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compositionComposition:FEXOFENADINE-120MG
prescription
Prescription Medicine
info
Histafree-120 Tablet 10's
Histafree-120 Tablet 10's
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

FEXOFENADINE-120MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Histafree-120 Tablet

Histafree-120 Tablet is an antihistamine medicine used to relieve symptoms of seasonal allergies and chronic, unexplained hives. It is commonly taken to manage frequent sneezing, a runny or itchy nose, watery eyes, and itchy skin rashes. By targeting the root cause of these allergic responses, this medicine helps you maintain your daily routine without discomfort.

To achieve the best results, Histafree-120 Tablet is typically taken once or twice daily, depending on your specific needs and your doctor's recommendations. For consistent control of seasonal allergies, it is most effective when taken daily around the same time throughout the allergy season. You can take this medicine with or without food, but you should always take it with a full glass of water rather than fruit juice. Incorporating simple lifestyle adjustments, such as using an indoor air purifier and keeping windows closed when pollen counts are high, can significantly support the effectiveness of your treatment.

While this medicine is highly effective and generally well-tolerated, some individuals may experience mild side effects like headaches, drowsiness, or dry mouth. These symptoms are usually temporary and resolve on their own. However, if you experience rare but serious side effects—such as severe dizziness, swelling of your face or throat, or difficulty breathing—you should seek emergency medical care immediately and consult your doctor.

Before you begin taking Histafree-120 Tablet , it is important to discuss your medical history with your healthcare provider. Talk to your doctor if you have kidney disease, as your body may require a modified dosing schedule. Do not take this medicine if you have had a known allergic reaction to it or any of its inactive ingredients in the past.

Certain substances can interfere with how this medicine works in your body. For instance, taking it alongside antacids containing aluminium or magnesium can reduce its absorption, making it less effective. Additionally, you should consult your doctor or pharmacist if you are pregnant, breastfeeding, or planning a pregnancy to ensure this treatment is appropriate for your situation.

Uses of Histafree-120 Tablet

A doctor may prescribe or recommend Histafree-120 Tablet for the following conditions:

  • Seasonal Allergic Rhinitis: Helps relieve outdoor allergy symptoms, including sneezing, runny nose, itchy throat, and red, watery eyes.
  • Chronic Idiopathic Urticaria: Reduces the severity of ongoing, unexplained hives, including skin swelling, redness, and intense itching.

Key Benefits

Histafree-120 Tablet provides reliable relief from bothersome allergy symptoms, helping you return to your normal daily activities. Key benefits include:

  • Non-Drowsy Relief: Unlike older allergy medications, this formula does not easily cross into the brain, meaning it provides effective relief without causing significant drowsiness. This allows you to stay alert and focused at work, school, or while driving.
  • Long-Lasting Control: A single dose provides up to 24 hours of continuous protection, preventing allergy symptoms from returning throughout the day or night.
  • Rapid Action: The medicine begins working within one to two hours, quickly easing discomfort from sudden allergy flare-ups or hives.
Side effects of Histafree-120 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

Directions for Use

To ensure you get the maximum benefit from Histafree-120 Tablet , follow these steps carefully:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can interfere with how the medicine is released into your body.
  • If you are taking the liquid suspension form, shake the bottle well before each dose to distribute the medicine evenly.
  • Always use the special dose-measuring spoon, syringe, or cup provided with the liquid medicine. Do not use a regular household spoon, as it may not provide the correct dose.
  • Take this medicine with or without food, but always avoid taking it with fruit juices.

Always take this medicine exactly as directed by your doctor or as outlined on the product packaging.

How Histafree-120 Tablet Works

Histafree-120 Tablet belongs to a class of medicines known as second-generation antihistamines. When your body encounters an allergen, such as pollen, dust mites, or pet dander, it releases a natural chemical called histamine. Histamine binds to specific receptors in your tissues, causing blood vessels to expand and fluids to leak, which leads to typical allergy symptoms like sneezing, watery eyes, swelling, and itching. The active ingredient, fexofenadine, works by selectively blocking these histamine receptors throughout the body. By preventing histamine from binding to these sites, the medicine stops the allergic response. Because it target-blocks peripheral receptors and does not significantly enter the central nervous system, it delivers powerful relief without the sedating effects common in older antihistamines.
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Alcohol

Unsafe

Avoid alcohol consumption while taking Histafree-120 Tablet as it may cause increased drowsiness.

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Pregnancy

Consult your doctor

Histafree-120 Tablet should not be used during pregnancy unless clearly necessary. Please consult your doctor.

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Breast Feeding

Consult your doctor

Caution should be exercised, it is advisable to consult a doctor before using it.

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Driving

Unsafe

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking Histafree-120 Tablet you should not drive or operate any machinery or vehicles.

