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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Gufistra 2mg Tablet is used for hormonal replacement therapy for treating hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). In addition to this, it also helps in preventing osteoporosis. It is prescribed when the body is not producing a sufficient amount of natural estrogen. It contains estradiol, which regulates the menstrual cycle and ovulation. It works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause. In some cases, it may cause side effects such as headache, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding.

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Whats That

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Composition :

ESTRADIOL-2MG

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Gufistra 2mg Tablet

Gufistra 2mg Tablet is indicated for hormonal replacement therapy for treating hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). In addition to this, it also helps in preventing osteoporosis. Gufistra 2mg Tablet is prescribed when the body is not producing a sufficient amount of natural estrogen.

Gufistra 2mg Tablet contains estradiol, which regulates the menstrual cycle and ovulation. Gufistra 2mg Tablet works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause. 

You are advised to take Gufistra 2mg Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. You may experience headaches, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding in some cases. Most of these side effects of Gufistra 2mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Inform your doctor if you have any history of vaginal bleeding, breast cancer, or blood clot in the legs or lungs. If you are pregnant or breastfeeding, please do not take Gufistra 2mg Tablet. While taking Gufistra 2mg Tablet, your doctor may advise regular tests to monitor its working. Grapefruit juice and St.John’s wort (a natural remedy for depression) should not be taken along with Gufistra 2mg Tablet.

Uses of Gufistra 2mg Tablet

Gufistra 2mg Tablet is used in the treatment of hormone replacement therapy, osteoporosis and hypoestrogenism. The detailed uses of Gufistra 2mg Tablet are as follows:
•Hormone Replacement Therapy (HRT): Gufistra 2mg Tablet is widely used in hormone replacement therapy to alleviate menopause symptoms, such as hot flashes and vaginal dryness, by supplying estrogen to the body.
•Regulation of Menstrual Cycle: Gufistra 2mg Tablet helps regulate menstrual cycles in women with hormonal imbalances, including conditions like polycystic ovary syndrome (PCOS).
•Support for Fertility Treatments: Gufistra 2mg Tablet is often utilized in fertility protocols, aiding in the preparation of the uterine lining for implantation during assisted reproductive technologies like IVF.
•Management of Menstrual Disorders: Gufistra 2mg Tablet is prescribed to manage various menstrual disorders, such as heavy menstrual bleeding (menorrhagia) and painful menstruation (dysmenorrhea).
•Bone Health: By providing estrogen, Gufistra 2mg Tablet supports bone density maintenance and helps reduce the risk of osteoporosis in postmenopausal women, promoting better bone health.

Directions for Use

Swallow Gufistra 2mg Tablet as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Gufistra 2mg Tablet contains a synthetic female hormone that regulates ovulation and menstruation in women. Gufistra 2mg Tablet is given as a hormone replacement therapy for estrogen. It is also used in the treatment to relieve symptoms of menopause, such as mood swings, reduced sex drive, hot flashes, night sweats and vaginal dryness.

How Gufistra 2mg Tablet Works

Gufistra 2mg Tablet contains estradiol, which regulates the menstrual cycle and ovulation. Gufistra 2mg Tablet works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Gufistra 2mg Tablet

  • Headache
  • Bloating
  • Hair loss
  • Nausea
  • Weight gain
  • Breast pain
  • Irregular vaginal bleeding

What if I have taken an overdose of Gufistra 2mg Tablet

Do not take more than the prescribed dose of Gufistra 2mg Tablet as it may cause overdose. The symptoms of overdose include vomiting, nausea and vaginal bleeding. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Gufistra 2mg Tablet if you are allergic to any of its ingredients. Inform your doctor if you have breast cancer, vaginal bleeding, blood clot in the leg (deep venous thrombosis), lungs (pulmonary embolism), vein (thrombosis), cancer of the endometrium (womb lining), any blood clotting disorder, recently had a heart attack, liver or kidney disease, porphyria (a group of liver disease), high blood pressure, if you are pregnant or breastfeeding. Avoid smoking as it greatly increases the risk of blood clots, stroke, and heart attack while taking Gufistra 2mg Tablet. Grapefruit juice and St. John’s wort (a natural remedy for depression) should not be taken along with Gufistra 2mg Tablet. 

Drug-Drug Interactions

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EstradiolBivalirudin
Critical
EstradiolLenalidomide
Severe

Drug-Drug Interactions

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EstradiolBivalirudin
Critical
How does the drug interact with Gufistra 2mg Tablet:
When Etodolac is taken with Bivalirudin, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Bivalirudin with Gufistra 2mg Tablet can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
EstradiolLenalidomide
Severe
How does the drug interact with Gufistra 2mg Tablet:
Coadministration of Gufistra 2mg Tablet and Lenalidomide can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Gufistra 2mg Tablet, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolAnastrozole
Severe
How does the drug interact with Gufistra 2mg Tablet:
Gufistra 2mg Tablet may interfere with anastrozole's function and make it less effective in treating your condition.

How to manage the interaction:
Co-administration of Anastrozole with Gufistra 2mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EstradiolThalidomide
Severe
How does the drug interact with Gufistra 2mg Tablet:
Taking thalidomide together with Gufistra 2mg Tablet may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Gufistra 2mg Tablet and thalidomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
EstradiolClindamycin
Severe
How does the drug interact with Gufistra 2mg Tablet:
When taken in combination, clindamycin can lower the amount or action of Gufistra 2mg Tablet.

