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Fibnib 150 Softgel Capsule is used to treat idiopathic pulmonary fibrosis (a disease that causes scarring of the lungs). It contains Nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NINTEDANIB-150MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Fibnib 150 Softgel Capsule

Fibnib 150 Softgel Capsule is a prescription medicine used to treat adults with chronic lung conditions that cause progressive scarring, such as idiopathic pulmonary fibrosis. This medicine is designed to help slow down the decline in lung function by targeting the pathways that lead to lung tissue stiffening. By reducing this scarring process, it helps preserve your remaining lung function and capacity.

To achieve the best results, you must take Fibnib 150 Softgel Capsule consistently every day exactly as your doctor directs. It is highly recommended to take this capsule with food and a full glass of water to help manage common stomach-related side effects. Incorporating healthy habits, such as stopping smoking and staying well-hydrated, can also support your overall lung health during treatment.

The most common side effects associated with this medication include diarrhoea, nausea, and stomach pain. It is important to watch for these symptoms and consult your doctor immediately if you experience severe diarrhoea, signs of liver damage, or unusual bleeding.

Do not take this if you are pregnant, planning to become pregnant, or have severe liver damage. Before starting this treatment, you must tell your doctor if you have a history of heart disease, liver problems, high blood pressure, or bleeding disorders.

Fibnib 150 Softgel Capsule may interact with certain medicines, including blood thinners, and smoking may reduce the amount of medicine in your body. Older adults can generally use this medicine, but they may need closer monitoring because liver problems and other health conditions are more common with age. Tell your doctor if you have any liver problems. People with mild liver impairment may need a lower dose and closer monitoring, while Fibnib 150 Softgel Capsule is generally not recommended for those with moderate or severe liver impairment. If you are pregnant, planning a pregnancy, or breastfeeding, consult your doctor before starting treatment.

Uses of Fibnib 150 Softgel Capsule

Your doctor may prescribe this medicine to treat several conditions, including:

  • Idiopathic Pulmonary Fibrosis (IPF): Fibnib 150 Softgel Capsule helps slow the progressive scarring and stiffening of the lungs, making it easier to maintain your breathing capacity over time.
  • Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): Fibnib 150 Softgel Capsule reduces the rate of decline in lung function in patients who have lung scarring related to autoimmune connective tissue diseases.
  • Chronic Fibrosing Interstitial Lung Diseases (ILDs) with a Progressive Phenotype: Fibnib 150 Softgel Capsule helps manage various long-term lung conditions where scarring continues to worsen despite other treatments, helping to preserve vital lung volume.

Key Benefits

The primary benefit of Fibnib 150 Softgel Capsule is its ability to protect and preserve your lung function over time. By targeting the underlying chemical signals that cause tissue scarring, this medicine helps you maintain your breathing capacity and perform daily tasks more comfortably.

  • Slower disease progression: It significantly reduces the speed at which lung scarring worsens, allowing you to maintain your active daily routines for a longer period.
  • Lower risk of sudden worsening: It helps lower the risk of sudden, severe breathing crises, which are medically known as acute exacerbations.
  • Better control over breathing decline: Regular use helps stabilise your overall lung health, giving you more predictability in managing your symptoms.
Side effects of Fibnib 150 Softgel Capsule
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Avoid other medicines that increase the risk of bleeding.
  • Use an electric razor and a soft-bristled toothbrush.
  • Monitor for signs of bleeding like bleeding gums, unusual bruising, blood in stool, nosebleeds, or heavy menstrual bleeding.
  • If you experience severe bleeding, apply direct pressure on the wound and consult a doctor promptly.
  • If the risk of bleeding is high, discuss with your doctor about possibility of switching to different medicine with a lower bleeding risk.

Directions for Use

  • Fibnib 150 Softgel Capsule should be taken with meals to enhance its effectiveness.
  • It is recommended to take Fibnib 150 Softgel Capsule twice daily or as advised by your doctor.
  • Swallow Fibnib 150 Softgel Capsule as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Fibnib 150 Softgel Capsule Works

Fibnib 150 Softgel Capsule contains nintedanib, which works by blocking certain proteins called tyrosine kinases. These proteins send signals that encourage cells in the lungs to grow and produce collagen, a major part of scar tissue. Too much scar tissue can make the lungs thick and stiff, making it harder to breathe. By blocking these signals, nintedanib helps slow the buildup of scar tissue and the decline in lung function. It does not remove existing lung scarring or cure the condition, but it may help preserve lung function for longer.
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Alcohol

Caution

It is not known if alcohol interacts with Fibnib 150 Softgel Capsule . However, as a precautionary measure, you are recommended not to consume alcohol with the Fibnib 150 Softgel Capsule to avoid unpleasant side effects.

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Pregnancy

Unsafe

Fibnib 150 Softgel Capsule is listed as pregnancy category D. Because Fibnib 150 Softgel Capsule can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Fibnib 150 Softgel Capsule .

