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Esketo Tablet is a combination medication used in the treatment of chronic kidney disease (CKD). This medicine contains amino acids which works by preventing the unnecessary increase in urea levels in the blood and improving the metabolism of proteins. Common side effects include nausea, vomiting, diarrhoea, and abdominal pain.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

About Esketo Tablet

Esketo Tablet is a nutritional supplement prescribed to help manage chronic kidney disease (CKD). It provides essential amino acids and ketoanalogues that help prevent the buildup of harmful nitrogen waste (waste products produced when your body breaks down protein) in your blood, which helps protect your remaining kidney function. This medicine is primarily used to delay the progression of kidney damage in patients with moderate to severe kidney disease.

To get the best results, you must take Esketo Tablet consistently and exactly as your healthcare provider instructs. It is typically taken during meals, as this helps your body absorb and utilise the nutrients properly while reducing the risk of an upset stomach. Pairing this medication with a strictly managed low-protein diet is essential to help reduce the workload on your kidneys.

Most people tolerate this supplement well, but some may experience mild side effects like nausea, vomiting, or an upset stomach. You should also watch out for signs of high calcium levels, such as extreme thirst, muscle weakness, or confusion. If you notice these or any other unusual symptoms, talk to your doctor right away.

Do not take this medicine if you already have high calcium levels in your blood or suffer from a condition that disrupts how your body processes amino acids. Before starting Esketo Tablet , tell your doctor if you have a history of kidney stones, heart disease, or thyroid issues.

This supplement can interact with certain antibiotics and mineral supplements, which can make those medicines less effective. If you are pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist before taking this supplement to ensure it is safe for your specific situation.

Uses of Esketo Tablet

Esketo Tablet is used in the treatment of chronic kidney disease. The detailed uses of Esketo Tablet are as follows:

  • Chronic Kidney Disease (CKD): Esketo Tablet helps manage moderate to severe CKD by providing nutritional building blocks that prevent the accumulation of harmful nitrogen waste in your blood.
  • Malnutrition in Kidney Patients: It helps maintain proper nutrition and prevents muscle loss in individuals who must follow a restricted low-protein diet.

Key Benefits

Esketo Tablet helps support nutritional needs and kidney function in people with chronic kidney disease (CKD) who are following a low-protein diet. The following are the benefits of this medication:

  • Helps preserve existing kidney function, which may delay the need for dialysis.
  • Reduces the buildup of urea and other harmful waste products in the bloodstream.
  • May help relieve kidney-related symptoms such as fatigue, nausea, and loss of appetite.
  • Supports safe adherence to a medically prescribed low-protein diet.
  • Helps maintain muscle mass while reducing the risk of malnutrition.
  • Supports healthy phosphate balance as part of chronic kidney disease management.

Directions for Use

  • Recommended to take Esketo Tablet with food to enhance its absorption, or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Esketo Tablet Works

When your kidneys are damaged, they struggle to filter out nitrogen waste produced from the proteins you eat. Esketo Tablet works through a unique recycling process in the body. It contains the following active ingredients: Alpha Ketoanalogue: It is an essential amino acid analogue that helps your body make essential amino acids by using excess nitrogen waste. This helps reduce the build-up of harmful waste in the blood while supporting muscle health without placing extra strain on the kidneys. Histidine: It is an essential amino acid that supports the building and repair of body tissues and helps maintain overall nutrition, especially when following a low-protein diet. Lysine: It is an essential amino acid that helps maintain muscle strength and supports tissue growth and repair. It also contributes to your body's daily protein needs. Threonine: It is an essential amino acid that helps support healthy muscles and body tissues. It also plays a role in maintaining overall nutritional balance. Tryptophan: It is an essential amino acid that supports your body's protein needs and helps maintain overall health and well-being during dietary protein restriction. Tyrosine: It is a non-essential amino acid that helps support normal body functions by contributing to the production of important proteins. It also helps maintain overall nutritional health. Nitrogen Content: It provides the nitrogen needed to support the formation of essential amino acids, helping your body make better use of nutrients while limiting waste build-up. Calcium: It helps maintain healthy bones and supports normal mineral balance, which is especially important in people with chronic kidney disease.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Esketo Tablet to avoid unpleasant side-effects.

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Pregnancy

Consult your doctor

Consult a doctor before using Esketo Tablet if you are pregnant. The doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult a doctor before using Esketo Tablet if you are breastfeeding. The doctor will prescribe if the benefits outweigh the risks.

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Driving

Caution

Drive only if you are physically stable and mentally focussed. If you experience drowsiness after taking this medication, you should not drive or operate any machinery or vehicles.

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Liver

Consult your doctor

Please consult your doctor before taking Esketo Tablet if you have liver problems.

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Kidney

Safe if prescribed

Esketo Tablet can be taken safely by patients with kidney problems when prescribed.

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Children

Unsafe

The safety and efficacy of Esketo Tablet in children are not yet determined. Please consult your doctor if you have any concerns.

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Heart

Consult your doctor

Inform your doctor if you have a history of heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

The safety and efficacy of Esketo Tablet in elders are not yet determined. Please consult your doctor if you have any concerns.

What if I have taken an overdose of Esketo Tablet

If you accidentally take too many tablets, seek immediate medical attention. Overdosing can lead to dangerously high levels of calcium in your blood, which requires prompt medical evaluation.