How to manage the interaction:
Co-administration of Gufistra 2mg Tablet with Clindamycin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EstradiolPomalidomide
Severe
How does the drug interact with Gufistra 2mg Tablet:
Co-administration of Gufistra 2mg Tablet and Pomalidomide can increase the risk of serious blood clots.

How to manage the interaction:
There may be a possibility of interaction between Gufistra 2mg Tablet and Pomalidomide, but it can be taken if prescribed by a doctor. However, if you experience symptoms like chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EstradiolTranexamic acid
Severe
How does the drug interact with Gufistra 2mg Tablet:
Co-administration of Gufistra 2mg Tablet with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Gufistra 2mg Tablet with Tranexamic acid can lead to an interaction; however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolDantrolene
Severe
How does the drug interact with Gufistra 2mg Tablet:
The usage of Gufistra 2mg Tablet with dantrolene might have significant adverse effects on your liver.

How to manage the interaction:
Taking Gufistra 2mg Tablet with Dantrolene together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, severe fatigue or weakness, unusual bleeding or bruising, skin rash or itching, lack of appetite, nausea, vomiting, or yellowing of the skin or whites of your eyes, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolLetrozole
Severe
How does the drug interact with Gufistra 2mg Tablet:
Letrozole may have a negative effect when used with Gufistra 2mg Tablet, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letrozole and Gufistra 2mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EstradiolCarfilzomib
Severe
How does the drug interact with Gufistra 2mg Tablet:
Carfilzomib can cause serious blood clots and taking it alongside Gufistra 2mg Tablet may enhance the risk.

How to manage the interaction:
Co-administration of Gufistra 2mg Tablet with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ESTRADIOL-2MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ESTRADIOL-2MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
The rate of absorption of oral estrogens may be increased by coadministration with grapefruit juice. Avoid or restrict the consumption of grapefruit juice while taking Gufistra 2mg Tablet.

Diet & Lifestyle Advise

  • Regular exercise and physical activity can minimize hot flashes and improve sleep. Weight-bearing exercises can also help strengthen bones. Aerobics, yoga, and activities like tai chi may help relax the body and mind.
  • Wear loose clothes before going to bed and sleep in a cool, well-ventilated room. This can prevent symptoms of hot flashes and night sweats. Get a minimum of 8 hours of sleep. 
  • Avoid or limit intake of caffeine-containing beverages, alcohol, and spicy food, as these are known triggering agents for hot flushes.
  • Try to be stress-free to improve your mood swings due to hormonal fluctuations. 
  • Quitting smoking will help reduce hot flashes and your risk of developing chronic conditions like heart disease, stroke, and cancer.

Habit Forming

No

Therapeutic Class

HORMONES

Gufistra 2mg Tablet Substitute

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Gufistra 2mg Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

Gufistra 2mg Tablet is not recommended during pregnancy as it may harm the baby and cause serious complications for the baby and mother.

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Breast Feeding

Unsafe

Gufistra 2mg Tablet is not recommended for breastfeeding mothers as it is known to cause harm to the baby.

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Driving

Safe if prescribed

It is not known to cause any side effects which may affect driving.

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Liver

Caution

Gufistra 2mg Tablet should be taken with caution, especially if you have a history of liver diseases. Your doctor may have to adjust the dose.

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Kidney

Caution

Gufistra 2mg Tablet should be taken with caution, especially if you have a history of kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

Gufistra 2mg Tablet is not recommended for children below 12 years of age.

FAQs

Gufistra 2mg Tablet is used to treat hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). This medicine is prescribed when the body is not producing a sufficient amount of natural estrogen.

Gufistra 2mg Tablet works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause.

Do not use Gufistra 2mg Tablet if you are allergic to peanuts, have unusual vaginal bleeding, have/had any cancer (breast or uterus cancer), or undergoing any other estrogen treatment. Tell your doctor if you had a heart attack, stroke, blood clot, or liver problems, if you are pregnant, breastfeeding, or planning to get pregnant.

No, Gufistra 2mg Tablet should not be taken if you are undergoing surgery. You should inform your doctor, and he might ask you to stop hormone replacement therapy about 4 to 6 weeks before surgery to reduce the risk of blood clots.

Gufistra 2mg Tablet may cause weight gain or loss, a common side effect. Regular exercise and a healthy diet can help prevent weight gain.

Do not discontinue Gufistra 2mg Tablet without consulting your doctor as stopping the medicine can cause your symptoms to come back. Consult the doctor, he/she might reduce the dose gradually.

If you miss a dose of Gufistra 2mg Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

You may experience side effects like headaches, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding. Consult the doctor if the side effects persist or worsen.

Foods like flaxseeds, soy, peaches, garlic, sesame seeds, kale, broccoli, Brussels sprouts, peanuts, almonds, cashews, and pistachios can be included in your diet for oestrogen deficiency.

Do not take Gufistra 2mg Tablet if you are allergic to any of its components or if you had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina or have undiagnosed vaginal bleeding, liver disease, or a bleeding disorder.

Gufistra 2mg Tablet should be swallowed as a whole with water; do not crush or chew it. It can be taken with or without food; taking with food or after meals may help prevent stomach upset.

Country of origin

India

Manufacturer/Marketer address

37,1St Floor, Kamala Bhavan Ii, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (India).
Other Info - GUFI665

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