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compositionComposition:EPLERENONE-50MG
prescription
Prescription Medicine
info
Epnone 50 Tablet 10's
Epnone 50 Tablet 10's
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

EPLERENONE-50MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Epnone 50 Tablet

Epnone 50 Tablet is a prescription medicine used to treat high blood pressure and to help protect the heart after a heart attack. It belongs to a group of medications that help block a hormone in your body that causes salt and water retention. By doing so, it helps lower your blood pressure and reduces the workload on your heart.

To get the best results, you should take Epnone 50 Tablet regularly at the same time every day as prescribed by your doctor. You can take this tablet with or without food. Combining this treatment with lifestyle changes, such as eating a low-salt diet and staying physically active, can significantly improve your cardiovascular health.

While taking Epnone 50 Tablet , you may experience mild side effects like dizziness, headache, or mild stomach upset. However, it can sometimes cause your body to hold onto too much potassium, which is a serious condition. If you experience muscle weakness, an irregular heart rate, or severe numbness, contact your doctor immediately.

Do not take this medicine if you have severe kidney disease, high levels of potassium in your blood, or if you are taking other potassium-sparing water pills. You should talk to your doctor before starting Epnone 50 Tablet if you have diabetes, mild-to-moderate kidney problems, or liver damage.

Let your healthcare provider know about all other medications you take, as certain pain relievers, heart medications, and alcohol can interact with Epnone 50 Tablet and affect your kidney function or blood pressure. Pregnant or breastfeeding women, as well as elderly individuals, should consult their doctor before starting this medication to ensure it is safe for them.

Uses of Epnone 50 Tablet

Epnone 50 Tablet is used to treat heart failure and high blood pressure. The detailed uses of Epnone 50 Tablet are as follows:

  • Heart failure after a heart attack: Helps improve survival rates and reduces the risk of hospitalization by easing the strain on the heart muscle.
  • High blood pressure (hypertension): Lowers blood pressure, which helps prevent future strokes, heart attacks, and kidney problems.

Key Benefits

Epnone 50 Tablet helps improve cardiovascular health by reducing the effects of excess fluid retention and lowering strain on the heart. It also helps control blood pressure, supporting better heart function and long-term protection of vital organs. Benefits may include:

  • Helps lower and maintain healthy blood pressure levels.
  • Reduces strain on the heart and supports improved heart function.
  • Helps relieve symptoms such as fatigue and shortness of breath associated with heart failure.
  • Reduces excess fluid retention and related discomfort.
  • Helps protect the kidneys, brain, and blood vessels from damage caused by high blood pressure.
  • May reduce the risk of serious cardiovascular complications and hospitalisation.
Side effects of Epnone 50 Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

To ensure you take this medicine safely and effectively, follow these step-by-step instructions:

  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break it.
  • You can take this medicine with or without food, but try to be consistent with how you take it.
  • Take your dose at the same time every day to help keep a steady amount of the medicine in your body.

Always follow your doctor's exact instructions regarding how much and how often to take this medicine. Do not change your dose without consulting your healthcare provider first.

How Epnone 50 Tablet Works

This medicine works by blocking the action of a naturally occurring hormone in your body called aldosterone. Aldosterone tells your kidneys to hold onto sodium (salt) and water while getting rid of potassium. By blocking this hormone, Epnone 50 Tablet helps your body flush out extra salt and water through urine, which lowers blood pressure and reduces the amount of work your heart has to do to pump blood. At the same time, it helps your body retain potassium, maintaining a proper balance of essential minerals.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Epnone 50 Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Epnone 50 Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks. Please consult your doctor if you are pregnant.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding. It should be used only if prescribed by a doctor and if the benefits outweigh the harms.

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Driving

Caution

Epnone 50 Tablet may cause dizziness. Dro not drive or operate machinery unless you are alert.

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Liver

Caution

Epnone 50 Tablet is not recommended for people with severe liver disease. Inform your doctor before starting Epnone 50 Tablet if you have a history of liver diseases/conditions.

