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compositionComposition:DALTEPARIN-2500IU
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Fragmin 2500Iu Injection is used to prevent deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung) and reduce the risk of getting clots in people who have undergone knee or hip replacement surgeries. Also, it helps to treat and prevent stroke risk, and heart attack in patients with atrial fibrillation (irregular heart rhythm). It contains Dalteparin which prevents the formation of blood clots by thinning the blood.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

DALTEPARIN-2500IU

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Fragmin 2500Iu Injection

Fragmin 2500Iu Injection is a prescription injection primarily used to prevent and treat blood clots in the blood vessels, particularly in the deep veins of the legs (deep vein thrombosis) or the lungs (pulmonary embolism). It is also prescribed to reduce the risk of clot formation in individuals with unstable chest pain or after certain surgical procedures. By preventing existing clots from growing and stopping new ones from forming, it helps maintain smooth blood flow throughout your body.

This medication is typically injected once or twice daily, depending on your specific condition and your doctor's instructions. Because it is given as a subcutaneous injection (under the skin), it does not depend on food intake and can be injected at any time of day, but it must be taken at the same time each day for the best results. To support your treatment, it is helpful to stay hydrated, avoid sitting still for long periods, and gently flex your legs when resting.

While using Fragmin 2500Iu Injection , you may experience mild side effects such as minor pain, redness, or bruising at the injection site. However, you must contact your doctor immediately if you notice signs of serious bleeding, such as unusual bruising, nosebleeds, dark stools, or coughing up blood. Your doctor will monitor your blood count regularly to ensure the medication is working safely.

Before you start injecting Fragmin 2500Iu Injection , tell your doctor if you have a history of bleeding disorders, stomach ulcers, kidney problems, or low blood platelets. Do not inject this medicine if you have active major bleeding, a severe allergy to heparin products, or a recent history of heparin-induced thrombocytopenia. It is also important to discuss if you have an upcoming spinal procedure, as this medicine can cause serious spinal complications in those cases.

Many medicines can interact with Fragmin 2500Iu Injection , especially other blood thinners, pain relievers like aspirin or ibuprofen, and certain herbal supplements, which can increase your risk of bleeding. You should also consult your doctor if you are pregnant, breastfeeding, or elderly, as your dose may need careful adjustment. Avoid heavy alcohol use and smoking, as they can affect blood vessel health and complicate your treatment.

Uses of Fragmin 2500Iu Injection

Fragmin 2500Iu Injection is used to prevent and treat blood clots in different parts of the body and to reduce the risk of clot-related complications in high-risk individuals, including:

  • Deep vein thrombosis (DVT): Helps prevent and treat blood clots in the deep veins, usually in the legs, reducing the risk of pain and swelling.
  • Pulmonary embolism (PE): Treats and prevents clots that have travelled to the lungs, helping to restore normal oxygen levels and blood flow.
  • Unstable coronary artery disease: Prevents blood clots from forming in the heart's blood vessels in patients with unstable chest pain (angina) or a minor heart attack.
  • Clot prevention during hemodialysis: Prevents blood from clotting in the tubing of the dialysis machine during kidney treatments.
  • Extended clot prevention in cancer patients: Protects cancer patients from recurring blood clots in their veins over a prolonged treatment period.
     

Key Benefits

Fragmin 2500Iu Injection provides reliable protection against life-threatening blood clots, helping you recover safely after surgery or during periods of limited mobility:

  • Prevents Serious Complications: By keeping blood clots from travelling to vital organs like your lungs, it protects you from severe, sudden health emergencies.
  • Supports Recovery After Surgery: It allows you to focus on healing after major operations, especially hip or knee replacements, without the fear of developing deep vein clots.
  • Manages Chronic Conditions Safely: For cancer patients or individuals with ongoing heart conditions, it offers a consistent, long-term way to manage clotting risks and maintain active daily living.
     