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Breast Feeding

Consult your doctor

Consult your doctor if you are breastfeeding; your doctor will decide whether Fibnib 150 Softgel Capsule can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Fibnib 150 Softgel Capsule may significantly influence your ability to drive and use machines. You should not drive or operate machinery if you feel sick.

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Liver

Consult your doctor

Dose adjustment may be needed. Fibnib 150 Softgel Capsule is not recommended for patients with severe hepatic impairment. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Dose adjustment may be needed. Fibnib 150 Softgel Capsule is not recommended for patients with an end-stage renal disease requiring dialysis. Please consult your doctor if you have kidney impairment or any concerns.

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Children

Unsafe

Fibnib 150 Softgel Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Inform your doctor if you have any existing heart disease. Your doctor will prescribe this medicine only if the potential benefits outweigh the risks.

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Geriatrics

Caution

Fibnib 150 Softgel Capsule should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Fibnib 150 Softgel Capsule .

What if I have taken an overdose of Fibnib 150 Softgel Capsule

If you take more than your prescribed dose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Stay hydrated by drinking water throughout the day, which helps prevent dehydration if you experience diarrhoea.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating small portions of bland foods throughout the day can make eating easier.
  • Avoid smoking completely: Smoking speeds up lung damage and can significantly reduce how well Fibnib 150 Softgel Capsule works in your body.
  • Get regular liver tests: Attend all scheduled appointments for blood tests, as your doctor needs to monitor your liver health closely during treatment.
  • Avoid grapefruit and grapefruit juice: This fruit can affect how your body processes the medicine, potentially increasing the risk of side effects.
health query

Have a query?

How Soon It Starts Working

The time required for Fibnib 150 Softgel Capsule to start to work: The exact onset time of Fibnib 150 Softgel Capsule has not been clinically established. 

The time for which the effects of Fibnib 150 Softgel Capsule last: The duration of Fibnib 150 Softgel Capsule ’s effect is clinically not established.

What if you forget to take Fibnib 150 Softgel Capsule

If you miss a dose, skip the missed dose entirely and take your next capsule at your next regularly scheduled time. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Fibnib 150 Softgel Capsule at room temperature, specifically between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original blister pack or container to protect it from direct light and moisture.

Drug Warnings

  • Use reliable birth control: Women who can get pregnant must use highly effective birth control during treatment and for at least 3 months after stopping Fibnib 150 Softgel Capsule , as it can cause severe harm to an unborn baby.
  • Watch for unusual bleeding: Tell your doctor immediately if you notice blood in your stool, cough up blood, or experience frequent nosebleeds.
  • Monitor your blood pressure: This medication can raise your blood pressure, so check it regularly at home and share the results with your doctor.
  • Check your skin and eyes: Regularly look for signs of yellowing (jaundice), which could indicate a liver problem.
  • Tell all your healthcare providers: Inform your dentist or surgeon that you take Fibnib 150 Softgel Capsule before any procedure, as it can affect wound healing.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Fibnib 150 Softgel Capsule and require closer monitoring or dose adjustments:

  • Blood thinners: Taking this medicine with anticoagulants (such as warfarin) can increase your risk of serious bleeding.
  • Enzyme blockers: Strong CYP3A4 inhibitors (like ketoconazole or erythromycin) can increase the levels of Fibnib 150 Softgel Capsule in your blood, making side effects more likely.
  • Enzyme inducers: Medicines like rifampicin can lower the level of Fibnib 150 Softgel Capsule in your blood, making it less effective.
  • Laxatives: Combining this medicine with laxatives can worsen severe diarrhoea.

Drug-Drug Interactions

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How does the drug interact with Fibnib 150 Softgel Capsule:
Coadministration of Fibnib 150 Softgel Capsule with Carbamazepine can reduce the levels and effects of Fibnib 150 Softgel Capsule.

How to manage the interaction:
Although taking carbamazepine and Fibnib 150 Softgel Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Fibnib 150 Softgel Capsule:
Coadministration of Dexamethasone may lower the blood levels of Fibnib 150 Softgel Capsule, making the medication less effective in treating your condition.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Fibnib 150 Softgel Capsule if prescribed by the doctor. Contact a doctor if your symptoms do not improve. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fibnib 150 Softgel Capsule:
Coadministration of Phenytoin and Fibnib 150 Softgel Capsule may decrease the blood levels of Fibnib 150 Softgel Capsule, which may reduce Fibnib 150 Softgel Capsule's effectiveness.

How to manage the interaction:
Although taking Phenytoin and Fibnib 150 Softgel Capsule together can result in an interaction, it can be taken when your doctor has prescribed it. Contact a doctor if your symptoms do not improve. Do not stop taking any drugs without consulting a doctor.
NintedanibFosphenytoin
Severe
How does the drug interact with Fibnib 150 Softgel Capsule:
Coadministration of Fibnib 150 Softgel Capsule with Fosphenytoin can reduce the levels of Fibnib 150 Softgel Capsule. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Fibnib 150 Softgel Capsule and Fosphenytoin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
NintedanibRifapentine
Severe
How does the drug interact with Fibnib 150 Softgel Capsule:
Coadministration of Fibnib 150 Softgel Capsule and Rifapentine can reduce the blood levels of Fibnib 150 Softgel Capsule.