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Kidney

Caution

Epnone 50 Tablet is not recommended for people with severe kidney disease. Inform your doctor before starting Epnone 50 Tablet if you have a history of kidney diseases/conditions.

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Children

Caution

Epnone 50 Tablet is not recommended for children below 12 years of age.

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Heart

Safe if prescribed

Epnone 50 Tablet can be safely used in cardiac patients with hypertension if prescribed by a physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Epnone 50 Tablet should be used under caution in elderly patients. Close monitoring of potassium levels and kidney function is important.

What if I have taken an overdose of Epnone 50 Tablet

If you take too much of this medicine, you may experience severe dizziness, weakness, or an irregular heartbeat. Seek immediate emergency medical attention or contact a poison control center right away.

Diet & Lifestyle Advise

  • Avoid potassium-containing salt substitutes: Do not use salt substitutes that contain potassium, as they may increase the risk of dangerously high potassium levels when taken with this medicine.
  • Be mindful of high-potassium foods: Limit foods rich in potassium, such as bananas, oranges, and leafy green vegetables, unless your doctor has advised otherwise.
  • Monitor your blood pressure: Check your blood pressure regularly at home and maintain a record to share with your healthcare provider during follow-up visits.
  • Stay properly hydrated: Drink fluids as recommended by your doctor, especially if you have heart failure or other conditions that require careful fluid management.

Have a query?

How Soon It Starts Working

  • The time required for Epnone 50 Tablet to start to work: The time required for Epnone 50 Tablet to start to work is 1 to 2 hours after administration.
  • The time for which the effects of Epnone 50 Tablet last: The effect of Epnone 50 Tablet lasts for 1 to 2 days.

What if you forget to take Epnone 50 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently forget your doses.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Avoid Epnone 50 Tablet if you have certain medical conditions: Do not take this medicine if you have high potassium levels in your blood, severe kidney impairment, or significantly reduced kidney function.
  • Be careful with other medicines that affect potassium: Avoid using potassium-sparing diuretics or potassium supplements unless specifically prescribed and monitored by your doctor.
  • Inform your doctor about all medications you take: Certain medicines, including ketoconazole, itraconazole, and clarithromycin, can interact with Epnone 50 Tablet and may increase the risk of side effects.
  • Do not use if you have a history of allergy: Avoid this medicine if you have ever experienced an allergic reaction to Epnone 50 Tablet or any of its ingredients.
  • Attend all monitoring appointments: Keep all scheduled blood test appointments so your doctor can regularly check your kidney function and potassium levels.
  • Consult your doctor before taking pain relievers: Avoid using over-the-counter pain medicines, such as ibuprofen or naproxen, without medical advice, as they may affect how this medicine works and increase the risk of kidney problems.
  • Change positions slowly: Rise gradually from a sitting or lying position to help reduce dizziness and prevent falls.
  • Do not stop treatment abruptly: Continue taking this medicine as prescribed, even if you feel well, as stopping it suddenly may cause your blood pressure or heart condition to worsen.
  • Monitor potassium levels: Your doctor may check your blood potassium levels before starting Epnone 50 Tablet and at regular intervals during treatment to help prevent complications from high potassium levels.
  • Check kidney function regularly: Kidney function tests may be performed periodically to ensure your kidneys are working properly and can safely handle the medication.
  • Attend scheduled follow-up tests: Potassium levels and kidney function are often assessed within the first week of treatment, again after about one month, and periodically thereafter as advised by your doctor.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Potassium supplements or potassium-sparing water pills: Taking these together with Epnone 50 Tablet can lead to dangerously high potassium levels in your blood.
  • ACE inhibitors or ARBs (blood pressure medicines): Combining these can increase the risk of elevated blood potassium and kidney strain.
  • NSAID pain relievers (like ibuprofen): May reduce the blood-pressure-lowering effect of Epnone 50 Tablet and increase the risk of severe kidney damage.
  • Strong CYP3A4 inhibitors (such as ketoconazole or clarithromycin): Can significantly increase the concentration of Epnone 50 Tablet in your body, raising the risk of severe side effects.

