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  3. Flupera 100mg/325mg Tablet

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Flupera 100mg/325mg Tablet, Pack of 1 Tablet
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Flupera 100mg/325mg Tablet is used in the treatment of acute and chronic pain, fever, headache, joint pains, dysmenorrhea (period pain), postoperative pain, toothache after dental extraction, and myalgia (muscle pain). It contains Flupirtine and Paracetamol, which works by blocking the transmission of pain signals to the brain to lower pain perception. Also, it works by blocking the release of certain chemical messengers that cause fever and pain. It may cause common side effects such as nausea, vomiting, wind, abdominal discomfort, diarrhoea, constipation, heartburn, drowsiness, dizziness, headache, and depression. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

FLUPIRTINE-100MG + PARACETAMOL-325MG

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Flupera 100mg/325mg Tablet

Flupera 100mg/325mg Tablet is a combination medication that belongs to the analgesic medication class. It is widely used in the treatment of acute and chronic pain, fever, headache, joint pains, dysmenorrhea (period pain), postoperative pain, toothache after dental extraction, and myalgia (muscle pain). Pain is a widely used term used to describe an unpleasant feeling or discomfort. It ranges from mild to severe. The severity of the pain depends on the underlying condition. Inflammation is the immune system's natural response to injury or infection.

Flupera 100mg/325mg Tablet contains flupirtine and paracetamol. Flupirtine is an analgesic (non-opioid analgesic) which works by blocking the transmission of pain signals to the brain to lower pain perception. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer), which works by blocking the release of certain chemical messengers that cause fever and pain. Thus Flupera 100mg/325mg Tablet alleviates pain and other associate conditions.

Use Flupera 100mg/325mg Tablet as directed by the physician only. The dose and duration of the medication depend on your condition and its severity. The common side effects of Flupera 100mg/325mg Tablet include nausea, vomiting, wind, abdominal discomfort, diarrhoea, constipation, heartburn, drowsiness, dizziness, headache, and depression. Most of these side effects of Flupera 100mg/325mg Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before taking Flupera 100mg/325mg Tablet, inform your doctor if you are allergic to flupirtine, paracetamol, or other ingredients. Besides, inform your doctor if you are pregnant, breastfeeding, or have any pre-existing conditions such as liver diseases such as hepatic encephalopathy (loss of brain function due to liver damage), chronic alcoholism, or cholestasis (reduced bile flow), renal impairment, myasthenia gravis (chronic neuromuscular disease), or heart diseases. If Flupera 100mg/325mg Tablet is given in patients with liver diseases, liver function should be monitored closely. Flupera 100mg/325mg Tablet causes drowsiness and dizziness, so drive only if you are alert. Flupera 100mg/325mg Tablet is not recommended for children younger than six years old.

Uses of Flupera 100mg/325mg Tablet

Flupera 100mg/325mg Tablet is used in the treatment of Pain relief. The detailed uses of Flupera 100mg/325mg Tablet are as follows:

  • Pain Relief: Flupera 100mg/325mg Tablet is a painkiller that effectively treats various types of pain, including muscle pain, joint pain, toothache, headache, post-surgery pain, and nerve pain, by blocking chemical messengers that cause pain and inflammation.
  • Fever Reduction: Flupera 100mg/325mg Tablet effectively reduces high fever, providing relief from discomfort and associated pain.

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Directions for Use

  • Flupera 100mg/325mg Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Flupera 100mg/325mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Flupera 100mg/325mg Tablet contains flupirtine (non-opioid analgesic) and paracetamol (analgesic and antipyretic). Flupirtine works by blocking the glutamate receptors that are involved in producing pain signals. It also has muscle relaxant properties. Paracetamol acts as an analgesic and antipyretic by inhibiting the release of prostaglandins (chemical mediators) that cause pain, inflammation, and fever. Altogether provide relief from pain and associated symptoms.

How Flupera 100mg/325mg Tablet Works

Flupera 100mg/325mg Tablet contains flupirtine and paracetamol. Flupirtine is an analgesic (non-opioid analgesic) which works by blocking the transmission of pain signals to the brain to lower pain perception. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer), which works by blocking the release of certain chemical messengers that cause fever and pain. Thus Flupera 100mg/325mg Tablet alleviates pain and other associate conditions.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Flupera 100mg/325mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

What if I have taken an overdose of Flupera 100mg/325mg Tablet

Do not take more than the prescribed dose of Flupera 100mg/325mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Avoid using Flupera 100mg/325mg Tablet if you are allergic to analgesics or painkillers. People with liver diseases, kidney diseases, and elderly people above 65 years of age may require dose adjustments. If Flupera 100mg/325mg Tablet is given to patients with liver impairment, liver function should be closely monitored. It is advised to discontinue use if you notice any signs of liver damage such as nausea, vomiting, yellowed skin and eyes (jaundice), abdominal pain, loss of appetite, itchy skin, and dark-coloured urine, etc.