Side effects of Fragmin 2500iu Inj
  • Increase iron intake through iron-rich foods like red meat, spinach, and beans.
  • Boost vitamin C intake through foods like citrus fruits, bell peppers, and broccoli.
  • Consume foods high in antioxidants, such as berries, leafy greens, and nuts, to help protect against oxidative stress.
  • Stay hydrated by drinking plenty of water.
  • Rest and recover from surgery and transfusion.
  • Avoid strenuous activities like heavy lifting, bending, or exercise.
  • Practice stress-reducing techniques, including meditation, yoga, and deep breathing exercises to help cope with stress and promote relaxation.
  • Follow medical advice and attend follow-up appointments.
  • Focus on consuming a variety of nutrient-dense foods, including plenty of colorful fruits and vegetables, along with whole grains for optimal nutrition.
  • Avoid excessive sugar, salt, and unhealthy fats.
  • Consider increasing foods high in antioxidants, such as berries and leafy greens.
  • Abstain from alcohol or significantly reduce consumption.
  • Achieve and maintain a healthy weight by balancing a nutritious diet with regular physical activity.
  • Engage in moderate exercise, such as brisk walking, most days of the week.
  • Find calm and reduce stress by practicing relaxation methods like mindfulness, meditation, or slow, deliberate breathing.
  • Review medications and supplements with your doctor to ensure they are not contributing to elevated liver enzymes.
  • Reduce saturated fat and sugar intake by limiting processed foods, sugary drinks, and fried foods.
  • Increase fiber intake through plenty of fruits, vegetables, and whole grains.
  • Focus on liver-friendly foods like garlic, turmeric, leafy greens, cruciferous vegetables, and berries.
  • Consider a low-sodium diet by monitoring salt intake.
  • Limit alcohol consumption as even moderate intake can elevate liver enzymes.
  • Engage in regular exercise with moderate-intensity activity most days of the week.
  • Manage weight, as losing a small amount can improve liver health.
  • Quit smoking to prevent worsening liver damage.
  • Practice stress management through relaxation techniques like yoga or meditation.
  • Consult a doctor if your AST and ALT levels are significantly elevated or if you experience symptoms such as fatigue, abdominal pain, jaundice, or loss of appetite.
  • Apply pressure for 5-10 minutes to reduce bleeding.
  • Apply cold compresses or ice packs for 15-20 minutes, repeat every few hours.
  • Consult the doctor and use antihistamines if advised to minimise injection site reaction.
  • Use pain relief medication, like acetaminophen if recommended by the doctor, but avoid NSAIDs if bleeding is a concern.
  • Rotate injection sites and use proper needle size and technique if you are self-administering the medication.
  • Monitor signs such as increased pain, redness, warmth, or pus, and seek medical attention if symptoms worsen.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Fragmin 2500Iu Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Fragmin 2500Iu Injection Works

Fragmin 2500Iu Injection contains dalteparin, a low-molecular-weight heparin (LMWH) that helps prevent and treat harmful blood clots. Fragmin 2500Iu Injection works by increasing the activity of a natural protein in the blood called antithrombin III. This protein blocks the action of certain clotting factors, particularly Factor Xa, which plays a key role in the formation of blood clots. By reducing the activity of these clotting factors, Fragmin 2500Iu Injection makes it more difficult for new blood clots to form and prevents existing clots from becoming larger. Together, these actions help prevent the formation of harmful blood clots, reduce the risk of complications such as deep vein thrombosis and pulmonary embolism, and allow the body's natural processes to gradually break down existing clots.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Fragmin 2500Iu Injection as it may increase the risk of bleeding.

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Pregnancy

Caution

Fragmin 2500Iu Injection is a Category C pregnancy drug and is given to pregnant women only if clearly needed and has more benefits than risks. Preservative-free forms are preferred in pregnant women as preservatives such as benzyl alcohol may cross the placenta.

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Breast Feeding

Caution

Fragmin 2500Iu Injection is not recommended for use in breastfeeding. If you are breastfeeding, inform your doctor before receiving Fragmin 2500Iu Injection .

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Driving

Caution

Fragmin 2500Iu Injection usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor if you have any pre-existing or a history of liver disease. Your doctor will weigh the benefits and potential risks before prescribing Fragmin 2500Iu Injection . However, it is not recommended for patients with severe liver diseases.

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Kidney

Caution

Inform your doctor if you have any pre-existing or a history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Fragmin 2500Iu Injection . However, it is not recommended in patients with severe kidney diseases.

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Children

Caution

Fragmin 2500Iu Injection should be given to children only if prescribed by a doctor.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Fragmin 2500Iu Injection . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Fragmin 2500Iu Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Fragmin 2500Iu Injection

If you suspect an overdose or have injected too much of this medicine, seek immediate medical attention or call a poison control centre. An overdose of this medication can lead to serious internal bleeding. Watch for immediate warning signs such as nosebleeds, blood in your urine, or unusual bruising.

