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  3. Gluxit-S 5/50 Tablet 10's

Gluxit-S 5/50 Tablet 10's, Pack of 10
Gluxit-S 5/50 Tablet 10's, Pack of 10
Gluxit-S 5/50 Tablet 10's, Pack of 10
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Gluxit S 5/50 Tablet is used to treat type-2 diabetes mellitus. It contains Dapagliflozin and Sitagliptin. Dapagliflozin lowers blood glucose levels and increases glucose excretion in the urine. By improving insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces. Thus, it helps control blood sugar levels. Common side effects of this medicine include diarrhoea, hypoglycaemia, headache, nausea, and vomiting.

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Composition :

DAPAGLIFLOZIN-5MG + SITAGLIPTIN-50MG

Manufacturer/Marketer :

Eris Life Sciences Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Gluxit S 5/50 Tablet

Gluxit S 5/50 Tablet is used to treat Type 2 diabetes. Type 2 diabetes is a common condition that causes the level of glucose (sugar) in the blood to become too high. It's a lifelong condition that can affect your everyday life. You may need to change your diet, take medicines and have regular check-ups to lead a normal life.

Gluxit S 5/50 Tablet contains Dapagliflozin and Sitagliptin. This medicine works by increasing the removal of sugar by your kidneys. Linagliptin works by increasing levels of natural substances called incretins. Incretins help regulate blood sugar levels by stimulating insulin release, particularly after meals. They also decrease the amount of sugar your liver makes.

Not everyone who is taking Gluxit S 5/50 Tablet will get these side effects. In some cases, you may experience certain common side effects, such as frequent urination, dizziness, or light-headedness. To reduce the risk of dizziness and light-headedness, get up slowly when rising from a sitting or lying position. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. The dosage is based on your medical condition and response to treatment. To help you remember, take it at the same time each day. Tell your doctor if your condition does not improve or worsens (if your blood sugar is too high or too low).

Before taking this medication, tell your doctor or pharmacist if you are allergic to empagliflozin or linagliptin; or have other allergies. Gluxit S 5/50 Tablet should not be stopped even if you feel better, without consulting your doctor as your sugar level keeps changing. If you stop taking Gluxit S 5/50 Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss, kidney damage, and nerve damage. Gluxit S 5/50 Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Consult the doctor if you are pregnant or breastfeeding.

It is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, limb loss, and sexual dysfunction. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

Uses of Gluxit S 5/50 Tablet

Gluxit S 5/50 Tablet is used in the treatment of Type-2 diabetes mellitus. The detailed uses of Gluxit S 5/50 Tablet are as follows:

  • Control blood sugar levels: Gluxit S 5/50 Tablet helps lower elevated blood glucose in adults with type 2 diabetes, especially when diet, exercise, and other medications alone are not enough.
  • Combination therapy: Gluxit S 5/50 Tablet improves insulin sensitivity, reduce glucose production in the liver, and increase glucose excretion through urine.
  • Reduce risk of diabetes-related complications: By maintaining better glycemic control, Gluxit S 5/50 Tablet may help lower the risk of long-term complications like kidney damage, nerve issues, and cardiovascular events.

Directions for Use

  • Take Gluxit S 5/50 Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Gluxit S 5/50 Tablet helps treat type 2 diabetes, along with a balanced diet and regular exercise. It works by removing excess sugar from the body through urine.
  • It helps control the rise of blood sugar levels in your body after a meal.
  • Gluxit S 5/50 Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.
  • This medicine is also used to treat chronic kidney disease in adults with reduced kidney function. It helps protect your kidneys from losing their function, which may help some people live longer.

How Gluxit S 5/50 Tablet Works

Gluxit S 5/50 Tablet contains Dapagliflozin (sodium-glucose cotransporter-2 inhibitors) and Sitagliptin (dipeptidyl peptidase-4 inhibitor). Dapagliflozin lowers blood glucose levels and increases the excretion of glucose in the urine. By increasing insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces. Thus, Gluxit S 5/50 Tablet helps control blood sugar levels.

Storage

• Store in a cool and dry place away from sunlight.• Keep Gluxit S 5/50 Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Gluxit-S 5/50 Tablet
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
  • To help reduce symptoms, eat foods high in vitamin C, such as oranges, bell peppers and strawberries.
  • Lightly blow your nose to remove mucus; steer clear of blowing hard.
  • Infections can be prevented from spreading by washing hands frequently and staying away from other people.
  • If you have allergies, do your best to avoid triggering allergens that could contribute to a runny nose.
  • Don't smoke, as irritating the nasal passages can make a runny nose worse.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Gluxit S 5/50 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Gluxit S 5/50 Tablet may include hypoglycemia and severe gastrointestinal problems. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

  • Before taking this medication, tell your doctor or pharmacist if you are allergic to any of its contents. 
  • Gluxit S 5/50 Tablet should not be stopped even if you feel better, without consulting your doctor, as your sugar level keeps changing. If you stop taking Gluxit S 5/50 Tablet abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). 
  • Please inform your doctor if you have heart disease.
  • It may be harder to control your blood sugar when your body is stressed (such as when you have a fever, infection, injury, or surgery). 
  • Also, if you eat less or cannot eat due to these conditions or any illness, this can lead to other side effects while taking this medication. 
  • Before surgery, tell your doctor or dentist about all the products you use (including prescription, nonprescription, and herbal products).
  • Be alert for signs of low blood sugar (hypoglycemia), such as sweating, dizziness, dry mouth, dry skin, fast heartbeat, shivering, intense thirst, or frequent urination. If you experience any of these symptoms, take honey or sugar candies right away.