Diet & Lifestyle Advise

  • Follow a low-protein diet: This medicine must be paired with a restricted-protein diet prescribed by a renal dietitian to prevent waste buildup in your blood.
  • Monitor your calcium intake: Since this supplement contains calcium, limit calcium-rich foods like dairy products unless advised otherwise by your healthcare provider.
  • Stay safely hydrated: Drink the exact amount of fluids recommended by your doctor; do not overhydrate or underhydrate, as fluid balance is critical in kidney care.
  • Keep track of blood tests: Attend all scheduled lab appointments to monitor your blood urea nitrogen (BUN - a test that shows how much waste your kidneys are clearing), creatinine (a marker of kidney function), calcium, and phosphate levels so your doctor can adjust your treatment if needed.
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How Soon It Starts Working

  • The time required for Esketo Tablet to start to work: Esketo Tablet ideally shows its action within 10 to 20 minutes after administration.
  • The time for which the effects of Esketo Tablet last: The duration of action for Esketo Tablet is clinically unknown.

What if you forget to take Esketo Tablet

Take the missed dose as soon as you remember during your next meal. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Esketo Tablet tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Take with food: Always take Esketo Tablet with meals. Taking it on an empty stomach may reduce its effectiveness and cause stomach discomfort.
  • Avoid extra calcium unless advised: Do not take calcium supplements or calcium-containing antacids unless your doctor tells you to. Too much calcium may increase the risk of side effects.
  • Check the tablets before use: Always check the expiry date and inspect the tablets before taking them. Do not use the medicine if it has expired or if the tablets are discoloured or damaged.
  • Inform your healthcare providers: Tell your doctor, dentist, or any other healthcare professional that you are taking this medicine, especially before surgery or medical imaging procedures.

verifiedApollotooltip
  • Antibiotics (e.g., tetracycline, ciprofloxacin): Esketo Tablet can bind to these antibiotics in the gut, reducing their absorption. Space them out by taking them at least two hours before or after this medicine.
  • Iron Supplements: May have reduced absorption when taken at the same time as this supplement.
  • Heart medications (e.g., digoxin): High calcium levels caused by this supplement can increase the risk of irregular heartbeats if you take digoxin.

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verifiedApollotooltip
  • High-protein foods: Eating too much protein while taking this medicine can overwhelm your kidneys and make the treatment less effective.
  • Calcium-fortified foods: Avoid excessive consumption of calcium-enriched products to prevent high blood calcium levels.

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FAQs

Esketo Tablet is used in the treatment of chronic kidney disease.Â
Esketo Tablet mimics the same catabolic pathways as amino acids and works by improving the protein metabolism, thereby improving renal function.
To treat your condition effectually, continue taking Esketo Tablet for as long as your doctor has prescribed. Please do not stop taking Esketo Tablet without consulting your doctor.
CKD is usually caused by various conditions such as high blood pressure, diabetes, high cholesterol, kidney infections, kidney inflammation, kidney stones that keep coming back, or an enlarged prostate, long-term, regular use of certain medicines lithium and non-steroidal anti-inflammatory drugs (NSAIDs).
CKD can be diagnosed using blood and urine tests such as glomerular filtration rate, serum creatinine levels and blood tests for urea nitrogen.
There are usually no symptoms of kidney disease in the early stages. At a more advanced stage, symptoms can include tiredness, swollen ankles, feet or hands, shortness of breath, feeling sick, blood in your pee (urine).
No, Esketo Tablet is not the same as arginine alpha-ketoglutarate. Esketo Tablet contains Alpha Ketoanalogue, Histidine, Lysine, Threonine, Tryptophan, Tyrosine, Nitrogen, and Calcium, whereas arginine alpha-ketoglutarate is a combination of alpha-ketoglutaric acid & essential amino acid arginine.
Esketo Tablet should be swallowed as a whole with water; do not crush or chew it.
Side effects of Esketo Tablet include nausea, vomiting, diarrhoea, and abdominal pain. Talk to your doctor if you experience these side effects persistently.
No, you should take Esketo Tablet with or during your meals. Taking it with food helps your body properly absorb and use the nutrients to recycle waste products. Talk to your doctor or pharmacist if you struggle to take it with meals.
Esketo Tablet works by recycling the nitrogen waste produced from protein metabolism. If you eat too much protein, your body will generate more waste than the medicine can handle, which puts extra strain on your kidneys. Talk to your doctor or a renal dietitian for a personalised diet plan.
No, Esketo Tablet does not cure chronic kidney disease, but it helps slow down its progression and preserves remaining kidney function. This can delay the need for dialysis. Talk to your doctor about your long-term treatment goals.
Mild digestive issues like constipation or upset stomach can happen. Do not start any over-the-counter laxatives or fibre supplements without guidance, as they can interfere with your mineral levels. Talk to your doctor or pharmacist for a safe solution.
Generally, you should avoid taking additional calcium supplements because Esketo Tablet already contains calcium. Combining them can lead to dangerously high blood calcium levels. Talk to your doctor before taking any other supplements.
Your doctor will likely order regular blood tests (usually every few weeks or months) to check your calcium, phosphate, and kidney function levels. This helps ensure the medicine is working safely. Talk to your doctor to understand your testing schedule.
The safety of this medicine during pregnancy is not fully established. If you are pregnant or planning to become pregnant, talk to your doctor to weigh the benefits and potential risks before taking this supplement.
While there is no direct interaction between alcohol and Esketo Tablet , alcohol can put extra strain on your liver and kidneys and affect your hydration. It is best to avoid or strictly limit alcohol. Talk to your doctor or pharmacist for specific advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Office No. C-247, Sobo Centre Near S.P. Ring Road, South Bopal Near Sun City, Ahmedabad Ahmedabad Gj 380058 India
Other Info - ESK0007

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