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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Espra DSR Capsule is used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers. It contains Esomeprazole and Domperidone, which blocks acid production and increases the movements and contractions of stomach muscles. Thus, helps in treating acidity-related problems. It may cause common side effects, such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Espra DSR Capsule

Espra DSR Capsule belongs to the class of drugs known as Proton pump inhibitors, which reduce the amount of acid your stomach produces. It treats gastroesophageal reflux disease (GERD), stomach ulcers, Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour), duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.

Espra DSR Capsule is a combination of Esomeprazole and Domperidone that helps reduce stomach acid by blocking the action of an enzyme (H+/K+ ATPase, also known as the gastric proton pump), thus preventing the release of stomach acid and relieving symptoms of food pipe lining inflammation (esophagitis), gastroesophageal reflux disease (GERD), or heartburn.

Not everyone who is taking Espra DSR Capsule will get these side effects. In some cases, you may experience certain common side effects, such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side effects do not require medical attention and will resolve over time. However, if you experience these side effects persistently, talk to your doctor.

Take Espra DSR Capsule as advised. Your physician will decide the dosage based on your medical condition. You should take Espra DSR Capsule 30 minutes before food. It is recommended not to exceed the recommended dose of Espra DSR Capsule . Do not chew, crush, or break the medicine.

Inform your physician if you are allergic to Espra DSR Capsule . Consult your doctor before taking Espra DSR Capsule if you are pregnant or breastfeeding. Espra DSR Capsule may cause dizziness, so drive only if you are alert. Espra DSR Capsule should not be given to children as safety has not been established. Avoid consuming alcohol and Espra DSR Capsule as it could lead to increased drowsiness and elevate stomach acid production.

Uses of Espra DSR Capsule

Espra DSR Capsule is used to treat Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and Stomach ulcers. The detailed uses of Espra DSR Capsule are as follows: <br/>

  • Gastric reflux disease (GERD): By lowering stomach acid, Espra DSR Capsule helps control GERD symptoms such as acid reflux, regurgitation, and heartburn.<br/>
  • Ulcer Treatment: Espra DSR Capsule promotes healing and inhibits recurrence by treating duodenal and stomach ulcers.<br/>
  • Zollinger-Ellison Syndrome: By lowering the production of excessive stomach acid, Espra DSR Capsule helps to control symptoms and avoid problems.<br/>
  • Management of Erosive Esophagitis: Espra DSR Capsule heals esophageal damage brought on by acid reflux by treating erosive esophagitis.<br/>
  • Relief from nausea and vomiting: Espra DSR Capsule offers immediate relief by blocking certain substances in the body that cause nausea and vomiting.<br/>

Directions for Use

• Take Espra DSR Capsule an hour before your meal, ideally in the morning or as advised by a doctor. • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety. • Swallow the medicine as a whole with glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

  • Espra DSR Capsule is effective in healing erosive esophagitis (inflammation of the food pipe), heartburn, Zollinger-Ellison syndrome, duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.
  • Espra DSR Capsule works by irreversibly blocking the proton pump gate, which secretes stomach acid. It can be prescribed to all age groups, including special populations like the elderly, pregnant, lactating mothers, and patients with kidney and liver disease.
  • Espra DSR Capsule helps manage acidity-related conditions, promotes digestion, and provides relief from associated discomfort.

How Espra DSR Capsule Works

Espra DSR Capsule is a combination of two drugs: Esomeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Esomeprazole works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Espra DSR Capsule helps in treating acidity-related problems.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Espra DSR Capsule

Do not take more than the prescribed dose of Espra DSR Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Avoid taking Espra DSR Capsule if you are allergic to Espra DSR Capsule or have any history of gastric cancer, liver disease, low magnesium levels, or low vitamin B1.
  • Inform your doctor before taking Espra DSR Capsule if you have severe kidney, heart or liver disease, or if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems or HIV infection.
  • Talk to your doctor if you experience weight loss, problems with swallowing, stomach pain, indigestion, vomit food or blood, or if you pass black stools while taking Espra DSR Capsule .
  • On long-term treatment, Espra DSR Capsule may cause low magnesium levels, vitamin B12 levels, and might increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition.
  • Consult your doctor if you are pregnant or breastfeeding.
  • Espra DSR Capsule may cause dizziness, so drive only if you are alert.
  • Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes).
  • Espra DSR Capsule should not be given to children as safety has not been established.
  • Avoid consuming alcohol along with Espra DSR Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.
  • A prolonged intake of Espra DSR Capsule is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor. 

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
How does the drug interact with Espra DSR Capsule:
Espra DSR Capsule may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Espra DSR Capsule with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Espra DSR Capsule:
Co-administration of Espra DSR Capsule with Meloxicam can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Meloxicam with Espra DSR Capsule is not advised as it can possibly result in an interaction, it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness.
How does the drug interact with Espra DSR Capsule:
Taking cidofovir with Espra DSR Capsule may increase the risk or severity of kidney problems

How to manage the interaction:
Taking Espra DSR Capsule with Cidofovir is generally avoided as it can possibly result in an interaction. You should seek immediate medical attention if you develop signs and symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
How does the drug interact with Espra DSR Capsule:
Coadministration of Ketorolac with Espra DSR Capsule can increase the risk or severity of gastric bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac with Espra DSR Capsule together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Espra DSR Capsule:
Espra DSR Capsule may interfere with the absorption of Acalabrutinib and reduce their efficacy.