How to manage the interaction:
There may be a possibility of interaction between Fibnib 150 Softgel Capsule and Rifapentine, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Fibnib 150 Softgel Capsule:
Coadministration of Teriflunomide and Fibnib 150 Softgel Capsule can increase the risk of liver problems.

How to manage the interaction:
Coadministration of Teriflunomide and Fibnib 150 Softgel Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, loss of appetite, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately.
How does the drug interact with Fibnib 150 Softgel Capsule:
Co-administration of Leflunomide and Fibnib 150 Softgel Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Fibnib 150 Softgel Capsule can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibLomitapide
Severe
How does the drug interact with Fibnib 150 Softgel Capsule:
Co-administration of Lomitapide and Fibnib 150 Softgel Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Fibnib 150 Softgel Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NintedanibTipranavir
Severe
How does the drug interact with Fibnib 150 Softgel Capsule:
Coadministration of Fibnib 150 Softgel Capsule and Tipranavir can reduce the blood levels of Fibnib 150 Softgel Capsule.

How to manage the interaction:
There may be a possibility of interaction between Fibnib 150 Softgel Capsule and Tipranavir, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Fibnib 150 Softgel Capsule:
Coadministration of Fibnib 150 Softgel Capsule and primidone can reduce the blood levels of Fibnib 150 Softgel Capsule.

How to manage the interaction:
Although there is an interaction between Fibnib 150 Softgel Capsule and primidone, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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Certain foods or drinks may affect the safety or tolerability of Fibnib 150 Softgel Capsule . Important interactions include:

  • Alcohol: Alcohol may increase the risk of liver problems and worsen side effects such as nausea, dizziness, or stomach discomfort. Ask your doctor whether it is safe to drink alcohol during treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Fibnib 150 Softgel Capsule is used to treat idiopathic pulmonary fibrosis (IPF), a disease marked by a progressive decline in lung function.
Fibnib 150 Softgel Capsule helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helping you breathe better.
Avoid smoking before starting the treatment while taking Fibnib 150 Softgel Capsule as smoking might alter the effectiveness of Fibnib 150 Softgel Capsule .
Fibnib 150 Softgel Capsule should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Fibnib 150 Softgel Capsule until your doctor asks you to stop it.
If you have any surgery, including dental surgery, please inform your doctor if you are taking Fibnib 150 Softgel Capsule as your doctor might stop Fibnib 150 Softgel Capsule before undergoing surgery.
In elderly patients, the risk of side effects is higher if you are taking Fibnib 150 Softgel Capsule . For the patients who are elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.
It is not recommended to discontinue the Fibnib 150 Softgel Capsule without consulting your healthcare provider. Abruptly stopping the medication can lead to disease progression or other complications. Consult your healthcare provider for personalised guidance if you have concerns or experience side effects.
If you forget to take a dose of Fibnib 150 Softgel Capsule , take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for the missed one, as this can increase the risk of side effects.
Common side effects of Fibnib 150 Softgel Capsule may include nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity in some individuals. Most of these side effects do not require medical attention and will resolve gradually over time. However, if you experience these side effects persistently, inform your doctor.
Fibnib 150 Softgel Capsule is not recommended for use in patients with severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns before Fibnib 150 Softgel Capsule .
Yes, you should always take Fibnib 150 Softgel Capsule with food. This helps to reduce common stomach-related side effects like nausea and diarrhoea. Talk to your doctor or pharmacist if you struggle to manage stomach issues.
If you develop diarrhoea, drink plenty of fluids to avoid dehydration and contact your doctor immediately. They may recommend an over-the-counter anti-diarrhoeal medicine or adjust your dose. Talk to your doctor or pharmacist before taking any new medicine.
No, Fibnib 150 Softgel Capsule does not cure lung scarring, and it cannot reverse scar tissue that has already formed. Instead, it works to slow down the progression of the disease and preserve your remaining lung function. Talk to your doctor or pharmacist for more information.
You should limit or avoid alcohol while taking Fibnib 150 Softgel Capsule because both alcohol and this medicine can put stress on your liver, increasing your risk of liver damage. Talk to your doctor or pharmacist about safe alcohol limits.
Your doctor will order regular blood tests to monitor your liver function. Since this medicine can cause liver damage, checking your blood helps ensure the medicine is safe for you to continue. Talk to your doctor or pharmacist if you have concerns about these tests.
No, you should not take Fibnib 150 Softgel Capsule if you are pregnant or planning to become pregnant, as it can cause severe harm to an unborn baby. Women who can get pregnant must use highly effective birth control during treatment and for at least 3 months after. Talk to your doctor or pharmacist about safe options.

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Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - FIB0135
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