Drug-Drug Interactions

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ParacetamolKetamine
Severe
ParacetamolKetoconazole
Severe

Drug-Drug Interactions

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ParacetamolKetamine
Severe
How does the drug interact with Flupera 100mg/325mg Tablet:
Co-administration of ketamine and Flupera 100mg/325mg Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Flupera 100mg/325mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolKetoconazole
Severe
How does the drug interact with Flupera 100mg/325mg Tablet:
Co-administration of Flupera 100mg/325mg Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Flupera 100mg/325mg Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Flupera 100mg/325mg Tablet:
Co-administration of Mipomersen with Flupera 100mg/325mg Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Flupera 100mg/325mg Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Flupera 100mg/325mg Tablet:
Co-administration of Flupera 100mg/325mg Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Flupera 100mg/325mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolValdecoxib
Severe
How does the drug interact with Flupera 100mg/325mg Tablet:
Co-administration of Flupera 100mg/325mg Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Flupera 100mg/325mg Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with Flupera 100mg/325mg Tablet:
Co-administration of Flupera 100mg/325mg Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Flupera 100mg/325mg Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolTeriflunomide
Severe
How does the drug interact with Flupera 100mg/325mg Tablet:
Co-administration of Teriflunomide with Flupera 100mg/325mg Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Flupera 100mg/325mg Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Flupera 100mg/325mg Tablet:
Co-administration of Lomitapide and Flupera 100mg/325mg Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Flupera 100mg/325mg Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do not take alcohol.
  • Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
  • Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
  • In the chronic condition of arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Consuming alcohol with Flupera 100mg/325mg Tablet is not advisable as it may cause unpleasant side effects, or you may become more sensitive to the effects of alcohol.

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Pregnancy

Caution

Flupera 100mg/325mg Tablet is not recommended during pregnancy. However, your doctor may prescribe it for you during pregnancy if he/she feels the benefit outweighs the risk.

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Breast Feeding

Unsafe

According to the studies available to date, a small percentage of flupirtine maleate passes into breast milk. Therefore, flupirtine maleate must not be administered during lactation unless necessary.

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Driving

Unsafe

Avoid driving or operating heavy machinery after taking Flupera 100mg/325mg Tablet, as it may cause dizziness.

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Liver

Unsafe

Flupera 100mg/325mg Tablet can cause liver toxicity. So, it should be avoided in patients with liver diseases. However, dose adjustments and close monitoring are necessary if it is used in patients with liver diseases.

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Kidney

Caution

In patients with kidney problems, dose adjustments of Flupera 100mg/325mg Tablet are required. Therefore, use Flupera 100mg/325mg Tablet only when prescribed by a doctor.

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Children

Caution

It is recommended to consult a doctor before using Flupera 100mg/325mg Tablet in children below six years.

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Heart

Caution

Flupera 100mg/325mg Tablet should be used under extreme caution in heart patients as it can cause potential risk in some patients.

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Geriatrics

Unsafe

Flupera 100mg/325mg Tablet should be avoided in geriatric patients, as it can cause serious adverse effects like liver/kidney damage, dizziness or drowsiness.

FAQs

Flupera 100mg/325mg Tablet is widely used in the treatment of acute and chronic pain, fever, headache, joint pains, dysmenorrhea (period pain), postoperative pain, toothache after dental extraction, and myalgia (muscle pain).

Flupera 100mg/325mg Tablet contains flupirtine (non-opioid analgesic) and paracetamol (analgesic and antipyretic). Flupirtine works by blocking the glutamate receptors that are involved in producing pain signals. Paracetamol acts as an analgesic and antipyretic by inhibiting the release of prostaglandins (chemical mediators) that cause pain, inflammation, and fever. Altogether provide relief from pain.

No, Flupera 100mg/325mg Tablet provides pain relief from menstrual pain (dysmenorrheal). It may not affect on periods. Please consult the doctor if you have any concerns regarding this.

Yes, Flupera 100mg/325mg Tablet can be used to treat pain associated with osteoarthritis. But, you should take it as advised by your doctor.

Flupera 100mg/325mg Tablet contains Paracetamol, known to cause liver damage when you take large dosages. Often, stop consuming alcohol when taking this drug, as this can further increase the risk of liver damage. The use of this drug in patients with underlying liver disease should preferably be avoided.

Usually, Flupera 100mg/325mg Tablet is used for a short period of time and can be stopped when the pain is relieved. It should be continued, however, if you are instructed to do so by your doctor.

The common side effects of Flupera 100mg/325mg Tablet include nausea, vomiting, wind, abdominal discomfort, diarrhoea, constipation, heartburn, drowsiness, dizziness, headache, and depression. Most of these side effects of Flupera 100mg/325mg Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

No, do not take a higher than the recommended dose of Flupera 100mg/325mg Tablet as it may lead to unpleasant side effects/overdose. Take it as per the dose advised by the doctor.

Store Flupera 100mg/325mg Tablet at room temperature, in a dry place. Keep it out of sight and reach of children.

Country of origin

India
Other Info - FL21491

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Nov 21, 2025 | 11:22 AM IST

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Reference

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339720/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557425/#:~:text=Adverse%20events%20commonly%20reported%20were,%2C%20depression%2C%20disorientation%20and%20hallucinations.
  3. https://www.medicines.org.uk/emc/files/pil.5916.pdfhttp://mri.cts-mrp.eu/download/DE_H_3430_001_FinalSPC_2of2.pdf
  4. https://www.ema.europa.eu/en/news/restrictions-use-flupirtine-containing-medicines-cmdh-endorses-prac-recommendation#:~:text=Flupirtine%20is%20a%20non%2Dopioid,following%20orthopaedic%20surgery%20or%20injuries.
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