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compositionComposition:GRANISETRON-1MG
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Granirex-1 Tablet is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy. It contains Granisetron, which works by blocking a natural substance (serotonin) in the body that causes nausea and vomiting. This medicine may sometimes cause side effects such as diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, and drowsiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Bennet Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Granirex-1 Tablet

Granirex-1 Tablet is a medicine used to prevent nausea and vomiting caused by medical treatments such as chemotherapy and radiation therapy. It belongs to a class of medicines that block natural chemicals in the body that trigger the urge to vomit. By targeting these signals, it helps manage discomfort during intensive medical therapies.

This medicine is typically taken only on the days you receive chemotherapy or radiation, shortly before the treatment begins. You can take it with or without food, depending on your doctor's guidance. Eating small, bland meals and staying hydrated with clear liquids can further support your recovery while using this medicine.

While taking Granirex-1 Tablet , some people may experience mild side effects, such as headaches or constipation. However, you should contact your doctor immediately if you experience serious side effects like an irregular heartbeat, severe dizziness, or signs of an allergic reaction.

Talk to your doctor before taking Granirex-1 Tablet if you have a history of heart rhythm problems, electrolyte imbalances, or severe constipation. Do not take this if you have had an allergic reaction to this medicine or similar medications in the past.

This medicine can interact with certain antidepressants and heart medications, which may increase the risk of serious side effects. If you are pregnant, breastfeeding, or an older adult, consult your healthcare provider to discuss whether this medicine is safe for you.

Uses of Granirex-1 Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • Chemotherapy-induced nausea and vomiting: Helps prevent you from feeling sick or throwing up on the days you receive chemotherapy treatments.
  • Radiation-induced nausea and vomiting: Prevents nausea and vomiting associated with radiation treatments, especially whole-body or abdominal radiation.

Key Benefits

Granirex-1 Tablet helps prevent and relieve nausea and vomiting caused by medical conditions or treatments, improving comfort and supporting recovery. Key benefits include:

  • Prevents and Relieves Nausea and Vomiting: By blocking the signals that trigger nausea and vomiting, Granirex-1 Tablet helps control these symptoms effectively, including those associated with certain medical treatments or conditions.
  • Supports Hydration and Nutrition: By reducing nausea and vomiting, Granirex-1 Tablet helps you maintain adequate fluid and food intake, supporting recovery and overall well-being.
  • Improves Comfort and Daily Functioning: By controlling persistent nausea and vomiting, Granirex-1 Tablet helps reduce physical exhaustion, preserve energy, and improve your ability to carry out daily activities comfortably.
Side effects of Granirex-1 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Granirex-1 Tablet can be taken with or without food, or as your doctor advises.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Granirex-1 Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Granirex-1 Tablet Works

During treatments like chemotherapy or radiation, your body releases a natural chemical called serotonin. Serotonin binds to specific receptors in your gut and brain, sending signals that trigger the vomiting reflex. Granirex-1 Tablet contains granisetron, which works by blocking these serotonin receptors, effectively stopping the signals before they can reach the brain's vomiting centre. This action prevents the sensation of nausea and the physical urge to vomit.
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Alcohol

Unsafe

You are recommended to limit or avoid alcohol consumption while taking Granirex-1 Tablet . Alcohol intake, along with Granirex-1 Tablet , may cause increased dizziness.

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Pregnancy

Consult your doctor

It is not known if Granirex-1 Tablet affects pregnancy. Please consult your doctor if you are pregnant or planning to conceive before using Granirex-1 Tablet .

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Breast Feeding

Caution

It is not known if this medicine passes into breast milk. Please consult your doctor before taking Granirex-1 Tablet if you are a nursing mother.

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Driving

Unsafe

Granirex-1 Tablet may make you feel dizzy that affects your mental ability. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

Granirex-1 Tablet should be cautiously used by patients with liver diseases. Please consult your doctor if you have a history of liver impairment before starting Granirex-1 Tablet .

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Kidney

Caution

Granirex-1 Tablet should be cautiously used by patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Consult your doctor

Safety and efficacy of Granirex-1 Tablet are not established in children below 2 years of age.

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Heart

Caution

Granirex-1 Tablet should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Granirex-1 Tablet .

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Geriatrics

Safe if prescribed

Granirex-1 Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Granirex-1 Tablet

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control centre immediately. Watch for symptoms such as a severe headache, dizziness, or a rapid heart rate.

Diet & Lifestyle Advise

  • Eat small, frequent meals: Instead of three large meals, eat five or six small, bland snacks throughout the day to keep your stomach settled.
  • Choose bland foods: Stick to simple options like dry toast, crackers, plain rice, oatmeal, or boiled potatoes. Avoid greasy, spicy, or very sweet foods.
  • Stay hydrated: Sip clear liquids like water, diluted juices, broth, or decaffeinated teas slowly throughout the day. Avoid drinking large amounts of fluids during meals.
  • Avoid strong odours: Stay away from strong cooking smells, perfumes, or smoke, as these can easily trigger nausea. Have someone else prepare food if possible.
  • Rest upright after eating: Sit or recline with your head elevated for at least 30 to 60 minutes after eating to aid digestion and prevent nausea.
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How Soon It Starts Working

The time required for Granirex-1 Tablet to start to work: Granirex-1 Tablet ideally shows its action within 30 to 60 minutes after administration. The time for which the effects of Granirex-1 Tablet last: The effect of Granirex-1 Tablet lasts for 24 hours.

