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compositionComposition:ETHIONAMIDE-250MG
prescription
Prescription Medicine
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Ethide 250 Tablet is an antibiotic used to treat tuberculosis (TB). It is used in combination with other tuberculosis medicines. It contains Ethionamide, which kills or prevents the growth of bacteria. It may cause common side effects such as nausea, vomiting, stomach pain, diarrhoea, increased saliva, strange metallic taste, or mouth sores.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ETHIONAMIDE-250MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Ethide 250 Tablet

Ethide 250 Tablet is a prescription medicine used alongside other medications to treat active tuberculosis (TB). It belongs to a class of medicines that target and stop the growth of the bacteria responsible for this serious infection. Because tuberculosis bacteria are highly resilient, this medicine is never used alone and must always be taken as part of a multi-drug treatment plan to ensure all bacteria are eliminated.

To get the best results, you must take Ethide 250 Tablet consistently and exactly as prescribed, usually once daily. Taking your doses at the same time every day helps maintain a steady level of the medicine in your body, which prevents the bacteria from becoming resistant to the treatment. You can take this tablet with or without food, though taking it with meals or at bedtime can help reduce common stomach upset. Alongside your medication, eating a nutritious, calorie-rich diet and staying well-hydrated will support your body's healing process.

While taking Ethide 250 Tablet , you may experience some common side effects such as nausea, a metallic taste, or a loss of appetite. However, you must contact your doctor immediately if you notice serious symptoms like yellowing of your skin or eyes, dark urine, or severe numbness and tingling in your hands or feet. These can be early signs of liver damage or nerve irritation that require prompt medical evaluation.

Do not take this if you have severe liver damage, as this medicine can place extra strain on your liver. Before starting Ethide 250 Tablet , it is highly important to talk to your doctor if you have a history of liver disease, kidney problems, diabetes, thyroid issues, or depression. Your doctor will weigh the benefits and risks to ensure this is the safest treatment option for your specific health profile.

This medicine can interact with several other substances, especially alcohol, which significantly increases the risk of severe liver damage and should be completely avoided. It may also interact with other prescription medicines, so you must share a complete list of everything you take with your healthcare provider. If you are pregnant, breastfeeding, or are an older adult, you must talk to your doctor, as your treatment may require closer monitoring or specialised dosage adjustments.

Uses of Ethide 250 Tablet

Ethide 250 Tablet is used in combination with other medicines to treat tuberculosis and certain other infections caused by susceptible mycobacteria. Its uses include:

  • Active Tuberculosis (TB): Ethide 250 Tablet is used in combination with other anti-tuberculosis medications to treat active infections, particularly cases that are resistant to first-line treatments.
  • Atypical Mycobacterial Infections: In specific cases, doctors may prescribe Ethide 250 Tablet to treat other complex, resistant bacterial infections caused by mycobacteria.

Key Benefits

Ethide 250 Tablet is an antibiotic used with other medicines to treat tuberculosis, particularly certain drug-resistant forms of the infection. Combination treatment helps control the bacteria and reduce the risk of further resistance.

  • Treats Drug-Resistant Tuberculosis: Helps control tuberculosis caused by bacteria that are resistant to some commonly used anti-tuberculosis medicines.
  • Stops Bacterial Growth: Interferes with processes that tuberculosis bacteria need to grow and survive, helping the other medicines in the treatment regimen clear the infection.
  • Supports Recovery: As the infection comes under control, symptoms such as persistent cough, night sweats, fatigue, and unintentional weight loss may gradually improve.
  • Helps Prevent Disease Progression: Effective treatment may reduce the risk of tuberculosis worsening or spreading to other parts of the body.
  • Supports Successful Combination Treatment: When taken consistently as part of the full prescribed regimen, Ethide 250 Tablet contributes to tuberculosis control and helps reduce the risk of additional drug resistance.
Side effects of Ethide 250 Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Regularly brush your tongue and teeth to prevent Excessive Saliva Production.
  • Avoid eating foods high in sugar or acid since these foods might increase saliva production, which increases the Excessive Saliva Production.
  • Keep your head up straight and maintain proper posture to prevent saliva from collecting in your mouth.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.