Drug-Food Interactions

  • Grapefruit and grapefruit juice: Can interfere with how your body processes this medicine, leading to increased levels in your blood and a higher risk of side effects.
  • Potassium-rich salt substitutes: Must be avoided to prevent dangerous potassium accumulation.

Drug-Disease Interactions

  • High blood potassium (hyperkalemia): Do not take this medicine if you already have high potassium levels.
    Severe kidney disease: Can worsen kidney function and lead to dangerous potassium buildup.
  • Diabetes with kidney complications: Increases the likelihood of developing dangerously high potassium levels in the blood.
EplerenoneItraconazole
Critical
EplerenoneClarithromycin
Critical

Drug-Drug Interactions

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EplerenoneItraconazole
Critical
How does the drug interact with Epnone 50 Tablet:
The blood levels and effects of Epnone 50 Tablet may be greatly increased when combined with itraconazole.

How to manage the interaction:
Although there is a possible interaction between Epnone 50 Tablet and Itraconazole, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.
EplerenoneClarithromycin
Critical
How does the drug interact with Epnone 50 Tablet:
Co-administration of Epnone 50 Tablet and Clarithromycin may significantly increase the blood levels and effects of Epnone 50 Tablet.This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Clarithromycin with Epnone 50 Tablet is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the Doctor's advice.
EplerenonePotassium iodide
Critical
How does the drug interact with Epnone 50 Tablet:
Combining Epnone 50 Tablet with Potassium iodide may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and Epnone 50 Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneNefazodone
Critical
How does the drug interact with Epnone 50 Tablet:
Coadministration of Nefazodone with Epnone 50 Tablet can increase the levels of Epnone 50 Tablet in the body.

How to manage the interaction:
Taking Nefazodone with Epnone 50 Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenoneSpironolactone
Critical
How does the drug interact with Epnone 50 Tablet:
Combining Epnone 50 Tablet with Spiranolactone may significantly increase potassium levels in the blood which can lead to kidney issues and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between spironolactone and Epnone 50 Tablet, it is not recommended as it can lead to an interaction. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenonePotassium chloride
Critical
How does the drug interact with Epnone 50 Tablet:
Using Epnone 50 Tablet together with Potassium chloride may significantly increase potassium levels in the blood.

How to manage the interaction:
Taking potassium chloride with Epnone 50 Tablet is not recommended. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat, consult the doctor immediately. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneKetoconazole
Critical
How does the drug interact with Epnone 50 Tablet:
Coadministration of Ketoconazole with Epnone 50 Tablet can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking ketoconazole with Epnone 50 Tablet is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenoneRitonavir
Critical
How does the drug interact with Epnone 50 Tablet:
Co-administration of Epnone 50 Tablet and Ritonavir may significantly increase the blood levels of Epnone 50 Tablet.

How to manage the interaction:
Taking Ritonavir and Epnone 50 Tablet together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenonePosaconazole
Critical
How does the drug interact with Epnone 50 Tablet:
Coadministration of posaconazole with Epnone 50 Tablet can increase the blood levels of Epnone 50 Tablet. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between posaconazole and Epnone 50 Tablet, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EplerenoneSaquinavir
Critical
How does the drug interact with Epnone 50 Tablet:
Co-administration of EPELENONE and SAQUINAVIR may significantly increase the blood levels and side effects of Epnone 50 Tablet. This can increase the risk of serious side effects like high blood potassium, which in severe cases can lead to kidney failure, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Taking saquinavir and Epnone 50 Tablet together is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Epnone 50 Tablet is used to treat heart failure and hypertension (high blood pressure).

Epnone 50 Tablet contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

Yes, Epnone 50 Tablet can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Epnone 50 Tablet . Please monitor your electrolyte level regularly to avoid increased blood potassium levels. Consult your doctor if you experience muscle cramps, diarrhoea, nausea, dizziness or headache.