What if you forget to take Granirex-1 Tablet

This medicine is usually taken shortly before a scheduled medical treatment. If you miss your dose, contact your doctor or healthcare team immediately for instructions. Do not take a double dose to make up for a missed one.

Storage

•Store Granirex-1 Tablet tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the medicine in its original packaging to protect it from direct light and moisture.

Drug Warnings

  • Take it at the prescribed time: Take your dose exactly as directed before your chemotherapy or radiation session so the medicine can work effectively to prevent nausea and vomiting.
  • Use caution when driving: Granirex-1 Tablet may cause dizziness, drowsiness, or fatigue. Avoid driving or operating machinery until you know how this medicine affects you.
  • Watch for constipation: Contact your doctor if you develop severe constipation, abdominal pain, or if you do not have a bowel movement for several days.
  • Tell your doctor about all your medicines: Inform your doctor if you are taking medicines for depression, anxiety, migraine, or other conditions, as some can interact with Granirex-1 Tablet and increase the risk of serious side effects such as serotonin syndrome or heart rhythm problems.
  • Use only as prescribed: Take Granirex-1 Tablet only at the prescribed dose and schedule. Do not take extra doses or continue treatment for longer than recommended unless advised by your doctor.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are using any of the following medicines or skin products, as they may interact with Granirex-1 Tablet .

  • Antidepressants (SSRIs, SNRIs, MAOIs): Combining these with Granirex-1 Tablet can increase the risk of serotonin syndrome, a rare but serious condition.
  • Heart rhythm medications (QT prolonging drugs): Medicines that affect your heart's electrical activity can increase the risk of irregular heartbeats when taken with Granirex-1 Tablet .
GranisetronSaquinavir
Critical

Drug-Drug Interactions

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How does the drug interact with Granirex-1 Tablet:
Taking Granirex-1 Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Granirex-1 Tablet with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronSaquinavir
Critical
How does the drug interact with Granirex-1 Tablet:
When Granirex-1 Tablet is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granirex-1 Tablet with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granirex-1 Tablet:
Taking Granirex-1 Tablet with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Granirex-1 Tablet with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granirex-1 Tablet:
Taking Granirex-1 Tablet with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Granirex-1 Tablet with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Granirex-1 Tablet:
Taking Granirex-1 Tablet with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granirex-1 Tablet with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronMesoridazine
Critical
How does the drug interact with Granirex-1 Tablet:
Taking Granirex-1 Tablet with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Granirex-1 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granirex-1 Tablet:
Taking Granirex-1 Tablet with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granirex-1 Tablet with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granirex-1 Tablet:
Taking Granirex-1 Tablet with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granirex-1 Tablet with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Granirex-1 Tablet:
Coadministration of Ivabradine with Granirex-1 Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Ivabradine with Granirex-1 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
GranisetronHalofantrine
Severe
How does the drug interact with Granirex-1 Tablet:
Taking Granirex-1 Tablet with halofantrine increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Granirex-1 Tablet with Halofantrine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No clinically significant food interactions are known with Granirex-1 Tablet when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Granirex-1 Tablet is used to treat nausea and vomiting caused by medical treatments.
Granirex-1 Tablet contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Granirex-1 Tablet relieves from post-operative nausea and vomiting symptoms.
Granirex-1 Tablet may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.
Granirex-1 Tablet should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.
You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.
Take Granirex-1 Tablet as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
Yes, you can take Granirex-1 Tablet with or without food. If you have a sensitive stomach, taking it with a small meal may help. Talk to your doctor for personalised advice.
While drowsiness is not the most common side effect, some people may feel tired, weak, or dizzy while taking this medicine. Avoid driving until you know how it affects you, and talk to your doctor if this concerns you.
There is limited information on the safety of Granirex-1 Tablet during pregnancy. You should only use it if your doctor determines the benefits outweigh the risks. Talk to your doctor if you are pregnant or planning to become pregnant.
Do not take an extra dose to replace the one you threw up. Contact your doctor or healthcare team immediately for instructions on what to do next.
No, Granirex-1 Tablet is specifically indicated to prevent nausea and vomiting associated with cancer chemotherapy and radiation therapy. It is not recommended for general stomach bugs. Talk to your doctor to find an appropriate treatment.
It is best to avoid alcohol while taking this medicine, as alcohol can increase side effects like dizziness and may worsen nausea. Talk to your doctor or pharmacist about safe drinking habits during your treatment.

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Country of origin

India

Manufacturer/Marketer address

608 B Wing, 6Th Floor, Manubhai Tower, Sayajigunj, Sayajigunj, Vadodara, Gujarat 390005
Other Info - GRA0406
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