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
DapagliflozinGatifloxacin
Critical

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
How does the drug interact with Gluxit-S 5/50 Tablet:
Co-administration of Gluxit-S 5/50 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Taking Gluxit-S 5/50 Tablet with Gatifloxacin is not recommended as it can lead to a possible interaction, However, it can be taken if advised by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without a doctor's advice.
DapagliflozinGatifloxacin
Critical
How does the drug interact with Gluxit-S 5/50 Tablet:
Co-administration of Gluxit-S 5/50 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Gatifloxacin can be taken with Gluxit-S 5/50 Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremor, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue the medication without consulting a doctor.
SitagliptinIvacaftor
Severe
How does the drug interact with Gluxit-S 5/50 Tablet:
When Gluxit-S 5/50 Tablet is taken with Ivacaftor, the amount of Gluxit-S 5/50 Tablet in the blood can go up.

How to manage the interaction:
Taking Gluxit-S 5/50 Tablet with Ivacaftor together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
DapagliflozinAliskiren
Severe
How does the drug interact with Gluxit-S 5/50 Tablet:
Co-administration of Gluxit-S 5/50 Tablet with Aliskiren may increase the risk of dehydration and low blood pressure.

How to manage the interaction:
If you are supposed to use Gluxit-S 5/50 Tablet and Aliskiren together, a doctor may adjust the dose and monitor you more frequently. However, if you experience dizziness, fainting, headache, lightheadedness, and/or changes in pulse or heart rate, contact a doctor. Do not discontinue the medication without consulting a doctor.
SitagliptinTirzepatide
Moderate
How does the drug interact with Gluxit-S 5/50 Tablet:
As tirzepatide and Gluxit-S 5/50 Tablet both work through similar pathways in the body, it is possible that using them together may result in an increase in side effects.

How to manage the interaction:
It is essential to inform your doctor about all other medications you are taking, including vitamins and herbal supplements. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat foods rich in healthy carbohydrates and fibre, fruits, whole grains, and vegetables.
  • Try eating food at regular intervals. Do not skip meals. Also, try not to overeat.
  • Follow a healthy diet and walk/exercise for at least 45 minutes.
  • Maintain a healthy weight by exercising regularly.
  • Rest properly and avoid stress by doing meditation or yoga.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Gluxit S 5/50 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol during treatment with Gluxit S 5/50 Tablet as it may cause serious side effects.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before starting treatment with Gluxit S 5/50 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Limited data is available on the effect of Gluxit S 5/50 Tablet on breastfeeding. Hence, if you are a nursing mother, inform your doctor before taking Gluxit S 5/50 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Gluxit S 5/50 Tablet may occasionally cause dizziness. Hence, drive only if you are alert after taking this medicine.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before taking Gluxit S 5/50 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Gluxit S 5/50 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Gluxit S 5/50 Tablet is not recommended for use in children below 12 years of age as the safety and efficacy are not established.

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Heart

Safe

Gluxit S 5/50 Tablet is safe to be used in heart conditions. This medicine shows potential benefits in patients with heart failure and other associated conditions.

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Geriatrics

Safe

Gluxit S 5/50 Tablet is not generally contraindicated in elderly patients, but caution is advised, and it should be used with careful consideration of potential risks and benefits.

Have a query?

FAQs

Gluxit S 5/50 Tablet is used to treat type-2 diabetes mellitus. Type-2 diabetes mellitus (also known as non-insulin-dependent diabetes or adult-onset diabetes) is a medical condition in which blood glucose levels are above normal due to insulin deficiency, insulin resistance, or both.

Low-fibre diets, high-fat diets, sugary diets, obesity, smoking, stress, lack of exercise, age, genetic factors, and certain medical conditions are the common causes of diabetes.

Gluxit S 5/50 Tablet is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin lowers blood glucose levels and increases the excretion of glucose in the urine. By increasing insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces.

Country of origin

India

Manufacturer/Marketer address

8Th Floor, Commerce House Iv, Prahladnagar, Ahmedabad 380015 Gujarat, India.
Other Info - GLU0843

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 8:50 AM IST

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Reference

  1. https://careformulationlabs.com/sitadose-d-100-10.html
  2. https://www.biospectrumindia.com/news/95/21584/-glenmark-launches-sitagliptin-for-adults-with-type-2-diabetes-in-india.html
  3. https://www.leeford.in/product/3379/dapzigard-s-100
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf

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