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  3. Fosaprepit 150 mg Injection 1's

Fosaprepit 150 mg Injection 1's, Pack of 1 INJECTION
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Fosaprepit 150 mg Injection is used to treat Chemotherapy-induced nausea and vomiting. It contains Fosaprepitant, an anti-emetic (a drug used to treat nausea and vomiting) which is converted to aprepitant in the body. It works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

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Composition :

FOSAPREPITANT-150MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Fosaprepit 150 mg Injection

Fosaprepit 150 mg Injection belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines). Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Fosaprepit 150 mg Injection contains Fosaprepitant, a neurokinin 1 (NK1) receptor antagonist which is converted to aprepitant in the body. It works by blocking neurokinin 1 receptors (causes a feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Fosaprepit 150 mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Fosaprepit 150 mg Injection may cause common side effects such as headache, hiccups, tiredness, loss of appetite, indigestion, and constipation. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult your doctor immediately. 

If you are allergic to Fosaprepitant or other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before receiving Fosaprepit 150 mg Injection. Drive only if you are alert after receiving Fosaprepit 150 mg Injection. If you are taking other prescription or non-prescription medicines, inform your doctor before receiving Fosaprepit 150 mg Injection.

Uses of Fosaprepit 150 mg Injection

Treatment of Chemotherapy-induced nausea and vomiting

Directions for Use

Fosaprepit 150 mg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Fosaprepit 150 mg Injection contains Fosaprepitant, an anti-emetic (a drug used to treat nausea and vomiting) which is converted to aprepitant in the body. It works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

How Fosaprepit 150 mg Injection Works

Fosaprepit 150 mg Injection contains Fosaprepitant, a neurokinin 1 (NK1) receptor antagonist which is converted to aprepitant in the body. It works by blocking neurokinin 1 receptors (causes a feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting.

Storage

Store in a cool and dry place away from sunlight
Side effects of Fosaprepit 150 mg Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

What if I have taken an overdose of Fosaprepit 150 mg Injection

As Fosaprepit 150 mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

If you are allergic to Fosaprepitant or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before receiving Fosaprepit 150 mg Injection. Drive only if you are alert after receiving Fosaprepit 150 mg Injection. If you are taking any other prescription or non-prescription medicines, inform your doctor before receiving Fosaprepit 150 mg Injection. If you are using warfarin (blood thinner), your doctor may recommend blood tests after you receive Fosaprepit 150 mg Injection to check your blood clotting.

Drug-Drug Interactions

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FosaprepitantTerfenadine
Critical
FosaprepitantLomitapide
Critical

Drug-Drug Interactions

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FosaprepitantTerfenadine
Critical
How does the drug interact with Fosaprepit 150 mg Injection:
When Fosaprepit 150 mg Injection is taken with Terfenadine, it can lower the rate at which Fosaprepit 150 mg Injection is broken down and increases its levels in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepit 150 mg Injection and Terfenadine together is generally avoided as it can show an interaction, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms like Chest discomfort, Shortness of breath, Weakness, or palpitations, it's important to call your doctor right away - they can be serious heart problems. Do not discontinue any medications without consulting a doctor.
FosaprepitantLomitapide
Critical
How does the drug interact with Fosaprepit 150 mg Injection:
When Fosaprepit 150 mg Injection is taken with Lomitapide, it can increase the levels of Lomitapide. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepit 150 mg Injection with Lomitapide together is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - diarrhea, nausea, vomiting, pain, discomfort, indigestion, constipation, liver damage, fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, dark colored urine, bleeding or vomiting - make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
FosaprepitantFlibanserin
Critical
How does the drug interact with Fosaprepit 150 mg Injection:
Coadministration of Fosaprepit 150 mg Injection with Flibanserin can increase the levels of Flibanserin in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepit 150 mg Injection with Flibanserin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
FosaprepitantAstemizole
Critical
How does the drug interact with Fosaprepit 150 mg Injection:
Coadministration of Fosaprepit 150 mg Injection with Astemizole can increase the levels of Astemizole in the body. This increases the risk or severity of side effects like irregular heart rhythms.

How to manage the interaction:
Taking Fosaprepit 150 mg Injection with Astemizole together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantEliglustat
Critical
How does the drug interact with Fosaprepit 150 mg Injection:
When Fosaprepit 150 mg Injection is taken with Eliglustat, can increase Eliglustat levels in the body. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Fosaprepit 150 mg Injection and Eliglustat, but it can be taken if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantCisapride
Critical
How does the drug interact with Fosaprepit 150 mg Injection:
Coadministration of Fosaprepit 150 mg Injection with Cisapride can increase the levels of Cisapride in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepit 150 mg Injection with Cisapride together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantPimozide
Critical
How does the drug interact with Fosaprepit 150 mg Injection:
When Pimozide is taken with Fosaprepit 150 mg Injection, it can increase the Pimozide levels in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepit 150 mg Injection with Pimozide is not recommended, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, prolonged diarrhea, or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantLemborexant
Severe
How does the drug interact with Fosaprepit 150 mg Injection:
Coadministration of Fosaprepit 150 mg Injection with Lemborexant can increase the blood levels of lemborexant. This may increase the risk of side effects.

How to manage the interaction:
Taking Fosaprepit 150 mg Injection with Lemborexant together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience abnormal sleep behaviors, worsening of depression, changes in heartbeat, or headache, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantEplerenone
Severe
How does the drug interact with Fosaprepit 150 mg Injection:
Co-administration of EPLERENONE and Fosaprepit 150 mg Injection may significantly increase the blood levels and side effects of eplerenone. This can increase the risk of serious side effects like high blood potassium, which in severe cases can lead to kidney failure, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Taking Fosaprepit 150 mg Injection with Eplerenone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantFentanyl
Severe
How does the drug interact with Fosaprepit 150 mg Injection:
Coadministration of fentanyl and Fosaprepit 150 mg Injection may significantly increase the blood levels and effects of fentanyl.

How to manage the interaction:
Although there is an interaction between Fosaprepit 150 mg Injection and fentanyl, it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience dizziness, confusion, excessive drowsiness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, skinless poultry, lean meats, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Fosaprepit 150 mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of alcohol with Fosaprepit 150 mg Injection is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Fosaprepit 150 mg Injection. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Fosaprepitant is excreted in breast milk. Hence, if you are a nursing mother, discuss with your doctor about the best way to feed your baby if you receive Fosaprepit 150 mg Injection.

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Driving

Caution

Fosaprepit 150 mg Injection may cause dizziness or sleepiness in some people. Therefore, if you feel dizzy or sleepy after receiving Fosaprepit 150 mg Injection, avoid driving or operating machinery.

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Liver

Caution

If you have liver disease, inform your doctor before receiving Fosaprepit 150 mg Injection.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before receiving Fosaprepit 150 mg Injection.

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Children

Caution

If you have any concerns regarding the use of Fosaprepit 150 mg Injection in children, please consult a doctor.

Have a query?

FAQs

Fosaprepit 150 mg Injection is used to treat Chemotherapy-induced nausea and vomiting.

Fosaprepit 150 mg Injection works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

Fosaprepit 150 mg Injection may cause constipation as a common side effect. However, if the condition persists or worsens, please consult your doctor.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain intrauterine devices (IUDs) as they may not work properly when taken together with Fosaprepit 150 mg Injection. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Fosaprepit 150 mg Injection and for up to 1 month after using Fosaprepit 150 mg Injection.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - FOS0046

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jan 1, 2025 | 9:32 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.5947.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210064s000lbl.pdf
  3. https://ec.europa.eu/health/documents/community-register/2017/20170111136630/anx_136630_en.pdf
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