor may schedule routine monitoring during treatment. This commonly includes liver function tests (LFTs), a complete blood count (CBC) to monitor blood cells and platelets, and serum valproate levels to ensure the medicine remains within an appropriate therapeutic range. Do not skip these appointments.
  • Do not stop taking this medicine suddenly: Stopping abruptly can cause severe, continuous seizures that can be dangerous. Always talk to your doctor before making any changes.
  • Avoid driving or operating machinery: Until you know exactly how this medicine affects you, avoid tasks that require alertness, as it can cause significant drowsiness.
  • Inspect your tablets: Before taking your dose, ensure the tablets are intact and have not been exposed to moisture, which can cause them to become sticky or degrade.
     

Drug-Drug Interactions

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Drug-Drug Interactions

  • Other anti-seizure medicines (e.g., phenytoin or carbamazepine): Taking Epilex Chrono 300 Tablet with certain anticonvulsants may alter the blood levels of either medicine, potentially reducing seizure control or increasing the risk of side effects. Your doctor may need to monitor treatment response and adjust doses accordingly.
  • Blood thinners (e.g., aspirin or warfarin): Combining Epilex Chrono 300 Tablet with anticoagulants or antiplatelet medicines may increase the risk of bruising, bleeding, or prolonged bleeding times. Closer monitoring may be required during treatment.

Drug-Food Interactions

  • Alcohol: Do not consume alcohol while taking Epilex Chrono 300 Tablet . Alcohol can significantly increase drowsiness, impair concentration and coordination, and may increase the risk of liver-related side effects.

Drug-Disease Interactions

  • Liver disease: Do not use Epilex Chrono 300 Tablet if you have active liver disease or a history of severe liver impairment. This medication can cause serious liver injury, and patients with pre-existing liver conditions may be at increased risk of severe complications.
  • Mitochondrial disorders (e.g., Alpers-Huttenlocher syndrome): Patients with certain inherited mitochondrial disorders are at a substantially increased risk of acute liver failure when taking Epilex Chrono 300 Tablet . Use is contraindicated in these individuals.
  • Urea cycle disorders: Do not take Epilex Chrono 300 Tablet if you have a urea cycle disorder. The medicine may increase ammonia levels in the blood, potentially leading to serious neurological complications and hyperammonaemia.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Epilex Chrono 300 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.
Epilex Chrono 300 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
Epilex Chrono 300 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.
Epilex Chrono 300 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.
Epilex Chrono 300 Tablet may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Epilex Chrono 300 Tablet only after consulting a doctor.
Epilex Chrono 300 Tablet may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.
No, you should not stop taking Epilex Chrono 300 Tablet without consulting your doctor, even if you feel well or your seizures have stopped. Abrupt discontinuation can worsen your condition and may trigger severe or continuous seizures. If treatment needs to be stopped, your doctor will gradually reduce the dose to minimize risks.
Before taking Epilex Chrono 300 Tablet , certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.
Epilex Chrono 300 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Epilex Chrono 300 Tablet .
Topiramate (anticonvulsant) should not be taken along with Epilex Chrono 300 Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
Epilex Chrono 300 Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
Yes, Epilex Chrono 300 Tablet can cause sleepiness, tiredness, dizziness, or drowsiness, especially when starting treatment or after a dose increase. Avoid driving or operating machinery until you know how the medicine affects you. If excessive drowsiness persists or becomes troublesome, consult your doctor.
Yes, Epilex Chrono 300 Tablet may cause hair loss or temporary hair thinning in some people. This side effect is often reversible with continued treatment or after dose adjustment. If you notice significant hair loss or if it concerns you, consult your doctor for advice.
Yes, Epilex Chrono 300 Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Epilex Chrono 300 Tablet , seeking medical attention is crucial.
Avoid consumption of alcohol while taking Epilex Chrono 300 Tablet as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking Epilex Chrono 300 Tablet , it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
An overdose of Epilex Chrono 300 Tablet can be a severe medical emergency. If you or someone you know has taken an overdose of Epilex Chrono 300 Tablet , it's crucial to seek immediate medical attention.
Epilex Chrono 300 Tablet can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
No, taking Epilex Chrono 300 Tablet during pregnancy carries a high risk of birth defects and developmental delays in the baby. You must use effective birth control while taking this medicine. If you are planning a pregnancy or become pregnant, talk to your doctor immediately.
Yes, weight gain is a known side effect for some people taking this medicine. Managing your diet and staying physically active can help control this, but if weight gain becomes a concern, talk to your doctor.
It may take several weeks of consistent use before you notice the full benefits of Epilex Chrono 300 Tablet in preventing seizures or stabilising your mood. Do not stop taking it if you do not see immediate results, and talk to your doctor.
No, you should not crush, chew, or break these tablets because they are specially designed to release the medicine slowly into your body. Crushing them can cause too much medicine to be released at once. If you struggle to swallow pills, talk to your doctor.
Generally, moderate caffeine intake is fine, but large amounts can trigger migraines or interfere with your sleep, which might affect your condition. If you notice a connection between caffeine and your symptoms, talk to your doctor.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - EPI0345

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