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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Grandem MD Tablet is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy. It contains Granisetron, which works by blocking a natural substance (serotonin) in the body that causes nausea and vomiting. This medicine may sometimes cause side effects such as diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, and drowsiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Whats That

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Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Grandem MD Tablet

Grandem MD Tablet belongs to the class of ‘anti-emetic’ drugs, primarily used to treat nausea and vomiting caused by medical treatments, such as chemotherapy or radiation treatment for cancer. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible, voluntary, or involuntary emptying of the contents of the stomach through the mouth.

Grandem MD Tablet contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the serotonin receptor antagonists or serotonin blockers class. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of Grandem MD Tablet include diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, drowsiness, trouble sleeping, and anxiety. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using Grandem MD Tablet. Let your doctor know if you have any liver, kidney, or heart diseases, stomach/intestinal problems, allergic reactions, or low potassium and magnesium levels in the blood before starting Grandem MD Tablet. Grandem MD Tablet may make you dizzy or drowsy, hence avoid driving if you are not mentally alert. Consult your doctor before taking Grandem MD Tablet if you are pregnant, planning for pregnancy, or breastfeeding. Avoid consuming alcohol along with Grandem MD Tablet as it could lead to increased drowsiness.

Uses of Grandem MD Tablet

Grandem MD Tablet is an antiemetic medication used primarily to prevent and treat nausea and vomiting, especially those caused by chemotherapy, radiation therapy, or surgery. The detailed uses of Grandem MD Tablet are as follows:
• Chemotherapy-Induced Nausea and Vomiting (CINV): Given before and sometimes after chemotherapy to prevent severe nausea and vomiting. Often used in combination with other antiemetics for a more effective result.
• Radiation-Induced Nausea and Vomiting (RINV): Prevents nausea associated with radiation therapy, especially to the abdomen or whole body.
• Postoperative Nausea and Vomiting (PONV): Used to prevent or treat nausea and vomiting after surgery under general anaesthesia.

Directions for Use

  • Grandem MD Tablet can be taken with or without food, or as your doctor advises.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Grandem MD Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Grandem MD Tablet contains an anti-emetic drug, 'Granisetron', that treats nausea and vomiting caused by cancer treatment (chemotherapy or radiation therapy) or after surgery, etc. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induce nausea and vomiting. Grandem MD Tablet works by blocking the brain's serotonin activity and preventing post-operative nausea and vomiting.

How Grandem MD Tablet Works

Grandem MD Tablet contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron' that belongs to the class of serotonin receptor antagonists or serotonin blockers. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Grandem MD Tablet

Take Grandem MD Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include a headache. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Grandem MD Tablet may cause serotonin syndrome/toxicity when used with other drugs like ecstasy (MDMA) and antidepressants. Hence it is suggested to seek medical advice if you are using any prescription or non-prescription medicines. Inform your doctor if you have a history of stomach/intestinal problems like stomach ache, wind, feeling or being sick, and difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Grandem MD Tablet. Please consult your doctor if you are pregnant or breastfeeding if the doctor has advised you Grandem MD Tablet. Grandem MD Tablet may make you feel dizzy, so drive only if you are alert. Avoid consuming alcohol as it could lead to increased dizziness. Grandem MD Tablet is not recommended in children below two years of age.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronMesoridazine
Critical
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Grandem MD Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSaquinavir
Critical
How does the drug interact with Grandem MD Tablet:
When Grandem MD Tablet is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronProcainamide
Severe
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with procainamide increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Grandem MD Tablet and Procainamide together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
GranisetronTryptophan
Severe
How does the drug interact with Grandem MD Tablet:
When Grandem MD Tablet is taken with tryptophan, can increase the risk of serotonin syndrome (condition in which a chemical called serotonin increase in body).

How to manage the interaction:
There may be a possibility of interaction between Grandem MD Tablet and Tryptophan, but it can be taken if prescribed by a doctor. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea, consult a doctor. Do not discontinue any medications without consulting a doctor

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol and smoking.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIEMETICS
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Alcohol

Unsafe

You are recommended to limit or avoid alcohol consumption while taking Grandem MD Tablet. Alcohol intake, along with Grandem MD Tablet, may cause increased dizziness.

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Pregnancy

Consult your doctor

It is not known if Grandem MD Tablet affects pregnancy. Please consult your doctor if you are pregnant or planning to conceive before using Grandem MD Tablet.

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Breast Feeding

Caution

It is not known if this medicine passes into breast milk. Please consult your doctor before taking Grandem MD Tablet if you are a nursing mother.

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Driving

Unsafe

Grandem MD Tablet may make you feel dizzy that affects your mental ability. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

Grandem MD Tablet should be cautiously used by patients with liver diseases. Please consult your doctor if you have a history of liver impairment before starting Grandem MD Tablet.

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Kidney

Caution

Grandem MD Tablet should be cautiously used by patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Consult your doctor

Safety and efficacy of Grandem MD Tablet are not established in children below 2 years of age.

Have a query?

FAQs

Grandem MD Tablet is used to treat nausea and vomiting caused by medical treatments.

Grandem MD Tablet contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Grandem MD Tablet relieves from post-operative nausea and vomiting symptoms.

Grandem MD Tablet may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.

Grandem MD Tablet should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.

You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.

Take Grandem MD Tablet as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3Rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai €“ 400 001, India.
Other Info - GRA0304

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