Directions for Use

  • Take Ethide 250 Tablet with or without food as advised by your doctor.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow Ethide 250 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Ethide 250 Tablet Works

Ethide 250 Tablet contains ethionamide, an antibacterial medicine that targets tuberculosis bacteria specifically. It works by blocking the chemical processes the bacteria need to build their protective outer wall. Without this essential outer shield, the bacteria cannot grow, multiply, or survive within your tissues. Because these bacteria are exceptionally strong, Ethide 250 Tablet works in tandem with other prescribed antibiotics to successfully break down the bacteria's defences and clear the infection completely.
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Alcohol

Unsafe

Avoid alcohol consumption while taking Ethide 250 Tablet as it could lead to increased dizziness or mental/mood changes.

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Pregnancy

Caution

Pregnancy Category C: There are no adequate and well-controlled studies in pregnant women. It is unknown whether Ethide 250 Tablet can cause fetal harm when administered to a pregnant woman. It should not be used in pregnant women.

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Breast Feeding

Unsafe

Ethide 250 Tablet may pass into breast milk. Do not breastfeed while taking Ethide 250 Tablet .

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Driving

Unsafe

Ethide 250 Tablet may cause dizziness, vision problems, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Unsafe

Do not use ethionamide if you have severe liver disease. consult your doctor if you have any concerns.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or kidney impairment/kidney disease before taking Ethide 250 Tablet .

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Children

Caution

Ethide 250 Tablet should not be used in children without a doctor's advice.

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Heart

Unsafe

Ethide 250 Tablet is not recommended for use in heart patients. This medicine has a block box warning- risk of blood clots.

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Geriatrics

Caution

Ethide 250 Tablet can be given in elderly patients with extreme caution, due to the increased risk of liver/kidney/heart problems.

What if I have taken an overdose of Ethide 250 Tablet

If you suspect an overdose, seek immediate emergency medical attention or contact a poison control centre. Symptoms of an overdose can include severe nausea, vomiting, extreme dizziness, or confusion.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Drinking alcohol while taking Ethide 250 Tablet greatly increases the risk of severe liver damage and can worsen dizziness or confusion.
  • Eat calorie- and protein-rich foods: Tuberculosis can weaken your body and cause weight loss. Focus on a highly nutritious diet filled with lean proteins, healthy fats, and whole grains to support tissue repair and boost your energy.
  • Ask about Vitamin B6: This medicine can interfere with how your body uses Vitamin B6, which may lead to nerve tingling or pain. Talk to your doctor about whether taking a daily Vitamin B6 (pyridoxine) supplement is right for you.
  • Manage nausea with smaller meals: If you struggle with appetite loss or nausea, eating five or six small meals throughout the day instead of three large ones can make it easier to maintain your nutrition.
health query

Have a query?

How Soon It Starts Working

The time required for Ethide 250 Tablet to start to work: Ethide 250 Tablet ideally shows its action within 2 to 4 hours after administration. The time for which the effects of Ethide 250 Tablet last: The effect of Ethide 250 Tablet lasts for 12 hours.

What if you forget to take Ethide 250 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor if you miss multiple doses in a row.

Storage

• Store Ethide 250 Tablet tablets at a controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Keep your lab appointments: Your doctor will need to run regular blood tests to check your liver health while you take Ethide 250 Tablet . Always attend these scheduled appointments so that your liver function can be monitored.
  • Monitor your blood sugar: If you have diabetes, this medicine can affect your blood glucose levels. Check your blood sugar closely and report any unusual changes to your doctor.
  • Schedule regular eye exams: Because this medicine can occasionally affect your eyesight, have your eyes checked before starting the medicine and report any vision changes immediately.
  • Avoid driving if you feel dizzy: This medicine can cause drowsiness or dizziness. Do not drive or operate machinery until you are certain how this medicine affects you.
  • Finish the entire course: Even if your symptoms go away quickly, you must finish the complete course of treatment to ensure the infection does not return.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Ethide 250 Tablet :

  • Other tuberculosis treatments (such as isoniazid or rifampin): Taking these in combination with Ethide 250 Tablet can increase the likelihood of liver damage and nerve irritation.
  • Anti-seizure medications: This medicine can raise the levels of certain seizure drugs in your body, increasing the risk of their side effects.
EthionamideLeflunomide
Severe
EthionamideMipomersen
Severe