Diet & Lifestyle Advise

  • Eat a stable diet: Maintain a consistent intake of foods rich in Vitamin K (like leafy greens), as sudden changes can affect how your blood clots, though this is less of an issue with Fragmin 2500Iu Injection than with oral blood thinners.
  • Stay well-hydrated: Drinking plenty of water throughout the day helps maintain healthy blood circulation and reduces the risk of clot formation.
  • Engage in gentle movement: Avoid prolonged sitting. If you travel or work at a desk, stand up to stretch or flex your calf muscles every hour to keep blood flowing in your legs.
  • Choose soft-bristle toothbrushes: To minimise the risk of bleeding gums, use a soft toothbrush and waxed dental floss.
  • Use an electric razor: Shave with an electric razor rather than a manual blade to lower your risk of skin cuts and subsequent bleeding.
  • Wear supportive footwear: Wear supportive shoes and avoid walking barefoot to prevent foot injuries that could lead to hard-to-stop bleeding.
     
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How Soon It Starts Working

The time required for Fragmin 2500Iu Injection to start to work: The time required for Fragmin 2500Iu Injection to show its action is unknown. The time for which the effects of Fragmin 2500Iu Injection last: The duration of action for Fragmin 2500Iu Injection is unknown.

What if you forget to take Fragmin 2500Iu Injection

If you miss a dose, inject it as soon as you remember. However, if it is almost time for your next scheduled injection, skip the missed dose and resume your regular schedule. Do not inject a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store Fragmin 2500Iu Injection at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Check the liquid first: Always inspect the syringe before injecting. The liquid should be clear and colourless to pale yellow. Do not inject it if it is cloudy, contains particles, or is discoloured.
  • Rotate injection sites: Inject in a different spot on your abdomen each time to prevent hard lumps, pain, or tissue damage from developing under your skin.
  • Do not clear the air bubble: Unless your doctor or pharmacist tells you otherwise, do not expel the air bubble from the pre-filled syringe before injecting, as it helps prevent medicine loss and irritation at the site.
  • Avoid rubbing the site: Press gently on the injection site with a clean tissue for a few seconds if needed, but do not rub it, as rubbing increases the risk of bruising and bleeding.
  • Report upcoming procedures: Inform any surgeon, dentist, or healthcare provider that you are using Fragmin 2500Iu Injection well before any surgery, dental work, or medical procedure is scheduled.
  • Never share needles: Always use a brand-new, sterile pre-filled syringe for every injection, and never share your medication or needles with anyone else.

Drug-Drug Interactions

verifiedApollotooltip

Fragmin 2500Iu Injection may interact with certain medicines, increasing the risk of bleeding or affecting how well your treatment works. Inform your doctor about all prescription medicines, over-the-counter products, herbal supplements, and vitamins you are taking, including:

  • Aspirin and other NSAIDs (like ibuprofen or naproxen): May increase the risk of severe stomach bleeding and interfere with blood clotting.
  • Other blood thinners (like warfarin, apixaban, or rivaroxaban): May significantly raise the risk of serious, uncontrolled bleeding when used together.
  • Antiplatelet drugs (like clopidogrel): Can compound the blood-thinning effect, making it much harder for bleeding to stop.
  • Certain herbal supplements (like Ginkgo Biloba, Ginseng, or Garlic pills): May increase your vulnerability to bleeding.
     
DalteparinDefibrotide
Critical

Drug-Drug Interactions

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How does the drug interact with Fragmin 2500iu Inj:
Combining Mifepristone with Fragmin 2500iu Inj can increase the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Fragmin 2500iu Inj with Mifepristone may possibly lead to an interaction, they can be taken if a doctor prescribes it. Emergency medical attention may be needed for persistent, excessive bleeding. Without consulting a doctor. Do not stop using any medications without talking to a doctor.
DalteparinDefibrotide
Critical
How does the drug interact with Fragmin 2500iu Inj:
Combining Defibrotide with Fragmin 2500iu Inj can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 2500iu Inj with Defibrotide may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Fragmin 2500iu Inj:
Combining Dipyridamole with Fragmin 2500iu Inj can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 2500iu Inj with Dipyridamole may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Fragmin 2500iu Inj:
Combining Urokinase with Fragmin 2500iu Inj can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 2500iu Inj with Urokinase may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Fragmin 2500iu Inj:
Co-administration of Fragmin 2500iu Inj and Cefuroxime can increase the blood levels and effects of Dlateparin.

How to manage the interaction:
Taking Cefuroxime with Fragmin 2500iu Inj together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fragmin 2500iu Inj:
Coadministration of Dasatinib with Fragmin 2500iu Inj can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 2500iu Inj and Dasatinib together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms - bruising, dizziness, severe headache, or weakness - make sure to contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fragmin 2500iu Inj:
Combining Tirofiban with Fragmin 2500iu Inj can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 2500iu Inj with Tirofiban may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Fragmin 2500iu Inj:
Combining Tenecteplase with Fragmin 2500iu Inj can increase the risk of bleeding.