How to manage the interaction:
Taking Espra DSR Capsule with Acalabrutinib together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
How does the drug interact with Espra DSR Capsule:
Espra DSR Capsule decreases the absorption of Pazopanib. This results in reduced efficacy of Pazopanib.

How to manage the interaction:
Although taking Espra DSR Capsule and Pazopanib can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.
How does the drug interact with Espra DSR Capsule:
Using Dasatinib together with Espra DSR Capsule may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Espra DSR Capsule together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Espra DSR Capsule:
Taking tacrolimus with Espra DSR Capsule may significantly increase the blood levels of tacrolimus, which can lead to an increased risk of side effects.

How to manage the interaction:
Although taking Espra DSR Capsule with Tacrolimus can result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience irregular heartbeat, blurring of vision, fever, chills, or muscle spasms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Espra DSR Capsule:
Combining Espra DSR Capsule with Citalopram can increase the risk of irregular heart rhythm. .

How to manage the interaction:
Co-administration of Espra DSR Capsule with Citalopram can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any symptoms like irregular heart rhythm, dizziness, fainting, or shortness of breath, it's important to contact your doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Espra DSR Capsule:
Espra DSR Capsule can make Dacomitinib less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Espra DSR Capsule with Dacomitinib can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating as it causes acid reflux.
  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
  • Practise relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Espra DSR Capsule . Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

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Pregnancy

Consult your doctor

Consult your doctor before taking Espra DSR Capsule if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Espra DSR Capsule ; your doctor will decide whether Espra DSR Capsule can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Espra DSR Capsule may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Dose adjustment may be needed. Consult your doctor before taking Espra DSR Capsule if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed. Consult your doctor before taking Espra DSR Capsule if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Espra DSR Capsule should not be given to children as safety and effectiveness were not established.

Have a query?

FAQs

Espra DSR Capsule is used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers.

Espra DSR Capsule contains Esomeprazole and Domperidone. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Espra DSR Capsule helps in treating acidity.

Diarrhoea might be a side-effect of Espra DSR Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you experience excessive diarrhoea or if you find blood in your stools.

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Dry mouth could be a side-effect of Espra DSR Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help stimulate saliva and thereby prevent drying of the mouth.

Espra DSR Capsule contains domperidone which helps in treating nausea and vomiting by increasing the movements and contractions of stomach muscles.

Do not take Espra DSR Capsule for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Espra DSR Capsule for 14days.

Espra DSR Capsule should not be taken along with HIV medicines such as atazanavir, ritonavir, nelfinavir, and saquinavir as Espra DSR Capsule might affect their absorption. Consult your doctor before taking Espra DSR Capsule with other medicines to avoid unpleasant side-effects.

On long-term treatment, Espra DSR Capsule might increase the risk of bone fracture in the spine, wrist or hip. Inform your doctor if you have osteoporosis or if you are taking corticosteroids, as they can increase the risk of bone fractures.

Espra DSR Capsule belongs to a group of gastrointestinal agents. It contains Esomeprazole and Domperidone, which help treat acidity-related conditions.

Yes, it is safe to use Espra DSR Capsule if prescribed by the doctor. Take it in the dose and duration prescribed by the doctor.

Take Espra DSR Capsule on an empty stomach, 1 hour before meals.

Espra DSR Capsule may cause abnormal heartbeat. Consult the doctor if you have symptoms of irregular heartbeat like fainting, dizziness, and palpitations.

Espra DSR Capsule should not be used if you are allergic to any of its components or other proton pump inhibitors (such as pantoprazole, rabeprazole, lansoprazole or omeprazole); if you are taking nelfinavir (used to treat HIV); if you have prolactinoma (tumour of the pituitary gland), blockage in intestines, bleeding in stomach or intestine, moderate to severe liver disease, low level of potassium or magnesium or high levels of magnesium, or heart problems.

Dry mouth could be a side effect of Espra DSR Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent mouth drying.

Espra DSR Capsule may cause dizziness. Do not drive or operate machinery unless you are alert.

Yes, inform the doctor if you are pregnant or breastfeeding before taking Espra DSR Capsule . The doctor will prescribe Espra DSR Capsule if the benefits outweigh the risks.

If you miss a dose of Espra DSR Capsule take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

Avoid consumption of alcohol while taking Espra DSR Capsule . Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

Store Espra DSR Capsule at room temperature (not exceeding 30°C) protected from light and moisture. Keep out of reach of children.

Side effects of Espra DSR Capsule include dry mouth, stomach pain, diarrhoea, headache, and flatulence. Talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - ESP0074

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