No, Epnone 50 Tablet is not a blood thinner. It is a selective aldosterone blocker used to treat heart failure and high blood pressure.

Epnone 50 Tablet contains Eplerenone. It is an aldosterone antagonist type of potassium-sparing diuretic.

For high blood pressure, it may take up to 4 weeks to see the full benefit. For heart failure, the medicine works internally to protect your heart even if you do not feel an immediate difference. Talk to your doctor if you have concerns about your progress.

No, Epnone 50 Tablet is not known to cause erectile dysfunction. It does not have any effect on fertility.

Do not discontinue Epnone 50 Tablet without consulting the doctor. To treat your condition effectively, keep taking Epnone 50 Tablet for the prescribed duration.

Potassium-sparing diuretics increase urine production without depleting potassium reserves. Epnone 50 Tablet permits the body to lose sodium while retaining potassium. The amount of potassium may rise as a result. Therefore, your doctor may regularly check your potassium levels.

Your doctor might have recommended Eplerenone instead of Losartan as a blood pressure medication because losartan may have been insufficient in lowering your blood pressure. However, Eplerenone increases the risk of elevated potassium levels, which may not be suitable for you. Hence, the doctor has prescribed Epnone 50 Tablet along with hydrochlorothiazide to prevent the rise in potassium levels.

Before starting Epnone 50 Tablet , let the doctor know if you are taking aspirin. Taking aspirin with Epnone 50 Tablet may decrease the effects of Epnone 50 Tablet . Contact your doctor if you experience signs of high blood pressure such as headache, blurred vision, trouble concentrating, or dizziness.

Epnone 50 Tablet may cause side effects like nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Most of these side effects of Epnone 50 Tablet do not require medical attention and resolve over time. However, if the side effects are persistent, reach out to your doctor.

Yes, you can take Epnone 50 Tablet with or without food. Taking it at the same time and in the same manner each day helps keep the medicine working consistently. Talk to your doctor if you have questions about your daily routine.

Your doctor will order blood tests to check your kidney function and measure the amount of potassium in your blood. Because Epnone 50 Tablet helps your body retain potassium, these tests ensure your levels remain in a safe range. Talk to your doctor for more details.

No, you should avoid salt substitutes because most of them contain potassium instead of sodium. Combining them with Epnone 50 Tablet can lead to dangerously high potassium levels in your blood. Talk to your doctor or pharmacist about safe dietary alternatives.

Unlike some other water pills, Epnone 50 Tablet does not typically cause a significant increase in urination for most patients. However, it still effectively helps your body remove excess salt and fluid. Talk to your doctor if you notice any unusual changes.

Dizziness can occur, especially when you first start taking this medicine or if your dose is increased. Rise slowly from sitting or lying down to help prevent this. If the dizziness is severe or does not go away, talk to your doctor.

You should avoid taking NSAID pain relievers like ibuprofen or naproxen without consulting your doctor first. These medicines can reduce the effectiveness of Epnone 50 Tablet and increase the risk of kidney problems. Talk to your doctor or pharmacist about safer pain relief options.

It is best to limit or avoid alcohol while taking Epnone 50 Tablet . Alcohol can increase the risk of side effects like dizziness, lightheadedness, or fainting by further lowering your blood pressure. Talk to your doctor about what is safe for you.

Epnone 50 Tablet can increase potassium levels in the blood and may affect kidney function in some people. Regular blood tests help your doctor ensure the medicine remains safe and effective and allow early detection of any problems.

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Reference

  1. U.S. Food and Drug Administration (FDA). 021437S013Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  2. MedlinePlus. A603004 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026] Check here
  3. Drugs.com Clinical Review Team. Eplerenone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  4. Electronic Medicines Compendium (EMC). Product Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  5. Eplerenone [Prescribing Information]. 2021. [Accessed on 22 Jun. 2023] Check here
  6. Hughes JC, Cassagnol M Eplerenone. [Updated 2023 May 1]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Check here
  7. Eplerenone Eplerenone. 2025. [Accessed on 11 Jan. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - EPN0003

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