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  3. Graniset 1 Tablet 4's

Graniset 1 Tablet 4's, Pack of 4 TABLETS
Graniset 1 Tablet 4's, Pack of 4 TABLETS
Graniset 1 Tablet 4's, Pack of 4 TABLETS
Graniset 1 Tablet 4's, Pack of 4 TABLETS
Graniset 1 Tablet 4's, Pack of 4 TABLETS
Graniset 1 Tablet 4's, Pack of 4 TABLETS
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Graniset 1 Tablet is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy. It contains Granisetron, which works by blocking a natural substance (serotonin) in the body that causes nausea and vomiting. This medicine may sometimes cause side effects such as diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, and drowsiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Graniset 1 Tablet

Graniset 1 Tablet belongs to the class of ‘anti-emetic’ drugs, primarily used to treat nausea and vomiting caused by medical treatments, such as chemotherapy or radiation treatment for cancer. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible, voluntary, or involuntary emptying of the contents of the stomach through the mouth.

Graniset 1 Tablet contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the serotonin receptor antagonists or serotonin blockers class. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of Graniset 1 Tablet include diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, drowsiness, trouble sleeping, and anxiety. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using Graniset 1 Tablet. Let your doctor know if you have any liver, kidney, or heart diseases, stomach/intestinal problems, allergic reactions, or low potassium and magnesium levels in the blood before starting Graniset 1 Tablet. Graniset 1 Tablet may make you dizzy or drowsy, hence avoid driving if you are not mentally alert. Consult your doctor before taking Graniset 1 Tablet if you are pregnant, planning for pregnancy, or breastfeeding. Avoid consuming alcohol along with Graniset 1 Tablet as it could lead to increased drowsiness.

Uses of Graniset 1 Tablet

Graniset 1 Tablet is an antiemetic medication used primarily to prevent and treat nausea and vomiting, especially those caused by chemotherapy, radiation therapy, or surgery. The detailed uses of Graniset 1 Tablet are as follows:
• Chemotherapy-Induced Nausea and Vomiting (CINV): Given before and sometimes after chemotherapy to prevent severe nausea and vomiting. Often used in combination with other antiemetics for a more effective result.
• Radiation-Induced Nausea and Vomiting (RINV): Prevents nausea associated with radiation therapy, especially to the abdomen or whole body.
• Postoperative Nausea and Vomiting (PONV): Used to prevent or treat nausea and vomiting after surgery under general anaesthesia.

Directions for Use

  • Graniset 1 Tablet can be taken with or without food, or as your doctor advises.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Graniset 1 Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Graniset 1 Tablet contains an anti-emetic drug, 'Granisetron', that treats nausea and vomiting caused by cancer treatment (chemotherapy or radiation therapy) or after surgery, etc. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induce nausea and vomiting. Graniset 1 Tablet works by blocking the brain's serotonin activity and preventing post-operative nausea and vomiting.

How Graniset 1 Tablet Works

Graniset 1 Tablet contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron' that belongs to the class of serotonin receptor antagonists or serotonin blockers. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Storage

Store in a cool and dry place away from sunlight
Side effects of Graniset 1 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

What if I have taken an overdose of Graniset 1 Tablet

Take Graniset 1 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include a headache. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Graniset 1 Tablet may cause serotonin syndrome/toxicity when used with other drugs like ecstasy (MDMA) and antidepressants. Hence it is suggested to seek medical advice if you are using any prescription or non-prescription medicines. Inform your doctor if you have a history of stomach/intestinal problems like stomach ache, wind, feeling or being sick, and difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Graniset 1 Tablet. Please consult your doctor if you are pregnant or breastfeeding if the doctor has advised you Graniset 1 Tablet. Graniset 1 Tablet may make you feel dizzy, so drive only if you are alert. Avoid consuming alcohol as it could lead to increased dizziness. Graniset 1 Tablet is not recommended in children below two years of age.

Drug-Drug Interactions

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GranisetronMesoridazine
Critical
GranisetronThioridazine
Critical

Drug-Drug Interactions

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GranisetronMesoridazine
Critical
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Graniset 1 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronThioridazine
Critical
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Graniset 1 Tablet with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSaquinavir
Critical
How does the drug interact with Graniset 1 Tablet:
When Graniset 1 Tablet is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Graniset 1 Tablet with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronPimozide
Critical
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Graniset 1 Tablet with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronSparfloxacin
Critical
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Graniset 1 Tablet with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronZiprasidone
Critical
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Graniset 1 Tablet with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronDronedarone
Critical
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Graniset 1 Tablet with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronCisapride
Critical
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Graniset 1 Tablet with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronBedaquiline
Severe
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with Bedaquiline, increases the risk of an abnormal heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Graniset 1 Tablet and Bedaquiline, but it can be taken if prescribed by a doctor. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
GranisetronVemurafenib
Severe
How does the drug interact with Graniset 1 Tablet:
Taking Graniset 1 Tablet with Vemurafenib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Graniset 1 Tablet and Vemurafenib, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol and smoking.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Graniset 1 Tablet Substitute

Substitutes safety advice

  • Grandem MD Tablet 10's

    by AYUR

    ₹10.35per tablet

  • Grandem-1 Tablet 10's

    by AYUR

    ₹9.45per tablet

  • Grandem Syrup 10 ml

    by Others

    ₹4.86per tablet

  • Graniforce Syrup 10 ml

    by Others

    ₹5.31per tablet

  • Granicip 1 DT Tablet 4's

    by Others

    ₹24.42per tablet

Product Substitutes

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Alcohol

Unsafe

You are recommended to limit or avoid alcohol consumption while taking Graniset 1 Tablet. Alcohol intake, along with Graniset 1 Tablet, may cause increased dizziness.

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Pregnancy

Consult your doctor

It is not known if Graniset 1 Tablet affects pregnancy. Please consult your doctor if you are pregnant or planning to conceive before using Graniset 1 Tablet.

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Breast Feeding

Caution

It is not known if this medicine passes into breast milk. Please consult your doctor before taking Graniset 1 Tablet if you are a nursing mother.

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Driving

Unsafe

Graniset 1 Tablet may make you feel dizzy that affects your mental ability. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

Graniset 1 Tablet should be cautiously used by patients with liver diseases. Please consult your doctor if you have a history of liver impairment before starting Graniset 1 Tablet.

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Kidney

Caution

Graniset 1 Tablet should be cautiously used by patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Consult your doctor

Safety and efficacy of Graniset 1 Tablet are not established in children below 2 years of age.

Have a query?

FAQs

Graniset 1 Tablet is used to treat nausea and vomiting caused by medical treatments.

Graniset 1 Tablet contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Graniset 1 Tablet relieves from post-operative nausea and vomiting symptoms.

Graniset 1 Tablet may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.

Graniset 1 Tablet should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.

You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.

Take Graniset 1 Tablet as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - GRA0013

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

May 13, 2025 | 7:29 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.webmd.com/drugs/2/drug-8545/granisetron-hcl-intravenous/details
  2. https://www.medicines.org.uk/emc/files/pil.2685.pdf
  3. https://www.drugs.com/mtm/granisetron.html
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