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  3. Gemibine 1000mg Injection 1's

Gemibine 1000mg Injection 1's, Pack of 1 INJECTION
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Gemibine 1000mg Injection is an anti-cancer medicine used in the treatment of breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. This medicine works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include nausea, hair loss, skin rash, vomiting, and oedema.
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Composition :

GEMCITABINE-1000MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Gemibine 1000mg Injection

Gemibine 1000mg Injection belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body.

Gemibine 1000mg Injection contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Gemibine 1000mg Injection is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers. 

A healthcare professional will administer Gemibine 1000mg Injection. Do not self-administer. Gemibine 1000mg Injection may cause certain common side effects such as nausea, hair loss, skin rash, vomiting, and oedema. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to any of the components. Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding. Talk to your doctor if you are planning to father a child before taking Gemibine 1000mg Injection; your doctor may advise you regarding sperm storage. Avoid taking alcohol with Gemibine 1000mg Injection.

Uses of Gemibine 1000mg Injection

Treatment of Breast Cancer, Pancreatic Cancer, Non-small-cell Lung Cancer, Bladder Cancer, and Ovarian Cancer

Directions for Use

A healthcare professional will administer Gemibine 1000mg Injection. Do not self-administer.

Medicinal Benefits

Gemibine 1000mg Injection is an anti-cancer drug used in the treatment of various types of cancers. Gemibine 1000mg Injection is used either independently or in conjunction with other chemotherapy medications to treat breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Gemibine 1000mg Injection works by interfering with DNA synthesis. It blocks the production of new DNA, by locking itself into the DNA strands and inhibiting any further proliferation or growth of the cell. Hence, Gemibine 1000mg Injection has widespread application in the field of oncology (cancer-related medicine) and chemotherapy.

How Gemibine 1000mg Injection Works

Gemibine 1000mg Injection contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Gemibine 1000mg Injection is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers.

Storage

Store in a cool and dry place away from sunlight
Side effects of Gemibine 1000mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Your doctor may recommend regular liver function tests (LFT) to monitor liver enzyme levels.
  • To support your liver, eat a healthy diet with lots of fruits, vegetables, lean proteins, and healthy fats.
  • Avoid eating processed meats, sugary foods, and unhealthy fats.
  • Limit your alcohol consumption, since too much can worsen liver function and contribute to high levels of Alkaline Phosphatase (ALP).
  • Stay active with regular exercise, drink plenty of water, and try to avoid harmful chemicals that can damage your liver.
  • Quit smoking to lower the risk of elevated ALP levels.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of Gemibine 1000mg Injection

Since Gemibine 1000mg Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as severe rash, pain, burning, or tingling in the hands or feet, unusual bleeding or bruising, red/black/tarry stools, pink/red/dark brown urine, coughing up or vomiting blood or material that looks like coffee grounds, signs of infection (fever, sore throat, ongoing cough and congestion), and extreme tiredness.

Drug Warnings

Gemibine 1000mg Injection should not be used in case of any known allergy to any of the components. Gemibine 1000mg Injection should be used with caution in case of high risk or previous history of heart disease, vascular disease, liver problems, kidney disease or alcoholism. Keep your doctor informed if you suffer from any shortness of breath, kidney problems, hypertension diabetes or epilepsy. Avoid Gemibine 1000mg Injection during pregnancy and breastfeeding. Offer a detailed medical history, vaccination history, and inform the doctor especially if you are on any radiotherapy.

Drug-Drug Interactions

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GemcitabineClozapine
Severe
GemcitabineKetoconazole
Severe

Drug-Drug Interactions

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GemcitabineClozapine
Severe
How does the drug interact with Gemibine 1000mg Injection:
Co-administration of Gemibine 1000mg Injection with Clozapine can increase the risk or severity of serious infections.

How to manage the interaction:
Taking Gemibine 1000mg Injection with Clozapine together can result in an interaction, but it can be taken if a doctor has advised it. If you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination it is important to contact a doctor. Do not stop using any medications without talking to a doctor.
GemcitabineKetoconazole
Severe
How does the drug interact with Gemibine 1000mg Injection:
Coadministration of Ketoconazole and Gemibine 1000mg Injection may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Gemibine 1000mg Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruises, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, or yellowing of the skin or eyes, consult a doctor. Do not discontinue any medication without consulting a doctor.
GemcitabineMipomersen
Severe
How does the drug interact with Gemibine 1000mg Injection:
Coadministration of Gemibine 1000mg Injection with Mipomersen can lead to or increase the risk of liver injury.