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Liver

Caution

Histafree-120 Tablet to be taken with caution, especially if you have a history of liver disease.

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Kidney

Caution

Histafree-120 Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Histafree-120 Tablet is not recommended for use in children below 12 years of age.

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Heart

Safe if prescribed

Histafree-120 Tablet can be used safely in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Consult your doctor

Please consult a doctor before giving Histafree-120 Tablet to geriatric patients. Your doctor will prescribe Histafree-120 Tablet if the benefits outweigh the risks

What if I have taken an overdose of Histafree-120 Tablet

Do not take more than the prescribed dose of Histafree-120 Tablet as it may cause overdose. The symptoms of overdose include dizziness, dry mouth or drowsiness. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Implementing these practical, evidence-based habits can help manage your allergy symptoms and support your treatment:

  • Avoid fruit juices: Do not drink grapefruit, orange, or apple juice within two hours before or after taking your medicine, as these juices contain compounds that significantly decrease how much medicine your body can absorb.
  • Monitor pollen counts: Keep doors and windows closed on days when pollen counts are high, and use an air conditioner with a clean filter to keep indoor air clean.
  • Shower after being outdoors: Wash your hair and skin after spending time outside to remove pollen and other outdoor allergens that can cling to your body.
  • Manage indoor allergens: Wash your bed linens weekly in hot water (at least 130°F or 54°C) to eliminate dust mites, and keep pets out of your bedroom to minimise dander exposure.

Health Queries

I have been taking Cetirizine daily for chronic urticaria for over a year. Is there a long-term treatment or alternative medication that can cure urticaria permanently so I can stop taking daily medication, and is there any link between masturbation and chronic urticaria?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Chronic urticaria often resolves on its own over time, but there is no instant permanent cure. Cetirizine is safe for long-term use. If you wish to stop daily pills, alternative options include other antihistamines (like fexofenadine), montelukast, or advanced targeted therapies like omalizumab, which can put hives into long-term remission. Please consult an allergist to safely discuss these options. Regarding your other concern, there is absolutely no scientific link between masturbation and chronic urticaria. Masturbation does not cause, trigger, or worsen hives, so you can be completely reassured.

Have a query?

How Soon It Starts Working

The time required for Histafree-120 Tablet to start to work: Histafree-120 Tablet ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Histafree-120 Tablet last: The effect of Histafree-120 Tablet lasts for 12 to 24 hours.

What if you forget to take Histafree-120 Tablet

If you miss a dose of Histafree-120 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store the tablets and liquid suspension at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the medicine in its original container, tightly closed, to protect it from moisture and direct light.

Drug Warnings

  • Avoid Antacids Around Dosing: Do not take antacids containing aluminium or magnesium within two hours of taking Histafree-120 Tablet , as they may significantly reduce its effectiveness.
  • Use the Correct Measuring Device: Always use the calibrated measuring device provided with the oral suspension, as household spoons may result in inaccurate dosing.
  • Stop Before Allergy Skin Tests: Discontinue Histafree-120 Tablet at least three to four days before undergoing allergy skin testing, as antihistamines may interfere with test results.
  • Consult Your Doctor if Symptoms Persist: Speak with your doctor if your allergy symptoms or hives do not improve after a few days of regular use.
  • Check the Expiry Date: Verify the expiration date before each use and do not take the medicine if it has expired.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Histafree-120 Tablet : 

  • Aluminium or magnesium antacids: Taking these antacids within two hours of your dose can decrease the absorption of Histafree-120 Tablet , making it less effective.
  • Erythromycin or ketoconazole: These medications may increase the concentration of Histafree-120 Tablet in your blood, though this rarely leads to an increase in side effects.


Drug-Food Interactions

The following foods and beverages may interact with Histafree-120 Tablet and affect its safety or effectiveness: 

  • Fruit juices: Grapefruit, orange, and apple juices can lower the amount of medicine your body absorbs, reducing its overall effectiveness. Take your dose with water instead.


Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Histafree-120 Tablet , as they may require closer monitoring or dose adjustments: 

  • Kidney disease: Your kidneys are responsible for clearing this medicine from your body. If you have decreased kidney function, the medicine may clear more slowly, which could require your doctor to adjust your dose.
FexofenadineEluxadoline
Severe
FexofenadineBosutinib
Severe

Drug-Drug Interactions

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FexofenadineEluxadoline
Severe
How does the drug interact with Histafree-120 Tablet:
When Histafree-120 Tablet and Eluxadoline are taken together, increase levels of Histafree-120 Tablet by decreasing metabolism.