Drug-Drug Interactions

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EthionamideLeflunomide
Severe
How does the drug interact with Ethide 250 Tablet:
Coadministration of leflunomide with leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although taking Ethide 250 Tablet with Leflunomide can result in an interaction, they can be taken together if prescribed by your doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
EthionamideMipomersen
Severe
How does the drug interact with Ethide 250 Tablet:
Taking mipomersen with Ethide 250 Tablet can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Ethide 250 Tablet and Mipomersen, but it can be taken if prescribed by a doctor. However, contact a doctor if you experience fever, joint pain, swelling, skin rash, vomiting, abdominal pain, or dark urine. Do not stop using any medications without talking to your doctor.
EthionamideLomitapide
Severe
How does the drug interact with Ethide 250 Tablet:
Coadministration of lomitapide with Ethide 250 Tablet can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Ethide 250 Tablet and Lomitapide, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain, swelling, skin rash, itching, bleeding, tiredness, stomach ache, dark urine. Do not stop using any medications without a doctor's advice.
EthionamideRifampicin
Severe
How does the drug interact with Ethide 250 Tablet:
Taking rifampicin with Ethide 250 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Ethide 250 Tablet and Rifampicin, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, joint pain, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
EthionamideKetoconazole
Severe
How does the drug interact with Ethide 250 Tablet:
Coadministration of Ketoconazole and Ethide 250 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ethide 250 Tablet with Ketoconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
EthionamideTeriflunomide
Severe
How does the drug interact with Ethide 250 Tablet:
Taking Teriflunomide with Ethide 250 Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking Ethide 250 Tablet with Teriflunomide together can result in an interaction, but it can be taken if your doctor has advised it. If you have any symptoms - fever, joint pain, swelling, skin rash, vomiting, abdominal pain, dark-coloured urine - immediately contact your doctor. Do not stop using any medications without talking to your doctor.
EthionamideEthanol
Severe
How does the drug interact with Ethide 250 Tablet:
Excessive alcohol use while taking Ethide 250 Tablet can increase the risk of side effects.

How to manage the interaction:
Although taking Ethide 250 Tablet and Ethanol together can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience hallucinations(seeing & hearing things that do not exist) and abnormal thinking. Do not stop using any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods or drinks may affect the safety or tolerability of Ethide 250 Tablet . Important interactions include:

  • Alcohol: Drinking alcohol while on this medicine significantly elevates your risk of severe liver damage and can trigger central nervous system side effects like confusion or coordination issues.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Ethide 250 Tablet is used to treat tuberculosis.
Ethide 250 Tablet is an antibiotic which works by inhibiting the synthesis of mycolic acid (a saturated fatty acid found in the bacterial cell wall), thereby stopping the synthesis of the bacterial cell wall. Eventually, this leads to bacterial cell wall disruption. Ethionamide may have bacteriostatic or bactericidal in action. Ethionamide indicated in the treatment of active tuberculosis in patients with Mycobacterium tuberculosis infection resistant to rifampin or isoniazid.
Do not stop taking Ethide 250 Tablet despite symptomatic relief. Treat your condition effectually, continue taking Ethide 250 Tablet for as long as it has been prescribed for you.
Ethide 250 Tablet might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking Ethide 250 Tablet . Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate contraception method.
Ethide 250 Tablet might affect vision rarely. It may cause blurred/decreased/double vision, colour blindness, or eye pain. Inform your doctor right away if you notice/experience any of these serious side effects. Do not drive if you experience any of these symptoms.
Ethionamide might interfere with live bacterial vaccines and cause them not to work as well. Do not have any immunizations/vaccinations while on this medication.
Yes, it is safe to use other tuberculosis medications with Ethide 250 Tablet if prescribed by the doctor.
Ethide 250 Tablet should not be given to children under 12 years of age as its safety and effectiveness were not established. Consult the doctor if you have any concerns.
Ethide 250 Tablet belongs to a group of medications called antibiotics. It treats tuberculosis, an infectious disease that primarily affects the lungs. It works by inhibiting the growth of the bacteria responsible for tuberculosis (Mycobacterium tuberculosis).
Ethide 250 Tablet contains ethionamide, which is classified as a second-line drug because it is used to treat tuberculosis (TB) when first-line drugs are ineffective, poorly tolerated, or result in resistance. These medications are generally reserved for more complex or drug-resistant TB cases.
Avoid breastfeeding while taking Ethide 250 Tablet as it passes into breast milk. Do not drink alcohol while taking Ethide 250 Tablet , as it may increase the risk of liver issues or cause changes in mood and mental state. Drive cautiously while taking Ethide 250 Tablet as it may cause dizziness and vision problems. If you have diabetes, check your blood sugar levels carefully. the doctor may suggest regular blood tests to monitor your liver and thyroid function, as well as frequent vision tests while taking Ethide 250 Tablet .
Ethide 250 Tablet should be taken for as long as it has been prescribed by the doctor. The dose and duration will be determined by the doctor based on your medical condition.
The doctor may suggest regular blood tests to monitor your liver and thyroid function, your health condition and the effectiveness of the medicine.
Contact the doctor immediately if you experience symptoms of liver toxicity like nausea, loss of appetite, dark urine, pale stools, jaundice (yellowing of the skin or eyes), or pain and tenderness in the upper right abdomen.
The doctor may recommend taking vitamin B6 (pyridoxine) with Ethide 250 Tablet , to help prevent certain side effects, such as nerve problems.
Ethide 250 Tablet may cause aggression as a side effect in some individuals. These symptoms may be related to Ethide 250 Tablet or other TB medications. It is important to discuss these changes with their family or doctor for proper management and care.
The side effects of Ethide 250 Tablet include diarrhoea, abdominal pain, nausea, vomiting, increased saliva, strange metallic taste, or sores in the mouth. Consult the doctor if any of these symptoms persist or worsen.
No, you should not drink alcohol while taking Ethide 250 Tablet . Combining alcohol with this medicine increases your risk of severe liver damage and can cause side effects like confusion, drowsiness, and dizziness. Talk to your doctor if you need support avoiding alcohol.
You can take Ethide 250 Tablet either with or without food. However, since upset stomach and nausea are very common side effects of this medicine, taking it with a meal or just before bed can help make it easier on your stomach. Talk to your doctor or pharmacist if stomach discomfort persists.
Numbness, tingling, or a burning sensation in your hands or feet can occur because this medicine sometimes interferes with your body's nerve function. This is often managed by taking a daily Vitamin B6 (pyridoxine) supplement. Talk to your doctor right away if you experience these sensations.
Tuberculosis treatment is a long-term process that can last anywhere from several months to two years, depending on your infection. You must continue taking Ethide 250 Tablet for the exact duration your doctor prescribes, even if you feel completely healthy. Talk to your doctor before making any changes to your therapy.
Yes, in rare cases, this medicine can affect your eyes, leading to blurred vision or difficulty distinguishing colours. Your doctor may recommend baseline and regular eye checkups during treatment. If you notice any sudden changes in your vision, talk to your doctor immediately.
This medicine is typically not recommended during pregnancy or breastfeeding unless your doctor decides that the health benefit to you clearly outweighs the potential risk to your baby. If you are pregnant or planning a pregnancy, talk to your doctor to discuss the safest options.
Regular blood tests are necessary to monitor your liver function, thyroid health, and blood sugar levels. This helps your healthcare team ensure that the medication is safe for you and is not causing silent side effects. Always attend your scheduled lab appointments and talk to your doctor about your results.
Yes, this medicine can sometimes cause mental health side effects, including depression, anxiety, confusion, or sudden mood changes. If you have a history of mental health conditions or if you or your family notice any worrying changes in your behaviour or mood, talk to your doctor right away.

Disclaimer

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Reference

  1. Mayo Clinic Staff. Drg 20063736 Inhalation and Dosage Monograph. Rochester, MN: Mayo Foundation for Medical Education; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Ethionamide Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Ethionamide Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Nbk247426 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  6. Ethionamide Ethionamide. 2016. [Accessed on 19 Jun. 2019]Check here
  7. Mayoclinic. Ethionamide.[Accessed on 23 Jan 2020]Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3Rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country Of Origin: India
Other Info - ETH0265
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