How to manage the interaction:
Although taking Fragmin 2500iu Inj with Tenecteplase may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Fragmin 2500iu Inj:
Taking cefdinir with Fragmin 2500iu Inj together may decrease the therapeutic effects of Fragmin 2500iu Inj.

How to manage the interaction:
Although taking Cefdinir and Fragmin 2500iu Inj can evidently cause an interaction, it can be taken if your doctor has suggested it. In case you experience aby unusual effects like lightheadedness, dizziness, unusual bruising, bleeding tendencies, blood in stools or urine, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Fragmin 2500iu Inj:
The combined use of Abciximab with Fragmin 2500iu Inj can increase the risk of bleeding.

How to manage the interaction:
Taking Abciximab with Fragmin 2500iu Inj together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as bleeding, severe bleeding, bruising, dark or black stools, severe headache, weakness, bleeding, or vomiting. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No clinically significant food interactions are known with Fragmin 2500Iu Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Fragmin 2500Iu Injection is used to prevent the risk of stroke, and heart attack in patients with atrial fibrillation (irregular heart rhythm) by reducing blood clot formation. Besides this, it is also used to prevent deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung) and reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries.
Fragmin 2500Iu Injection contains Dalteparin, an anticoagulant (blood thinner) that inhibits the production of clotting factors Xa (a protein that causes clotting). It prevents the conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helps prevent blood clot formation.
No, you are not recommended to take clopidogrel with Fragmin 2500Iu Injection as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.
It is recommended to avoid taking grapefruit and grapefruit juice while taking Fragmin 2500Iu Injection . It contains compounds that slow down the metabolism of Fragmin 2500Iu Injection and increase the activity leading to bleeding.
Do not stop taking Fragmin 2500Iu Injection without consulting your doctor to worsen the condition. Therefore, take Fragmin 2500Iu Injection for as long as your doctor has prescribed it.
Yes, Fragmin 2500Iu Injection may increase potassium levels in the blood (hyperkalaemia), especially when given for a long period. Therefore, it is advised to inform your doctor if you are taking any medicines that increase potassium levels in the blood.
Yes, Fragmin 2500Iu Injection consists of Dalteparin is a blood-thinning agent and can increase the risk of bleeding. It is advised to be cautious during your daily activities like shaving, cutting fingernails or using sharp objects. Also, please consult your doctor beforehand if you undergo any surgery.
While Fragmin 2500Iu Injection is most commonly injected into the fat layer of your abdomen (stomach), your doctor may occasionally direct you to inject it into the thigh. Always follow the specific injection site instructions given by your healthcare provider. Talk to your doctor or pharmacist if you are unsure where to inject.
Mild bruising is a very common side effect of injecting Fragmin 2500Iu Injection . To help prevent this, do not rub or massage the area after injecting, and make sure to rotate your injection sites daily. If you notice unusually large, dark, or painful bruising, talk to your doctor.
No, you should avoid taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen while using Fragmin 2500Iu Injection . These medicines can irritate your stomach lining and thin your blood further, greatly increasing your risk of bleeding. Talk to your doctor or pharmacist about safe pain relief alternatives.
You should limit or avoid alcohol while taking Fragmin 2500Iu Injection . Alcohol can affect your liver, increase the risk of stomach ulcers, and make you more prone to accidental falls or injuries that could cause serious bleeding. Talk to your doctor about what is safe for you.
Yes, your doctor will likely order regular blood tests to check your platelet levels and monitor how your kidneys are functioning while you use Fragmin 2500Iu Injection . This ensures the medication remains safe and effective for your body. Talk to your doctor for more details about your monitoring schedule.
Fragmin 2500Iu Injection is sometimes prescribed during pregnancy to prevent or treat blood clots. However, it requires close medical supervision and precise dosing adjustments, especially around the time of delivery. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Do not try to push the air bubble out of the pre-filled syringe before injecting Fragmin 2500Iu Injection . This bubble is specifically designed to remain in the syringe to ensure the entire dose of medicine is delivered and to prevent the drug from leaking out of the injection site. Talk to your doctor or pharmacist for a demonstration on proper injection techniques.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18Th Floor , Plot No. C-70, ˜G♠Block , Bandra Kurla Complex, Bandra East , Mumbai 400051
Other Info - FRA0003
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