How to manage the interaction:
Taking Histafree-120 Tablet with Eluxadoline together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any symptoms related to your condition, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
FexofenadineBosutinib
Severe
How does the drug interact with Histafree-120 Tablet:
Histafree-120 Tablet can considerably increase blood levels of bosutinib. This may exacerbate the adverse effects of bosutinib.

How to manage the interaction:
Although there is a possible interaction between Bosutinib and Histafree-120 Tablet, you can take these medicines together if prescribed by your doctor. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIHISTAMINE]

FAQs

Histafree-120 Tablet is used to treat allergic conditions such as hay fever (an allergy caused by pollen or dust), conjunctivitis (red, itchy eye), eczema (dermatitis), hives (red, raised patches or dots), reactions to insect bites and stings and some food allergies.

Histafree-120 Tablet contains fexofenadine (anti-histamine), which is used to treat allergies as it blocks the effects of a chemical messenger known as ‘histamine,’ which is naturally involved in allergic reactions.

Hay fever is an allergy caused due to outdoor or indoor allergens, such as pollen, dust mites, or tiny flecks of skin and saliva shed by cats, dogs, and other animals with fur or feathers (pet dander). It leads to cold-like symptoms (running nose, watery eyes).

Histafree-120 Tablet is known as a non-drowsy antihistamine. It's less likely to make you sleepy than some other antihistamines; however, in some people, it may cause sleepiness and induce drowsiness during the day. Hence you are recommended to take it in the nighttime in case you are experiencing excessive drowsiness during the day.

You should not take Histafree-120 Tablet if you have had an allergic reaction to Histafree-120 Tablet , food additives containing E218 or E216, are intolerant to lactose or sorbitol, have liver or kidney failure, epilepsy (fits), or difficulty in peeing. Tell your doctor that you are taking Histafree-120 Tablet and have booked an allergy test as it might affect the diagnostic result.

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take Histafree-120 Tablet and skip the missed dose. Do not take extra medicine to make up the missed dose.

Depending upon the severity of allergic conditions due to allergens, Histafree-120 Tablet can be safely taken daily until you get complete relief and as long as your doctor has advised you to take it.

While taking Histafree-120 Tablet , avoid drinking grapefruit, orange, or apple juice. It may increase your chances of experiencing side effects.

No, do not take two doses of Histafree-120 Tablet at the same time. Take Histafree-120 Tablet only as per the dose and duration prescribed by the doctor.

Inform the doctor if you are allergic to any medicines, have any other medical conditions or if you are pregnant or breastfeeding.

Histafree-120 Tablet should not be taken by people who are allergic to any of its components.

Do not discontinue Histafree-120 Tablet without consulting your doctor. Continue taking Histafree-120 Tablet for the prescribed duration even though you feel better.

No, Histafree-120 Tablet is not an antibiotic. It contains fexofenadine, an antihistamine used to treat allergy conditions.

Histafree-120 Tablet may cause side effects like headaches, nausea, or dizziness. If the side effects are persistent, reach out to your doctor.

Yes, you can take Histafree-120 Tablet with or without food. However, always take it with water and avoid taking it with fruit juices like apple, orange, or grapefruit juice, as they can reduce the medicine's absorption. Talk to your doctor or pharmacist if you are unsure.

This medicine typically starts working within one to two hours of taking a dose. Its effects generally last for up to 24 hours, providing all-day relief. Talk to your doctor if your symptoms do not improve after a few days of use.

While this medicine is non-drowsy, it is generally recommended to limit or avoid alcohol during treatment. Combining alcohol with antihistamines can sometimes increase the risk of side effects like dizziness or mild drowsiness. Talk to your doctor for specific advice.

You should consult your healthcare provider before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. They will help you evaluate the risks and benefits to determine the safest option. Talk to your doctor before starting this medication.

Yes, Histafree-120 Tablet is available in strengths and formulations suitable for children, such as an oral liquid suspension. The dose depends on the child's age and weight. Always consult a paediatrician before giving any medication to a child. Talk to your doctor for proper dosing instructions.

You must temporarily stop taking Histafree-120 Tablet at least three to four days before your scheduled allergy skin test. Antihistamines can suppress the skin swelling and redness that the test is looking for, resulting in inaccurate findings. Talk to your doctor or the testing clinic for exact instructions.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Fexofenadine - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Pil.3487 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Fexofenadine hydrochloride [EMC SmPC]. 2018. [Accessed on 08 Oct. 2020] Check here
  5. Drugs and Lactation Database (LactMed®) [Internet]. 2006. [Accessed on 26 June 2023] Check here
  6. National Health Services National Health Services. 2021. [Accessed on 26 June 2023] Check here
  7. Fexofenadine: antihistamine that relieves allergy symptom [Internet]. nhs.uk. 2025 [Accessed on 25 Nov 2025]Check here

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase III, New Delhi - 110020
Other Info - HIS0016

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