How to manage the interaction:
Taking Gemibine 1000mg Injection with Mipomersen together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, or bleeding contact a doctor immediately. Do not stop using any medications without talking to a doctor.
GemcitabineTofacitinib
Severe
How does the drug interact with Gemibine 1000mg Injection:
Coadministration of Tofacitinib and Gemibine 1000mg Injection can lead to or increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Tofacitinib and Gemibine 1000mg Injection, but it can be taken if advised by a doctor. Contact your doctor immediately if you develop symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
GemcitabineFingolimod
Severe
How does the drug interact with Gemibine 1000mg Injection:
Using Fingolimod together with Gemibine 1000mg Injection may increase the risk or severity of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Gemibine 1000mg Injection and Fingolimod, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not discontinue any medications without consulting a doctor.
GemcitabineLomitapide
Severe
How does the drug interact with Gemibine 1000mg Injection:
When Gemibine 1000mg Injection is taken with Lomitapide, the amount of Gemibine 1000mg Injection in the blood can go up. This can increase the risk or severity of liver injury.

How to manage the interaction:
Co-administration of Gemibine 1000mg Injection with Lomitapide can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - liver problems, fever, joint pain, swelling, rash, itching, loss of appetite, tiredness, nausea, vomiting, stomach pain, dark urine, or bleeding please call a doctor right away. Do not stop using any medications without talking to a doctor.
GemcitabineCladribine
Severe
How does the drug interact with Gemibine 1000mg Injection:
Taking Cladribine with Gemibine 1000mg Injection can increase the risk and severity of developing serious infections.

How to manage the interaction:
Co-administration of Gemibine 1000mg Injection with Cladribine can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning urination, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
GemcitabineNatalizumab
Severe
How does the drug interact with Gemibine 1000mg Injection:
Combining Gemibine 1000mg Injection with Natalizumab can increase the risk of side effects.

How to manage the interaction:
Co-administration of Gemibine 1000mg Injection with Natalizumab can result in an interaction, but it can be taken if your doctor has advised it. If you experience any symptoms such as fever, diarrhea, sore throat, muscle aches, or vision changes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
GemcitabineInfliximab
Severe
How does the drug interact with Gemibine 1000mg Injection:
Combining Infliximab with Gemibine 1000mg Injection can increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Gemibine 1000mg Injection and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination. Do not discontinue any medications without consulting a doctor.
GemcitabineEtanercept
Severe
How does the drug interact with Gemibine 1000mg Injection:
Taking Etanercept with Gemibine 1000mg Injection can increase the risk of infections.

How to manage the interaction:
Taking Etanercept with Gemibine 1000mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Cancer can take a toll on anyone. Make sure you regularly see a therapist and take care of your mental health.
  • Meditation and yoga have also proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Avoid taking Gemibine 1000mg Injection with alcohol as there may be an interaction.
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid tobacco use.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Gemibine 1000mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

It is not recommended to use alcohol with Gemibine 1000mg Injection as it might lead to increased drowsiness.

bannner image

Pregnancy

Unsafe

Gemibine 1000mg Injection should be avoided during pregnancy. Please consult your doctor if you have any concerns.

bannner image

Breast Feeding

Unsafe

Gemibine 1000mg Injection is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

bannner image

Driving

Caution

Gemibine 1000mg Injection may cause drowsiness and sleepiness, which may affect your ability to drive. Do not drive if you experience any side effects after using Gemibine 1000mg Injection.

bannner image

Liver

Caution

Exercise caution before using Gemibine 1000mg Injection in case of established liver disease. Please consult your doctor to address any concerns.

bannner image

Kidney

Caution

Exercise caution before using Gemibine 1000mg Injection in case of established kidney disease. Please consult your doctor to address any concerns.

bannner image

Children

Unsafe

Gemibine 1000mg Injection is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

Have a query?

FAQs

Gemibine 1000mg Injection belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer.

Gemibine 1000mg Injection works blocking DNA synthesis and causing cell death, thereby preventing the cells from proliferating beyond normal.

Men taking Gemibine 1000mg Injection are advised not to father a child during the treatment with Gemibine 1000mg Injection and for 6months after the treatment. Consult your doctor before starting Gemibine 1000mg Injection if you are planning to father a child. Your doctor may advise you regarding sperm storage.

If you suffer from CKD, please consult with your doctor before using Gemibine 1000mg Injection and discuss any concerns with them. Gemibine 1000mg Injection is to be used with caution in those suffering from kidney and liver problems.

Gemibine 1000mg Injection might cause low white blood cell count leading to increased risk of infections. Consult your doctor if you have a fever, sweating, and any signs of infections.

Gemibine 1000mg Injection may cause bleeding and bruising due to less platelet count. Consult a doctor if you notice unexpected bruising, pinkish or reddish urine, bleeding from gums, mouth, or nose.

Gemibine 1000mg Injection contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. It is very effective in controlling cancer cells from multiplying and is used for the treatment of various types of cancers.

The side effects of Gemibine 1000mg Injection include hair loss, vomiting, nausea, skin rash and oedema. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

INDIA

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - GEM0073

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:46 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.2839.pdf
  2. https://chemocare.com/chemotherapy/drug-info/gemcitabine.aspx
  3. https://pubmed.ncbi.nlm.nih.gov/7481842/
  4. https://www.cancer.gov/about-cancer/understanding/what-is-cancer
  5. https://www.webmd.com/drugs/2/drug-13451/gemcitabine-intravenous/details
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649805/
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