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  3. Eplerender-25 mg Tablet 10's

Eplerender-25 mg Tablet 10's, Pack of 10 TabletS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Eplerender-25 mg Tablet 10's is used to treat heart failure and high blood pressure. This medicine contains Eplerenone, which works by blocking the action of aldosterone and slowing the progression of heart failure, while also lowering blood pressure. In some cases, you may experience nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Before starting Eplerender-25 mg Tablet 10's, inform the doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Composition :

EPLERENONE-25MG

Manufacturer/Marketer :

Elder Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Eplerender-25 mg Tablet 10's

Eplerender-25 mg Tablet 10's is used to treat your heart failure. It reduces the risk of death or the need for hospitalisation due to heart failure. Besides this, Eplerender-25 mg Tablet 10's is also used to treat high blood pressure.

Eplerender-25 mg Tablet 10's contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

In some cases, Eplerender-25 mg Tablet 10's may cause side effects like nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Most of these side effects of Eplerender-25 mg Tablet 10's do not require medical attention and resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Eplerender-25 mg Tablet 10's if you are allergic to any of its components. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your medical conditions and medicines to prevent any potential interactions.

Uses of Eplerender-25 mg Tablet 10's

Eplerender-25 mg Tablet 10's is used to treat heart failure and high blood pressure. The detailed uses of Eplerender-25 mg Tablet 10's are as follows:

  • Treatment of heart failure: Eplerender-25 mg Tablet 10's is indicated for patients with heart failure following a recent heart attack. It helps improve heart function, reduce symptoms, and lower the risk of hospitalisation and death due to heart-related complications.
  • Management of high blood pressure: Eplerender-25 mg Tablet 10's is also prescribed to lower elevated blood pressure, either alone or in combination with other antihypertensive medications.

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Directions for Use

  • Eplerender-25 mg Tablet 10's can be taken with or without food.
  • Follow your doctor's instructions regarding the dosage and duration for effective results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Eplerender-25 mg Tablet 10's contains Eplerenone, an aldosterone antagonist that helps improve heart function and control blood pressure.
  • Eplerender-25 mg Tablet 10's is beneficial for stable patients with left ventricular systolic dysfunction and congestive heart failure following an acute myocardial infarction (heart attack).
  • It improves survival after a heart attack and helps reduce the risk of cardiovascular death and hospitalisation.
  • Eplerender-25 mg Tablet 10's is used in patients with mild but persistent heart failure symptoms, especially when previous treatments are insufficient.
  • Eplerender-25 mg Tablet 10's effectively lowers elevated blood pressure, which in turn reduces the risk of serious cardiovascular events such as stroke, heart attack (myocardial infarction), and heart failure. 
  • By blocking aldosterone (a hormone that can worsen heart failure and increase blood pressure), Eplerender-25 mg Tablet 10's helps treat heart failure and high blood pressure.

How Eplerender-25 mg Tablet 10's Works

Eplerender-25 mg Tablet 10's contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Eplerender-25 mg Tablet
  • Limit fruit intake to two servings a day, choose a low-potassium options like apples and strawberries.
  • Restrict starchy vegetables like potatoes and pumpkin to half a cup daily.
  • Avoid or limit foods like tomato products, high-bran cereals, and salty or sugary snacks.
  • Limit dairy products to 200g of yoghurt or 300ml of milk per day.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Limit fruit intake to two servings a day, choose a low-potassium options like apples and strawberries.
  • Restrict starchy vegetables like potatoes and pumpkin to half a cup daily.
  • Avoid or limit foods like tomato products, high-bran cereals, and salty or sugary snacks.
  • Limit dairy products to 200g of yoghurt or 300ml of milk per day.

What if I have taken an overdose of Eplerender-25 mg Tablet 10's

Do not take more than the prescribed dose of Eplerender-25 mg Tablet 10's as it may cause an overdose. Symptoms of overdose include dizziness, fainting, blurred vision, stomach upset, tingling in arms and legs, weakness, lack of energy, loss of muscle tone, irregular or slow heartbeat, and cold/grey skin. If you experience any of these symptoms or suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Eplerender-25 mg Tablet 10's if you are allergic to any of its components, have severe liver or kidney disease, or high levels of potassium.
  • Inform your doctor if you have kidney or liver disease, fungal infection, depression, HIV infection, bacterial infection or if you are taking immunosuppressants, or lithium (used to treat manic disorders).
  • Consult your doctor if you are pregnant or breastfeeding.
  • Eplerender-25 mg Tablet 10's is not recommended for children as the safety and effectiveness have not been established.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
EplerenonePotassium iodide
Critical
EplerenoneRitonavir
Critical

Drug-Drug Interactions

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EplerenonePotassium iodide
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Combining Eplerender-25 mg Tablet with Potassium iodide may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and Eplerender-25 mg Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneRitonavir
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Co-administration of Eplerender-25 mg Tablet and Ritonavir may significantly increase the blood levels of Eplerender-25 mg Tablet.

How to manage the interaction:
Taking Ritonavir and Eplerender-25 mg Tablet together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenoneSaquinavir
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Co-administration of EPELENONE and SAQUINAVIR may significantly increase the blood levels and side effects of Eplerender-25 mg Tablet. This can increase the risk of serious side effects like high blood potassium, which in severe cases can lead to kidney failure, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Taking saquinavir and Eplerender-25 mg Tablet together is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenonePotassium citrate
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Taking Eplerender-25 mg Tablet with Potassium citrate may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium citrate and Eplerender-25 mg Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneSpironolactone
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Combining Eplerender-25 mg Tablet with Spiranolactone may significantly increase potassium levels in the blood which can lead to kidney issues and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between spironolactone and Eplerender-25 mg Tablet, it is not recommended as it can lead to an interaction. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneNefazodone
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Coadministration of Nefazodone with Eplerender-25 mg Tablet can increase the levels of Eplerender-25 mg Tablet in the body.

How to manage the interaction:
Taking Nefazodone with Eplerender-25 mg Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenonePosaconazole
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Coadministration of posaconazole with Eplerender-25 mg Tablet can increase the blood levels of Eplerender-25 mg Tablet. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between posaconazole and Eplerender-25 mg Tablet, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EplerenoneClarithromycin
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Co-administration of Eplerender-25 mg Tablet and Clarithromycin may significantly increase the blood levels and effects of Eplerender-25 mg Tablet.This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Clarithromycin with Eplerender-25 mg Tablet is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the Doctor's advice.
EplerenoneKetoconazole
Critical
How does the drug interact with Eplerender-25 mg Tablet:
Coadministration of Ketoconazole with Eplerender-25 mg Tablet can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking ketoconazole with Eplerender-25 mg Tablet is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenoneItraconazole
Critical
How does the drug interact with Eplerender-25 mg Tablet:
The blood levels and effects of Eplerender-25 mg Tablet may be greatly increased when combined with itraconazole.

How to manage the interaction:
Although there is a possible interaction between Eplerender-25 mg Tablet and Itraconazole, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich foods such as blueberries, cherries, tomatoes, squash, and bell peppers.
  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid the consumption of too much salt or salty food.
  • Maintain a healthy weight with a BMI of 19.5-24.9.
  • Regular physical activity or exercise, like walking, improves your blood flow.
  • Avoid standing or sitting for extended periods.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ALDOSTERONE ANTAGONISTS

Eplerender-25 mg Tablet 10's Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Eplerender-25 mg Tablet 10's to avoid unpleasant side effects.

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Pregnancy

Caution

Eplerender-25 mg Tablet 10's should be used in pregnant women only if clinically needed, and the benefits outweigh the risks. Please consult your doctor if you are pregnant.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding. It should be used only if prescribed by a doctor and if the benefits outweigh the harms.

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Driving

Caution

Eplerender-25 mg Tablet 10's may cause dizziness. Dro not drive or operate machinery unless you are alert.

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Liver

Caution

Eplerender-25 mg Tablet 10's is not recommended for people with severe liver disease. Inform your doctor before starting Eplerender-25 mg Tablet 10's if you have a history of liver diseases/conditions.

bannner image

Kidney

Caution

Eplerender-25 mg Tablet 10's is not recommended for people with severe kidney disease. Inform your doctor before starting Eplerender-25 mg Tablet 10's if you have a history of kidney diseases/conditions.

bannner image

Children

Caution

Eplerender-25 mg Tablet 10's is not recommended for children below 12 years of age.

FAQs

Eplerender-25 mg Tablet 10's is used to treat heart failure and hypertension (high blood pressure).

Eplerender-25 mg Tablet 10's contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

Yes, Eplerender-25 mg Tablet 10's can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Eplerender-25 mg Tablet 10's. Please monitor your electrolyte level regularly to avoid increased blood potassium levels. Consult your doctor if you experience muscle cramps, diarrhoea, nausea, dizziness or headache.

No, Eplerender-25 mg Tablet 10's is not a blood thinner. It is a selective aldosterone blocker used to treat heart failure and high blood pressure.

Eplerender-25 mg Tablet 10's contains Eplerenone. It is an aldosterone antagonist type of potassium-sparing diuretic.

Eplerender-25 mg Tablet 10's may take up to 4 weeks to show its full effect. Keep taking Eplerender-25 mg Tablet 10's for the prescribed duration.

No, Eplerender-25 mg Tablet 10's is not known to cause erectile dysfunction. It does not have any effect on fertility.

Do not discontinue Eplerender-25 mg Tablet 10's without consulting the doctor. To treat your condition effectively, keep taking Eplerender-25 mg Tablet 10's for the prescribed duration.

Potassium-sparing diuretics increase urine production without depleting potassium reserves. Eplerender-25 mg Tablet 10's permits the body to lose sodium while retaining potassium. The amount of potassium may rise as a result. Therefore, your doctor may regularly check your potassium levels.

Your doctor might have recommended Eplerenone instead of Losartan as a blood pressure medication because losartan may have been insufficient in lowering your blood pressure. However, Eplerenone increases the risk of elevated potassium levels, which may not be suitable for you. Hence, the doctor has prescribed Eplerender-25 mg Tablet 10's along with hydrochlorothiazide to prevent the rise in potassium levels.

Before starting Eplerender-25 mg Tablet 10's, let the doctor know if you are taking aspirin. Taking aspirin with Eplerender-25 mg Tablet 10's may decrease the effects of Eplerender-25 mg Tablet 10's. Contact your doctor if you experience signs of high blood pressure such as headache, blurred vision, trouble concentrating, or dizziness.

Eplerender-25 mg Tablet 10's may cause side effects like nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Most of these side effects of Eplerender-25 mg Tablet 10's do not require medical attention and resolve over time. However, if the side effects are persistent, reach out to your doctor.

Country of origin

India

Manufacturer/Marketer address

Elder House Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai 400053.
Other Info - EPL0023

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 30, 2025 | 8:04 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021437s013lbl.pdf
  2. https://www.nps.org.au/assets/medicines/0ebbd413-7e5c-40cc-897d-a77600780bee-reduced.pdf
  3. https://medlineplus.gov/druginfo/meds/a603004.html
  4. https://www.drugs.com/mtm/eplerenone.html
  5. https://www.medicines.org.uk/emc/product/9207/pil

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